Lifestyle Status Research Articles

Psychotropic drug use and suggestive depression symptoms associated with NR3C1 DNA methylation

Introduction: Psychiatric disorders have become a global problem that leads millions of people to use psychotropic medications, especially benzodiazepines. The effects of these substances are widely known regarding tolerance and chemical dependence, however, from epigenetics perspective, there are still little known.
 Objective: To evaluate the association between psychotropic drug use, NR3C1 gene methylation and its relation with symptoms suggestive of depression in adult individuals assisted in the public health system.
 Methods: 385 adult volunteers (20-59 years) users of the Brazilian Unified Health System were recruited to evaluate socioeconomic, health, lifestyle conditions in a cross sectional study. BDI-II evaluated symptoms suggestive of depression and pyrosequencing evaluated NR3C1 DNA methylation. Bivariate and multivariate Poisson regression model with robust variance (p < 0.05) evaluated the association between psychotropic drug use and NR3C1 gene methylation.
 Results: Specific depressive symptoms such as irritability, insomnia and fatigability were associated with psychotropic drug use. Symptoms of past failure, indecision and loss of appetite were associated with hypermethylation patterns in CpGs 40 to 47 of NR3C1 gene. Moreover, psychotropic drug use is associated with 50% reduction in NR3C1 gene methylation, through model adjusted with socioeconomic, health and lifestyle confounding variables.
 Conclusions: Psychotropic drug use and depressive symptoms was associated with changes in NR3C1 DNA methylation. In this context, epigenetic modification resulting from psychotropic drug use and depressive symptoms could be considered, mainly in population studies with epigenetic evaluation, where these factors may be influencing the findings of future studies.

Changes in work/sleep patterns due to the COVID-19 pandemic are associated with psychological distress among Japanese workers.

The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted working life quality. This study investigated whether changes in work/sleep patterns due to the pandemic are related to poor psychological status among Japanese workers during the third wave of the COVID-19 pandemic (December 2020). We hypothesized that workers who experienced drastic changes in working hours and sleep duration would be at an increased risk of psychological distress. A cross-sectional self-administered Internet survey was conducted that included questions regarding socio-demographics, lifestyle, health, and occupational background and conditions. Multivariable logistic regression models were utilized to examine the association between psychological distress and a combination of changes in working hours and sleep duration. Among 25,762 workers, decreased work hours and decreased sleep duration presented 2.59 times higher odds of psychological distress (95% confidence interval [CI] = 2.05-3.28) compared to those who had no changes in work hours combined with unchanged sleep duration (reference group). Increased work hours and decreased sleep duration were associated with 1.98 times higher odds of psychological distress (95% CI = 1.64-2.39). Our observations confirmed that decreased sleep duration could be a key factor for psychological distress, irrespective of working hours. Interestingly, workers with a combination of decreased work hours and sleep duration posed the highest risk of psychological distress. Decreased work hours accompanied by financial difficulties in the early stage of the pandemic may have caused decreased sleep duration, resulting in a high prevalence of psychological distress. Our study underlined the importance of sleep management in maintaining workers' mental health, moreover, the need to consider situations and conditions of other daily tasks, such as work hours, for better sleep management.

Symbiotic Effect of Herbal Blend on Lifestyle Conditions and Diseases

Symbiotic Effect of Herbal Blend on Lifestyle Conditions and Diseases

Adolescent Sleep Quality in Palangka Raya City

Abstract : Sleep quality is the individual's ability to stay asleep, not just the amount or duration of sleep. Sleep quality shows the individual's ability to sleep and get the amount of rest that suits his needs. The quality of a person's sleep can be influenced by environmental, physical, activity, and lifestyle conditions. This study aims to determine the factors that can affect the quality of sleep in adolescents in the city of Palangka Raya. Methods Cross-sectional research with a cross sectional design. The number of samples was 98 students of class XI at two public high schools in Palangka Raya City, the sample was taken using proportiona (PSQI ),te stratified random sampling. Adolescent sleep quality was measured using The Pittsburgh Sleep Quality Index questionnaire. Data were analyzed through Chi Square test. The results showed that female adolescent students were more dominant in having poor sleep quality as much as 59.2%. Adolescents' poor sleep quality due to an uncomfortable environment was 82.7% (p value 0.773), poor sleep quality in students who did not do physical exercise/not tired as much as 84.9% (p value 0.34). Students with light activities had poor sleep quality as much as 84.9% (p value 0.346). Students with light activity have poor sleep quality as much as 82.4% (p value 0.720). Students who have bad sleep habits before bedtime are 80.9% (p value 0.848). Factors that affect the quality of sleep for adolescents in the city of Palangka Raya are physical exercise and fatigue

Covid 19 and its Impact on Indigenous Peoples: An Ethnographic Study on Garo community at Tangail District

People around the world have been affected in some way by the coronavirus pandemic. Garo people have been disproportionately impacted by COVID-19, which has had a high impact on their daily lives. The present study was an attempt to explore the impact of covid-19 pandemic in the Garo Community at Madhupur Upazila in Tangail District. Attaining broad objective of the study has also focused on some relevant objectives such as, gathering information about the socio-demographic condition of the Garo people, knowing the psycho-social problem faced by the affected person, observing the psychological conditions of the respondents, knowing the economic condition and gaining broad base knowledge about their lifestyle during Covid time and post-Covid time, to incorporate the recommendation and suggestion to improve their lifestyle and socioeconomic condition in post-Covid time. Our main research approach is Qualitative research and we used the Ethnographic method for collecting information we also used the case study method by using purposive sampling taking five in-depth interviews on the basis of our study objectives. The research shows the actual picture of the Garo community during Covid time. The research found that the Garos have faced great trouble during the worldwide pandemic situation. Most of the Garos are farmers and day laborers, during the lockdown, they lose their work; farmers didn’t buy fertilizer and pesticides so their production decreased and they faced an economic crisis, during lockdown they lose their communication system and social isolation which creates loneliness and psychological problem. Due to government instruction, they maintain social isolation and could not perform religious programs, marriage, and other cultural programs limited within the family. They live in a remote place, with no hospital or healthcare facility available there, they suffered a lot of health problems, and Covid positive people did not get enough healthcare support so the death rate was so high.

Prevalence of Risk Indicators of Heart Diseases Among Professional Male Bus Drivers

The study aims to determine the prevalence of heart disease risk indicators among male professional bus drivers. A quarter of all mortality is attributable toheart disease. The risk of heart disease is now more common among male professional bus drivers due to irregular diet, lifestyle and shift of work. This observational study included 100 male professional drivers selected by convenience sampling from an MTC bus stand (Chennai bus depot) and ACS medical college and hospital drivers. Face-to-face questioning strategies were administered to obtain information about their lifestyle conditions and shift of work from all participants. The Anthropometric measurement such as body mass index, blood pressure, and fasting blood glucose level is measured by a handheld BMI machine, sphygmomanometer and glucometer. The risk score for the indicators of cardiovascular diseases (CVD)is estimated using a gender-specific Framingham risk score. The data analysis shows nearly 55% of subjects are in the low-risk category, 35% of issues are in the intermediate-risk category, and 10% are subjects in the high-risk category of developing a cardiovascular disease based on the estimation of 10 years of cardiovascular disease risk. The study concluded that bus drivers are at intermediate and high risk of developing CVD.Cardiovascular diseases have now become the leading cause of mortality in India. The risk of heart disease is more common among male professional bus drivers. The drivers are exposed to several possible risk indicators of cardiovascular diseases. Low physical activity levels were associated with higher CVD among male professional bus drivers.

Study of the Health-promoting Lifestyle Status in Nursing Students of Ardabil School of Nursing and Midwifery 2019

Study of the Health-promoting Lifestyle Status in Nursing Students of Ardabil School of Nursing and Midwifery 2019

Abstract P231: Physical Activity During Adolescence and Adulthood Associated to Risk of Diabetes in Mexican Women

Background: Mexico has declared an epidemiological emergency in the country due to diabetes. Although the benefits of physical activity in middle age are established, the health effects of long-term changes in PA from adolescence to middle age have not been documented. Our aim is to explore the pattern of vigorous physical activity (VPA) in adolescence and adulthood and the risk of DM2 in a cohort of middle-age women. Methods: The Mexican Teacher′s Cohort (MTC) is an ongoing study of 115,307 public school teachers. Every three years participants answered sociodemographic, lifestyle, and medical conditions, including self-reported IPA(hours/wk) for age 15 to18 years, and at the previous year of baseline. Cases of diabetes were identified and validated through electronic health records. We estimated Hazard ratios and IC95% intervals. Based on VPA in adolescence and adulthood respectively, women were classified as: consistently inactive (reference), consistently lower activity, low active in adolescence but increase in adulthood, active in adolescence but reduced in adulthood, and consistently higher. To explore recall bias we performed analyzes stratified by age. Results: in a sample of 69,970 women with 41.6 ± 7.3 years of age at enrolment, we identified 4,564 DM cases from 2006-2008 to 2019. Compared with participants who were consistently inactive in both stages, women who increase activity had a lower risk of DM; HR = 0.86 (95% CI 0.74, 1.01). Compared with the reference category, maintaining higher amounts of VPA was associated with lower diabetes risk HR = 0.85, (95% CI 0.75, 0.96). In stratified analyses by age, we observed the same association even in people who reported physical activity up to 35 years before the reference questionnaire. Conclusions: Maintaining higher VPA levels during adolescence and adulthood and increasing VPA in adulthood were associated with a similar low risk of diabetes.

HUBUNGAN PERILAKU MENYUSUI, POLA HIDUP SEHAT DAN KONDISI KESEHATAN DENGAN PEMBERIAN ASI

WHO stated that the COVID-19 pandemic had a special impact on breastfeeding mothers. This is due to concerns about COVID-19 and the safety of breastfeeding. Mothers are worried and stressed because of the reduced supply of breast milk, limited access to maternal and child health services, and delays in medical care. The purpose of this study was to determine breastfeeding behavior, healthy lifestyle and health conditions of post partum mothers regarding breastfeeding during the Covid-19 pandemic in the Ayah I Community Health Center area.This research is a type of correlational research with a retrospective approach. The population in this study were breastfeeding mothers in the area of the Ayah I Health Center as many as 105 people using the total sampling technique. Data analysis uses Chi-square to obtain the relationship between the two variables. Meanwhile, multivariate analysis used logistic regression at 95% confidence intervals.The results of the analysis showed that the factors influencing breastfeeding in the Ayah I Health Center area were breastfeeding behavior (OR=14.92; CI=3.96-81.51), and healthy lifestyle ((OR=6.28; CI=1.66-34.85) while health conditions do not affect breastfeeding.There is a relationship between breastfeeding behavior and a healthy lifestyle with breastfeeding.

Skeletal Muscles of Sedentary and Physically Active Aged People Have Distinctive Genic Extrachromosomal Circular DNA Profiles.

To bring new extrachromosomal circular DNA (eccDNA) enrichment technologies closer to the clinic, specifically for screening, early diagnosis, and monitoring of diseases or lifestyle conditions, it is paramount to identify the differential pattern of the genic eccDNA signal between two states. Current studies using short-read sequenced purified eccDNA data are based on absolute numbers of unique eccDNAs per sample or per gene, length distributions, or standard methods for RNA-seq differential analysis. Previous analyses of RNA-seq data found significant transcriptomics difference between sedentary and active life style skeletal muscle (SkM) in young people but very few in old. The first attempt using circulomics data from SkM and blood of aged lifelong sedentary and physically active males found no difference at eccDNA level. To improve the capability of finding differences between circulomics data groups, we designed a computational method to identify Differentially Produced per Gene Circles (DPpGCs) from short-read sequenced purified eccDNA data based on the circular junction, split-read signal, of the eccDNA, and implemented it into a software tool DifCir in Matlab. We employed DifCir to find to the distinctive features of the influence of the physical activity or inactivity in the aged SkM that would have remained undetected by transcriptomics methods. We mapped the data from tissue from SkM and blood from two groups of aged lifelong sedentary and physically active males using Circle_finder and subsequent merging and filtering, to find the number and length distribution of the unique eccDNA. Next, we used DifCir to find up-DPpGCs in the SkM of the sedentary and active groups. We assessed the functional enrichment of the DPpGCs using Disease Gene Network and Gene Set Enrichment Analysis. To find genes that produce eccDNA in a group without comparison with another group, we introduced a method to find Common PpGCs (CPpGCs) and used it to find CPpGCs in the SkM of the sedentary and active group. Finally, we found the eccDNA that carries whole genes. We discovered that the eccDNA in the SkM of the sedentary group is not statistically different from that of physically active aged men in terms of number and length distribution of eccDNA. In contrast, with DifCir we found distinctive gene-associated eccDNA fingerprints. We identified statistically significant up-DPpGCs in the two groups, with the top up-DPpGCs shed by the genes AGBL4, RNF213, DNAH7, MED13, and WWTR1 in the sedentary group, and ZBTB7C, TBCD, ITPR2, and DDX11-AS1 in the active group. The up-DPpGCs in both groups carry mostly gene fragments rather than whole genes. Though the subtle transcriptomics difference, we found RYR1 to be both transcriptionally up-regulated and up-DPpGCs gene in sedentary SkM. DifCir emphasizes the high sensitivity of the circulome compared to the transcriptome to detect the molecular fingerprints of exercise in aged SkM. It allows efficient identification of gene hotspots that excise more eccDNA in a health state or disease compared to a control condition.

The challenges of time for studies on the population effects of the COVID-19 pandemic on perinatal outcomes.

The challenges of time for studies on the population effects of the COVID-19 pandemic on perinatal outcomes.

Impact Of Pandemic Covid 19 On Obesity in Adolescent: A Review Article

The COVID-19 pandemic has changed human life, including health-related lifestyles. This literature review aims to analyse the incidence of obesity in adolescents during the Covid 19 pandemic. This study used the article analysis method to obtain an overview of the incidence of obesity in adolescents during the Covid 19 pandemic. Of the ten articles that met the criteria for our analysis, we found that influencing obesity during the Covid 19 period is the problem of lack of activity, increasing sedentary lifestyle, high excessive calorie intake, and the emergence of anxiety factors. Therefore, in dealing with the problem of obesity in adolescents during the COVID-19 period, they are more likely to pay attention to shifting lifestyle conditions and mental health awareness in handling it.

Gut-muscle crosstalk. A perspective on influence of microbes on muscle function.

Our gastrointestinal system functions to digest and absorb ingested food, but it is also home to trillions of microbes that change across time, nutrition, lifestyle, and disease conditions. Largely commensals, these microbes are gaining prominence with regards to how they collectively affect the function of important metabolic organs, from the adipose tissues to the endocrine pancreas to the skeletal muscle. Muscle, as the biggest utilizer of ingested glucose and an important reservoir of body proteins, is intricately linked with homeostasis, and with important anabolic and catabolic functions, respectively. Herein, we provide a brief overview of how gut microbiota may influence muscle health and how various microbes may in turn be altered during certain muscle disease states. Specifically, we discuss recent experimental and clinical evidence in support for a role of gut-muscle crosstalk and include suggested underpinning molecular mechanisms that facilitate this crosstalk in health and diseased conditions. We end with a brief perspective on how exercise and pharmacological interventions may interface with the gut-muscle axis to improve muscle mass and function.

Contribution of Genetic Polymorphisms in Human Health.

Human health is influenced by various factors; these include genetic inheritance, behavioral lifestyle, socioeconomic and environmental conditions, and public access to care and therapies in case of illness, with the support of the national health system. All these factors represent the starting point for the prevention and promotion of a healthy lifestyle. However, it is not yet clear to what extent these factors may actually affect the health of an entire population. The exposures to environmental and occupational factors are several, most of which might be poorly known, contributing to influencing individual health. Personal habits, including diet, smoking, alcohol, and drug consumption, together with unhealthy behaviors, may inevitably lead people to the development of chronic diseases, contributing to increasing aging and decreasing life expectancy. In this article, we highlight the role of susceptibility biomarkers, i.e., the genetic polymorphisms of individuals of different ethnicities, with particular attention to the risk factors in the response to specific exposures of Europeans. Moreover, we discuss the role of precision medicine which is representing a new way of treating and preventing diseases, taking into account the genetic variability of the individual with each own clinical history and lifestyle.

Standardization of naturopathy treatment equipment: A Review of hip bathtub

Abstract Naturopathy is a traditional science of healing and health care and found to be more effective in the management of lifestyle related disease conditions apart from promotion of health, prevention of disease as well as restoration of health. It is a system of treatment which is believed to be based on the panchamahabhutas theory of which this body and the entire universe is made up of. These panchamahabhutas, that is., five elements are Prithvi, Jala, Sun, Air, and Ether. Different naturopathy treatment modalities have been developed based on these elements theory which are categorized under different sections such as fasting therapy, diet therapy, mud therapy, hydrotherapy, massage therapy, chromo therapy, air therapy, and yoga therapy. The naturopathy treatments are executed with the help of different equipment which have been developed gradually by the naturopathy practitioners based on their prolonged experiences. These were prepared locally under the guidance of the naturopathy physician which were need based. Gradually with the promotion and propagation of system of naturopathy it was found necessary to prepare the equipment on a bigger scale. Hence, the manufacturing units came into the picture. It was observed that the equipment developed so, needs certain modifications/improvements to make them more accurate and user friendly. In view of above, a review was done on hip bathtub. The present paper highlights the need and advantages of standardization of hip bathtub, a naturopathy treatment equipment which is one of the most frequently used treatment in the naturopathy centers all over the country.

The pecten oculi comparison of the different bird species

The pecten oculi is a unique and highly specialized structure found in the eyes of birds. It is a thin, folded, fan-like membrane that extends from the optic nerve region into the vitreous fluid of the eyeball. This membrane is primarily composed of pigment cells, an extensive network of blood vessels, and a thick basal lamina. The pecten's main function is to supply nutrients and oxygen to the retina, maintain the internal eye temperature, and support sharp vision, especially during activities such as migration and hunting. The number of folds in the pecten varies between diurnal and nocturnal birds, with diurnal birds generally having larger and more complex pecten structures. The pigmentation of the pecten, especially at the apical and peripheral regions, plays a role in protecting the blood vessels from UV radiation and oxygen radicals. Different bird species exhibit variations in the number, size, and thickness of pecten folds, reflecting their specific visual requirements. For example, species like the emu have a more primitive, pleated pecten, while birds like the seagull and quail have a greater number of folds and capillaries. Additionally, the presence of melanocytes and their interactions with capillaries and blood vessels contribute to the pecten's structural integrity. The study of the pecten oculi's histology reveals that it is essential for the bird's visual health and can be linked to their lifestyle and environmental conditions. The structure and size of the pecten are tailored to the bird's daily activities, with diurnal birds having larger and more complex pecten structures compared to their nocturnal counterparts. This specialized organ's morphology and vascularization are crucial for delivering nutrients to the retina and protecting it from UV radiation. In summary, the pecten oculi is a remarkable anatomical feature in the avian eye, and its structure and function are closely related to the lifestyle and visual requirements of different bird species. This study provides valuable insights into the diverse adaptations of the pecten across bird species and its significance in maintaining avian visual health.

Age- and sex-specific modifiable risk factor profiles of dementia: evidence from the UK Biobank.

Dementia constitutes a worldwide concern. To characterize the age- and sex-specific modifiable risk factor profiles of dementia, we included 497,401 UK Biobank participants(mean age= 56.5 years) without dementia at baseline (2006-2010) and followed them until March 2021. Cox proportional hazard models were used to estimate the age- and sex-specific hazard ratios (HRs) of incident dementia associated with socioeconomic (less education and high Townsend deprivation index), lifestyle (non-moderate alcohol intake, current smoking, suboptimal diet, physical inactivity, and unhealthy sleep duration), and health condition factors (hypertension, diabetes, cardiovascular diseases, and depressive symptoms).We also calculated the population attributable fractions (PAFs) of these factors. During follow-up (mean = 11.6years), we identified 6564 dementia cases. HRs for the risk factors were similar between the sexes, while most factors showed stronger associations among younger participants. For example, the HRs of smoking were 1.74 (95% CI: 1.23, 2.47) for individuals aged < 50years, and 1.18 (1.05, 1.33) for those aged ≥ 65years. Overall, 46.8% (37.4%, 55.2%) of dementia cases were attributable to the investigated risk factors. The PAFs of the investigated risk factors also decreased with age, but that for health condition risk factors decreasedwith lower magnitude than socioeconomic and lifestyle risk factors. The stronger associations and greater PAFs of several modifiable risk factors for dementia among younger adults than older participants underscored the importance of dementia prevention from an earlier stage across the adult life course.

Student Athlete Rewarding System In Bandung City

The purpose of this study was to obtain empirical data related to the analysis of student lifestyles at the Indonesian Education University during the COVID-19 pandemic. The method that will be used in this research is descriptive. By creating a database related to student physical activity at the Indonesian Education University during the COVID-19 pandemic. The instrument that will be used in this research is an instrument developed by Douglas &amp; Donna named Fantastic Lifestyle Assessment. The results of the analysis show that the lifestyle or lifestyle of students within the Indonesian Education University during the Covid-19 Pandemic showed poor results where out of a total of 274 respondents 38% were in the low category and there were even 2 respondents in the dangerous zone category, and only a total of 13% were in poor condition. ideal and 48% are in the sufficient category. The Covid-19 pandemic has greatly disrupted the stability of lifestyle conditions through the parameters measured, namely the condition of family and friends, physical activity, nutritional or nutritional intake, cigarette consumption, alcohol consumption, sleep quality and stress levels, personality, ability to understand events, and satisfaction with career.

Decline of Sperm Quality over the Last Two Decades in the South of Europe: A Retrospective Study in Infertile Patients.

Semen quality has a direct relation to male fertility. Whether sperm variables in humans have decreased over the last years is still uncertain, with some studies showing a decline and others reporting no changes. In this regard, previous research has suggested that lifestyle and environmental conditions may contribute to this variability, calling for regional studies. The present work is a retrospective, unicentric study that includes semen samples analyzed between 1997 and 2017 at the Parc Taulí Hospital (Barcelona metropolitan area). First, a multivariate analysis including the age as a confounding factor showed a statistically significant decrease in semen volume, pH, progressive motility, morphology and total motile sperm over time. Contrarily, no significant variation in sperm count or concentration was observed. Mean reductions per year were -0.02 mL for volume, -0.57% for progressively motile sperm and -0.72% for sperm with normal morphology. Interestingly, the average annual temperature registered by the Spanish Meteorology Agency negatively correlated to sperm morphology and sperm count (Rs = -0.642; p = 0.002 and Rs = -0.435; p = 0.049, respectively). In conclusion, the present study based on infertile patients from the Barcelona area found a decline in sperm motility and morphology, without effects on sperm count. Changes in temperature appeared to be associated to this decline, but further studies are needed to address the mechanisms linked to the observed variations.

Психологические ресурсы совладания со страхом перед COVID-19 и негативными психоэмоциональными состояниями у студентов России и Казахстана

&lt;p&gt;The article presents the analysis results of stress resistance and basic beliefs as psychological resources for coping with fear of COVID-19 and negative psychological and emotional states on the sample of Russian (N=2310) and Kazakh (N=500) students (71.2% &amp;mdash; women, average age 19.7). A higher level of stress resistance and basic belief expression in &lt;em&gt;Benevolence of the World Around &lt;/em&gt;and &lt;em&gt;Perceiving the World as Meaningful and Social Justice&lt;/em&gt; among Kazakh students in comparison with Russian ones is revealed, which is determined by the peculiarities formed in the conditions of the nomadic lifestyle of the Kazakh culture, based on the principles of mutual support and mutual assistance, trust and openness. It is shown that, regardless of the country and gender, high level of stress resistance and expression of basic beliefs are accompanied by lower indicators of fear of COVID-19 and the absence of negative psychological and emotional states associated with it, which suggests the universality of these psychological resources as a buffer that mitigates the traumatic effect of the pandemic situation.&lt;/p&gt;