Abstract P231: Physical Activity During Adolescence and Adulthood Associated to Risk of Diabetes in Mexican Women

Abstract

Background: Mexico has declared an epidemiological emergency in the country due to diabetes. Although the benefits of physical activity in middle age are established, the health effects of long-term changes in PA from adolescence to middle age have not been documented. Our aim is to explore the pattern of vigorous physical activity (VPA) in adolescence and adulthood and the risk of DM2 in a cohort of middle-age women. Methods: The Mexican Teacher′s Cohort (MTC) is an ongoing study of 115,307 public school teachers. Every three years participants answered sociodemographic, lifestyle, and medical conditions, including self-reported IPA(hours/wk) for age 15 to18 years, and at the previous year of baseline. Cases of diabetes were identified and validated through electronic health records. We estimated Hazard ratios and IC95% intervals. Based on VPA in adolescence and adulthood respectively, women were classified as: consistently inactive (reference), consistently lower activity, low active in adolescence but increase in adulthood, active in adolescence but reduced in adulthood, and consistently higher. To explore recall bias we performed analyzes stratified by age. Results: in a sample of 69,970 women with 41.6 ± 7.3 years of age at enrolment, we identified 4,564 DM cases from 2006-2008 to 2019. Compared with participants who were consistently inactive in both stages, women who increase activity had a lower risk of DM; HR = 0.86 (95% CI 0.74, 1.01). Compared with the reference category, maintaining higher amounts of VPA was associated with lower diabetes risk HR = 0.85, (95% CI 0.75, 0.96). In stratified analyses by age, we observed the same association even in people who reported physical activity up to 35 years before the reference questionnaire. Conclusions: Maintaining higher VPA levels during adolescence and adulthood and increasing VPA in adulthood were associated with a similar low risk of diabetes.