Lifestyle Disorders Research Articles

Secondary Infertility (Kakvandhya)-A Single Case Study

Vandhyatwa (infertility) is the burning challenge in front of todays fastest and behind the money society. Approximately 8%-10% couples will suffer from infertility worldwide in between that 15-20 million cases are present in India alone. 57.33% are the primary infertility cases and 42.66% are secondary infertility cases observed in 26-30 years age group in India recently. Vandhyatwa is explained by ayurveda scholars in their own way but Aacharya Harita specifically mentioned total 6 types of Vandhyatwa in detail which covers all types of infertility according to modern science. As it is mentioned as lifestyle disorder by medical science, ayurveda plays key role to successful treatment of this. In present article the single case study of Kakvandhya (secondary infertility ) is explained.

Diabetes Mellitus and Other Comorbidities: Outcome among Covid-19 Patients in Kerala: A Retrospective Observational Study.

Covid-19 was declared by the WHO as a pandemic in 2020; India was also severely affected. Diabetes, a major lifestyle disorder, has seen its prevalence rate rising in developing countries. India is home to the world's second-largest population of diabetes. Several studies have reported greater severity and mortality of Covid-19 in diabetic patients. This was a hospital-based retrospective study done in a rural-based medical college in Kerala State. Data was collected using a semi-structured proforma and analysis was performed using Statistical Package for Social Sciences software version 25. The study was part of the STS research program of the Indian Council of Medical Research (ICMR). There were 567 patients in the study. Those with pre-existing diabetes had a worse outcome compared to those with newly detected diabetes. The presence of CKD was associated with a poor outcome. Patients admitted to the ICU, and those on assisted ventilation also had a lower survival rate; within the subgroup, those on non-invasive ventilation had a better outcome. Mortality in Covid-19 is multifactorial. Those with diabetes have a poor outcome. Comorbidities have been reported to confer a high mortality rate in Covid-19 but this was not so in our study (except for CKD). Variability in outcome with respect to comorbidities and better outcomes in those who were non-invasively ventilated calls for more research to establish the relationship between pre-existing conditions and severity of disease. The use of non-invasive ventilation could also provide succor to resource-limited communities.

Future Scope and Strategies for Preservation of Health through Ayurveda

Introduction: The progress of human life largely depends on healthy body. The labor for money, status in the society and honor is not possible for an unhealthy man. As Acharya says “Dharma Artha kama mokshanam Arogya mulamuttamam” Health is most important worldwide term for ‘developing and developed countries.’ But still a confused and unaware term for common people and world also. In present scenario despite of fast progress made by modern medical science, there are continues rise in health - related disorders and people start to give importance to health when they got any life style disease element. So many health - related issues we are facing in today's life in society and we can clearly explain that we are not conscious about the real meaning of health, its importance and its management in our life. The present study focus about following Aims & objectives: To explore future scope and strategies for preservation of health through Ayurveda. To study concept of health in Ayurveda classics and other contemporary health systems. to design practical guidelines for implementing concept of health in today's society. To set model health care system and its propagation for management of life style diseases. Discussion: In present era life style disorder are very common and the root cause is not focusing and understanding what health is and if a person understands this one there is nothing left to him or her to understand. Some life style disorder are Diabetes mellitus type 2, hypertension, over weight, obesity, cardiovascular diseases, dyslipidemia. We may design some protocol for prevention and protection of life style diseases. Conclusion: The Swastha is not ideal state but process of continuous change and adjustment. It is the need of time to understand the actual meaning of health and preservation of life style disorders.

Awareness of Night Eating Syndrome Among College Students (18-29 Years) Native to Manipur

Abstract: Night Eating Syndrome (NES) is a stress-related disorder characterized by morning aphagia, evening hyperphagia and insomnia with the presence of nocturnal ingestions and mood variations which worsen in the evening and night. Presence of eating disorders, psychological disorders, sleep issues like trouble getting to sleep or staying asleep also contribute to this disorder . Night eating syndrome may lead to obesity, metabolic syndrome, diabetes and other life style disorders. The aim of this study is to create awareness of NES and its consequences among college students aged 18-29 years who are native to Manipur. The study collected demographic details and anthropometry measurements of the students and also studied their awareness of NES. Their knowledge about the association of regularly eating post dinner and adverse health outcomes was also studied. The following parameters were considered like age, gender, educational status, BMI category, physical level to study and to create awareness of NES among them. The study used descriptive and exploratory survey design with a quantitative approach to collect data from college students (18-29 years) who are native to Manipur. The sample size was 78 (as per inclusion criteria) consisting of both males and females together. This study revealed that the college students with a percentage of 61.5% from among the total respondents of 52, were not aware of NES and it’s consequences. The limitations of the study suggest further research in the area of Night Eating Syndrome to increase the awareness amongst the population and prevent the occurrence of lifestyle diseases.

Ayurvedic intervention with Pachana Aushadhi and Lekhan Basti in Obesity: A case study

In the 21st century, the prevalence of lifestyle disorders has surged, exacerbated by sedentary habits and increased stress, particularly in the aftermath of the COVID-19 pandemic. This has led to a substantial rise in cases of Sthaulya, affecting approximately one-third of the global population with overweight or obese. Obesity, a complex and multifaceted disease, has tripled in global prevalence since 1980, impacting diverse age groups, genders, and socio-economic strata. Although rates have plateaued in some developed nations, the consequences of obesity extend beyond physical appearance, causing both physical and mental harm and significantly affecting overall quality of life. Furthermore, obesity serves as a precursor to various secondary health conditions, including but not limited to diabetes, hypertension, ischemic heart disease, dyslipidemia, and more. Ayurveda classifies Athisthaulya as one of the eight undesirable conditions under Ashtanindita purusha. It arises from the vitiation of Kapha dosha, Vata dosha, and Medo dhatu, aligning with the contemporary understanding of obesity as a chronic metabolic disorder. Ayurveda's holistic approach, incorporating Pachana chikitsa and Lekhana basti, shows promise in managing Sthaulya. This case study involves a 52-year-old female patient with a weight of 112 kg and a BMI of 41.1. Over 30 days, the patient underwent a comprehensive Ayurvedic management plan, including Pachana aushadhi for 7 days and Lekhana basti for 21 days. The outcome demonstrated a significant weight loss of 11 kg, reducing her weight to 101 kg. and achieving a BMI of 37.1 without complications. This case underscores the potential of Ayurvedic interventions in addressing the challenges of obesity.

Melatonin-mediated corrective changes in gut microbiota of experimentally chronodisrupted C57BL/6J mice

ABSTRACT Chronic consumption of a high-calorie diet coupled with an altered sleep-wake cycle causes disruption of circadian clock that can impact the gut microbiome leading to metabolic syndrome and associated diseases. Herein, we investigate the effects of a high fat high fructose diet (H) alone or in combination with photoperiodic shifts induced chronodisruption (CD) on gut microbiota of C57BL/6J male mice. Further, the merits of daily evening intraperitoneal administration of melatonin in restoring gut microbiota are studied herein. Experimental groups viz. H, CD and HCD mice recorded higher levels of serum pro-inflammatory cytokines (TNF-α and IL-6) and lower levels of the anti-inflammatory cytokine, IL-10. These findings correlate with a concomitant increase in the transcripts of TLR4, TNF-α, and IL-6 in small intestine of the said groups. A decrement in mRNA levels of Ocln, ZO-1 and Vdr in these groups implied towards an altered gut permeability. These results were in agreement with the observed decrement in percentage abundance of total gut microflora and Firmicutes: Bacteroidetes (F/B) ratio. Melatonin administration accounted for lower-level inflammation (serum and gut) along with an improvement in gut permeability markers. The total abundance of gut microflora and F/B ratio showed an improvement in all the melatonin-treated groups and the same is the highlight of this study. Taken together, our study is the first to report perturbations in gut microbiota resulting due to a combination of photoperiodic shifts induced CD and a high fat high calorie diet-induced lifestyle disorder. Further, melatonin-mediated rejuvenation of gut microbiome provides prima facie evidence of its role in improving gut dysbiosis that needs a detailed scrutiny.

Therapeutic role of yoga in hypertension.

Systemic hypertension is an established risk factor for coronary artery disease and cerebrovascular accident and control of blood pressure reduces the risk of a major cardiovascular event. Both non-pharmacological and pharmacological treatment options are available to treat hypertension. Yoga, recently received more attention as a treatment modality for various lifestyle disorders, even though practiced in India since ancient times. In this review, we are analyzing the role of yoga in the treatment of systemic hypertension.

A REVIEW ARTICLE ON STRENGTH IN AYURVEDA AND ITS DEVELOPMENT

Ayurved has given importance to strength by stating that health is directly proportional to the strength of an individual. Today’s competitive era has increased speed of life. People are running with life irrespective of their health. It is ultimately leads to various lifestyle disorders and deterioration of the strength. Hence this is the time to inculcate people about importance of strength. A good strength leads to healthy life and avoids physical worsening. Ayurvedic directives of Ahara and Vihara will improve the strength i. e. Yuktikrita Bala.

Millets (Kshudra Dhanya): Nurturing Health And Preventing Lifestyle Disorders

Ayurveda is based on the theory of Trayo-Upsatamba i.e., which refers to the pillars of Ayurveda: Ahara (diet), Nidra (sleep) and Bramhcharya. The key to adhering the first principal of Ayurveda, Swasthasya Swasthya Raksham (to sustain a healthy life), is Ahara (nutritious food), or we can say that balanced diet. WHO has declared 2023 “International Year of Millets” with the theme “Harnessing the untapped potential of millets for food security, nutrition, and sustainable agriculture’’. According to Ayurveda, keeping healthy eating habits can regulate and avoid all ailments. In Ayurveda different Acharya have specified various type of Aahar varga. Millets are described under Kudhanya of Bhavparkash Dhanyavarga (category of cereals). Kshudra dhanya (millets) is a group of small seeded cereals used by humans by ages. Millets (Kshudra dhanya) are drought resistant, serves as a good source of proteins, micronutrient, phytochemicals and gluten free. Due to an imbalance diet of high-calorie, fast foods, there are issues with health that must be resolved on a global scale. The so-called general diseases of present day include obesity, diabetes, cardiac arrest, porous bones and depression etc. This attempt at a review of Kshudra dhanya may be helpful to understand their complete health benefits for daily lifestyle disorders and for balancing the disease condition as well.

Evaluation of the Impact of Saara w.s.r to Obesity and Its Ayurvedic Management: A Retrospective Analysis

Obesity, the name itself causes a social as well as mental trauma for the individuals suffering from it. Although in the initial stage of the disease, the individuals overlook the problem, but later, it becomes the cause of much other upbringing disease. So the question arises, what is the cause of the sudden rise in obesity? Does it relate only to the lifestyle disorder or there is a genetic makeup in an individual, in which the tissues starts proliferating and storing adipose tissue, when it gets any favourable condition and environment. In Ayurveda, the genotype and the phenotype has been explained in the term of Saara (essence). Therefore an attempt has been made to understand the effect of Saara. Materials and Methods: 124 case papers diagnosed with obesity and had undergone any Panchakarma treatment at KLEU Shri BMK Ayurveda hospital, Belgaum, Karnataka, India. Complete before and after assessment of total cholesterol, HDL, LDL, triglyceride, circumference measurement, BMI, weight. Result: In Medosaara population and in Mamsasaara individuals, significant decrease observed in total cholesterol (3.76%) and mid- abdomen circumference (34.97%), and triglyceride (10.3%), LDL (6.52%), Mid-thigh circumference (7.36%), abdominal circumference (7.11%), and BMI (6.73%). Conclusion: The Saara of any individual determines the possible outcome of any disease, irrespective of the treatment the individual is undergoing. Therefore, in this study of obesity, it was concluded that Medosaara individuals has significant weight reduction from the baseline.

Lifestyle modification for mental health and well-being.

Unhealthy life-style leads to mental ill-health and poor quality of life and is the major determinant of a wide range of lifestyle disorders. The aim was to 1) review the work relating to life style modification for promoting mental health and 2) Present recommendations on life-style modification for mental health and wellbeing. The work on life style changes for promotion of mental health was retrieved from the scientific literature and critically reviewed. Recommendations on 'Life-style modification for mental health and wellbeing' are presented. 20 specific components of healthy life style included are: Routine, time management, prayer, basic activities, reading newspaper, study/work, exercise, recreation/ relaxation/ talent promotion, education, cognitive activities, social networking, guidelines for behavior, peer group, social group, marriage/family, life skills, physical health, health education, mobile use, and digital media. The lifestyle modification package is comprehensive and geared to promote mental health and well-being.

A CLINICAL STUDY IN THE MANAGEMENT OF GARBHASHAYA GRANTHI WITH SARJADI LEPA WITH SPECIAL REFERENCE TO FIBROID UTERUS

Background: Uterine fibroids are the most common gynaecological disorder, and as such, it should not be surprising that, over the countries. It is also a well-known fact that fibroid is one of the lifestyle disorders that have risen to numbers that never existed before. Uterine fibroid, considered as Garbhashaya Granthi in this study, is one of the forms of current lifestyle disorder. When the fibroid size is small, it may or may not show symptoms. In the presence of symptoms, the patient may suffer from menorrhagia, dysmenorrhea, anaemia, etc. Fibroid is dependent on oestrogen, and therefore, a hyperestrogenic state will be there. It will grow potentially in the childbearing period. An attempt is made to reverse this pathogenesis and reduce the fibroid growth. Aim: To analyse the efficacy of Sarjadi lepa along with oral Chitraka moola churna in the management of Garbhashaya Granthi with special reference to fibroid uterus. Method: A randomised open-labelled controlled clinical study of two groups of 15 patients, the control and trial groups, in each group. Results: Size of fibroid reduction was seen in both the groups, but Group B patients had a little more size reduction compared to Group A. Conclusion: Combined Chitraka moola churna orally along with Sarjadi lepa and alone Chitraka moola churna orally is equally effective in Garbhashaya Granthi with special reference to fibroid uterus.

IMPLICATION OF LEECH THERAPY AND ASBAB-E-SITTA ZAROORIYAH IN THE PREVENTION AND TREATMENT OF VARICOSE VEINS: A COMPREHENSIVE REVIEW

Varicose veins are characterized by abnormally twisted, dilated superficial vessels that are caused by the inefficient or defective valves within the vein. It is currently a prevalent disease with the incidence varying globally between 10% and 60%. The Unani Medicine (also called Greco-Arab medicine) is the ancient system of medicine practiced all around the world. According to the Unani classical text, Leech therapy (Irsal-e-Alaq) is one of the most important regimenal therapy for the successful treatment and management of varicose vein and a unique combination of Asbab-e-Sitta Zarooriyah (Six essential factors) is involved in the prevention of this disease. The research studies have proved that medicinal leech therapy displays anticoagulant, antimicrobial, anti-inflammatory and analgesic effects. Leech saliva contains medicinally useful bioactive molecules like hirudin, histamine, etc. that shows anti-coagulant effect and hence improve microcirculation in diseases like varicose vein. Leech therapy is reliable, well tolerated, cost effective treatment that has the potential of preventing varicose vein complications. This review seeks to describe medicinal leech therapy, present therapeutic leech species, and highlight the processes by which leech saliva affects wound healing. Additionally, the review paper highlights the role of Asbab-e-Sitta Zarooriyah in prevention and control of varicose veins. Irregularity in diet and lifestyle may cause disturbance in normal body functioning, which may lead to lifestyle disorder that is a major risk factor thought to influence the susceptibility of varicose vein. The Unani System exerts a major influence on preventing the development of varicose vein by making modification in Asbab-e-Sitta Zarooriyah.

Lifestyle Disorders and Ayurveda with special reference to Raktagata Vata (Hypertension)

As the name indicates, lifestyle disorders are disorders or diseases caused by improper lifestyle. They are also called non-communicable diseases (NCDs). According to WHO non-communicable diseases are the cause of 73% of deaths all over the world. These diseases are classified under Santarpanjanya Vyadhis according to Ayurveda. In India, 53% of deaths and 44 % of disability are caused by non-communicable diseases. As per the WHO report it is estimated that an estimated 1.28 billion adults aged 30-79 years worldwide have hypertension, most (two-thirds) living in low and middle-income countries. Raktagata Vata or Hypertension is not considered as Vyadhi by Ayurveda. It is the pathophysiology involves Prasaravastha of Doshas along with Rasa, Rakta and Meda Dhatu from their respective sites to hamper respective Srotas for blood circulation that leads to severe and chronic diseases of the brain, heart, kidneys etc. Ayurveda deals with the prevention of diseases first then cure of diseases. Ayurveda mainly focuses on Ahaar, Vihaar and Aushadha for the treatment of any disease. Ahaar along with Vihara is very important for the maintenance of health. For this, concepts of Dincharya, Ritucharya, Sadvritta and Rasayana therapy have been given in Ayurvedic texts.

Ahara Vidhi Vidhana: Ayurvedic Concepts of Food Consumption and Their Relevance in the Modern Age

In the modern world, when everyone is focused on attaining their goals, people often forget their balanced dietary routines, which leads to a number of lifestyle disorders. The three basic pillars of Ayurveda are Ahara, Nidra and Brahmacharya Among these, Ahara has been placed first which shows it is important to maintain and sustain life. Food habits like excessive intake, high protein diet, spicy, oily, harmful combination together, taking food without analysing one’s Agnibala are leading causes for diseases. For achieving complete benefits of food, one should also follow certain rules as told in Ayurveda regarding what, when, where, and how the food should be consumed. In Vimansthana, Charakacharya explains about Aharavidhividhana are the foundation of dietetics, which indicates the method of taking Ahara, which is useful for mankind. Aim & Objectives – To elaborate such principle of Ayurveda known as Ahara Vidhi Vidhan and their relevance in the modern age. Materials and Methods - Different classical Ayurvedic texts, websites, journals and research articles were referred in above context. Discussion and conclusion - The time, place, quantity and manner of Ahara intake are necessary. Ahara taken in proper manner helps in the proper growth of the body on contrary if taken in improper manner leads to various diseases. Thus, Aharavidhividhana plays a significant task in both causation and curing of the disease. Nidanaparivarjana is considered to be the main line of treatment. Properly followed Aharavidhividhana keeps the body healthy and prevents the diseases.

CLINICAL STUDY OF YOGASANA AND PATHYAAHARA IN MANAGEMENT OF MADHUMEHA (DIABETES MELLITUS-2)

Introduction: About 422 million people worldwide, most of whom reside in low and middle-income nations, have diabetes (metabolic lifestyle disorder), according to the World Health Organisation, contributing to 1.5 mil-lion deaths annually. Aahara (diet) and Yoga asanas are essential for controlling and preventing lifestyle disor-ders. Thus, this study assessed how yoga techniques and the Aahara contribute to managing diabetes mellitus. Methodology: A single arm open randomised clinical study was conducted on 30 clinically diagnosed patients with diabetes mellitus 2 for Yoga asanas (Mandukasana, Kurmasana, Vakrasana, and Ardhamatsyendrasana) and Ayurvedic Aahara plan in the Postgraduate Institute of Ayurved, DSRRAU, Jodhpur. The study evaluates their role in the management of Prabhoot Mutrata (Polyuria), Avila Mutrata (Urine turbidity), Pipasadhikya (Polydipsia), Kshuda Adhikya (Polyphagia), Sweda Adhikya (The excessive sweating) The, Dourbalya The (Weakness The/Tiredness The), The Alasya (The Laziness) The, Atinidra (Excessive sleep), Karpada Daha (Burning sensation in hands and feet) and blood sugar level (i.e. FBS and PPBS, HbA1c). Result: The result of the study depicts that Yoga asanas and Ayurvedic Aahara have significantly helped in reducing the Prabhoot Mutrata, Avila Mutrata, Pipasadhikya, Kshuda Adhikya, Sweda Adhikya, Dourbalya, Alasya, Atinidra, Karpada Daha and blood sugar level. Conclusion: The study concluded that Yoga therapy and the Aahara plan have a role in managing diabetes mellitus by lowering medication dosages, increasing physical and mental alertness, and preventing complications. Results should be validated in larger sample sizes and multicentric models to es-tablish it as a well-known treatment.

A CRITICAL REVIEW ARTICLE ON THE EFFICACY AND SAFETY OF VACHADI GANA IN THE MANAGEMENT OF DYSLIPIDEMIA

Ayurveda is a treasure for humanity. Ancient Acharya very smartly binds all knowledge together into texts. There is a solution to every problem in ancient classical texts either related to physical health or mental health. Due to a fast-forward busy lifestyle people suffer from many lifestyle disorders. These disorders can be easily treated with the help of a proper ancient regimen, but when the condition gets worse there are many drugs, drug formulations, or groups of drugs which can easily cure the chronic condition. The ancient classical texts like Sushruta Samhita, Ashtanga Hridya, Brihatnighantu Ratnakar, and Nighantu Adarsha elaborated Vachadi Gana very nicely. According to these classical texts, the drugs under Vachadi Gana have properties like Tikta-Katu Rasa and can treat Kapha & and Vata-related disease conditions. Dyslipidemia is a condition in which Vata and Kapha both are involved. In the present study, we compile the properties of these drugs and also try to prove their action on dyslipidemia conceptually.

A Study on Effectiveness of Yoga for Improvement of Work Productivity among Millennials in Tiruchirappalli

Yoga has been great art and science of healthy living. Positive health is an important means of leading meaningful life filled with happiness and inner harmony. With rapid economic development and increasing westernization of lifestyle in past few decades there is a change in the behavioural pattern of human being. This article focuses on the effectiveness of yoga for improvement of work productivity among millennials. The regular practice of yoga is a solution for the many psychological and lifestyle disorders of the modern life with the revitalization of the traditional inheritance along the lines of the sustainable approach. It was observed that, all the responders said that yoga is beneficial in their life as it helps them to attain inner peace, productive mind, strong immunity and balanced work life as well. Thus, it can be concluded that, practicing yoga makes life healthy and increased their productivity.

Barley (Yav) a complete therapy for life style disorders: millet literary research

Millet is known as a staple diet of current era. If it is being included in day- today life, can save many lives of human beings from untimely morbidity and mortality. In Ayurveda it has a great importance in healthy and unhealthy persons simultaneously. It is the most powerful neutraceutical. Ayurveda clearly explains that foods are neutraceuticals. Foods balance Vaata (air), Pitta (fire) & Kapha (water) Dhatus, to keep the body in a healthy state. These three Dhatus are the main cause of disease formation in body and are denoted by name Dosha when being vitiated. One among the best neutraceuticals is millet known as Yav (Barley), is the food or drug of choice in prognostic as well as diagnostic state of disease as per Ayurveda contexts. More importantly, barley crop can survive in case of drought land, containing sand. It also requires less water for irrigation. It grows faster within 7- 10 days. Sunlight is also not a bigger necessity for its growth. So, in indoor places where direct sunlight is not available can be useful for its cultivation. These days overweight (obese) & underweight (fitness freak) is the biggest problem for everyone. These are well known causes for life style disorders. Because in both cases untimely death can occur if life style cannot be taken into consideration on a long run. If our diet will be added with Yav daily then these health issues can be solved as it contains various healthy chemical compounds. According to Ayurveda, its Rasa (taste properties) has miraculous effects in overall well-being of a person. In Ayurveda it can be used in various forms to keep body in homeostatic state.

Molecular Docking Studies of Thiazolidinediones on Receptor for Advanced Glycation End Products (RAGE)

Background: Advanced glycation end products (AGE), are abnormal glycation of molecular proteins and nucleic acid, and its interaction with receptors for advanced glycation end products (RAGE) culminates in metabolic, neurodegenerative, and lifestyle disorders. Thiazolidinediones are insulin sensitizers with anti-glycation activity and are currently used clinically as anti-diabetic drugs. Research rationale: Studies show that thiazolidinediones also exhibit antioxidant and antiglycation activity; hence we proposed that this anti-glycation activity of thiazolidinedione may be due to its anti-RAGE action, thus preventing further RAGE-AGE interaction. Purpose of the study: Aim of the current study is to assess In-silico anti-RAGE activity of nine thiazolidinediones namely pioglitazone, rosiglitazone, ciglitazone, darglitazone, englitazone, netoglitazone, rivoglitazone, troglitazone and balaglitazone with RAGE. Materials and Methods: Nine thiazolidinediones namely, pioglitazone, rosiglitazone, ciglitazone, darglitazone, englitazone, netoglitazone, rivoglitazone, troglitazone and balaglitazone were downloaded from PubChem database. RAGE protein was downloaded from the PDB database. The nine thiazolidinediones were docked with RAGE protein using Auto Dock software and interaction parameters were studied. Result: All nine thiazolidinediones showed acceptable binding energy below (-8Kcal/mol) with 1-5 hydrogen bonds. Rosiglitazone exhibits the highest binding energy (-8.24Kcal/mol) with 2 hydrogen bonds for RAGE. Troglitazone exhibits the lowest binding energy (-9.95Kcal/mol) with 3 hydrogen bonds for RAGE. Conclusion: Thus our Insilco docking studies of thiazolidinedione derivatives with RAGE conclude that these nine thiazolidinedione derivatives exhibit anti-glycation activity by direct interaction with receptors of RAGE. Thus, this work warrants future preclinical studies to claim its RAGE receptor modulation activity.