The paper studies the influence of building function and orientation, level of thermal insulation on energy efficiency and occupant thermal comfort dynamic interdependence. Energy state dynamic modelling of the typical preschool educational facility (Kyiv, Ukraine) was carried out with different levels of thermal comfort in each of the zones, taking into account occupants' activity, metabolism, clothing, etc. The research was conducted for the heating and cooling periods, taking into account the operational peculiarities of the building. Increasing the thermal resistance from the base version to the Swedish norms reduces energy consumption by 32% for the heating period, compared to the base version. The introduction of intermittent heating leads to a reduction of energy consumption by 14%, compared to the base version. Intermittent heating and ventilation and increased thermal protection to Swedish standards can reduce energy consumption by 42%. The investigation of comfort indicators revealed that during the transition period when the heating is turned off, electric heating of the premises is required to maintain the comfort conditions, which increases the heating energy consumption by 18%. Three different options for children's clothing in the summer period to avoid feeling cold were investigated.