Stress Levels Research Articles

B - 13 Effects of Individual and Community-Level Adverse Childhood Experiences and Current Psychopathology among Monolingual Spanish-Speaking Adult Neuropsychology Referrals

Abstract Objective The link between adverse childhood experiences (ACEs) and higher rates of psychopathology in adulthood has been well-established, though far less analogue research has examined this relationship among Latinx patients. This study assessed the relationship between ACEs and symptoms of anxiety, depression, and perceived stress among monolingual Spanish-speaking neuropsychology referrals. Method Data were culled from 27 adult neuropsychology referrals (mean age = 61.70; mean education = 8.59) neuropsychological referrals administered the ACE Questionnaire, Beck Depression Inventory (BDI-II), Geriatric Depression Scale (GDS), Beck Anxiety Inventory (BAI), and Perceived Stress Scale (PSS). Linear regression analyses examined the effect of exposure to individual (e.g., emotional, physical, sexual abuse, neglect, domestic violence) and community-level ACEs on depression, anxiety, and perceived stress symptom endorsement. Results Endorsement of more individual ACEs predicted higher levels of anxiety (R2 = 0.281; p = 0.009) and depression (R2 = 0.127; p = 0.075) symptoms, but not perceived stress levels (R2 = 0.037; p = 0.365. By contrast, endorsement of more community-level ACEs marginally predicted higher anxiety symptoms (R2 = 0.124; p = 0.071), but not depression symptoms (R2 = 0.020; p = 0.568) or perceived stress levels (R2 = 0.045; p = 0.319). Conclusions Experiencing more individual-level ACEs predicted greater anxiety and, to a lesser extent, depressive symptoms, whereas community-level ACEs did not predict similar levels of endorsement of active psychopathology among monolingual Spanish-speaking adults referred for neuropsychological evaluation. Findings emphasize the need of neuropsychologists to consider routinely assessing patient’s childhood trauma history and current psychopathology symptoms during evaluation to improve diagnostic accuracy and recommendations for Latinx patients.

Effects of marine environment and fatigue pre-damage on the residual tensile properties of SFCBs

Steel-fiber reinforced polymer (FRP) composite bars (SFCBs) present a promising solution to corrosion issues associated with conventional reinforcement in marine environments, offering a viable alternative. While the performance of SFCBs under marine environments or fatigue loading is well understood, their behavior under combined conditions remains unreported. This study conducted tension-tension fatigue tests on seawater-immersed SFCBs to assess the effects of fatigue loading (at a stress level of 0.36), various aging temperatures (23°C, 40°C, and 60°C), and durations (30, 180, and 360 days) on their residual properties. Microscopic analysis was used to investigate the degradation mechanisms due to environmental aging. The results indicate that environmental aging deteriorates the GFRP matrix in the outer layer of SFCBs, with fatigue loading further causing matrix cracking and reducing the quasi-static tensile strength. The residual tensile strength of SFCBs decreases with increasing aging times or temperatures, while aging shows no significant effect on their fatigue life. Additionally, a model predicting the residual tensile strength of SFCBs based on damage accumulation was proposed. According to the model, tensile strength initially rapidly decreases with aging time and eventually stabilizes. These findings offer practical insights for the application of SFCBs in concrete structures.

Protective role of TRPM7 knockdown in ulcerative colitis via blocking NLRP3 inflammasome-mediated pyroptosis

Transient receptor potential melastatin 7 (TRPM7) has been emerged as a potent drug target for immunomodulation with ion conductance and kinase activities. The research is projected to characterize the influences of TRPM7 on the course of ulcerative colitis (UC) and dissect the latent response mechanisms. The in vivo murine model and in vitro cell model of UC were both stimulated by DSS. RT-qPCR and western blotting tested the abundance of TRPM7. Colonic damage was estimated by Hematoxylin-eosin staining, calculation of colon length, measurement of DAI and MPO assay kit. CCK-8 method and TUNEL staining severally ascertained cell activity and apoptosis. ELISA method assayed the inflammatory levels and relevant assay kits determined oxidative stress levels. FITC-dextran flux, immunohistochemistry, TEER as well as western blotting evaluated intestinal barrier function. Immunofluorescence staining and western blotting appraised NLR family pyrin domain containing 3 (NLRP3)-dependent pyroptosis. Depleted TRPM7 retarded inflammation, oxidative damage as well as intestinal barrier damage both in vitro and in vivo. TRPM7 reduction repressed the pyroptosis mediated by NLRP3 inflammasome. NLRP3 agonist nigericin partly abolished the protection elicited by TRPM7 silencing against inflammation, oxidative damage as well as intestinal barrier damage in vitro. Collectively, TRPM7 deletion might possess the therapeutic potential in UC, the working mechanism of which might involve the inactivation of NLRP3-dependent pyroptosis.

CYR61/CCN1: A novel mediator of redox response in corneal stromal cells of keratoconus

Keratoconus (KC) is a progressive, multifactorial and ectatic corneal disorder that characterized by steepening thinning of the cornea. It was previously demonstrated that oxidative stress has a strong link with KC progression. However, the molecular mechanism underlying oxidative stress response in KC remains unclear. Hence, the present study analyzed the heterogeneity of response of corneal stromal cells (CSCs) to oxidative stress in order to further illustrate how oxidative shape the pathophysiology of KC. Single-cell transcriptomics analysis revealed that CSCs demonstrated significant higher oxidative stress score in the KC group compared to the Ctrl group. The expression of oxidative markers verified by experiments illustrated elevated oxidative stress levels and insufficient antioxidant levels in CSCs of KC. In further single-cell transcriptomics analysis, we identified CYR61 to distinguish different subgroups of CSCs responding to oxidative stress. The cornea stroma cells in KC could be differentiated into CYR61high cells and CYR61low cells. Of note, the CYR61high cells showed lower score in collagen production process and higher score in collagen catabolic process. Further experiments illustrated that CYR61 was elevated in KC and associated with collagen production.

The Effect of External Distractions on Simulated Laparoscopic Performance.

Background: Surgeons are exposed to unavoidable distractions while operating. Distractions can cause stress, and stress can impair cognition and motor skills to the detriment of surgeon performance. This study assessed the impact of distractions on surgeon stress levels and surgeon performance during simulated laparoscopic tasks. Methods: Twelve surgical trainees completed a peg-thread transfer task three times on a laparoscopic simulator in a neutral environment. Six trainees then completed the task three more times in an environment overlain with distractions commonly found in the operating theatre. Six others completed three more tasks in a neutral environment. Stress was measured by recording heart rate and by assessing responses to the NASA Task Load Index. Performance was measured using instrument tracking metrics and time to complete the task. Results: The distracted participants reported significantly higher effort, frustration, and physical demand than the neutral group, as measured by the NASA Task Load Index, (P = .001, .031, and .044, respectively). The neutral group completed their final task significantly faster compared with baseline (P = .049), while the distracted group failed to show this improvement. The distracted group showed higher hand discordance, suggesting reduced ambidexterity. Conclusion: Distraction negatively impacted some aspects of performance and resulted in subjective increased stress. In future, simulation may have a role in "stress inoculation," enabling surgeons to maintain performance, despite distractions.

Parenting stress in infancy was associated with neurodevelopment in 24-month-old children with congenital heart disease.

Having a child with congenital heart disease (CHD) is stressful for parents, but research on the impact this stress can have on child development has been lacking. We investigated the associations between parenting stress when children were infants and neurodevelopmental outcomes in toddlers with CHD. This study was carried out at the Neurocardiac Clinic at the Sainte-Justine University Hospital in Montréal, Canada. Patients born from 2012 to 2019 and followed up to 24 months of age were recruited. Parenting stress levels were measured when the child was 4-6 months and 24 months and the child's neurodevelopment was assessed at 24 months. Multiple linear regressions analyses were carried out. We studied 100 children (56% boys) with CHD. Most of the parenting stress scores were below the clinical threshold. However, they accounted for a significant part of the variance in the children's cognitive (15%-16%), receptive language (14%-15%) and gross motor outcomes (15%-18%). They had no impact on the children's expressive language or fine motor outcomes. Higher parenting stress was associated with poorer neurodevelopmental outcomes in toddlers with CHD. Early screening of parenting stress in CHD clinics is necessary to provide individualised intervention for parents and optimise neurodevelopmental outcomes in children.

Experimental study on bending fatigue performance of ambient-cured ultra-high-performance concrete thin plate with embedded steel wire mesh

Ambient-cured ultra-high-performance concrete (ACUHPC) with embedded steel wire mesh (SWM) was studied experimentally. ACUHPC-SWM thin plates having different SWM wire ratios and fatigue load stress levels were tested to clarify the effects of SWM on static and fatigue bending behavior. Subsequently, the fatigue equations for ACUHPC-SWM materials (with different failure probabilities) and reinforcement efficiency of the SWM were proposed. Finally, the reinforcement mechanism of the SWM was revealed by comparing it with ACUHPC thin plates. The results show that the inclusion of wire mesh significantly improved the cracking strength, ultimate static strength, energy dissipation performance, and fatigue ultimate strength of ACUHPC, with maximum increases of 23.63 %, 260.32 %, 940.42 %, and 196.34 %, respectively. As the wire mesh ratio increased, the improvement in fatigue ultimate strength initially increased and then decreased once the wire mesh ratio exceeded 1.884 %. The mechanism according to which SWM enhances ACUHPC involves the action of the mesh as a bridge to delay crack development and increase toughness.

Climate change impact on water scarcity in the Hub River Basin, Pakistan

The Hub River Basin (HRB), a critical transboundary water source for Sindh and Baluchistan provinces in Pakistan, may face worsening water scarcity due to climate change and population growth. This study aims to assess the current state of water scarcity in the HRB and assesses its vulnerability to these pressures in future. To evaluate the baseline water scarcity in the HRB, a calibrated and validated Soil and Water Assessment Tool (SWAT) was established. Five General Circulation Models (GCMs) were employed to project the future climate under Representative Concentration Pathways (RCP 4.5 and 8.5) for the HRB. Sector-specific indicators were also used to assess the temporal and altitudinal sensitivity of the basin to climate change. These climate projections were incorporated in the SWAT model to simulate flows for three different periods: Early Future (EF; 2010–2039), Mid Future (MF; 2040–2069), and Far Future (FF; 2070–2099). The SWAT model results indicate significant increase in mean flows simulated by SWAT, ranging from 15.27 to 52.78 m3/s under RCP 4.5 and RCP 8.5 compared to baseline flows at HRB. Additionally, the study examines the temporal variation in basin stress and scarcity levels using Falkenmark and Water scarcity indicators. The findings indicate a general decrease in the basin's stress and scarcity levels, potentially benefiting water users of the HRB, especially under RCP8.5. This study offers crucial insights for shaping policies and strategies to adapt to climate change and population growth, ultimately aiming to minimize their impacts on HRB's water resources. By informing water managers and promoting sustainable water management practices, this research can help prevent future conflicts over water allocation and infrastructure development linked with the HRB.

Effectiveness of a home-based, post-discharge early intervention program for very preterm infants in reducing parental stress: a randomized controlled trial

BackgroundThis study aims to evaluate the impact of a home-based, post-discharge early intervention (EI) program on reducing parental stress levels in families with preterm infants born between 28+ 0 and 31+ 6 weeks gestational age.MethodsA randomized controlled trial was conducted, with families randomly allocated to either the EI or standard care (SC) group. A term reference group was also recruited for comparison. The Parental Stress Index-Short Form was used to assess parental stress levels, yielding a total stress score and three subdomain scores. Assessment was performed at baseline, at the 60-day mark of the study, and when the infants reached six corrected months of age. Parents in the reference group were assessed only at six months of corrected age for infants. The intervention comprised three sections: intellectual, physical, and social training, which was administered to the infants in the EI group immediately after discharge and to those in the SC group after 60 days of enrollment.ResultsSeventy-three families were enrolled in this study, with 37 allocated to the EI group, and 36 to the SC group. Prior to intervention, higher stress levels were reported by mothers in both groups than fathers, with no difference observed between the EI and SC groups. Re-assessment performed at 60 days of the study showed that mothers and fathers in the EI group had significantly lower total stress score than those in the SC group (82.00 ± 5.64 vs. 94.26 ± 7.99, p < 0.001; 80.74 ± 7.14 vs. 89.94 ± 9.17, p < 0.001, respectively), which was predominantly due to the lower scores in parental distress and parental-child dysfunction interaction subdomains in the EI group (both had p < 0.001). Mothers in the EI group exhibited a more pronounced reduction in total stress score after intervention when compared to fathers (13.15 ± 4.68 vs. 8.26 ± 4.03, p < 0.001). At six months of infant age, the total stress score and subdomain scores of parents in the EI and SC groups were similar, but significantly higher than those of the reference group.ConclusionThe home-based, post-discharge EI program demonstrated significant effectiveness in reducing parental stress levels among the parents of very preterm infants.Trial registrationThis study was registered in the Chinese Clinical Trial Registry (registration number: CTR1900028330). Registration date: December 19, 2019.

Simulation and experimental study of tool passivation based on magnetic elastic abrasive particles

The presence of micro-cracks and serrations on the tool often leads to its premature failure. However, these microscopic defects can be mitigated through passivation treatment of the tool. Magnetoelastic abrasive particles are new composite particles formed by using abrasive phase particles, magnetic media phase particles and polymer matrix according to a certain ratio, the abrasive particles have both viscoelasticity and magnetic conductivity. The introduction of magnetoelastic abrasive grains into the dual-disk tool passivation equipment can effectively improve the surface quality of the tool and increase the passivation efficiency. At the outset, a model for tool passivation was crafted employing the ABAQUS simulation software. This model aimed to evaluate the effects of diverse passivation variables on the stress levels, the shape of the impact, and the depth of the impact experienced by the tool. Subsequently, by applying statistical theory combined with fitting function techniques, a mathematical model was constructed to determine the passivation volume of the tool subjected to multiple magnetic elastic abrasive particles. This model was then used to examine the impact count and passivation volume associated with each passivation factor. Finally, a tool passivation experiment was conducted using a dual-disk magnetic tool passivation device. The results showed that the smaller the impact velocity of magnetic elastic abrasive particles, the stress and impact depth of the cutting tool are decreasing, and the deformation of the cutting edge is caused by compressive stress. The error of impact depth calculated by simulation and mathematical model is within 20 %, which proves that the mathematical model can better calculate the impact depth of magnetic elastic abrasive particles on the cutting edge of the tool.

Prolonged Grief, Posttraumatic Stress and Depression Symptoms Before and After COVID-19 in Brazil.

This study aims to explore the differences in prolonged grief (PDG), posttraumatic stress (PTSD), and depression symptoms (MDD) following the loss of a loved one before and after the COVID-19 pandemic. Using a cross-sectional design, 888 bereaved individuals were classified on different groups according to the cause of death. Results indicate that participants who experienced a loss during the pandemic, regardless of the cause, presented higher levels of prolonged grief, posttraumatic stress and depression when compared to those who lost a loved one before the pandemic. This study sheds light on the environmental influences (ex: the COVID-19 pandemic) on the grieving process, emphasizing the need to take the context into account when tailoring interventions in bereavement and mental health care.

Professional Quality of Life Among Mental Health Nurses: A Systematic Review and Meta-Analysis.

The professional quality of life (ProQOL) is increasingly applied to nurses and is a measure of the positive and negative aspects of their work. This systematic review and meta-analysis evaluated the level of compassion satisfaction, burnout and secondary traumatic stress (STS) in empirical studies. Electronic databases Scopus, PubMed and Web of Science were searched on 7th February 2024, and the review followed PRISMA guidelines. The pooled estimate of compassion satisfaction, burnout and secondary traumatic stress mean scores using a random-effects model for meta-analyses was undertaken. R statistical software and the dmetar program were used to execute the analysis. Heterogeneity was evaluated with the I2 statistics, while publication bias was evaluated using Egger's regression test. Twenty-four studies (sample size = 4274) were systematically reviewed and 18 studies (n = 3163) were incorporated into the meta-analysis. Burnout, secondary traumatic stress and compassion satisfaction are found to be at moderate levels in this research. The qualitative analysis informs that variables such as healthy lifestyle, work environment and psychological resilience contribute towards optimum ProQOL scores. The pooled mean estimate was 32.79 (95% CI = 29.57-36) for compassion satisfaction, 24.99 (95% CI = 23.75-26.23) for burnout and 21.99 (95% CI = 18.93-25.06) for secondary traumatic stress, respectively. Mental health nurse managers need to address the factors in the work environment and promote interventions to enhance coping with burnout and STS. Subgroup analyses of country-based economies & regions and years revealed significant results.

Ready or not…here we grow! Evaluating the competency of nursing faculty in supporting nursing student mental health: A quantitative investigation

BackgroundCollege students are amid a mental health crisis with campuses seeing the highest rates of mental health disorders in over a decade. College nursing students stand out as particularly affected, experiencing elevated levels of anxiety, stress, and depression compared to the general student population. At the forefront of addressing this issue are college faculty, especially nursing faculty, who play a unique role in identifying and referring students with mental health needs due to their close interactions in smaller teaching-learning settings such as clinicals, simulations, and one-on-one validations. AimThis study evaluated the perceived competency, knowledge, engagement, and fear levels of nursing faculty in supporting the mental health of Bachelor of Science in Nursing students. Additionally, the study explored whether faculty members with prior MH training differed in these levels. MethodsSurvey data from 63 faculty members employed across six prominent nursing schools in the southeast region of the United States, all offering Bachelor of Science in Nursing programs, were analyzed. Employing a cross-sectional design, the study utilized the “College Mental Health Perceived Competency Scale” (CMHPCS) to assess faculty's competence, knowledge, engagement and fear in supporting student mental health. ResultsAmong the 63 participants, significant differences were observed in engagement levels between nursing faculty with and without prior mental health training (p < .012). Overall, the surveyed nursing faculty demonstrated high levels of competence, engagement and knowledge and low levels of fear in supporting the nursing student's mental health. ConclusionThe results prompt recommendations for future research aimed at developing a comprehensive approach to equip nursing faculty with effective mental health training and interventions. Such efforts seek to empower student nurses with the tools necessary to support their own mental health, enabling them to competently care for patients and communities.

Animal-Assisted Stress Management for Veterinary Staff.

High levels of stress have a detrimental impact on veterinary staff, negatively influencing their mental health and contributing to high rates of suicide. Veterinary social workers are tasked with providing interventions to reverse these consequences and support the professional's health and well-being. Twenty-one veterinary staff participated in a study to evaluate the impact of animal-assisted support. Over three months, participants attended one or two therapy dog visits per month, interacting with therapy dogs for a minimum of 10 minutes each session. Pre- and postmeasures of blood pressure, heart rate, and self-reported stress were taken at each session. A measure to assess compassion fatigue and satisfaction was administered at the end of each session, and at the conclusion of the study participants' thoughts about the visits from the therapy dogs were assessed. Significant reductions in systolic and diastolic blood pressure were found as well as significantly lower ratings of self-reported stress. Additionally, participants looked forward to these visits stating they made them happy, helped them feel better, and took their mind off their troubles. Considering the growing utilization of therapy dogs, this timely study adds to the body of evidence, highlighting the benefits of animal-assisted interventions with veterinarian staff.

Too stressed to think? A scoping review of the literature for healthcare educators utilising high acuity clinical scenarios

BackgroundThe practise of paramedicine can be highly stressful particularly where urgent lifesaving decisions need to be made. Traditionally, educators have adopted the approach of placing students in simulated stressful situations as a way of learning to cope with these challenges. It is unclear from the literature whether traditional stress inoculation enhances or hinders learning. This scoping review aims to identify and examine both the peer-reviewed and grey literature reporting physiological stress responses to high-acuity scenarios in paramedicine and cognate healthcare disciplines.MethodsAdhering strictly to JBI Evidence Synthesis Manual for conducting a scoping review, medical subject headings and areas, keywords and all other possible index terms were searched across EBSCOhost (Medline, CINAHL and APA PsycInfo), Scopus and, PubMed. English language articles both published (peer-reviewed academic papers, reports and conference proceedings) and unpublished (grey literature, Google Scholar reports) were included, and publications citing retrieved articles were also checked.ResultsSearches performed across five electronic databases identified 52 articles where abstracts indicated potential inclusion. From this, 22 articles which reported physiological or psychophysiological responses to stressful scenario-based education were included.ConclusionThis review identified that an acceptable level of stress during simulation can be beneficial, however a point can be exceeded where stress becomes a hinderance to learning resulting in underperformance. By identifying strategies to moderate the impact of acute stress, educators of paramedic and other healthcare students can utilise high-acuity clinical scenarios to their andragogical armamentarium which has the potential to improve real-world clinical outcomes.

Exploring nursing students’ experiences of contemplating self-injury during their clinical practicums: A phenomenological study

AimTo explore nursing students’ thoughts and feelings about self-injuring during their clinical practicums. BackgroundUnfamiliar clinical environments pose challenges for nursing students, potentially leading to high levels of stress. When students find it difficult to cope with emotional triggers, some contemplate self-injury. Yet, it is rare to explore nursing students’ thoughts and feelings related to self-injury during their clinical practicums. DesignA phenomenological approach was used. MethodsPurposive sampling was used and the participants were drawn from nursing students who graduated from universities in Taiwan. In-depth, semi-structured interviews were conducted from August to November 2023. Data saturation was reached after interviewing 15 participants. Colaizzi's seven steps and NVivo software were used for data analysis. ResultsFour themes and 14 subthemes emerged. They were: (1) Sensing an emotional crescendo: participants experienced anxieties about clinical educators, assignments, homework and the clinical practicums and these intensified across time. (2) Physical and mental dysregulation: participants experienced physical discomfort, psychological distress and negative thoughts when subjected to overwhelming pressures during their clinical practicums. (3) Unwholesome self-protective behaviors: participants expressed thoughts of self-injury, engaged in self-injurious behaviors, experienced suicidal ideations and attempted suicide as measures of relieving stress. (4) Compassionate self-protective behaviors: participants coped with stress through emotional voicing, modifying situations to adjust stress, reaching out for help, self-compassion and self-care. ConclusionsFindings raise awareness of the need for clinical educators to demonstrate empathy with nursing students who have thoughts of self-injury during their clinical practicums. Further, it is crucial for them to offer timely guidance on the healing process while simultaneously creating nurturing clinical environments wherein students could flourish and grow.

Efficacy of ozonated autohemotherapy for improvement of myocardial injury following traumatic brain injury

BackgroundTraumatic brain injury is a kind of injury caused by external violence on the head. Its danger is not limited to life rescue in the early stage of the disease. Moreover, the subsequent inflammatory reaction and the change in its oxidative stress level will cause secondary myocardial injury. The purpose of this study is to explore the myocardial protective effect of ozone autohemotherapy (OA) in the progression of acute traumatic brain injury (TBI).MethodsForty patients with acute TBI were recruited and divided into The treatment group (Group OA, n = 18) and the Control group (Group C, n = 19). Patients in Group OA received OA before surgery and on the 1st and 2nd postoperative days, while patients in Group C underwent autologous blood transfusion. Venous blood was collected from all patients before (T0) and after 7 days (T1) days of surgery for measurement of cardiac troponin T (cTnT) and amino-terminal pro-B-type natriuretic peptide (NT-proBNP). At T0 and T1, transthoracic cardiac ultrasound was performed to measure left ventricular ejection fraction (LVEF), tricuspid annular plane systolic excursion (TAPSE), and venous blood was sampled to determine the contents of superoxide dismutase (SOD) and malondialdehyde (MDA). NIH Stroke Scale (NIHSS) and Glasgow Coma Scale (GCS) scores were calculated, and other clinical indexes were recorded.Results(1) The levels of cTnT at T1 were significantly higher as compared with that at T0 in both groups (p < 0.01). Compared with Group C, a remarkable decline in the content of NT-proBNP was found in Group OA at T1 (p = 0.021). (2) The LVEF (p = 0.002) and serum SOD (p = 0.015) at T1 were significantly increased in Group OA as compared with those in Group C. (3) The length of Intensive Care Unit and hospitalization time for patients in Group OA was distinctly shorter than that for patients in Group C (p = 0.021, p = 0.015, respectively).ConclusionPerioperative OA treatment can alleviate the secondary myocardial injury during the disease course of TBI, which might be associated with its myocardial protective effect against oxidative stress.Trial registrationThis study was approved by the Ethical Committee of Changzhou NO.2 People's Hospital. The protocol was registered prospectively with the Chinese Clinical Trial Registry (ChiCTR2000029612) on February 02, 2020.

Parental stress interaction with environmental factors in childhood allergic asthma: Early life significance

Although stress and indoor/outdoor environments have been independently linked with asthma, their interactions on childhood physician-diagnosed allergic asthma (PDAA) remain undisclosed. We aimed to research the effect of parental stress and their interactions with indoor/outdoor environmental factors on childhood PDAA. A retrospective cohort study was undertaken of preschoolers at Changsha, a city in central China. We collected information on parental stress levels and various indoor environmental exposures, through questionnaire surveys. Outdoor air pollution exposure was obtained from ten ambient pollution monitoring stations in Changsha, and individual pollution exposure were calculated. Using logistic regression models, we assessed the individual and synergistic impacts of parental stress and indoor/outdoor factors on childhood PDAA. We found that preschoolers' PDAA showed a significant association with high parental gross annual income and psychological stress indicators including fatigue, headache, and inattention, with ORs = 2.10 (1.31–3.35), 1.38 (1.04–1.82), 1.33 (1.07–1.65), and 1.42 (1.14–1.76), respectively. Furthermore, in preschoolers with high parental economic stress, the association between indoor mold/moisture spots and PDAA was notably more pronounced. Significantly stronger association between outdoor SO2 exposure in the past year in preschoolers with socially stressed parents. Parental headache and inattention exacerbated the effects of PM2.5-10 and PM10 exposure during the 7-9th months before pregnancy and throughout the pregnancy on PDAA. Preschoolers with high parental psychological stress and high exposure to outdoor atmospheric pollutants showed an increased likelihood of developing PDAA. Our research suggests that both parental stress and its interaction with hazardous environments from indoor sources and atmospheric pollutants contribute to PDAA.

Partnership Status And Prevalence Of Mental Disorders In Women And Men With Cancer

Patients facing the diagnosis of cancer are confronted with high stress levels, which increase the risk of developing a mental disorder. Being in a relationship moderates patients' mental health and can have a risk-reducing effect. We aim to describe the influence of partnership status on the 4-week-prevalence of mental disorders in cancer patients and how it varies by gender. As part of the secondary data analysis of a multicenter cross-sectional study, 1857 patients with cancer (51,6% women, age 18-75 years, Ø age 57 years, 79,7% in a partnership) were assessed using a written questionnaire and, for the diagnosis of psychological disorders (4-week prevalence), the CIDI-O interview. Frequency calculations and binary logistic analyses were carried out. In the univariate analyses, the frequency of the presence of at least one mental disorder is significantly lower in patients who are in a relationship (25,4% vs. 35,3%, p<0,001). They are also less likely to simultaneously suffer from multiple mental disorders. These differences are also evident for individual classes of disorders. The multivariate gender-differentiated analysis confirms this trend. In addition to age and income as significant predictors, only men experience a significant protective effect of their relationship against the occurrence of a mental disorder (OR=2,5, p<0,001). There has been very limited research on the links between partnership status, gender, and mental disorders in cancer patients. The results found in our analyses should be further explored, particularly regarding the protective role of partnership against developing mental disorders. In the context of psycho-oncological care the status of living alone should be considered as a possible risk factor for developing mental disorders, especially in men.

Testing the causal relationship of fat and sugar intake with depression and cortisol: a Mendelian Randomisation study

Unhealthy diets high in fat and sugar content may have an impact on psychological health and increase the risk of Major Depressive Disorder (MDD) and stress levels. On the other hand, MDD and stress might be related to food choices and intake. However, it is not clear whether diet, and specifically fat and sugar intake, is causally related to stress and MDD, and whether this relationship may be bi-directional. This study utilised Mendelian Randomisation (MR) to investigate the causal nature of the relationship of fat and sugar intake with MDD and cortisol (as a proxy of stress), and to shed light on the direction of this relationship. Summary-level data for all exposure and outcome variables were obtained from large-scale, non-overlapping GWASs in individuals of European ancestry. Bidirectional analyses were performed: one with macronutrients as exposures and one with MDD/cortisol as exposures. Random-effects inverse-variance weighted regression was used as the primary analytic method for genetic instruments with at least two single nucleotide polymorphisms (SNPs) available (and individual Wald ratio was used when only one SNP was available). Higher levels of genetically predicted relative sugar intake were causally associated with lower MDD risk, for both genome-wide significant p-value threshold of p < 1 × 10−8, (OR = 0.553, 95% CI: 0.395-0.775) and relaxed p-value threshold of p < 1 × 10−6 (OR = 0.786, 95% CI: 0.630–0.981). No reverse causality was detected in the opposite direction as MDD was not associated with sugar consumption. The associations observed for all the other pairs of variables were weak and imprecise. A number of limitations was present in the study, such as low-SNP based heritability for some exposures, inability to prove whether variants were correlated with unmeasured confounders and self-reporting of MDD data. Lifestyle and/or pharmacological interventions targeting sugar-related physiological mechanisms may help to reduce depressive symptoms. However, more research is necessary on short- and long-term effects of sugar on the risk of MDD. Additionally, future studies should investigate whether the amount and type of sugar consumed may underlie the impact of sugar on mood and stress levels.