Learning is a complex creative process based on the use of modern technologies and taking into account the psycho-physiological properties of an individual. The martial law introduced significant changes in the operation mode of higher education institutions in Ukraine. Therefore, the problem of organization and implementation training in higher education institutions is very relevant in current conditions. The purpose is the study and application of those modern forms and methods of education that would provide a sufficient level of knowledge in martial law, as well as the study of the peculiarities of student’s motivation in martial law. Methodology. We conducted a comprehensive analysis of sources about various teaching methods and generalization own experience of teaching Medical Biology in online format at Zaporizhzhia State Medical University. Results. It was implemented the interaction concept of higher education students with the teaching staff and educational activity was monitored, Zaporizhzhia State Medical University introduced a remote form of education using MS Teams and the edX platform. Based on Teams, the work was carried out to create and fill in online platforms with an educational material, a content visualization with a large amount of illustrative materials, video materials, packages of test tasks in MS Forms, along with educational methods adaptation, including interactive ones, to a distance form. Interactive distance learning means are very diverse. They include synchronous tools such as video conferencing and virtual classroom discussions, as well as asynchronous tools such as online forums and chats. Interactive distance learning means are crucial for several reasons: increasing contact, improving communication and collaboration, and contributing to a more dynamic and collaborative learning environment. While our teachers in real-time use synchronous interactive methods, asynchronous methods provide great flexibility for students regarding when and where they can participate in classes, that is especially important for students in complex real-world settings of martial law. Conclusions: Distance learning in modern higher education has become a forced alternative to traditional forms despite the difficulties ensuring the educational process under challenging conditions. Interactive means are becoming increasingly important in distance learning, as they help boost student’s communication and interaction, improve collaboration, and provide greater flexibility and convenience in the distance learning process for students and teachers. Modern technologies and means will be appropriate if we take into account the students’ psycho-physiological state and the degree of their motivation.