Laser-accelerated Proton Beams Research Articles

High transmission efficiency collection system for laser-accelerated proton beams based on permanent magnet quadrupoles prefocusing

A new high transmission efficiency, easily tunable, and cost-effective beam collection system is proposed for laser-accelerated proton beams with large divergence angles and wide energy spectra. In previous experiments conducted at the compact laser plasma accelerator platform of Peking University, a beamline was initially constructed with a collection system based on an electromagnetic quadrupoles (EMQs) triplet. However, due to the limited acceptance angle, the EMQs exhibited a monoenergetic transmission efficiency of only 10% to 20% for laser accelerated proton beams. Permanent magnet quadrupoles (PMQs), known for their high magnetic field gradients, compact size, and lower expenses, are well suited for integration with other readily adjustable transmission elements like EMQs and solenoids, effectively enhancing the beam collection capabilities of the system. In this paper, we show that by introducing a pair of centimeter-sized PMQs in front of the EMQs for beam prefocusing, the beam’s transverse size is quickly compressed, enabling transmission of highly divergent protons. Experimental results demonstrate that the prefocusing by PMQs increased the system’s transmission efficiency by a factor of 2.44 to 6.01 compared to the original setup, while also enhancing the energy selection based on stronger chromatic effect. This method can be extended to 100 MeV high-energy proton beamlines and is crucial for applications of laser plasma accelerators. Published by the American Physical Society 2024

Design and simulation of a radius-varying active plasma lens for focusing laser-accelerated protons

With plasma as the medium, laser driven accelerator can generate high energy pulsed particles with initially micron scale source size and broad energy spread. Efficient transport of the beam with above characteristics is a challenging task. Active plasma lenses (APLs) provide strong, tunable, axisymmetric focusing with weak chromatic dependencies, making them highly beneficial for compact laser accelerators. However, due to the large divergence angle of the laser-accelerated proton beams, a majority of the protons cannot be transmitted through the APLs, resulting in losses. In this study, we propose a radius-variable APL (RV-APL) that optimizes the capillary’s geometry based on the beam envelope. The collection angle of RV-APL under the design parameters in the article can be increased by about 80% compared to a cylindrical APL (C-APL) with a constant radius, achieving the transmission capacity of traditional magnets. The magnetic field distribution of the RV-APL was predicted using a two-dimensional axisymmetric plasma discharge model, and the focused beam’s chromaticity and emittance properties were theoretically analyzed through particle tracking simulation.

Energetic laser-driven proton beams from near-critical-density double-layer targets under moderate relativistic intensities

Double-layer targets composed of near-critical-density carbon nanotube foams (CNFs) and solid foils have shown their advantages in laser-driven ion acceleration under high relativistic intensity. Here, we report the experimental and numerical results on the laser-accelerated proton beams from such targets under moderate relativistic intensities I∼5×1019W/cm2. 40-TW femtosecond laser pulses were used to irradiate CNF-based double-layer targets. Compared to single-layer targets, significant enhancements on the cutoff energy and numbers of ions were observed. It was found that the CNF layer also leads to a larger divergence angle and a more homogeneous spatial distribution profile of the proton beam. Particle-in-cell simulations reveal the reason for the enhanced proton acceleration. It is found that the lateral electric field and the strong magnetic field built by the directly accelerated electrons from the CNF layer contribute to the enlarged divergence angle.

Introduction of Research Work on Laser Proton Acceleration and Its Application Carried out on Compact Laser–Plasma Accelerator at Peking University

Laser plasma acceleration has made remarkable progress in the last few decades, but it also faces many challenges. Although the high gradient is a great potential advantage, the beam quality of the laser accelerator has a certain gap, or it is different from that of traditional accelerators. Therefore, it is important to explore and utilize its own features. In this article, some recent research progress on laser proton acceleration and its irradiation application, which was carried out on the compact laser plasma accelerator (CLAPA) platform at Peking University, have been introduced. By combining a TW laser accelerator and a monoenergetic beamline, proton beams with energies of less than 10 MeV, an energy spread of less than 1%, and with several to tens of pC charge, have been stably produced and transported in CLAPA. The beamline is an object–image point analyzing system, which ensures the transmission efficiency and the energy selection accuracy for proton beams with large initial divergence angle and energy spread. A spread-out Bragg peak (SOBP) is produced with high precision beam control, which preliminarily proved the feasibility of the laser accelerator for radiotherapy. Some application experiments based on laser-accelerated proton beams have also been carried out, such as proton radiograph, preparation of graphene on SiC, ultra-high dose FLASH radiation of cancer cells, and ion-beam trace probes for plasma diagnosis. The above applications take advantage of the unique characteristics of laser-driven protons, such as a micron scale point source, an ultra-short pulse duration, a wide energy spectrum, etc. A new laser-driven proton therapy facility (CLAPA II) is being designed and is under construction at Peking University. The 100 MeV proton beams will be produced via laser–plasma interaction by using a 2-PW laser, which may promote the real-world applications of laser accelerators in malignant tumor treatment soon.

Transport of an intense proton beam from a cone-structured target through plastic foam with unique proton source modeling.

Laser-accelerated proton beams are applicable to several research areas within high-energy density science, including warm dense matter generation, proton radiography, and inertial confinement fusion, which all involve transport of the beam through matter. We report on experimental measurements of intense proton beam transport through plastic foam blocks. The intense proton beam was accelerated by the 10ps,700J OMEGA EP laser irradiating a curved foil target, and focused by an attached hollow cone. The protons then entered the foam block of density 0.38g/cm^{3} and thickness 0.55 or 1.00mm. At the rear of the foam block, a Cu layer revealed the cross sectionof the intense beam via proton- and hot electron-induced Cu-K_{α} emission. Images of x-ray emission show a bright spot on the rear Cu film indicative of a forward-directed beam without major breakup. 2D fluid-PIC simulations of the transport were conducted using a unique multi-injection source model incorporating energy-dependent beam divergence. Along with postprocessed calculations of the Cu-K_{α} emission profile, simulations showed that protons retain their ballistic transport through the foam and are able to heat the foam up to several keV in temperature. The total experimental emission profile for the 1.0mm foam agrees qualitatively with the simulated profile, suggesting that the protons indeed retain their beamlike qualities.

High energy electron beam generation during interaction of a laser accelerated proton beam with a gas-discharge plasma

The study of the interaction between ion beam and plasma is very important to the areas of inertial fusion energy and high energy density physics. With detailed one-dimensional electromagnetic particle-in-cell simulations, we investigate here the interaction of a laser-accelerated proton beam assuming an ideal monoenergetic beam with a gas-discharge plasma. After the saturation stage of the two-stream instability excited by the proton beam, significant high energy electrons are observed, with maximum energy approaching 2 MeV, and a new two-stream instability occurs between the high energy electrons and background electrons. The trajectories of plasma electrons are studied, showing the process of electron trapping and de-trapping from the wakefield.

Tumour irradiation in mice with a laser-accelerated proton beam

Recent oncological studies identified beneficial properties of radiation applied at ultrahigh dose rates, several orders of magnitude higher than the clinical standard of the order of Gy min–1. Sources capable of providing these ultrahigh dose rates are under investigation. Here we show that a stable, compact laser-driven proton source with energies greater than 60 MeV enables radiobiological in vivo studies. We performed a pilot irradiation study on human tumours in a mouse model, showing the concerted preparation of mice and laser accelerator, dose-controlled, tumour-conform irradiation using a laser-driven as well as a clinical reference proton source, and the radiobiological evaluation of irradiated and unirradiated mice for radiation-induced tumour growth delay. The prescribed homogeneous dose of 4 Gy was precisely delivered at the laser-driven source. The results demonstrate a complete laser-driven proton research platform for diverse user-specific small animal models, able to deliver tunable single-shot doses up to around 20 Gy to millimetre-scale volumes on nanosecond timescales, equivalent to around 109 Gy s–1, spatially homogenized and tailored to the sample. The platform provides a unique infrastructure for translational research with protons at ultrahigh dose rates.

Laser-Driven Proton-Boron Fusions: Influences of the Boron State

The proton-boron (p 11 B) reaction is regarded as the holy grail of advanced fusion fuels, where the primary reaction produces 3 energetic α particles. However, due to the high nuclear bounding energy and bremsstrahlung energy losses, energy gain from the p 11 B fusion is hard to achieve in thermal fusion conditions. Owing to advances in intense laser technology, the p11 B fusion has drawn renewed attention by using an intense laser-accelerated proton beam to impact a boron-11 target. As one of the most influential works in this field, Labaune et al. first experimentally found that states of boron (solid or plasma) play an important role in the yield of α particles. This exciting experimental finding rouses an attempt to measure the nuclear fusion cross section in a plasma environment. However, up to now, there is still no quantitative explanation. Based on large-scale, fully kinetic computer simulations, the inner physical mechanism of yield increment is uncovered, and a quantitative explanation is given. Our results indicate the yield increment is attributed to the reduced energy loss of the protons under the synergetic influences of degeneracy effects and collective electromagnetic effects. Our work may serve as a reference for not only analyzing or improving further experiments of the p 11 B fusion but also investigating other beam-plasma systems, such as ion-driven inertial confinement fusions.

Manipulation of laser-accelerated proton beam spatial distribution by laser machined microstructure targets

Experimental study of laser proton acceleration was carried out using laser machined line targets and cross targets with tens of micrometers scale. We have found that both the shape and material of the microstructure targets have significant influences on the distribution of the proton beam. For the aluminum line target, the proton beam spot expands in a direction perpendicular to the boundary of the target; while for the plastic line target, it expands parallel to the boundary of the target. Detailed PIC simulations of the aluminum target have been carried out, which show that due to the lateral transport of hot electrons and the sheath fields accumulated at the edge of the microstructure target, the divergence angle of the accelerated proton beam is changed accordingly, thereby modulating the spatial distribution: the elliptical beam spot can be obtained from the line target, and the quasi-square beam spot can be obtained from the cross target. Simulations of the plastic target indicate that the difference in the electron transport properties for the two types of targets may be the reason for the completely different beam spot shapes. This work shows that the microstructure targets can be a potential method to manipulate the spatial distribution and uniformity of the proton beam.

Dosimetric Optimization of a Laser-Driven Irradiation Facility Using the G4-ELIMED Application

ELIMED has been developed and installed at ELI beamlines as a part of the ELIMAIA beamline to transport, monitor, and use laser-driven ion beams suitable for multidisciplinary applications, including biomedical ones. This paper aims to investigate the feasibility to perform radiobiological experiments using laser-accelerated proton beams with intermediate energies (up to 30 MeV). To reach this goal, we simulate a proton source based on experimental data like the ones expected to be available in the first phase of ELIMED commissioning by using the G4-ELIMED application (an application based on the Geant4 toolkit that simulates the full ELIMED beamline). This allows the study of transmission efficiency and the final characteristics of the proton beam at the sample irradiation point. The Energy Selector System is used as an active energy modulator to obtain the desired beam features in a relatively short irradiation time (around 6 min). Furthermore, we demonstrate the capability of the beamline to filter out other ion contaminants, typically co-accelerated in a laser-plasma environment. These results can be considered as a detailed feasibility study for the use of ELIMED for various user applications such as radiobiological experiments with ultrahigh dose rate proton beams.

Improving laser-accelerated proton beam divergence by electric and magnetic fields induced in flat channel-like targets

Improving parameters of laser-driven proton and ion beams becomes one of the most important goals in the field of laser acceleration in order to fulfill requirements of foreseen applications. This work presents parametric 2D and 3D particle-in-cell simulations of various target designs in order to reduce proton beam divergence without significant drop in maximum energies or in proton number. The optimal target design proved to be a channel-like target which produces not only a long-lasting focusing transverse electric field in contrast to a flat foil, but also a magnetic quadrupole with strong octupole component inside the guiding channel. A combination of both electric and magnetic features results in a strong proton beam divergence reduction, accompanied by a higher uniformity of the beam, which is studied as a function of proton energy.

Radiobiology Experiments With Ultra-high Dose Rate Laser-Driven Protons: Methodology and State-of-the-Art

The use of particle accelerators in radiotherapy has significantly changed the therapeutic outcomes for many types of solid tumours. In particular, protons are well known for sparing normal tissues and increasing the overall therapeutic index. Recent studies show that normal tissue sparing can be further enhanced through proton delivery at 100 Gy/s and above, in the so-called FLASH regime. This has generated very significant interest in assessing the biological effects of proton pulses delivered at very high dose rates. Laser-accelerated proton beams have unique temporal emission properties, which can be exploited to deliver Gy level doses in single or multiple pulses at dose rates exceeding by many orders of magnitude those currently used in FLASH approaches. An extensive investigation of the radiobiology of laser-driven protons is therefore not only necessary for future clinical application, but also offers the opportunity of accessing yet untested regimes of radiobiology. This paper provides an updated review of the recent progress achieved in ultra-high dose rate radiobiology experiments employing laser-driven protons, including a brief discussion of the relevant methodology and dosimetry approaches.

Demonstration of tailored energy deposition in a laser proton accelerator

In order to implement radiotherapy based on a laser accelerator, it is necessary to precisely control the spatial distribution and energy spectrum of the proton beams to meet the requirements of the radiation dose distribution in the three-dimensional biological target. A compact laser plasma accelerator has been built at Peking University, which can reliably generate and transport MeV-energy protons with a specified energy onto the irradiation platform. In this paper, we discuss several technologies for the accurate control of a laser-accelerated proton beam with large divergence angle and broad energy spread, including the determination of the beam source position with micron accuracy, a tuning algorithm for the transport line which we refer to as ``matching-image-point two-dimensional energy analysis'' to realize accurate energy selection, and the control of beam distribution uniformity. In the prototype experiment with low energy protons and 0.5-Hz irradiation rate, a tailored energy deposition is demonstrated, which shows the potential feasibility of future irradiation based on laser-accelerated proton beams.

Experiments and simulations of isochorically heated warm dense carbon foam at the Texas Petawatt Laser

An experimental and simulation study of warm dense carbon foams at ambient density (ne ∼ 1021 cm−3) is presented. This study of isochorically heated foams is motivated by their potential application in carbon-atmosphere white-dwarf envelopes, where there are modeling uncertainties due to the equation of state. The foams are heated on an approximately picosecond time scale with a laser-accelerated proton beam. The cooling and expansion of the heated foams can be modeled with appropriately initialized radiation-hydrodynamics codes; xRAGE code is used in this work. The primary experimental diagnostic is the streaked optical pyrometer, which images a narrow band of radiation from the rear surface of the heated material. Presented are xRAGE modeling results for both solid aluminum targets and carbonized resorcinol-formaldehyde foam targets, showing that the foam appears to cool slowly on the pyrometer because of partial transparency. So that simulations of cooling foam are processed properly, it is necessary to account for finite optical depth in the photosphere calculation, and the methods for performing that calculation are presented in depth.

Observation of a high degree of stopping for laser-accelerated intense proton beams in dense ionized matter

Intense particle beams generated from the interaction of ultrahigh intensity lasers with sample foils provide options in radiography, high-yield neutron sources, high-energy-density-matter generation, and ion fast ignition. An accurate understanding of beam transportation behavior in dense matter is crucial for all these applications. Here we report the experimental evidence on one order of magnitude enhancement of intense laser-accelerated proton beam stopping in dense ionized matter, in comparison with the current-widely used models describing individual ion stopping in matter. Supported by particle-in-cell (PIC) simulations, we attribute the enhancement to the strong decelerating electric field approaching 1 GV/m that can be created by the beam-driven return current. This collective effect plays the dominant role in the stopping of laser-accelerated intense proton beams in dense ionized matter. This finding is essential for the optimum design of ion driven fast ignition and inertial confinement fusion.

Optimization of radiochromic film stacks to diagnose high-flux laser-accelerated proton beams.

Here, we extend flatbed scanner calibrations of GafChromic EBT3, MD-V3, and HD-V2 radiochromic films using high-precision x-ray irradiation and monoenergetic proton bombardment. By computing a visibility parameter based on fractional errors, optimal dose ranges and transitions between film types are identified. The visibility analysis is used to design an ideal radiochromic film stack for the proton energy spectrum expected from the interaction of a petawatt laser with a cryogenic hydrogen jet target.

Development of a Platform at the Matter in Extreme Conditions End Station for Characterization of Matter Heated by Intense Laser-Accelerated Protons

High-intensity short-pulse lasers have made possible the generation of energetic proton beams, unlocking numerous applications in high energy density science. One such application is uniform and isochoric heating of materials to the warm dense matter (WDM) state. We have developed a new experimental platform to simultaneously create and probe WDM at the matter in extreme conditions (MEC) end station at the Linac Coherent Light Source (LCLS). The short pulse optical laser (delivering up to 1 J in 45 fs) and the ultrabright LCLS X-ray laser with tunable frequency, respectively, deliver high power required to heat materials to WDM and precision-timed high-resolution X-rays to probe them. The laser-accelerated proton beam driven from a flat 1.5- $\mu \text{m}$ Cu foil was first measured then directed to a secondary sample of Al or polypropylene (PP), typically 300– $400~\mu \text{m}$ away. The time evolution of the sample electron temperature was measured using streaked optical pyrometry, where we observed a peak temperature of 0.9 ± 0.15 eV on the rear surface of an Al sample heated by the proton beam. Simulations using the hybrid-PIC code LSP and the rad-hydro code HELIOS show that a measured proton beam can heat Al to approximately 4 eV and PP to 1 eV if instead focused by a hemispherical Cu target. Through additional LSP simulations, we anticipate creating hotter WDM states (~20 eV) by increasing the laser energy to 10 J and keeping the other laser parameters fixed.

Collection and focusing of laser accelerated proton beam by an electromagnetic quadrupole triplet lens

To make use of laser-accelerated protons in real-world applications, specially-designed beamlines are required to control and improve the quality of the beam. At Peking University, the Compact LAser Plasma Accelerator (CLAPA) has been built, and is now coupled with an image-relaying beamline. The primary collection component of this beamline is an electromagnetic quadrupole triplet lens. As this lens is the first and the most crucial step for successful beam transport, we have systematically studied the focusing effect on the laser-driven protons, in terms of emittance, beam profile, and collection efficiency. We found that the normalized rms emittance of the protons can increase significantly, from the order of a fraction of mm⋅mrad to several mm⋅mrad, due to the dispersion of the phase space ellipse caused by the joint effect of the wide energy spread and the nonlinear field at the edge of the quadrupoles. The focusing profile and efficiency are also sensitive to the position and angular deviations of the injected proton beams. With fine adjustment, we found that the collection efficiency can be improved from lower than 10% up to 29%, for protons at the reference energy for CLAPA.

Shaping of a laser-accelerated proton beam for radiobiology applications via genetic algorithm

Laser-accelerated protons have a great potential for innovative experiments in radiation biology due to the sub-picosecond pulse duration and high dose rate achievable. However, the broad angular divergence makes them not optimal for applications with stringent requirements on dose homogeneity and total flux at the irradiated target. The strategy otherwise adopted to increase the homogeneity is to increase the distance between the source and the irradiation plane or to spread the beam with flat scattering systems or through the transport system itself. Such methods considerably reduce the proton flux and are not optimal for laser-accelerated protons. In this paper we demonstrate the use of a Genetic Algorithm (GA) to design an optimal non-flat scattering system to shape the beam and efficiently flatten the transversal dose distribution at the irradiated target. The system is placed in the magnetic transport system to take advantage of the presence of chromatic focusing elements to further mix the proton trajectories. The effect of a flat scattering system placed after the transport system is also presented for comparison. The general structure of the GA and its application to the shaping of a laser-accelerated proton beam are presented, as well as its application to the optimisation of dose distribution in a water target in air.

Experimental investigation on nuclear reactions using a laser-accelerated proton and deuteron beam

We report an experimental investigation on nuclear reactions using an intense, ultra-short laser-accelerated proton and deuteron beam generated by the interaction of 25 fs, 150 TW Ti: sapphire laser pulse with normal thin foils and foils containing deuterium atoms. The production of a positron-emitting short-lived 11C radio-isotope from the interaction of protons and deuterium ions with a solid boron palette by means of 11B (p, n)11C and 10B (d, n)11C nuclear reactions was studied. The maximum radioactivity in the optimized laser irradiation condition was found to be 5.2 kBq per laser shot, which corresponds to ∼9 × 106 atoms of 11C isotopes using the 11B (p, n)11C reaction. The relative efficiency of 11C production using a proton and deuteron beam was also explored experimentally. About 30 % enhancement in 11C activity was observed with CD2 coated targets. It was also found that because of the relatively low deuteron energy threshold of the reaction 10B (d, n)11C, even the low energy part of the accelerated deuterons in the spectrum can be used for efficient 11C production. In the same setup, the proton-induced fusion reaction in the boron target (p + 5B11 ⇒ 3α + 8.7 MeV) was also studied. The resultant fusion yield and alpha particle energy spectrum was measured.