Laser-accelerated Proton Beams Research Articles

Experimental investigation on nuclear reactions using a laser-accelerated proton and deuteron beam

We report an experimental investigation on nuclear reactions using an intense, ultra-short laser-accelerated proton and deuteron beam generated by the interaction of 25 fs, 150 TW Ti: sapphire laser pulse with normal thin foils and foils containing deuterium atoms. The production of a positron-emitting short-lived 11C radio-isotope from the interaction of protons and deuterium ions with a solid boron palette by means of 11B (p, n)11C and 10B (d, n)11C nuclear reactions was studied. The maximum radioactivity in the optimized laser irradiation condition was found to be 5.2 kBq per laser shot, which corresponds to ∼9 × 106 atoms of 11C isotopes using the 11B (p, n)11C reaction. The relative efficiency of 11C production using a proton and deuteron beam was also explored experimentally. About 30 % enhancement in 11C activity was observed with CD2 coated targets. It was also found that because of the relatively low deuteron energy threshold of the reaction 10B (d, n)11C, even the low energy part of the accelerated deuterons in the spectrum can be used for efficient 11C production. In the same setup, the proton-induced fusion reaction in the boron target (p + 5B11 ⇒ 3α + 8.7 MeV) was also studied. The resultant fusion yield and alpha particle energy spectrum was measured.

Irradiation and dosimetry arrangement for a radiobiological experiment employing laser-accelerated protons

The Bragg Peak is a unique characteristic of ion beams which makes their use beneficial in cancer treatment as it allows the majority of dose deposition to be localised in a precise volume. The use of a laser system for particle acceleration is currently investigated as a potential alternative to the conventional RF accelerators currently used for hadrontherapy. The biological response of cells irradiated by high dose-rate laser-driven ions is currently being explored in this context. The experiment reported here was carried out as part of the A-SAIL project, a UK-wide collaboration aiming to develop innovative techniques for accelerating ions for future clinical applications. In this contest, a radiobiological experiment was carried out on the pico2000 laser beamline at LULI-'Ecole Polytechnique using an energetically spread, laser-accelerated proton beam. This paper will discuss the arrangement used in the experiment, and the techniques employed for an accurate estimation of the dose deposited, supported by Monte Carlo simulations of the particle propagation through the irradiation system.

Proton acceleration through a charged cavity created by ultraintense laser pulse

The potential of laser-driven ion beam applications is limited by high quality requirements. The excellent “point-source” characteristics of the laser accelerated proton beam in a broad energy range were found by using proton radiographs of a mesh. The “virtual source” of protons, the point where the proton trajectories are converging and form a waist, gradually decreases and moves asymptotically to the target with increasing particles' energy. Computer simulations confirmed that the beam profile at the center is fully conserved, the virtual source of higher energy protons gradually moves closer to the target, and if the particle energy is further increased, the virtual source will be located on the target front surface (for portions above 13 MeV, in this case) with a size comparable to the laser spot size. The laser ponderomotive force pushes the electrons deep into the target creating a bipolar charge structure, i.e., an electron cavity and spike which produces strong accelerating field, realizing a point-size source of accelerated protons. This behavior has not previously been predicted. These results contribute to the development of next generation laser-accelerators suitable for many applications.

Laser-PIXE using laser-accelerated proton beams

Laser-driven proton acceleration is a field of growing interest, in particular for its numerous applications, including in the field of materials science. A benefit of these laser-based particle sources is their potential for a relative compactness in addition to some characteristics at the source that differ from those of conventional, radio-frequency based proton sources. These features include, e.g., a higher brilliance, a shorter duration, and a larger energy spread. Recently, the use of laser-accelerated protons has been proposed in the field of Cultural Heritage, as alternative source for the Particle Induced X-ray Emission diagnostic (“laser-PIXE”), a particular ion beam analysis (IBA) technique that allows to precisely analyse the chemical composition of the material bulk. In this paper we study the feasibility of the laser-PIXE using laser-accelerated proton beams. We focus on materials specifically of interest for the Cultural Heritage domain. Using Geant4 simulations, we show that the laser-PIXE allows analysing a larger volume than conventional PIXE, profiting from the large energy spread of laser-accelerated protons. Furthermore, for specific materials, the large energy spread allows investigating multilayer materials, providing an advantage compared to conventional PIXE technologies.

Absolute calibration of GafChromic film for very high flux laser driven ion beams.

We report on the calibration of GafChromic HD-v2 radiochromic film in the extremely high dose regime up to 100 kGy together with very high dose rates up to 7 × 1011 Gy/s. The absolute calibration was done with nanosecond ion bunches at the Neutralized Drift Compression Experiment II particle accelerator at Lawrence Berkeley National Laboratory (LBNL) and covers a broad dose dynamic range over three orders of magnitude. We then applied the resulting calibration curve to calibrate a laser driven ion experiment performed on the BELLA petawatt laser facility at LBNL. Here, we reconstructed the spatial and energy resolved distributions of the laser-accelerated proton beams. The resulting proton distribution is in fair agreement with the spectrum that was measured with a Thomson spectrometer in combination with a microchannel plate detector.

Detection and analysis of laser driven proton beams by calibrated Gafchromic HD-V2 and MD-V3 radiochromic films.

The radiochromic film (RCF) is a high-dose, high-dynamic range dosimetry detection medium. A stack of RCFs can be used to detect both spatial and energetic distribution of laser driven ion beams with a large divergence angle and continuous energy spectrum. Two types of RCFs (HD-V2 and MD-V3, from Radiation Products Design, Inc.) have been calibrated using MeV energy protons and carbon ions produced by using a 2 × 6 MV tandem electrostatic accelerator. The proportional relationship is obtained between the optical density and the irradiation dose. For protons, the responses are consistent at all energies with a variation of about 15%. For carbon ions, the responses are energy related, which should be noted for heavy ion detection. Based on the calibration, the broad energy spectrum and charge distribution of laser accelerated proton beam with energy from 3 to 8 MeV and pC charge were detected and reconstructed at the Compact LAser Plasma Accelerator at Peking University.

Transversal dose distribution optimization for laser-accelerated proton beam medical applications by means of Geant4

The main purpose of this paper is to quantitatively study the possibility of delivering dose distributions of clinical relevance with laser-driven proton beams. A Monte Carlo application has been developed with the Geant4 toolkit, simulating the ELIMED (MEDical and multidisciplinary application at ELI-Beamlines) transport and dosimetry beam line which is being currently installed at the ELI-Beamlines in Prague (CZ). The beam line will be used to perform irradiations for multidisciplinary studies, with the purpose of demonstrating the possible use of optically accelerated ion beams for therapeutic purposes. The ELIMED Geant4-based application, already validated against reference transport codes, accurately simulates each single element of the beam line, necessary to collect the accelerated beams and to select them in energy. Transversal dose distributions at the irradiation point have been studied and optimized to try to quantitatively answer the question if such kind of beam lines, and specifically the systems developed for ELIMED in Prague, will be actually able to transport ion beams not only for multidisciplinary applications, such as pitcher-catcher nuclear reactions (e.g. neutrons), PIXE analysis for cultural heritage and space radiation, but also for delivering dose patterns of clinical relevance in a future perspective of possible medical applications.

Graphitization of diamond by laser-accelerated proton beams

In this work, we investigate the interaction between fast energetic proton beams generated by laser-plasma based accelerators with carbon lattices of graphite and diamond. Theoretical and experimental results indicate that these proton beams cause both, a low sputtering of carbon atoms from lattices (estimated to be in the order of 3 × 10−8 displacements per atom for each single shot), and a heating (inside the target and within a depth of about 10 μm below the surface) at a temperature close to the sp3/sp2 transition. The defects generated inside the lattices by the atom displacements cause the random formation of amorphous carbon islands, while the higher temperature causes the start of diamond partial graphitization. All the results suggest the impossibility to use diamond as detector in laser-driven accelerators when placed close to the source, while they confirm that proton beams can be used as alternative to classical laser or ion beam methods to graphitize diamond in specific optoelectronic applications.

Efficient monoenergetic proton beam from ultra-fast laser interaction with nanostructured targets

The broad energy spectrum of laser-accelerated proton beams is the most important difficulty associated with such particle sources on the way to future applications such as medical therapy, proton imaging, inertial fusion, and high-energy physics. The generation of proton beams with enhanced monoenergetic features through an ultra-intense laser interaction with optimized nanostructured targets is reported. Targets were irradiated by 40 fs laser pulses of intensity 5.5×1020 W cm−2 and wavelength 1 μm. The results of multi-parametric Particle-in-Cell calculations showed that proton beams with considerably reduced energy spread can be obtained by using the proposed nanostructured target. At optimized target dimensions, the proton spectrum was found to exhibit a narrow peak at about 63 MeV with a relative energy spread of ΔE/Epeak∼ 5% which is efficiently lower than what is expected for unstructured double layer targets (∼70%).

Influence of micromachined targets on laser accelerated proton beam profiles

High intensity laser-driven proton acceleration from micromachined targets is studied experimentally in the target-normal-sheath-acceleration regime. Conical pits are created on the front surface of flat aluminium foils of initial thickness 12.5 and 3 μm using series of low energy pulses (0.5–2.5 μJ). Proton acceleration from such micromachined targets is compared with flat foils of equivalent thickness at a laser intensity of 7 × 1019 W cm−2. The maximum proton energy obtained from targets machined from 12.5 μm thick foils is found to be slightly lower than that of flat foils of equivalent remaining thickness, and the angular divergence of the proton beam is observed to increase as the depth of the pit approaches the foil thickness. Targets machined from 3 μm thick foils, on the other hand, show evidence of increasing the maximum proton energy when the depths of the structures are small. Furthermore, shallow pits on 3 μm thick foils are found to be efficient in reducing the proton beam divergence by a factor of up to three compared to that obtained from flat foils, while maintaining the maximum proton energy.

Manipulation of laser-accelerated proton beam profiles by nanostructured and microstructured targets

Nanostructured and microstructured thin foils have been fabricated and used experimentally as targets to manipulate the spatial profile of proton bunches accelerated through the interaction with high intensity laser pulses (6 x 1019 W/cm(2)). Monolayers of polystyrene nanospheres were placed on the rear surfaces of thin plastic targets to improve the spatial homogeneity of the accelerated proton beams. Moreover, thin targets with grating structures of various configurations on their rear sides were used tomodify the proton beam divergence. Experimental results are presented, discussed, and supported by 3D particle-in-cell numerical simulations.

An analytical reconstruction model of the spread-out Bragg peak using laser-accelerated proton beams

With the development of laser technology, laser-driven proton acceleration provides a new method for proton tumor therapy. However, it has not been applied in practice because of the wide and decreasing energy spectrum of laser-accelerated proton beams. In this paper, we propose an analytical model to reconstruct the spread-out Bragg peak (SOBP) using laser-accelerated proton beams. Firstly, we present a modified weighting formula for protons of different energies. Secondly, a theoretical model for the reconstruction of SOBPs with laser-accelerated proton beams has been built. It can quickly calculate the number of laser shots needed for each energy interval of the laser-accelerated protons. Finally, we show the 2D reconstruction results of SOBPs for laser-accelerated proton beams and the ideal situation. The final results show that our analytical model can give an SOBP reconstruction scheme that can be used for actual tumor therapy.

Laser-Accelerated Proton Beams as Diagnostics for Cultural Heritage

This paper introduces the first use of laser-generated proton beams as diagnostic for materials of interest in the domain of Cultural Heritage. Using laser-accelerated protons, as generated by interaction of a high-power short-pulse laser with a solid target, we can produce proton-induced X-ray emission spectroscopies (PIXE). By correctly tuning the proton flux on the sample, we are able to perform the PIXE in a single shot without provoking more damage to the sample than conventional methodologies. We verify this by experimentally irradiating materials of interest in the Cultural Heritage with laser-accelerated protons and measuring the PIXE emission. The morphological and chemical analysis of the sample before and after irradiation are compared in order to assess the damage provoked to the artifact. Montecarlo simulations confirm that the temperature in the sample stays safely below the melting point. Compared to conventional diagnostic methodologies, laser-driven PIXE has the advantage of being potentially quicker and more efficient.

Laser-accelerated ion beam diagnostics with TOF detectors for the ELIMED beam line

Laser-accelerated ion beams could represent the future of particle acceleration in several multidisciplinary applications, as for instance medical physics, hadrontherapy and imaging field, being a concrete alternative to old paradigm of acceleration, characterized by huge and complex machines. In this framework, following on from the ELIMED collaboration, launched in 2012 between INFN-LNS and ELI-Beamlines, in 2014 a three-years contract has been signed between the two institutions for the design and the development of a complete transport beam-line for high-energy ion beams (up to 60 MeV) coupled with innovative diagnostics and in-air dosimetry devices. The beam-line will be installed at the ELI-Beamlines facility and will be available for users. The measurement of the beam characteristics, such as energy spectra, angular distributions and dose-rate is mandatory to optimize the transport as well as the beam delivery at the irradiation point. In order to achieve this purpose, the development of appropriate on-line diagnostics devices capable to detect high-pulsed beams with high accuracy, represents a crucial point in the ELIMED beamline development. The diagnostics solution, based on the use of silicon carbide (SiC) and diamond detectors using TOF technique, will be presented together with the preliminary results obtained with laser-accelerated proton beams.

Experimental studies with two novel silicon detectors for the development of time-of-flight spectrometry of laser-accelerated proton beams

Laser-accelerated proton beams exhibit remarkably different beam characteristics as compared to conventionally accelerated ion beams. About 105 to 107 particles per MeV and msr are accelerated quasi-instantaneously within about 1 ps. The resulting energy spectrum typically shows an exponentially decaying distribution. Our planned approach to determine the energy spectrum of the particles generated in each pulse is to exploit the time-of-flight (TOF) difference of protons with different kinetic energies at 1 m distance from the laser-target interaction. This requires fast and sensitive detectors. We therefore tested two prototype silicon detectors, developed at the Centre for Medical Radiation Physics at the University of Wollongong with a current amplifier, regarding their suitability for TOF-spectrometry in terms of sensitivity and timing properties. For the latter, we illuminated the detectors with short laser pulses, measured the signal current and compared it to the signal of a fast photodiode. The comparison revealed that the timing properties of both prototypes are not yet sufficient for our purpose. In contrast, our results regarding the detectors’ sensitivity are promising. The lowest detectable proton flux at 10 MeV was found to be 25 protons per ns on the detector. With this sensitivity and with a smaller pixelation of the detectors, the timing properties can be improved for new prototypes, making them potential candidates for TOF-spectrometry of laser-accelerated particle beams.

Proton probing of laser-driven EM pulses travelling in helical coils

The ultrafast charge dynamics following the interaction of an ultra-intense laser pulse with a foil target leads to the launch of an ultra-short, intense electromagnetic (EM) pulse along a wire connected to the target. Due to the strong electric field (of the order of $\text{GV m}^{-1}$ ) associated to such laser-driven EM pulses, these can be exploited in a travelling-wave helical geometry for controlling and optimizing the parameters of laser accelerated proton beams. The propagation of the EM pulse along a helical path was studied by employing a proton probing technique. The pulse-carrying coil was probed along two orthogonal directions, transverse and parallel to the coil axis. The temporal profile of the pulse obtained from the transverse probing of the coil is in agreement with the previous measurements obtained in a planar geometry. The data obtained from the longitudinal probing of the coil shows a clear evidence of an energy dependent reduction of the proton beam divergence, which underpins the mechanism behind selective guiding of laser-driven ions by the helical coil targets.

Focusing effect of channel target on ultra-intense laser-accelerated proton beam

In laser proton acceleration, the inevitable transverse divergence of proton beam restricts its applications in many fields. In this paper, a structured target with a properly wide channel attached to the backside of a foil is proposed, and the interaction of the ultra-short laser pulse with the structured channel target is investigated via two-dimensional particle-in-cell simulation. The simulations show that for the structured channel target, electrons on the front surface are heated by the incident high-intensity laser pulse and then the induced hot electrons transport through the target to the rear surface, building an electrostatic field in the longitudinal direction to accelerate the protons to high energies as the typical target normal sheath acceleration scheme. In the case of the structured channel target, the simulation results indicate that a strong transverse electrostatic field is created by charge separation along the inner surface of the channel while hot electrons propagate along the channel side walls under the guidance of self-induced magnetic and electric fields, which can focus the emitted proton beam transversely, leading to a smaller divergence. By comparing the channel target case with the traditional foil target case under the same conditions, it is found that the divergence angle of the proton beam from the channel target is reduced significantly. Protons with energies above 3 MeV have a divergence angle of 5.3° at the time of 500 fs in the channel target case, while the value is 17.1° in the foil case for a laser intensity of 5.4×1019 W/cm2. Additionally, the effect of the channel target on the maximum proton energy is considered. The simulation results of the energy spectra reveal that the maximum proton cut-off energy of the channel target is about 1 MeV lower than that of the foil target. This small energy loss is due to the refluxing of the cold electrons on the channel walls, which suppresses the increasing of the sheath potential. Therefore, it is concluded that the focusing electric field can work on the proton beam effectively, leading to a better collimation with conserving the proton energy by using the proposed channel target. Especially when the inner diameter of the channel target is comparable to the laser focal spot size, the proton beam can be confined to a small divergence, and a relatively higher laser energy conversion efficiency can be ensured as well.

1568P - Development of laser-driven proton beam therapy

ABSTRACT Aim: Proton beams by their advantageous dose profile over conventional photon and electron beams may provide higher dose conformity and better healthy tissue sparing. But due to high costs and huge size of existing facilities, proton therapy is limited to few centers. A novel proton acceleration, on µm scale by ultra-intense lasers, promises compact accelerators and beam delivery systems. Unlike conventional proton beams, laser-accelerated proton (LAP) beam is characterized by short ultra-intense pulses with peak dose rates exceeding conventional values by ∼9 orders of magnitude but low repetition rate, broad energy spread and large divergence. They require completely new techniques of beam transport, dose delivery and quality assurance along with radiobiological characterization. Methods: The presented work is an ongoing joint translational research project of several institutions in Germany aiming to establish LAP therapy. In parallel to the development of high power laser systems and laser targets to generate stable and reproducible LAP beams, a dedicated radiation oncology focused research program is being followed. Results: Laser-based technology was established for cell and small animal irradiation. The high power laser system DRACO was setup and optimized for long-term stable proton acceleration. A dedicated fixed-beam transport system with integrated energy selection and field shaping as well as real time dose monitoring was established. The suitability and reliability of all components was proven in systematic radiobiological studies over months. No overall difference in the biological effectiveness between laser-accelerated and conventional beams was detected to date. For translation towards patient irradiation, increase of proton energy from ∼25 to ∼230 MeV by increasing the laser power from ∼100 TW to ∼1 PW is required and the development of PW laser is in progress. Furthermore, a compact 360° isocentric proton gantry was designed, based on novel light-weight high-field pulsed magnets. This gantry is ∼2.5x smaller than conventional proton gantries. The necessary pulsed magnets are being developed together with novel dose delivery strategy for LAP. Conclusions: LAP therapy is a promising alternative, yet require substantial development with a clinical prototype in some years. Supported by German BMBF, no. 03Z1N511. Disclosure: All authors have declared no conflicts of interest.

Fusion Energy and Stopping Power in a Degenerate DT Pellet Driven by a Laser-Accelerated Proton Beam**Supported by the Research Council of University of Guilan

In this paper, we have improved the fast ignition scheme in order to have more authority needed for high-energy-gain. Due to the more penetrability and energy deposition of the particle beams in fusion targets, we employ a laser-to-ion converter foil as a scheme for generating energetic ion beams to ignite the fusion fuel. We find the favorable intensity and wavelength of incident laser by evaluating the laser-proton conversion gain. By calculating the source-target distance, proton beam power and energy are estimated. Our analysis is generalized to the plasma degeneracy effects which can increase the fusion gain several orders of magnitude by decreasing the ion-electron collisions in the plasma. It is found that the wavelength of 0.53 μm and the intensity of about 1020 W/cm2, by saving about 10% conversion coefficient, are the suitable measured values for converting a laser into protons. Besides, stopping power and fusion burn calculations have been done in degenerate and non-degenerate plasma mediums. The results indicate that in the presence of degeneracy, the rate of fusion enhances.

Laser-accelerated proton beam for fast ignition considering formation factor of a cloud and penetrability in P11B reaction

In this work proton beam is proposed in fast ignition of P11B fuel considering uniform density equal to 300 g cm−3. The total stopping power and range of protons are estimated by introducing the stopping power contribution of electrons and ions as a function of initial energy and temperature in the fuel. Also bonus energy and total deposition energy due to the additional fusion reactions are calculated. The bonus energy and total deposited energy are remarkable at smaller beam energy and higher electron temperature. Also this article show that the cross section of P11B fusion reaction is increased by increasing the penetrability of nuclei through the Coulomb barrier. In this approach, an intense laser field of more than 100 PW is required to distort the Coulomb barrier to obtain enough penetrability. We have calculated the penetrability of nuclei and the formation factor using available relations.