ABSTRACT Based on field survey data, a numerical simulation method that combines an indoor settling experiment with the Mixture multiphase flow model and the Population Balance Model (PBM) was adopted in this article to study and analyze the sedimentation law of water-containing crude oil in a tank under different initial particle sizes and different continuous-phase viscosities. The results indicate that the maximum error in the comparison of the water content changes at different positions in the sedimentation cylinder after 1 h with experimental values is approximately 8.34%, confirming the precision of the developed settling model. When the initial particle size of liquid droplets in the tank increases from 8 μm to 64 μm, the maximum water content in the tank increases by 1.115%, and the magnitude of the increase in the average droplet size decreases by 90%. As the viscosity of the oil increases (from 35.26 mPa · s to 77.77 mPa · s), the maximum water content in the tank decreases by 1.331%, while the height of the stable water content region increases by 13.2%.