Large Group Research Articles

The Political Economy of the Roof: The New Village Movement in 1970s South Korea

This study investigates South Korea’s rural modernization project conducted under the name of the New Village Movement during the rapid industrialization period of the 1970s. The focus is on a specific event called the Roof Improvement Project within this Movement. In the 1970s, rural poverty was often portrayed through images of monochromatic village landscapes populated by dilapidated mud-walled houses crowned with coverings of faded grass thatch. Replacing the thatched roofs with something more colorful and modern was quickly identified as one of the most effective ways of showcasing ‘rural development.’ By 1978, an astonishing 2,618,000 thatched houses throughout the countryside had their old roofs replaced with a new material known as ‘slate.’ The rural ‘change’ particularly manifested through the brightly colored slate roofs lining the highways. This technicolor display propagandized development and, ultimately, legitimized the military regime’s rule. However, the new ‘modern’ roofs actually eroded farmers’ financial status and bolstered the accumulation of capital by specific industries. To trace the flow of capital extracted from farmers, this study also delves into the history of two large corporate groups - KCC and Pyŏksan - that were able to solidify the early foundation for their current business formation in the 1970s.

A new species of the genus Ropalidia Guérin-Méneville from central Africa (Insecta, Hymenoptera, Vespidae)

Ropalidia chromissp. nov. is described from the Democratic Republic of the Congo. It is characterized by a mixture of morphological features present in two large species groups of that genus, suggesting a separate phylogenetic lineage.

ANALISA DAMPAK RASIO KEUANGAN PERBANKAN TERHADAP PROFITABILITAS BANK BERDASARKAN MODAL INTI (KBMI) PADA KELOMPOK BANK DI INDONESIA

This research aims to investigate the analysis of the relationship between banking financial ratios and profitability using the purposive sampling technique in the form of panel data. The research sample was derived from 47 banking sectors listed on the BEI stock exchange from 2013 to 2022, with a total of 470 firm-year observations. The regression method employed was the Ordinary Least Squares (OLS) data panel, and it underwent tests for regression model selection, classical assumptions, robustness, and the Generalized Least Squares (GLS) method. The research findings indicate that CASA is a determining factor for banks in general to enhance Return on Assets (ROA), especially in the small bank group (KBMI 1 and 2). BOPO has been a hindering factor for banks in general to achieve profitability (ROA and ROE) over the past 10 years. In the pre and POST economic crisis of Covid-19, the Loan to Deposit Ratio (LDR) is a hindering factor for banks in general to achieving profitability. Interestingly, as long as the economic crisis, the opposite is true, LDR became a determining factor in increasing profitability, especially in the large bank group (KBMI 3 and 4).

A review on Persian Gulf brown algae as potential source for anticancer drugs

Cancer remains one of the most formidable challenges in modern medicine, and its global impact on human health underscores the urgency for advancing treatment methods. Despite the significant progress in understanding the complex biology of cancer and the development of different therapeutic approaches, the search for new anticancer agents for cancer treatment is very important. Marine organisms are a valuable source for the development of new agents for clinical application. Brown algae, a group of marine macroalgae abundant in the Persian Gulf, have emerged as a promising source of bioactive compounds with potent anticancer properties. This comprehensive review provides an overview of the current advances regarding the anti-cancer activity of the Persian Gulf brown algae as a valuable reservoir of anticancer agents. Among marine organisms, algae are a large and diverse group of organisms from which a wide range of secondary metabolites have been isolated. This review shows the active components of the Persian Gulf brown algae along with their antitumor potential for cancer treatment according to their structure. It also describes and discusses various extraction techniques and compound modification methods. The species of Sargassum seaweed is the most researched for anticancer properties in the Persian Gulf. The results of various studies in this study show that Persian Gulf brown algae extracts and fractions have different cytotoxic effects on various types of cancer cell lines. These organisms have the ability to produce compounds with promising properties that can be used in the biomedicine field. These compounds have shown antioxidant, anti-inflammatory and anti-cancer properties, which can be useful for medicinal chemists in the development of effective anti-cancer drugs.

How Does the Elimination of Group Mean-Differences Affect Factor Score Determinacy?

The present study investigates to what degree the common variance of the factor score predictor with the original factor, i.e., the determinacy coefficient or the validity of the factor score predictor, depends on the mean-difference between groups. When mean-differences between groups in the factor score predictor are eliminated by means of covariance analysis, regression, or group specific norms, this may reduce the covariance of the factor score predictor with the common factor. It is shown that in a one-factor model with the same group mean-difference on all observed variables, the common factor cannot be distinguished from a common factor representing the group mean-difference. It is also shown that for common factor loadings equal or larger than .60, the elimination of a d = .50 mean-difference between two groups in the factor score predictor leads to only small decreases of the determinacy coefficient. A compensation-factor k is proposed allowing for the estimation of the number of additional observed variables necessary to recover the size of the determinacy coefficient before elimination of a group mean-difference. It turns out that for factor loadings equal or larger than .60 only a few additional items are needed in order to recover the initial determinacy coefficient after the elimination of moderate or large group mean-differences.

The genomic study of repetitive elements in Solea senegalensis reveals multiple impacts of transposable elements in the evolution and architecture of Pleuronectiformes chromosomes

Pleuronectiformes are flatfishes with high commercial value and a prominent example of successful marine adaptation through chromosomal evolution. Hence, the aim of this study was to analyze the 14 relative abundance of repetitive elements (satellite DNA and transposable elements (TE)) in the 15 genome of 10 fish species (8 flatfish) delving into the study of the species of special relevance, 16 Senegalese sole, Solea senegalensis. The results showed differences in the abundance of repetitive elements, with S. senegalensis exhibiting the highest frequency and coverage of these elements reaching the 40% of the genome and not at random distribution. It is noteworthy the presence of relevant peaks of Helitrons in centromeric/pericentromeric positions mainly in the bi-armed chromosomes 1, 2, 4, 6, 7, and 9. The position of the centromeres of this species determined through the genomic localization of the family of satellite DNA PvuII, and other repetitive sequences was obtained de novo. This allowed us to know the genomic position of the centromeres in 19 out of the 21 chromosomes of S. senegalensis. Helitrons showed an accumulation of tandem copies mainly in the pericentromeric positions of chromosomes 1 and 2, occupying a region, in the first case, of 600Kb of tandem repeats. That has only been previously described in mammals and plants. Divergence and copy number studies indicated the presence of active families in the species’ genome and the existence of two important events of transposon activity (burst) in the genome of S. senegalensis, mainly accentuated in Helitrons. The results showed that only the families of DNA transposons exhibited a landscape with symmetrical bell-shaped distribution. The phylogenetic analysis of Helitron families revealed the presence of two large groups of families and the presence of four groups of sequences with heterogeneous distribution among chromosomes. Finally, the phylogenomic analysis of 8615 sequences belonging to Helitron insertions from 5 families of flatfish and two external species, allowed to classify the copies into nine groups of sequences with different levels of divergence and clusters, including some branches with distant phylogenetically species. The implications of this study will help to expand the knowledge of chromosome structure and evolution of these species.

Procedural characteristics and cardiovascular outcomes in patients undergoing drug-coated balloon angioplasty for de novo lesions in large coronary arteries: an observational study.

Limited data exist regarding drug-coated balloon (DCB) treatment in de novo large coronary arteries. We sought to demonstrate procedural characteristics, residual stenosis, and clinical outcomes following DCB angioplasty for de novo lesions in large versus small coronary arteries. The study included 184 consecutive patients with 223 de novo coronary lesions undergoing paclitaxel DCB angioplasty between January 2019 and August 2020, who were divided according to whether the DCB diameter was ≥ 3.0mm (large group, n = 58) or < 3.0mm (small group, n = 125). The large group had a higher proportion of acute coronary syndrome more commonly with ostial, bifurcation, and calcified lesions in large vessels and received lesion preparation with more frequent use of scoring or cutting balloons and atherectomy devices compared to the small group. Postprocedural angiographic diameter stenosis was smaller in the large group compared to the small group (31% [22-37] vs. 35% [26-42], p = 0.032), and intravascular ultrasound revealed no significant difference in postprocedural area stenosis between the groups (66.2 ± 7.7% vs. 67.9 ± 7.8%; p = 0.26). The median follow-up duration was 995days. The incidence of a composite of all-cause death, myocardial infarction, stroke, or target lesion revascularization was similar between the groups (log-rank p = 0.41) and was influenced by the presence of acute coronary syndrome and anemia but not by DCB diameter. The rate of cardiovascular outcomes after DCB treatment was comparable in de novo large and small coronary arteries. Notably, well-planned lesion preparation with intravascular imaging guidance was prevalent in large vessels.

Кратък обзор върху микробиологични аспекти на компостирането

Recycling and disposal of urban waste is one of the goals set by the European Union. The process of composting, which is a cost-effective and environmentally friendly method of processing organic residues, is considered to be one of the ways to achieve these goals. Composting is a biological oxidation process in which organic residues are broken down by a large group of different microorganisms. The present publication presents a brief overview on the composting of organic residues and the participation of individual groups of microorganisms in this process. The decay of materials during composting follows the general biochemical pathways of any other degradation process. In the composting processes and in the finished compost, non-sporeforming bacteria and bacilli, which are most actively involved in the initial stages of degradation of organic substances, occupy a major share in the composition of the general microflora. The share of actinomycetes and micromycetes, which are generally more active in the final stages of organic matter decomposition, is smaller. The amount of actinomycetes increases with increasing temperature in the composting phases. The biogenicity of compost depends on the type of biodegradable agricultural waste used.

Partial purification and characterization of protease extracted from kinema

Proteases are large group of highly demanded enzymes having huge application in food and pharmaceutical industries. Numerous sources, including plants, microorganisms, and animals, can be used to obtain protease. Due to its affordability and safety consideration, fermented foods have recently attracted more attention as a source of microbial protease. The present study aimed to extract protease from kinema, partially purify the extracted protease following dialysis after precipitation with ammonium sulfate, and determine general characteristics of protease. The kinema having highest proteolysis activity after three days of control fermentation (Temperature 30±2 °C, RH 66 ± 2%) was taken for the study. About 2.45 fold of purification with overall recovery of 63.21% was achieved after precipitation with ammonium sulfate at 30–70% saturation level followed by dialysis of crude extracted protease. The dialysed kinema protease had specific activity of 7.90 U/mg. The enzyme remained actively functional across a wider pH (5–9) and temperature (40-60 °C) range. SDS-PAGE and Zymogram confirmed the presence of three major active bands respectively of 29.04 kDa, 36.09 kDa and 46.35 kDa in the kinema protease extract. The enzyme kinetics data on casein, fitted to Mechaelis Mentens’ plots showed the protease had Vmax of 1.001 U/ml with corresponding Km value of 0.825 mg/ml. Metal ions such as iron, mercury and aluminium showed the inhibition effect whereas presence of sodium, zinc, and calcium shows the activation effect on protease performance. The enzyme was active over various natural substrates; showing maximal activity on casein, and subsequent to bovine serum albumin, gelatin, hemoglobin and whey protein respectively. Furthermore, molecular weight distribution of the protease extract and activity inhibition with ethylenediaminetetraacetic acid and phenylmethylsulfonyl fluoride, suggesting the protease from kinema could be a metal dependent serine protease or mixture of them.

Outcome of Epilepsy Surgery in MRI-Negative Patients Without Histopathologic Abnormalities in the Resected Tissue.

Patients with presumed nonlesional focal epilepsy-based on either MRI or histopathologic findings-have a lower success rate of epilepsy surgery compared with lesional patients. In this study, we aimed to characterize a large group of patients with focal epilepsy who underwent epilepsy surgery despite a normal MRI and had no lesion on histopathology. Determinants of their postoperative seizure outcomes were further studied. We designed an observational multicenter cohort study of MRI-negative and histopathology-negative patients who were derived from the European Epilepsy Brain Bank and underwent epilepsy surgery between 2000 and 2012 in 34 epilepsy surgery centers within Europe. We collected data on clinical characteristics, presurgical assessment, including genetic testing, surgery characteristics, postoperative outcome, and treatment regimen. Of the 217 included patients, 40% were seizure-free (Engel I) 2 years after surgery and one-third of patients remained seizure-free after 5 years. Temporal lobe surgery (adjusted odds ratio [AOR]: 2.62; 95% CI 1.19-5.76), shorter epilepsy duration (AOR for duration: 0.94; 95% CI 0.89-0.99), and completely normal histopathologic findings-versus nonspecific reactive gliosis-(AOR: 4.69; 95% CI 1.79-11.27) were significantly associated with favorable seizure outcome at 2 years after surgery. Of patients who underwent invasive monitoring, only 35% reached seizure freedom at 2 years. Patients with parietal lobe resections had lowest seizure freedom rates (12.5%). Among temporal lobe surgery patients, there was a trend toward favorable outcome if hippocampectomy was part of the resection strategy (OR: 2.94; 95% CI 0.98-8.80). Genetic testing was only sporadically performed. This study shows that seizure freedom can be reached in 40% of nonlesional patients with both normal MRI and histopathology findings. In particular, nonlesional temporal lobe epilepsy should be regarded as a relatively favorable group, with almost half of patients achieving seizure freedom at 2 years after surgery-even more if the hippocampus is resected-compared with only 1 in 5 nonlesional patients who underwent extratemporal surgery. Patients with an electroclinically identified focus, who are nonlesional, will be a promising group for advanced molecular-genetic analysis of brain tissue specimens to identify new brain somatic epilepsy genes or epilepsy-associated molecular pathways.

Use of chemotherapy in patients with oesophageal, stomach, colon, rectal, liver, pancreatic, lung, and ovarian cancer: an International Cancer Benchmarking Partnership (ICBP) population-based study

There are few data on international variation in chemotherapy use, despite it being a key treatment type for some patients with cancer. Here, we aimed to examine the presence and size of such variation. This population-based study used data from Norway, the four UK nations (England, Northern Ireland, Scotland, and Wales), eight Canadian provinces (Alberta, British Columbia, Manitoba, Newfoundland and Labrador, Nova Scotia, Ontario, Prince Edward Island, and Saskatchewan), and two Australian states (New South Wales and Victoria). Patients aged 15-99 years diagnosed with cancer in eight different sites (oesophageal, stomach, colon, rectal, liver, pancreatic, lung, or ovarian cancer), with no other primary cancer diagnosis occurring from within the 5 years before to 1 year after the index cancer diagnosis or during the study period were included in the study. We examined variation in chemotherapy use from 31 days before to 365 days after diagnosis and time to its initiation, alongside related variation in patient group differences. Information was obtained from cancer registry records linked to clinical or patient management system data or hospital administration data. Random-effects meta-analyses quantified interjurisdictional variation using 95% prediction intervals (95% PIs). Between Jan 1, 2012, and Dec 31, 2017, of 893 461 patients with a new diagnosis of one of the studied cancers, 111 569 (12·5%) did not meet the inclusion criteria, and 781 892 were included in the analysis. There was large interjurisdictional variation in chemotherapy use for all studied cancers, with wide 95% PIs: 47·5 to 81·2 (pooled estimate 66·4%) for ovarian cancer, 34·9 to 59·8 (47·2%) for oesophageal cancer, 22·3 to 62·3 (40·8%) for rectal cancer, 25·7 to 55·5 (39·6%) for stomach cancer, 17·2 to 56·3 (34·1%) for pancreatic cancer, 17·9 to 49·0 (31·4%) for lung cancer, 18·6 to 43·8 (29·7%) for colon cancer, and 3·5 to 50·7 (16·1%) for liver cancer. For patients with stage 3 colon cancer, the interjurisdictional variation was greater than that for all patients with colon cancer (95% PI 38·5 to 78·4; 60·1%). Patients aged 85-99 years had 20-times lower odds of chemotherapy use than those aged 65-74 years, with very large interjurisdictional variation in this age difference (odds ratio 0·05; 95% PI 0·01 to 0·19). There was large variation in median time to first chemotherapy (from diagnosis date) by cancer site, with substantial interjurisdictional variation, particularly for rectal cancer (95% PI -15·5 to 193·9 days; pooled estimate 89·2 days). Patients aged 85-99 years had slightly shorter median time to first chemotherapy compared with those aged 65-74 years, consistently between jurisdictions (-3·7 days, 95% PI -7·6 to 0·1). Large variation in use and time to chemotherapy initiation were observed between the participating jurisdictions, alongside large and variable age group differences in chemotherapy use. To guide efforts to improve patient outcomes, the underlying reasons for these patterns need to be established. International Cancer Benchmarking Partnership (funded by the Canadian Partnership Against Cancer, Cancer Council Victoria, Cancer Institute New South Wales, Cancer Research UK, Danish Cancer Society, National Cancer Registry Ireland, The Cancer Society of New Zealand, National Health Service England, Norwegian Cancer Society, Public Health Agency Northern Ireland on behalf of the Northern Ireland Cancer Registry, DG Health and Social Care Scottish Government, Western Australia Department of Health, and Public Health Wales NHS Trust).

Human Capital Formation and Territorial Governance at the Heart of Building a Skill's Local Economy: The Exemplarity of Corsica

In Corsica, the island economy is characterized by the absence of large multinational groups that direct and shape the global economy. Nor is there any mention of the existence of medium-sized enterprises, which in many other regions, like the Third Italy, constitute the spearhead of a dynamic economy. The Corsican economic fabric consists mainly of very small businesses, small farmers and producers, artisans, and traders. Given the hypertrophy of the public sector, private companies seem to be the only option likely to trigger a dynamic of territorial development. The latter necessarily involves the development of strategies for the formation of human capital and a technological research process whose objective is to increase the level of skills, responding to the immanent needs of the island territory. In this perspective, the mode of territorial governance prefigures a model of economic development to be favored.

No clinical outcome difference between varus phenotypes after medial opening-wedge high tibial osteotomy at 2 years follow-up.

Clinical studies regarding medial open-wedge high tibial osteotomy (MOWHTO) often analyse a large group of mechanical varus knees rather than differentiating for its primary varus-inducing component. This study aims to compare the radiological and clinical outcomes of the most prevalent varus malalignment phenotypes using the coronal plane alignment of the knee (CPAK) classification. MOWHTO cases with minimal 2-year clinical follow-up were retrospectively selected from a knee osteotomy database (2016-2020). Based on the medial proximal tibial angle (MPTA) and lateral distal femoral angle (LDFA), subjects were allocated to the correct CPAK phenotype pre- and postoperatively. Clinical outcomes were the numeric rating scale (NRS), the knee injury and osteoarthritis outcome score (KOOS) and the therapeutic response rate (TRR) at 2-year follow-up. Inter-observer correlation coefficient (ICC) and unpaired student t test were performed for cross-phenotype comparison. One hundred thirty-five (135) subjects were found eligible (53.0 years old ±9.6 [19-77], 72% male, 53% left-sided). The most prevalent preoperative phenotype was CPAK 1 (n = 70 (52%)) and the postoperative phenotype was CPAK 6 (n = 66 (49%)). All CPAK phenotypes improved significantly relative to baseline but cross-phenotype comparison yielded no significant differences in clinical outcome. The TRR at 2 years was 67% for CPAK 1, 69% for CPAK 2and 87% for CPAK 4. The TRR for CPAK 6 was 64% compared with 80% for CPAK 9, which was not significantly different. At 2-yearfollow-up, no clinically significant differences are observed between different CPAK phenotypes. Accurate MOWHTO corrections provide significant clinical improvement even in the femoral-driven varus knee and the constitutional varus knee dominated by intra-articular wear. The clinical indication for MOWHTO performance should not be reduced to the medial arthritic varus knee with underlying tibial varus alone. Level IV, retrospective comparative study.

Vitamin D Status in Belgian Children: A Regional Study.

Background: Vitamin D deficiency is the most frequent cause of impaired skeletal growth, and can lead to the development of nutritional rickets. The aim of this study was to evaluate the vitamin D status in a large group of children aged 0-18 years. Methods: We collected laboratory data on vitamin D levels from children who underwent blood sampling between 2014 and 2021. Results: We included 14,887 samples. In this group, 17.7% were vitamin D severely deficient (<12 ng/mL), 25.2% were insufficient (12-20 ng/mL), and another large proportion (28.3%) was borderline (20-30 ng/mL). Sufficient levels (>30 ng/mL) were met in 28.8% of children. We observed no association between gender and vitamin D status (p = 0.132). Adolescents aged 13-18 years (n = 3342) had the highest prevalence of severe vitamin D deficiency (24.9%). Vitamin D levels were higher in summer/autumn compared to winter/spring. Conclusions: Vitamin D deficiency/insufficiency has a high prevalence in children, mostly in children above 7 years of age. Many of these children (over 80%) do not meet the 30 ng/mL sufficiency threshold. It is essential that Belgian Health Authorities are aware of this high prevalence, as the current Belgian recommendation suggests ceasing vitamin D supplementation at the age of six. Additional research is required to investigate the consequences of our findings, and what specific approach is needed to achieve normal vitamin D levels in children aged 0 to 18 years.

The Role of Non-State Actors in Establishing the Halal Ecosystem in Indonesia

Amidst the global growth of the Muslim population, the need for products or services that comply with sharia law has become unavoidable. As the country with the largest Muslim population in the world, Indonesia has declared itself to become a major player in the global halal industry. This can be seen from the changes made by Indonesia in the last decade, both in policy and governance aspects to form an effective halal sector ecosystem as planned in the Indonesia Islamic Economic Masterplan 2019-2024. However, amid several policies implemented by the government, the role of non-state actors, including but not limited to large industries, business groups and MSMEs, community organizations or NGOs, and product influencers, increases and mainstreaming the halal industry in Indonesia cannot be ruled out. Based on a study of several literature related to the halal industry in Indonesia, researchers see that most of the research on the halal industry in Indonesia focuses on discussing strategy and the government as well as opportunities and challenges for Indonesia in developing the halal industry. Therefore, the study aims to discuss the role of non-state actors in forming the halal industrial ecosystem in Indonesia.

Development of Ethnoscience Project-Based Worksheets "Jidor Art" for PGSD Students

Natural science and ethnoscience can help combine local knowledge with modern scientific knowledge to overcome problems in learning. The aim of this research is to determine the feasibility of a worksheet based on the "Jidor art" ethnoscience project for PGSD students, as well as to determine student responses in learning the Physics of sound concept course through a project assignment integrating the Jidor art ethnoscience approach. The subject used is the tanjidor musical instrument. The research method used is the development of the Borg and Gall R &amp; D Model. From data collection to large group operational validation (Step 8). The feasibility results obtained an average score of 4.1 in the good category. Student responses stated that 69.75% agreed that it was acceptable. Thus, it can be concluded that the worksheet based on the ethnoscience project "Jidor Art" for PGSD students is declared suitable for use. Student responses stated that they agreed that it could provide insight, challenge, make things easier and fun, as well as foster the 4C.

International judicial symposium on family court reform: Final report

AbstractOn May 30, 2023, the Association of Family and Conciliation Courts (AFCC) and the National Council of Juvenile and Family Court Judges (NCJFCJ) co‐sponsored an international symposium to explore the subject of family court reform. Twenty‐eight judges representing eight countries and including numerous North American states and provinces met in Los Angeles, California, to identify the most pressing challenges facing family courts and to document promising approaches to improve practice and outcomes in family court cases. They focused on domestic relations cases, as opposed to child welfare and juvenile justice matters. Prior to the symposium, participants responded to a survey about family court reform efforts in each participant's jurisdiction. Judicial officers attending the symposium represented diverse legal systems with some common and many different practices and challenges. After a day filled with small and large group discussions, participants identified key takeaways and made recommendations emanating from the day's discussions.

Attention to the domains of Revised Hasegawa Dementia Scale and Mini-Mental State Examination in patients with Alzheimer's disease dementia.

In Japan, Alzheimer's disease dementia (AD) is the most common cognitive disease, and the most widely used dementia screening tests are the Revised Hasegawa Dementia Scale (HDS-R) and Mini-Mental State Examination (MMSE). This study sought to elucidate the relationships of the individual domains of these tests with age and duration of school education in a large group of patients with AD. Participants were 505 new outpatients diagnosed with AD who completed the HDS-R and MMSE at the first visit. We investigated the relationships of total and individual domains of these tests with age and duration of school education using the least squares method. Next, we plotted regression lines of the individual domain scores against the total test scores. Younger age and longer duration of school education were significantly associated with higher total HDS-R and MMSE scores in AD. Domain-specific results indicated that younger age was significantly associated with a higher immediate memory score on both the HDS-R and MMSE and with a higher orientation (time), repetition score on the MMSE. Longer duration of school education was significantly associated with a higher working memory score on the HDS-R and with higher serial 7, repetition and writing scores on the MMSE. In addition, shorter duration of school education was significantly associated with higher naming score on the MMSE. The regression lines of orientation of time, remote memory, visual memory, and verbal frequency hit the bottom on the HDS-R (4/30, 8/30, 4/30, and 6/30, respectively) and of orientation of time, serial 7, remote memory, and writing also hit the bottom on the MMSE (8/30, 9/30, 11/30, and 8/30, respectively). We should pay attention to age, duration of school education, and the individual domains when using the HDS-R or MMSE to assess patients with AD.

Choice of tools of anti-crisis management at industrial enterprises of Ukraine

The relevance of the research of the tools of anti-crisis management at domestic enterprises and the prerequisites for its optimization in conditions of systemic financial and economic crisis and military conflict are substantiated. The structure of the anti-crisis management system and peculiarities of choosing the anti-crisis management toolkit are defined, which includes tools for identifying the crisis at the enterprise, tools for developing anti-crisis management decisions and tools for assessing the effectiveness of adopted anti-crisis management decisions. It is substantiated that the concept of anti-crisis management determines the relationship between the components of the "reactive" and "preventive" character in the anti-crisis management system, the role and place of the anti-crisis component in the general strategy of enterprise management. The concept of crisis management should take into account such features of the enterprise as: size, industry, methods of capital formation, stage of the life cycle of the enterprise, types of production and financial strategy, market position, types of risks inherent in this enterprise. The tools of crisis management at the enterprise are investigated within two large groups: diagnostic methods and methods aimed at overcoming the crisis. The tools of crisis management are considered in terms of the stages of crisis at the enterprise. The priority of preventive measures in the anti-crisis management system has been determined. The model of anti-crisis management tools is proposed taking into account the factors of crisis, stages of crisis, tasks of anti-crisis management at the enterprise. Therefore, during the study, stages, crisis factors, the structure of the crisis management toolkit, which includes both tools for diagnosing the crisis state at the enterprise and directly tools for overcoming the crisis, which can be the basis for optimizing the crisis management system at the enterprise, are determined.

Reversing the trend of agrobiodiversity decline by co-developing food chains with consumers: A European survey for change

Agrobiodiversity is in rapid decline, due to the intensification of agriculture and the development of food value chains based on industrial processing techniques. However, consumers are not generally involved in developing solutions to reverse this trend and their relation to agrobiodiversity remains largely unknown. As part of a European project, and with the aim of involving consumers in guiding research, innovation and policies, a large online survey (n = 2397) and focus groups (n = 82) were carried out in seven countries to gather consumers' preferences and aversions regarding the use of agrobiodiversity in food chains in relation to their environmental concerns, food consumption practices and knowledge. Using the majority judgment approach typically used to improve political votes, different options for using of agrobiodiversity in food chains were proposed to citizen-consumers. Results first showed that the decline of agrobiodiversity is a concern for consumers, but does not guide food schoices. Then, the alternative options for using agrobiodiversity in food chains, previously documented as favourable to its conservation and development, received positive votes from a large majority of respondents, regardless of their socio-economic category. However, the research showed that respondents seem to have limited knowledge on the subject. This study calls for more research and policies to support alternative options for using agrobiodiversity in food chains. It also encourages the co-development of agrobiodiversity-based markets with citizen-consumers as well as the creation of food environments conducive to learning on agrobiodiversity.