Large Group Research Articles

The genetic status and rescue measure for a geographically isolated population of Amur tigers

The Amur tiger is currently confronted with challenges of anthropogenic development, leading to its population becoming fragmented into two geographically isolated groups: smaller and larger ones. Small and isolated populations frequently face a greater extinction risk, yet the small tiger population’s genetic status and survival potential have not been assessed. Here, a total of 210 samples of suspected Amur tiger feces were collected from this small population, and the genetic background and population survival potentials were assessed by using 14 microsatellite loci. Our results demonstrated that the mean number of alleles in all loci was 3.7 and expected heterozygosity was 0.6, indicating a comparatively lower level of population genetic diversity compared to previously reported studies on other subspecies. The genetic estimates of effective population size (Ne) and the Ne/N ratio were merely 7.6 and 0.152, respectively, representing lower values in comparison to the Amur tiger population in Sikhote-Alin (the larger group). However, multiple methods have indicated the possibility of genetic divergence within our isolated population under study. Meanwhile, the maximum kinship recorded was 0.441, and the mean inbreeding coefficient stood at 0.0868, both of which are higher than those observed in other endangered species, such as the African lion and the grey wolf. Additionally, we have identified a significant risk of future extinction if the lethal equivalents were to reach 6.26, which is higher than that of other large carnivores. Further, our simulation results indicated that an increase in the number of breeding females would enhance the prospects of this population. In summary, our findings provide a critical theoretical basis for further bailout strategies concerning Amur tigers.

Differences in help-seeking behaviour between males and females with multiple pelvic floor symptoms: A qualitative study

BackgroundPelvic floor symptoms (PFS) are common and frequently co-occur, but few patients seek help despite negative effects on their quality of life. Moreover, most studies assessing help-seeking behaviour have only focused on a single PFS. AimWe aimed to explore the barriers to and facilitators of help-seeking behaviour in males and females with at least two PFS. Design and SettingThis interview-based study included participants by age and symptoms (number and type) from a larger group taking part in a survey on PFS in the general population. MethodTwo researchers independently encoded and analyzed the semi-structured interviews, which continued to saturation for both the male and female cohorts. ResultsOf the 25 participants (13 male and 12 female), 9 sought help for all PFS, 10 did not seek help for any PFS, and 6 sought help for some PFS. We identified themes in domains related to the patient, healthcare professional, environment, and symptoms. Although most themes applied to both sexes, some had greater sex specificity. ConclusionMales and females have more similarities than differences in help-seeking behaviour. Healthcare providers should know that patients who seek help for one symptom probably have multiple PFS that the patient has not reported.

Obesity and Aging: Optimizing Health at the Intersection of Ageism and Weight Bias

Obesity is a chronic and complex disease that can negatively impact health, functioning and quality of life. In the past decade, obesity's largest prevalence growth occurred in older adults, particularly among racial and ethnic minorities. By the year 2030, an estimated 50% of the population over 65 is likely to be living with obesity. Until recently, little attention has been given to obesity as a chronic disease, and those living with obesity have encountered challenges accessing high quality medical care. Despite growing evidence for bariatric and obesity medicine, these treatments remain inaccessible for most patients, especially for older adults. Obesity research focused on older adults has been very limited and ideal weight standards for older adults are more controversial, especially in later life where frailty and sarcopenia may develop. As concerns about the public health effects of obesity have risen in the U.S., so too have negative and stigmatized views of individuals with obesity. Weight stigma has serious negative emotional and physical health consequences including low self-esteem, negative body image, engagement in disordered eating patterns, reduced physical activity and may promote weight gain. Older adults with obesity may encounter the double stigma of both ageism and weight bias, which are two of the most socially acceptable forms of bias and discrimination in the U.S. This interactive session will focus on three areas related to obesity and older adults. Through case examples, small and large group discussions, the presenters will: i) explore potential weight bias amongst participants and discuss strategies to mitigate this bias in working with older adults; ii) discuss complex connections between obesity and frailty syndrome in older adults, and the risks associated with weight loss in later life; iii) introduce evidence-based assessment and treatment recommendations for older adults interested in obesity treatment. This session will focus on the role of psychiatrists and other mental health clinicians in the care of older patients with co-morbid obesity and mental health disorders. Also, presenters will discuss the importance of increasing awareness, advocacy, and practical strategies to combat the impact of weight bias and ageism in healthcare settings. Ultimately, the goal is to raise awareness of this complex problem and provide clinically helpful information to improve care for older patients with obesity. This symposium is sponsored by the AAGP's IDEA committee.

Determination of Pomological and Molecular Characteristics of Some Pomegranate (Punica granatum L.) Cultivars and Selected Genotypes

In this study, it was aimed to determine the quality, phytochemical contents and molecular characterization of the best thirteen pomegranate genotypes selected as a result of the selection study carried out between 2019-2020 in the İnhisar district of Bilecik province. As a result of the research, the fruit weight of the selected promising genotypes and cultivars was between 208.00 and 601.3 g, fruit width was 74.54-103.47 mm, fruit length was 63.08-92.32 mm, hundred-aril weight was 28.00-66.25 g, aril yield was determined as 35.48-85.00%. The amount of soluble solid was determined between 14.33 and 18.77%, while pH values were between 3.22 and 4.36% and titratable acidity was between 0.23 and 1.72%. The total antioxidant capacity, which was determined with the TEAC method, was 3.28-8.48 µmol TE g-1, while the total amount of phenolic substances was 956.10-2116.10 g GAE kg−1, and the total amount of anthocyanins was 45.50-344 µg Plg-3-glu/g. Seven UBC-ISSR primers were employed to conduct molecular analyses aiming to determine polymorphism levels among the selected thirteen genotypes, along with the comparative Fellahyemez, Katırbaşı, and Hicaznar varieties. The resulting dendrogram is divided into two main clusters at a 25% dissimilarity level, one smaller and the other larger. All local genotypes clustered within the larger group, with Genotype 9 and Genotype 10 exhibiting the closest similarity. When the criteria determined as a result of the study were examined, it was determined that among the selected pomegranate genotypes, there were individuals that could be registered as table and industrial.

Curious minds to aspiring pharmacists: Impact of high school outreach on pharmacy knowledge and interest

ObjectiveTo analyze the impact of a pharmacy student delivered presentation on prospective rural high school students' interest toward the pharmacy profession and knowledge regarding a career in pharmacy. MethodsPresentations about applying to pharmacy school, the Doctor of Pharmacy degree, and pharmacist careers were given at ten high schools across North Dakota and Minnesota by third year pharmacy students attending North Dakota State University. Each pharmacy student presenter received training to ensure that all high school students received clear and consistent information. A pre-post survey was used to understand the impact of the presentation on high school student interest and knowledge regarding a career in pharmacy. Data was analyzed using a chi-square test and McNemar's test. ResultsFive hundred and eight students consented to the study and completed the pre-post surveys. Of these students, the largest group was high school juniors (number (n) = 239, 47%), followed by sophomores (n = 161, 32%), seniors (n = 104, 20%) and freshmen (n = 3, 1%). The majority of students attended school in North Dakota (n = 469, 92%). Similarly, most students planned to attend a four-year college (n = 451, 89%) and were interested in a medical/healthcare related career (n = 310, 61%). All interest and knowledge questions showed a statistically significant increase in score pre-post. ConclusionPresentations delivered by pharmacy students to prospective rural high school students improved overall interest and knowledge regarding pharmacy school and the profession. Presentations are a useful tool for pharmacy programs to help promote their school and the profession of pharmacy.

Dynamical order and many-body correlations in zebrafish show that three is a crowd

Zebrafish constitute a convenient laboratory–based biological system for studying collective behavior. It is possible to interpret a group of zebrafish as a system of interacting agents and to apply methods developed for the analysis of systems of active and even passive particles. Here, we consider the effect of group size. We focus on two– and many–body spatial correlations and dynamical order parameters to investigate the multistate behavior. For geometric reasons, the smallest group of fish which can exhibit this multistate behavior consisting of schooling, milling and swarming is three. We find that states exhibited by groups of three fish are similar to those of much larger groups, indicating that there is nothing more than a gradual change in weighting between the different states as the system size changes. Remarkably, when we consider small groups of fish sampled from a larger group, we find very little difference in the occupancy of the state with respect to isolated groups, nor is there much change in the spatial correlations between the fish. This indicates that fish interact predominantly with their nearest neighbors, perceiving the rest of the group as a fluctuating background. Therefore, the behavior of a crowd of fish is already apparent in groups of three fish.

Abstract 2565: Vitamin D deficiency and outcomes in prostate cancer patients: A real-world database

Abstract Introduction: Vitamin D is essential for many bodily functions, including bone health and the prevention of osteoporosis and rickets. In recent years, the importance of vitamin D metabolism in immune system regulation and cancer prevention has been studied with increased focus. With the advent of cancer immunotherapies this has become more important. Multiple recent publications document that vitamin D deficiency is prevalent in cancer patients. This has also been observed specifically in prostate cancer patients, with a high percentage of these deficient patients being of African- American ancestry. It has been theorized that high levels of vitamin D deficiency among African American prostate cancer patients could contribute to worse cancer outcomes and increased health disparities. However, routine vitamin D testing has not been commonly performed in the oncologic community. We hypothesized that deficient levels of vitamin D could lead to inferior prostate cancer outcomes in men with a wide range of ethnic and socio-economic backgrounds. In this project we recorded vitamin D levels in prostate cancer patients at a large community oncology group and evaluated them by stage, pathologic data, survival, race/ethnicity, and other clinical features. Methods: This study is a retrospective, observational study of the data from the electronic medical records of patients with prostate cancer who received vitamin D level testing at Florida Cancer Specialists & Research Institute from 2008- 2023, throughout the state of Florida. All data used in this study will constitute secondary data, it will have been collected originally for clinical use in the general oncology practice setting. No date parameters or patient limits will be applied to this study, and all eligible patients are included. Results: 451 patients with prostate cancer had determination of vitamin D levels, out of a total of 27,772 prostate cancer patients in the database. 38% of the prostate cancer patients analyzed had low 25-OH vitamin D levels (<32 ng/ml). Patients with low vitamin D levels had an average Gleason score of 7.46. Patients with low vitamin D levels who died had an average survival of 144 months. Patients with low vitamin D levels who presented with localized disease had a 35% chance of eventually developing castrate-resistant disease. 45% of the low vitamin D group developed metastatic disease during their course of treatment. Further comparisons of vitamin D levels with pathologic data, survival/longevity, race/ethnicity, and clinical course will be evaluated and presented. Citation Format: Lowell L. Hart, James Reeves, Stacey Garofalo, William Amick. Vitamin D deficiency and outcomes in prostate cancer patients: A real-world database [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2565.

Depth Range Extension for the Misty Grouper Hyporthodus mystacinus Documented via Deep-Sea Landers throughout the Greater Caribbean

Misty Groupers (Hyporthodus mystacinus) are one of the largest and most geographically widespread grouper species and one of the few grouper species known to occur at depths greater than 200 m. However, aspects of their basic biology, behavior, and ecology remain poorly understood, leaving significant gaps in our ability to evaluate their functional role throughout the vertical water column, as well as our understanding of their conservation needs in a changing ocean. Through in-situ video observation obtained using deep-sea landers in both The Bahamas and Cayman Islands over multiple years, we documented Misty Grouper occurrence up to 470 m depth in the mesopelagic zone. These observations provide a new depth range extension for the species and illuminate the potential importance of deep-water habitats for large grouper species in the wider Caribbean.

Crowdsourcing a diagnosis? Exploring the accuracy of the size and type of group diagnosis: an experimental study

BackgroundThe consultation process, where a clinician seeks an opinion from another clinician, is foundational in medicine. However, the effectiveness of group diagnosis has not been studied.ObjectiveTo compare individual diagnosis to...

A comparative study of mortality rate in operated elderly patients of fracture neck of femur, within 90 days of surgery before and during COVID-19 pandemic in the Indian population

Fracture neck of the femur is a significant cause of morbidity and mortality in the elderly and surgical interventions are the preferred treatment. The COVID-19 pandemic caused a reduction in operative cases and emphasized non-operative management. We studied the impact of the COVID-19 pandemic on post-operative 90 days mortality of hip fracture in the elderly Indian population. We, retro-prospectively compared data from our hospital over a two-year time frame on a large group. The first confirmed case in Maharashtra was reported on 9th March 2020 in Pune. The cases reported until one year from this date were termed ‘Covid period’ and cases one year before this date were termed ‘Pre-covid period’. After applying exclusion criteria to 638 patients from 2 years of data, 379 patients(208 in Pre-covid and 171 in Covid period) were included and analyzed for mortality rate and secondary outcomes.The pandemic caused a statistically significant increase in postoperative 90 days mortality in the elderly by 75.7% compared to pre-covid mortality. The decrease in incidence of operated fracture neck femur was non-significant during Covid compared to incidence in pre-covid. Pneumonia caused six times more mortality during Covid period.The COVID-19 pandemic caused a statistically significant increase in postoperative mortality. Pneumonia was the significant cause of death in Covid period and should be diagnosed and treated early. A specific subset of the consent process is a must in elderly neck femur fracture undergoing surgery and shared guidelines of this study will help in the decision-making process of future covid pandemic situations.

Spectrum of malignant and premalignant skin lesions in 505 adult subjects at risk of skin cancers

Patients at risk of skin cancers can develop varying types of cutaneous malignancies. However, some subjects may develop only one type of lesion. In this cross-sectional study, the spectrum of premalignant (PM) and malignant skin lesions and their risk factors were studied. Therefore, 505 adult subjects (aged 21–79 years, 256 males and 249 females, 96 with immunosuppression) at risk of any type of skin cancer were examined for cutaneous malignancies, nevi, actinic keratoses, photodamage, and possible risk factors. First, 12 different groups were identified with a varying set of PM and/or malignant skin lesions. Next, 5 larger groups were formed from them: basal cell carcinoma (BCC) only, malignant melanoma (MM) only, squamous cell carcinoma (SCC) and/or PM, BCC + SCC and/or PM, and MM + keratinocyte carcinoma (KC) and/or PM. The groups with BCC or MM only were younger and showed less photodamage than the mixed groups, while SCC/PM showed similarity with them. In logistic regression analyses, the platelet-to-lymphocyte ratio was associated with an increased risk of concomitant KC (OR 1.028, p = 0.023) or SCC/PM (OR 1.009, p = 0.047) in subjects with MM or BCC, respectively. Actinic keratoses produced ORs 0.246–0.252 (p = 0.008–0.020) for BCC in subjects with SCC/PM. Interestingly, atypical mole syndrome decreased the risk of SCC/PM in subjects with BCC (OR 0.092, p = 0.001). Advanced age was a significant risk factor for an additional type of lesion in all 3 comparisons (ORs 1.088–1.388, p = 0.001). In conclusion, even though there are numerous patients with only one lesion type, advancing age may determine the final lesion multiplicity.

Circular Dichroism Sensing: Strategies and Applications.

The analysis of the absolute configuration, enantiomeric composition, and concentration of chiral compounds are frequently encountered tasks across the chemical and health sciences. Chiroptical sensing methods can streamline this work and allow high-throughput screening with remarkable reduction of operational time and cost. During the last few years, significant methodological advances with innovative chirality sensing systems, the use of computer-generated calibration curves, machine learning assistance, and chemometric data processing, to name a few, have emerged and are now matched with commercially available multi-well plate CD readers. These developments have reframed the chirality sensing space and provide new opportunities that are of interest to a large group of chemists. This review will discuss chirality sensing strategies and applications with representative small-molecule CD sensors. Emphasis will be given to important milestones and recent advances that accelerate chiral compound analysis by outperforming traditional methods, conquer new directions, and pioneering efforts that lie at the forefront of chiroptical high-throughput screening developments. The goal is to provide the reader with a thorough understanding of the current state and a perspective of future directions of this rapidly emerging field.

Circular Dichroism Sensing: Strategies and Applications

AbstractThe analysis of the absolute configuration, enantiomeric composition, and concentration of chiral compounds are frequently encountered tasks across the chemical and health sciences. Chiroptical sensing methods can streamline this work and allow high‐throughput screening with remarkable reduction of operational time and cost. During the last few years, significant methodological advances with innovative chirality sensing systems, the use of computer‐generated calibration curves, machine learning assistance, and chemometric data processing, to name a few, have emerged and are now matched with commercially available multi‐well plate CD readers. These developments have reframed the chirality sensing space and provide new opportunities that are of interest to a large group of chemists. This review will discuss chirality sensing strategies and applications with representative small‐molecule CD sensors. Emphasis will be given to important milestones and recent advances that accelerate chiral compound analysis by outperforming traditional methods, conquer new directions, and pioneering efforts that lie at the forefront of chiroptical high‐throughput screening developments. The goal is to provide the reader with a thorough understanding of the current state and a perspective of future directions of this rapidly emerging field.

Development Development of the One in Diversity Application for Class V Students on Indonesian Diversity Material

This study employs Research and Development (RnD) methodology, utilizing the ADDIE model, to develop the One In Diversity application aimed at enhancing grade V students' learning of Indonesian Diversity in PPKn. The application's development involved analysis, design, development, implementation, and evaluation stages. Media and material experts evaluated the application, achieving scores of 82.5% and 95.3% respectively, indicating high quality. Large and small group trials further validated its effectiveness, with scores of 86.29% and 87.47% respectively. This innovative approach offers promising implications for educators seeking to integrate technology into their teaching methods, fostering enhanced student engagement and comprehension in diverse subject matter.
 Highlights:
 
 
 Innovative Learning Solution: "One In Diversity" app enhances PPKn learning
 
 
 Systematic Development: ADDIE model ensures effective app creation.
 
 
 Expert Validation: High scores from assessments and trials validate app's efficacy.
 
 
 Keywords: Application Development, PPKn, Indonesian Diversity

What means civic education in a digitalized world?

The hope of reaching diverse and large target groups has motivated civic education practitioners to offer their content on social media. The question has therefore long ceased to be whether civic education should take place on the internet, but rather how civic education goals can be implemented digitally to foster civic literacy. At first glance, the possibility of reaching a broad audience in a short time seems tempting. At a second glance, social media reveals several challenges that can impair educational processes. The present paper discusses the following questions: What are the opportunities and pitfalls of civic education in social media? How can we ensure successful civic education in a digitalized world? In our article, we want to provide an interdisciplinary perspective on the topic by drawing among others from the literature in the fields of media psychology, communication studies, and education science. By integrating insights from various disciplines, our paper seeks to enrich the academic dialogue and to promote a nuanced understanding of the evolving dynamics of civic education in the digital realm. With its practical focus, our paper further aims to underscore the applicability of scientific research.

Explore the possibilities of the artificial intelligence program in the diagnosis of diabetic macular edema, age-related macular degeneration, central serous choriopathy and vitreomacular interface anomalies on the structural optical coherence tomography scans.

Background: macular diseases present a large group of pathological conditions leading to vision loss and poor vision. Early diagnosis of such changes plays an important role in the treatment tactics and comes one of the crucial factors in predicting results.
 Aims: study the possibilities of the artificial intelligence program in the diagnosis of the macular diseases based on the scans of structural OCT analysis.
 Materials and methods: the study included patients undergoing examination and treatment at the Federal Medico-Biological Agency Federal Research Clinical Center and the Moscow Regional Research Clinical Institute named after M.F. Vladimirsky. 200 eyes with the macular diseases and also eyes without macular pathology were examined. A comparative clinical analysis of structural OCT scans performed on an RTVue XR 110-2 tomograph was carried out. Retina AI software was used to analyze OCT scans.
 Results: during the OCT scans analysis various pathological structures of the macular were identified, and then a probable diagnosis was defined. The obtained results were compared with the diagnosis of the ophthalmologists. The sensitivity of the method was 95.16%; specificity - 97.76%; accuracy - 97.38%.
 Conclusions: Retina.AI allows ophthalmologists to successfully perform automated analysis of the OCT scans and identify various pathological conditions of the eye fundus.

The experience of seeking and accessing help from mental health services among young people of Eastern European backgrounds: A qualitative interview study.

Most lifetime mental health problems (MHP) start before the age of 25. Yet young people-particularly those of minority backgrounds-often do not seek or access professional help. In the UK, young people of Eastern European (EE) backgrounds represent a large minority group; however, little is known about their experiences of MHP and help-seeking. In this study, we aim to understand the help-seeking process from the perspectives of EE young people. We used a qualitative study design with semi-structured individual interviews. The results were analysed using reflexive thematic analysis. Twelve young people (18-25 years) of EE backgrounds, living in Oxfordshire, UK, took part. All participants had experienced a severe MHP and were identified in the community. EE young people's experiences of MHP and help-seeking were driven by a sense of being caught between different cultures and simultaneously needing to navigate the potentially contrasting expectations of both cultures. This process was reinforced or tempered by the perceived continuing influence of young people's families, that is, families with more open views about MHP made it easier for young people to navigate through the process of help-seeking. Young people's internalised cultural and familial beliefs about MHP affected their decision-making when experiencing difficulties, their levels of trust in services, and perceived sense of resourcefulness and ability to cope. Recognising and responding to the cultural tension that young people of EE backgrounds may experience can help us to develop more accessible and inclusive mental health services.

Fault diagnosis of rolling bearings based on dynamic convolution and dual-channel feature fusion under variable working conditions

Addressing the challenge of inconsistent data feature distribution and the difficulty of fault diagnosis in rolling bearings operating under variable conditions, a novel approach is proposed for bearings fault diagnosis. Dynamic convolution and dual-channel feature fusion are utilized in our method. In the shallow network layer, we employ a dual-channel convolutional structure, combining a large convolutional group with a small convolutional group to enhance the extraction of high-low frequency fault information from images. The improved GhostNetV2 bottleneck layer was used in the deeper layer of the network to obtain more beneficial features through the dynamic convolution and attention mechanism. Finally, fault classification and evaluation under variable working conditions was performed on the Case Western Reserve University and Drivetrain Dynamic Simulator (DDS) datasets. Our results showed that the methods and model used in this study can effectively handle the precision fault detection across various operational scenarios.

A Charge-Charge Flux-Dipole Flux Analysis of Simple Molecular Systems with Halogen Bonds.

The presence of halogen bonds (R-X···B; R = substituent group, X = halogen, and B = Lewis base) provides quite amazing molecular systems for electronic structure investigations, presenting unique characteristics of fundamental relevance to supramolecular chemistry among other areas. Here, we use a double-hybrid approach from Density Functional Theory and triple-ζ basis sets augmented with diffuse functions (B2PLYP/def2-TZVPD) to deal with a large group of simple molecular systems containing halogen bonds (XBs), focusing on geometrical structures, binding energies, harmonic vibrational frequencies, and fundamental infrared intensities. Next, the electron densities and their variations on vibrations are carefully studied with the Quantum Theory of Atoms in Molecules (QTAIM) formalism and the charge-charge flux-dipole flux (CCFDF) model. We notice that the R-X stretching mode usually shows vibrational frequency decrements and infrared intensifications during the XB formation. Such features were also observed in hydrogen bonds, although the explanation for the band strengthening is different. Surprisingly, the most important contribution to these intensity increments due to complexation is now the interaction term between the charge flux and dipole flux (CF × DF). Thus, the use of atomic dipoles is mandatory to fully understand this phenomenon. In fact, the huge charge flux contributions to changes in dipole moment derivatives of R-X stretchings on halogen bonding are no longer accompanied by opposite variations of similar magnitudes in polarizations described by atomic dipole fluxes, which provided nearly unaltered values during the XB formation. Thus, the electronic charge flux direction change that takes place in complexes (from B to R) now reinforces dipole moment derivative terms from such atomic polarizations (mainly from the X atom). This intermolecular charge flux seems to be responsible for the unusual features noticed in the R-X stretching mode with the CCDDF/QTAIM model.

Detailed chemical composition of the globular cluster Sextans A GC-1 on the outskirts of the Local Group

The chemical composition of globular clusters (GCs) across the Local Group provides information on chemical abundance trends. Studying GCs in isolated systems in particular provides us with important initial conditions plausibly unperturbed by mergers and tidal forces from the large Local Group spirals. We present a detailed chemical abundance analysis of Sextans A GC-1. The host galaxy, Sextans A, is a low-surface-brightness dwarf irregular galaxy located on the edge of the Local Group. We derive the dynamical mass of the GC together with the mass-to-light ratio and the abundances of the alpha , Fe-peak, and heavy elements. Abundance ratios were determined from the analysis of an optical integrated-light spectrum of Sextans A GC-1, obtained with UVES on the VLT. We apply non-local thermodynamic equilibrium (NLTE) corrections to Mg, Ca, Ti, Fe, and Ni. The GC appears to be younger and more metal-poor than the majority of the GCs of the Milky Way, with an age of 8.6pm 2.7 Gyr and $ Fe/H dex. The calculated dynamical mass is dyn odot $, which results in an atypically high value of the mass-to-light ratio, 4.35pm 1.40 M$_ odot $/L$_ V odot $. Sextans A GC-1 has varying alpha elements -- the Mg abundance is extremely low, Ca and Ti are solar-scaled or mildly enhanced, and Si is enhanced. The measured values are $ Mg/Fe Ca/Fe Ti/Fe and $ Si/Fe which makes the mean alpha abundance (excluding Mg) to be enhanced $ <Si,Ca,Ti>/Fe NLTE The Fe-peak elements are consistent with scaled-solar or slightly enhanced abundances: $ Cr/Fe Mn/Fe Sc/Fe and $ Ni/Fe The heavy elements measured are Ba, Cu, Zn, and Eu. Ba and Cu have sub-solar abundance ratios ($ Ba/Fe and $ Cu/Fe <-0.343$), while Zn and Eu are consistent with their upper limits being solar-scaled and enhanced, $ Zn/Fe <+0.171$ and $ Eu/Fe The composition of Sextans A GC-1 resembles the overall pattern and behaviour of GCs in the Local Group. The anomalous values are the mass-to-light ratio and the depleted abundance of Mg. There is no definite explanation for such an extreme abundance value. Variations in the initial mass function or the presence of an intermediate-mass black hole might explain the high mass-to-light ratio value.