Indicators of labor productivity in Russian regions have been compared. Opportunities and vectors for activating regional factors of labor productivity growth have been identified. The results of dynamic analysis and interregional differentiation of labor productivity based on data of the Russian Federal State Statistics Service (Rosstat) and labor productivity assessments by region and by aggregated economic activity are presented. A trend of reduction in differences in the dynamics of interregional labor productivity levels has been identified. The assessment of hourly productivity by economic activity has shown quintessential interregional differences in mining, construction, and agriculture. The results of comparative analysis of jobs available in the Russian economy are shown in terms of their sectoral distribution, labor productivity, and salary. The Rosstat-developed methods of determining highly productive jobs have been critically overviewed. It is shown that the growth rate of highly productive jobs calculated according to this methodology relates weakly to the labor productivity dynamics and real personal incomes. The vectors of activating regional factors of labor productivity proposed in government documents have been considered. The possibilities and limitations that characterize measures to improve labor mobility are shown based on Russian regional migration data.