Background: Dental caries is a global problem; however, it is entirely preventable. Fluoride is considered as effective method in lowering dental caries. The amount of knowledge, awareness and its method of implementation in prevention process among general population are challenging. Objectives: 1. To review and analyse the knowledge of fluoride action, therapeutic uses, method of application, possible combination of fluoride exposure, its deleterious effects and create evidence about awareness among the Odisha population and knowledge, attitude and practice (KAP) of fluoride in management of dental caries among the dental professionals. 2. To recommend the dental council, dental professionals, teaching institutions, primary health care centres, community health centres, social media and health care consumers for active involvement in spreading the awareness regarding Pros and Cons of fluoride to the general population, based on the available evidence. Method: A survey was conducted for 918 general populations and 474 dental professionals of Odisha based on knowledge, attitude and practice (KAP study) regarding fluorosis, fluoridated water, dental caries and fluoride therapy and validated. The questionnaire for general population was translated from English to local language (Odia). Google and physical questionnaire were circulated among the general population and dental professionals. Dimensionality and local dependency were also tabulated. The data obtained was subjected to statistical analysis. Results: The evidence revealed that dental professionals (ANOVA, p < 0.05) practicing in Odisha had significant knowledge regarding fluoride therapy and fluorosis; however, its implementation in practice is compromised. Approximately, 65% of general population irrespective of age and gender, lack the basic knowledge, 65% of attitude and 77% of practice regarding fluorides and fluorosis. Conclusion: This evidence will be a strong enforcement and implementation in primary practice by dental professionals for prevention of dental caries.