speed were obtained using the Short Physical Performance Battery (SPPB) test. Pain and physical function were measured using the WOMAC. Pearson partial correlations and linear regression analyses adjusted for age, sex, and BMI were used to examine the relationships among the variables of interest. Results: A lower percent lower extremity fat (thigh + leg) was significantly associated with reduced pain (r=0.54; p=0.02), greater physical function (r=0.66; p=0.003), and higher knee extensor strength (r=-0.58, p=0.01). No significant associations were found between percent trunk fat and these measures. Greater knee extensor strength was also significantly associated with reduced pain (r=-0.42; p=0.02) and greater physical function (r=-0.46; p=0.01). In addition, higher leg extensor power was significantly associated with faster chair rise time (r=-0.76; p=0.001) and walking speed (r=0.54; p=0.03). Conclusions: These results suggest that lower extremity fat, but not trunk fat, and weak knee extensor strength and power may play important roles in the increased pain and poor function common in older adults with knee OA. Improving knee extensor strength and reducing thigh fat may provide long-term improvements in pain and function.
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