Forest fires, though part of a natural forest renewal process, when frequent and on a large -scale, have detrimental impacts on biodiversity, agroforestry systems, soil erosion, air, and water quality, infrastructures, and the economy. Portugal endures extreme forest fires, with a record extent of burned areas in 2017. These complexes of extreme wildfire events (CEWEs) concentrated in a few days but with highly burned areas are, among other factors, linked to severe fire weather conditions. In this study, a comparison between several fire danger indices (named ‘multi-indices diagnosis’) is performed for the control period 2001–2021, 2007 and 2017 (May–October) for the Fire Weather Index (FWI), Burning Index (BI), Forest Fire Danger Index (FFDI), Continuous Haines Index (CHI), and the Keetch–Byram Drought Index (KBDI). Daily analysis for the so-called Pedrógão Grande wildfire (17 June) and the October major fires (15 October) included the Spread Component (SC), Ignition Component (IC), Initial Spread Index (ISI), Buildup Index (BUI), and the Energy Release Component (ERC). Results revealed statistically significant high above-average values for most of the indices for 2017 in comparison with 2001–2021, particularly for October. The spatial distribution of BI, IC, ERC, and SC had the best performance in capturing the locations of the two CEWEs that were driven by atmospheric instability along with a dry environment aloft. These results were confirmed by the hotspot analysis that showed statistically significant intense spatial clustering between these indices and the burned areas. The spatial patterns for SC and ISI showed high values associated with high velocities in the spread of these fires. The outcomes allowed us to conclude that since fire danger depends on several factors, a multi-indices diagnosis can be highly relevant. The implementation of a Multi-index Prediction Methodology should be able to further enhance the ability to track and forecast unique CEWEs since the shortcomings of some indices are compensated by the information retrieved by others, as shown in this study. Overall, a new forecast method can help ensure the development of appropriate spatial preparedness plans, proactive responses by civil protection regarding firefighter management, and suppression efforts to minimize the detrimental impacts of wildfires in Portugal.