JIA ACR30 (62%), JIA ACR50 (59%), JIA ACR70 (54%) and JIA ACR90 (35%) response than ADA monotherapy (53%, 49%, 44% and 26%, respectively). On MTX background therapy and a JIA ACR30 placebo response of 53%, ADA had a higher expected probability of response at JIA ACR30 (76%), JIA ACR50 (75%), JIA ACR70 (66%) and JIA ACR90 (49%) than TCZ (72%, 70%, 61% and 44%, respectively). In neither monotherapy nor combination therapy did differences between TCZ and ADA reach statistical significance. Differences in the study populations, including previous use of biologics, were explored with sensitivity analysis. Conclusion Based on JIA ACR response rates from this analysis, the expected efficacy of ADA vs TCZ appears comparable in pcJIA. These data should be interpreted in the context of differences in the duration of the withdrawal phase, which was shorter in the TCZ study (CHERISH) than in the ADA trial and might have resulted in a smaller difference in the number of flares observed between placebo and TCZ. Differences in previous exposure to biologics might also have affected the results.