Abstract
The balance between regulatory (Treg) and effector T cells (Teff) is crucial for immune regulation in juvenile idiopathic arthritis (JIA). How methotrexate (MTX), the cornerstone treatment in JIA, influences this balance in vivo is poorly elucidated.
Highlights
The balance between regulatory (Treg) and effector T cells (Teff) is crucial for immune regulation in juvenile idiopathic arthritis (JIA)
Treg numbers and phenotype were determined by flow cytometry and suppressive function in allogeneic suppression assays
Effector cell cytokines in supernatants of proliferation and suppression assays and in plasma were measured by cytokine multiplex assay
Summary
The balance between regulatory (Treg) and effector T cells (Teff) is crucial for immune regulation in juvenile idiopathic arthritis (JIA). PReS-FINAL-2100: Methotrexate treatment affects effector, but not regulatory T cells in juvenile idiopathic arthritis S Vastert1*, M Bulatovic-Calasan2, R Scholman3, M Klein3, N Wulffraat3, B Prakken3, FV Wijk3 From 20th Pediatric Rheumatology European Society (PReS) Congress Ljubljana, Slovenia.
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