Abstract. Introduction. Acromegaly prevalence is 4.6 cases per 1 million person-years, and its rate is 116.9 new cases per 1 million person-years. At the same time, acromegaly manifestations can be insidious, and despite advances in this area, there are significant delays in the diagnosis of the disease, thereby worsening the prognosis for patients. Aim. To study the clinical course of acromegaly in a female patient with rheumatoid arthritis. Materials and Methods. This article presents a clinical case of a 47-year-old female patient with the proven diagnoses of rheumatoid arthritis and acromegaly. Results and Discussion. Essentially, pathological process in rheumatoid arthritis is systemic autoimmune inflammation that most intensively affects the synovial membrane of joints with maximum intensity. Acromegaly-related arthropathy is a non-inflammatory disease, in which hypertrophy and hyperplasia of cartilage lead to the joint geometry perturbations and metabolic disorders in chondrocytes and, eventually, to degenerative changes. This clinical case is interesting, given the coexistence of two severe diagnoses that have a similar clinical picture of musculoskeletal damages. Conclusions. Related to the findings from this clinical case, attention should be paid to the importance of timely diagnosing acromegaly, considering potential influence of concomitant pathology on the clinical course of the disease