To accurately characterize the dynamic deformation mechanical properties of hot forming steels 6Mn6 and 22MnB5 under collision conditions, quasi-static tensile tests (0.001s−1) and Hopkinson compression bar tests (∼2000s−1, ∼3000s−1, ∼4000s−1) were conducted to analyze the influence of strain rate on the material mechanical properties. Based on the experimental results, four constitutive models including Johnson-Cook (JC), modified JC (m-JC), Cowper-Symond (CS), and Khan-Huang (KH) models were established for both 6Mn6 and 22MnB5. Additionally, a modified model based on the Swift-Voce strain hardening model coupled with the Cowper-Symond model was proposed. A numerical simulation model for compression bar tests was developed using JC and m-JC models. The experimental results indicate that both hot forming steels exhibit strain rate sensitivity, with 6Mn6 performed a more pronounced effect than 22MnB5. The average absolute error (AARE) and correlation coefficient (R) of the m-JC and CS models were 0.99 and 0.29 %, 0.95 and 0.4 %, respectively. The dynamic deformation behavior of 6Mn6 and 22MnB5 at high strain rates was accurately predicted. Comparing with the JC model, the utilization of the m-JC user subroutine has resulted in a significant improvement in simulation accuracy by 58 % and 84 % for these two materials, which laying a solid foundation for high-precision vehicle collision simulation.