High-order nonlinearity, strong coupling, and external disturbances constrain the high-precision servo tracking control of the missile seeker coordinator, which compromises the guidance accuracy of guided weapons. The individual differences in the seekers cause model parameter perturbations, leading to uncertainty and time-varying disturbances, which reduces the tracking performance of the seeker servo system. To cope with these uncertainties various traditional Iterative learning control (ILC) strategies have been designed to suppress high-order nonlinear disturbances. However, these are very sensitive to system uncertainties, external disturbances and model parametric perturbations. In response to this challenge, this paper proposes a hybrid adaptive iterative learning sliding mode control (AILS) methodology. The iterative learning sliding mode control (ILSMC) strategy is used to reduce the impact of periodic disturbances in the system, ensuring a rapid system response. The enhanced adaptive learning law (EAL) strategy offers an estimation of the lumped disturbances of the system, encapsulating both parameter shifts and residual disturbances. Through this appropriate adaptive control, both disturbances compensation and the chattering effect due to sliding mode control are simultaneously minimized. Simulation and experimental results show that compared with the traditional open-loop iterative learning control, the learning convergence speed and convergence accuracy of the proposed hybrid AILS are highly significant. Experimental results also show that the control algorithm designed in this paper can also perform adaptively, has fast learning capability and ensures convergence while guaranteeing the tracking accuracy of the seeker coordinator servo system.