With computational inverse problems, it is desirable to develop an efficient inversion algorithm to find a solution from measurement data through a mathematical model connecting the unknown solution and measurable quantity based on the first principles. However, most of mathematical models represent only a few aspects of the physical quantity of interest, and some of them are even incomplete in the sense that one measurement corresponds to many solutions satisfying the forward model. In this paper, in light of the recently developed iNETT method in (2023 Inverse Problems 39 055002), we propose a novel iterative regularization method for efficiently solving non-linear ill-posed inverse problems with potentially non-injective forward mappings and (locally) non-stable inversion mappings. Our approach integrates the inexact Newton iteration, the non-stationary iterated Tikhonov regularization, the two-point gradient acceleration method, and the structure-free feature-selection rule. The main difficulty in the regularization technique is how to design an appropriate regularization penalty, capturing the key feature of the unknown solution. To overcome this difficulty, we replace the traditional regularization penalty with a deep neural network, which is structure-free and can identify the correct solution in a huge null space. A comprehensive convergence analysis of the proposed algorithm is performed under standard assumptions of regularization theory. Numerical experiments with comparisons with other state-of-the-art methods for two model problems are presented to show the efficiency of the proposed approach.