This paper addresses a complex parallel machine scheduling problem with jobs divided into operations and operations grouped in families. Non-anticipatory family setup times are held at the beginning of each batch, defined by the combination of one setup-time and a sequence of operations from a unique family. Other aspects are also considered in the problem, such as release dates for operations and machines, operation’s sizes, and machine’s eligibility and capacity. We consider item availability to define the completion times of the operations within the batches, to minimize the total weighted completion time of jobs. We developed Iterated Greedy (IG) algorithms combining destroy and repair operators with a Random Variable Neighborhood Descent (RVND) local search procedure, using four neighborhood structures to solve the problem. The best algorithm variant outperforms the current literature methods for the problem, in terms of average deviation for the best solutions and computational times, in a known benchmark set of 72 instances. New upper bounds are also provided for some instances within this set. Besides, computational experiments are conducted to evaluate the proposed methods’ performance in a more challenging set of instances introduced in this work. Two IG variants using a greedy repair operator showed superior performance with more than 70% of the best solutions found uniquely by these variants. Despite the simplicity, the method using the most common destruction and repair operators presented the best results in different evaluated criteria, highlighting its potential and applicability in solving a complex machine scheduling problem.