Objective — to study the state of nasopharyngeal microflora in children with psoriasis depending on the clinical features of dermatosis and determine antibiotic susceptibility of isolated microorganisms. Materials and methods. The isolation of nasopharyngeal microorganisms and determination of their antibiotic susceptibility were performed in 57 children with psoriasis aged 4 to 17 using the bacteriological method (culture). Microbial growth was assessed according to four degrees of growth. Susceptibility to antibacterial drugs was evaluated based on the following criteria: sensitive, moderately resistant, and resistant. Study materials were statistically processed using the StatTech v. 3.1 software. Results and discussion. Most often, Staphylococcus aureus (S. aureus) associations were cultured from the nasopharynx (56.15 %) of children with psoriasis — in 12.28 % of cases, Enterococcus faecium (Ent. faecium) — in 21.05 %. Statistically significant differences in children with psoriasis were found between the colony growth rates of Ent. faecium and S. aureus (p < 0.001): massive microbial growth of Ent. faecium prevailed (64.91 %), and S. aureus was not isolated at all in the majority of children (29.82 %). Ent. faecium growth rates were statistically significantly different (p = 0.016) depending on psoriasis severity according to PASI: massive growth of microorganisms at PASI > 10 was found in 87.5 % of cases, and at PASI ≤ 10 — in 54.2 % of cases. The proportion of Ent. faecium resistant to antimicrobial drugs (43.18 ± 7.47) % was found to be more than two times higher than that of S. aureus (20.00 ± 6.32) %. The susceptibility testing for each microorganism individually showed that enterococci were 28 to 100 % susceptible to antibacterial drugs, while staphylococci had 42 to 100 % susceptibility. Statistically significant differences were found between the percentage of sensitivity of Ent. faecium to antibacterial drugs between the group of children with the first diagnosis of psoriasis and the group of children with its recurrences (p = 0.005), as well as by the duration of the disease (p < 0.001). Conclusions. The results of the study of children with psoriasis showed that there were bacterial associations isolated from the nasopharynx in the most significant number of cases with the predominance of Ent. faecium, which had massive growth in almost 65 % of cases and affected psoriasis severity according to PASI (OR 5.923; 95 % CI 1.387—25.300). The proportion of Ent. faecium resistant to antibiotics was higher than of S. aureus (p < 0.05), but with increasing duration of psoriasis, Ent. faecium susceptibility to antimicrobials increased (r = 0.439; p = 0.004). In general, S. aureus isolated from the nasopharynx of children with psoriasis had more pronounced antibiotic susceptibility than Ent. faecium.