Occupational safety and health are concerned with all aspects of employees' physical, mental, and social health and safety. Being a labor-related issue, several legislations in every country ensure the safety, health, and welfare of people engaged in work. Therefore, it becomes the legal responsibility of the employer to provide a safe workplace for employees. However, without employee participation, the state legislations and employers' efforts can do little to make the workplace safe and healthy. Employee behavior is considered the key element to ensure safety at the workplace. Human behavior includes the way an individual acts based on various factors such as genetics, social norm, core faith, and attitude. Thus, religion plays a vital role in reinforcing safe work behaviors. Islam has a strong effect on the lifestyle and behavior of its adherents. In this conceptual paper, principles and guidelines offered by Islam related to safety and health are highlighted. The effort has been made to look into the basic sources of Islam to find out principles and guidelines related to safety, health, and the environment. Behavior-based safety from in Islamic perspective is concerned with creating a work environment based on the principles of brotherhood, mutuality, cooperation, mercy, kindness, and benevolence. It is observed that the Islamic approach to occupational safety and health is not limited to compliance with the organizational safety procedures. Still, also it is a religious obligation and Divine Calling.