Looking at scientists (in the life sciences), we focus on the sense of meaninglessness associated with bureaucratization. We define the sense of meaninglessness as a perception of meaning deficit or meaning conflict in particular situations that can be associated with frustration, irritation, and/or boredom. We show that it can be caused by identity disturbance - particularly the incongruence between the ideal self as a researcher and the imposed self as a bureaucrat. We claim that the sense of meaninglessness is more likely to emerge in those activities that are further from an individual's core identity, and more identity work is needed to make them meaningful. We also claim that processes of rationalization imposed by external agendas, particularly transitions from substantive to formal rationality (predictability, control and calculability, efficiency) contribute to the proliferation of meaninglessness in academia. The sense of meaninglessness is, therefore, ignited by the external forces colonizing academic life and constitutes an instance of the 'irrationality of rationality'. It is an outcome or side effect of the collision between two incompatible logics of practice: bureaucratic and scientific. To show the incongruence of those competing logics, we analyze the data derived from a mixed-method study conducted between 2013 and 2014 among beneficiaries of an international research grant project. As a supplementary source of reference, we use our research on academic boredom and laboratory scientists' work and careers.