Irradiation Dose Research Articles

LBE corrosion behavior of helium pre-irradiated martensitic steel

In the design of the spallation target of CiADS, T91 steel was selected for the most critical component, the beam window. A Si-modified martensitic steel (SIMP) has been currently developed, which has better corrosion resistance and is planning to replace T91 as a material of beam window in the future. In order to assess the effect of irradiation damage on the microstructure evolution and corrosion behavior of the SIMP, the pre-irradiated samples with irradiation doses from 5 × 1015 to 3 × 1017 He/cm2 exposed in static lead-bismuth eutectic (LBE) with saturated oxygen at 350 °C for 4000 h were investigated. Results show that pre-irradiation neither change the double-layer structure of the oxide layer nor significantly affect the corrosion rate. This may be due to the slow diffusion of elements at low temperatures, and the low irradiation dose not reaching the threshold for triggering accelerated corrosion.

Biological responses of an elite centipedegrass [Eremochloa ophiuroides (Munro) Hack.] cultivar (Ganbei) to carbon ion beam irradiation.

Carbon ion beam irradiation (CIBI) is a highly efficient mutagenesis for generating mutations that can be used to expand germplasm resources and create superior new germplasm. The study investigated the effects of different doses of CIBI (50 Gy, 100 Gy, 150 Gy, 200 Gy and 300 Gy) on seed germination and seedling survival, seedling morphological and physiological traits of an elite centipedegrass cultivar Ganbei. The results showed that irradiation greater than 50 Gy cause inhibition of seed germination, and the semi-lethal dose (LD50) is around 90 Gy for CIBI treated seeds of Ganbei. A carbon ion beam-mutagenized centipedegrass population was generated from Ganbei, with irradiation dosages from 50 Gy to 200 Gy. More than ten types of phenotypic variations and novel mutants with heritable tendencies mainly including putative mutants of stolon number, length and diameter, of internode length, of leaf length and width, of leaf chlorophyll content, of stolon growth rate, of aboveground tissue dry weight, of sward height were identified. While the total sugar content of the plants from irradiated seeds showed no obvious change in all treatments as compared to the control, the crude protein content displayed significant reduction at a high-dose treatment of 200 Gy. Genetic polymorphism was detected in mutagenized centipedegrass population using SSR-PCR analysis, suggesting that CIBI caused alteration of larger fragments of the DNA sequence. As a result, a preliminary batch of mutants was screened in this study. In summary, carbon ion beam mutagenesis is an effective way for developing centipedegrass germplasm with wider variation, and treating seeds with CIBI at a dosage of ~100 Gy could be effective in centipedegrass mutation breeding.

Study on the preservation effect of 60Co-γ ray irradiation on potatoes

To evaluate the effect of irradiation on the preservation of potatoes, fresh potatoes were selected as the irradiation objects, and irradiated with 60Co-γ radiation source for 0, 100, 200, 500 and 1000 Gy, respectively. During the irradiation, the well-packaged Y1.79Bi0.01Eu0.2MgTiO6 novel thermoluminescence dosimeter material was placed together with the potatoes at the same position. Then, the potatoes were stored in the same temperature and humidity environment, and the quality changes of the potatoes were observed. The Y1.79Bi0.01Eu0.2MgTiO6 material had good performance indicators, and was used to measure the irradiation dose of the potatoes. The experiment showed that irradiation could appropriately extend the storage time of potatoes, and gamma irradiation of about 1000 Gy could achieve the best preservation effect. The main pathogenic fungi that cause dry rot of potatoes were Fusarium solani and Fusarium oxysporum, and the appropriate dose of 60Co-γ irradiation could effectively inhibit the spread and growth of these fungi.

Photodynamic Therapy Using a Rose-Bengal Photosensitizer for Hepatocellular Carcinoma Treatment: Proposition for a Novel Green LED-Based Device for In Vitro Investigation.

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Despite new treatments, the HCC rate remains important, making it necessary to develop novel therapeutic strategies. Photodynamic therapy (PDT) using a Rose-Bengal (RB) photosensitizer (RB-PDT) could be a promising approach for liver tumor treatment. However, the lack of standardization in preclinical research and the diversity of illumination parameters used make comparison difficult across studies. This work presents and characterizes a novel illumination device based on one green light-emitting diode (CELL-LED-550/3) dedicated to an in vitro RB-PDT. The device was demonstrated to deliver a low average irradiance of 0.62 mW/cm2 over the 96 wells of a multi-well plate. Thermal characterization showed that illumination does not cause cell heating and can be performed inside an incubator, allowing a more rigorous assessment of cell viability after PDT. An in vitro cytotoxic study of the RB-PDT on an HCC cell line (HepG2) demonstrated that RB-PDT induces a significant decrease in cell viability: almost all the cells died after a light dose irradiation of 0.3 J/cm2 using 75 µM of RB (<10% of viability). In conclusion, the RB-PDT could be a therapeutic option to treat unresectable liver lesions and subclinical disease remaining in the post-resection tumor surgical margin.

Accelerated formation of M2C carbides by proton irradiation inhibits molten salt corrosion in Ni-based alloy

The effect of displacement damage on the corrosion behavior in a molten FLiBe salt environment was investigated. The element distribution and microstructure around the grain boundaries (GBs) after corrosion were characterized. The results show a decrease in corrosion thickness with increasing irradiation dose and the presence of intergranular corrosion. Nanoscales M2C carbides were observed to be distributed, with a denser and thicker distribution in samples with higher irradiation doses. Their distribution depth is related to the Cr depletion region, inhibiting Cr diffusion toward the GBs and surface. Furthermore, the nucleation mechanism of M2C carbides along the GBs and in irradiated regions was revealed, attributed to the combined effects of thermal influences, element preferential dissolution due to corrosion, and irradiation-induced segregation.

DEGRADATION KINETICS OF TEXTILE AZO DYE REACTIVE ORANGE-16 BY GAMMA IRRADIATION

Gamma radiation have become attention since their high potential for degrading compounds, especially organic pollutants. In this research, gamma radiation was studied for degrading the Reactive Orange-16 (RO-16) dye, a toxic and carcinogenic pollutant. The radiolytic degradation process was studied in a batch reactor with a gamma-ray dose rate of 2.930 kGy/h. The effect of experimental variable such as initial peroxide concentration, initial pH, initial dye concentration, and addition of inorganic anion were studied. The highest degradation rates were achieved at a peroxide concentration ranging from 2 to 4 mM. In contrast, the higher peroxide concentration indicated the slower degradation process caused by the scavenging effect of the peroxide. Degradation of 88% RO-16 dye with 0.1 mM initial concentration, was achieved at 2.0 kGy irradiation dose and 97.4% degradation in the presence of 4 mM peroxide. The dose constant (d) for those degradation processes was 1.0657 kGy-1 and 1.8420 kGy-1 respectively. The degradation was more efficient in acid pH. The degradation process increased with lower initial dye concentrations. The degradation of RO-16 dye by gamma-ray was inhibited by the presence of inorganic anions in the following sequence: NO3-→ CO32− → HCO3− → CH3COO-→ Cl-.

The influence of different radiotherapy doses on the mechanical properties and microstructure of the enamel and dentin of human premolar teeth.

Radiation therapy is applied in the treatment of head and neck cancer patients. However, oral-health-related side effects like hyposalivation and ahigher prevalence of caries have been shown. This study aims to assess the influence of different radiotherapy doses on the mechanical properties, roughness, superficial microstructure, and crystallinity of the enamel and dentin of human premolar teeth. Specimens (n = 25) were categorized into five groups based on the radiation dose received (0, 10, 30, 50, and 70 Gy). The enamel and dentin of these specimens were subjected to amicrohardness tester, profilometer, atomic force microscopy (AFM), scanning electron microscopy (SEM), and X‑ray diffraction (XRD) before and after different irradiation doses and compared to hydroxylapatite in each group. The data were analyzed using repeated-measures analysis of variance (ANOVA). Therapeutic radiation doses of 30, 50, and 70 Gy led to adecrease in the microhardness and an increase in the average roughness of the enamel, and rougher surfaces were observed in the mixed three-dimensional images. Moreover, in the dentin, asimilar outcome could be observed for more than 10 Gy. The main crystalline phase structure remained hydroxylapatite, but the crystallinity decreased and the crystalline size increased above 10 Gy. The superficial micromorphology revealed granulation, fissures, and cracks in adose-dependent manner. Radiation below 70 Gy had little effect on the hydroxylapatite concentration during the whole experiment. Above aradiation dose of 30 Gy, the micromorphology of the tooth enamel changed. This occurred for dentin above 10 Gy, which indicates that dentin is more sensitive to radiotherapy than enamel. The radiation dose had an effect on the micromorphology of the hard tissues of the teeth. These results illustrate the possible mechanism of radiation-related caries and have guiding significance for clinical radiotherapy.

Synergistic effect of Gemcitabin-loaded metal organic frameworks nanoparticles with particle therapy

Combination of nanoagents with radiations has opened up new perspectives in cancer treatment, improving both tumor diagnosis and therapeutic index. This work presents the first investigation of an innovative strategy that combines porous metal–organic frameworks (nanoMOFs) loaded with the anti-cancer drug Gemcitabine monophosphate (GemMP) and particle therapy-a globally emerging technique that offers more precise radiation targeting and enhanced biological efficacy compared to conventional radiotherapy. This radiochemotherapy has been confronted with two major obstacles limiting the efficacy of therapeutics when tested in vivo: (i) the presence of hypoxia, one of the most important causes for radiotherapy failure and (ii) the presence of a microenvironment, main biological barrier to the direct penetration of nanoparticles into cancer cells.On the one hand, this study explore the effects of hypoxia on drug delivery systems in combination with radiation, demonstrating that GemMP-loaded nanoMOFs significantly enhance the anticancer efficacy of particle therapy under both normoxic (pO2 = 20 %) and hypoxic (pO2 = 0.5 %) conditions. Notably, the presence of GemMP-loaded nanoMOFs allows the irradiation dose to be reduced by 1.4-fold in normoxia and at least 1.6-fold in hypoxia, achieving the same cytotoxic effect (SF=10 %) as carbon or helium ions alone. Synergistic effects between GemMP-loaded nanoMOFs and radiations have been observed and quantified. On the other hand, we also highlighted the ability of the nanoMOFs to diffuse through an extracellular matrix and accumulate in cells. An higher effect of the encapsulated GemMP than the free drug was observed, confirming the key role of the nanoMOFs in transporting the active substance to the cancer cells as a Trojan horse. This paves the way to the design of “all-in-one” nanodrugs where each component plays a role in the optimization of cancer therapy to maximize cytotoxic effects on hypoxic tumor cells while minimizing toxicity on healthy tissue.

Comparative analysis of irradiation-stimulated hardening in the austenite and ferrite phases of F321 stainless steel

F321 stainless steel is renowned for its outstanding mechanical properties and corrosion resistance, making it a crucial structural material in light water reactors and high-temperature gas reactors. With irradiation (IR), F321 stainless steel undergoes microstructural alterations, such as the formation of IR-stimulated defects (e.g., stacking fault tetrahedrons (SFTs), dislocation loops (DLs), and clusters), resulting in IR hardening. This study compares the IR-stimulated hardening in the austenitic and ferritic phases of F321 stainless steel through both experimental methods and numerical simulations. In the austenitic phase, the size and number density of IR defects (DLs and SFTs) were determined, which were proportional to the IR dose. In the ferritic phase, IR-induced DL parameters were quantified, and the effects of IR on spinodal decomposition were analyzed. The interaction processes and mechanisms between dislocations and IR defects in the austenitic phase were evaluated using molecular dynamics (MD) simulations, leading to the development of a model for IR defect-induced hardening strength. Additionally, an MD data-driven crystal-plasticity-finite-element-model (CPFEM) was established. The nano-indentation hardness of the austenitic and ferritic phases was measured and calculated through both experimental methods and CPFEM simulations. The results show that the nano-indentation hardness of the ferritic phase is reduced compared to the austenitic phase, due to a lower density of IR defects. Understanding these effects provides deeper insights into how IR influences the mechanical and microstructural properties of F321 steel, which is essential for predicting the material's long-term performance and reliability.

Studying the structure, photoluminescence and thermoluminescence properties of LiCaBO3 pseudoternary glass-ceramic co-doped with Ce3+, Sm3+ ions

The lithium-calcium-borate (LiCaBO3) glass co-doped with Ce3+ and Sm3+ ions were successfully fabricated by the conventional melt quenching method. Annealing heat at 710 °C for 2 or 4 h formed the nanocrystals in the glass matrix. The X-ray diffraction patterns have proved the formation of the nanocrystals in materials. The appearance of these nanocrystals changed the glass lattice structure as well as the physical and optical properties of the material. The radiative properties of the LiCaBO3 glass and glass ceramics were analyzed within the framework of Judd-Ofelt theory. The thermoluminescence (TL) properties of the materials were studied by analyzing the glow curve and the TL spectra. The application potential of the materials in the field of dosimetry was proposed based on the investigation results of the parameters such as TL response to irradiation dose, fading rates, and the standard deviation.

Glycosylated gelatin prepared based on electron beam irradiation and its physicochemical properties

The influence of electron beam irradiation (EBI) treatment on the modification of gelatin-galactose glycosylation was thoroughly examined. The results of the degree of grafting and browning revealed that EBI triggered the glycosylation reaction of gelatin. The degree of glycosylation exhibited a gradual increase with the rising irradiation dose, reaching a maximum of 25 kGy. Moreover, the irradiation process opened up gelatin's internal structure, exposing its hydrophobic groups. This exposure led to an enhancement in sample surface hydrophobicity. The fluorescence intensity at the maximum emission wavelength of the fluorescence spectra decreased; Fourier infrared spectroscopy demonstrated a new absorption peak at 1074 cm−1 for the glycosylation product. These findings substantiate that gelatin formed a new product through covalent bonding with galactose. Glycosylation boosted the emulsification stability of gelatin from 1.92 min to 10.42 min and improved its emulsification and rheological properties. These outcomes affirm that EBI can effectively induce the glycosylation reaction of gelatin, thereby enhancing its functional properties. In addition, EBI has the potential to supplant the conventional heating glycosylation method. This study lays a solid theoretical foundation for the future application of glycosylation and gelatin.

Radiation Effects in Tungsten and Tungsten-Copper Alloys Treated with Compression Plasma Flows and Irradiated with He Ions.

The paper presents the results of studying the structure and phase state of tungsten and tungsten-copper alloy after pulsed action of compression plasma flows and irradiation with helium ions. The compression plasma flows were used to modify the surface layer of tungsten, as well as to create an alloy based on tungsten and copper. Using scanning electron microscopy and X-ray structural analysis, the formation of radiation defects on the tungsten surface was detected in the form of local areas of exfoliation and destruction, which begin to form at helium ion irradiation doses of 2 × 1017 cm-2. It is shown that preliminary plasma treatment of the surface in the melting mode leads to the complete disappearance of surface radiation defects up to a dose of 2 × 1017 cm-2, which may be associated with the formation of a fine-crystalline grain structure, the intergranular boundaries of which serve as effective sinks for primary radiation defects.

Study on the effects of preparation processes on OSL and TL properties of NaMgF3:Dy,Eu

OSL fading with storage time after irradiation remains a major obstacle in the development of ideal OSL materials. Dy and Eu co-doped NaMgF3 are attractive candidates for various rare earth doped matrix materials. In this study, NaMgF3:Dy,Eu was synthesized by a solid-state reaction, and the effects of heating temperature, duration, atmosphere, and cooling rate on XRD, TL and OSL properties were studied. A simple, safe, efficient, and time-saving solid-state reaction was identified as a potential method for the preparation of NaMgF3:Dy,Eu, which could be optimally prepared by heating at 750 °C for 2 h under nitrogen atmosphere (2 l/min) followed by rapid cooling. The results show that NaMgF3:Dy,Eu has a more stable OSL response and an excellent TL glow curve, with only a 0.4% decrease in the OSL signal read after 1 d of dose irradiation compared to that immediately after irradiation, and a high main TL peak at ∼320 °C. It has been indicated the OSL signal in this material seems to be strongly related to the main TL peak. The material has a considerable OSL sensitivity and decay rate than the Luxel Detector. NaMgF3:Dy,Eu will have a promising future in the field of OSL dosimetry due to its near tissue equivalence, low OSL fading without preheating, fast OSL decay rate, and predictable and easily reusable dose elimination.

Research on the Stability and Response of Food Packaging Polystyrene Resin Materials to γ-ray Irradiation.

Radiation stability of food packaging materials is the key to ensuring food quality. In this study, 60Co γ-ray was selected to investigate the radiation resistance of food packaging polystyrene (PS) resin material, although the FTIR analysis showed that the intensity of several peaks decreased slightly. The gel permeation chromatography (GPC) results displayed that the value of peak molecular weight (Mp) of PS went from 2.68 × 105 g/mol down to 2.22 × 105 g/mol. Moreover, the residual mass (Res) of PS increased from 7.208 to 30.23%, indicating that the tendency of coking of PS was stronger after irradiation. In addition, the peak intensities of the three main pyrolysis products -CH2-, CH4, and CH2=CH2 increased by more than 30% compared to unirradiated PS, and a large number of them were detected in the whole pyrolysis process. Moreover, mechanical property analysis finds that both breaking strength and elongation data increased before irradiation dose of 50 kGy, then, decreased sharply with further increase of irradiation dose. The theoretical bond order analysis confirmed that the tertiary carbon bond attaching the benzene ring had the lowest bond energy. This study can give helpful guidance when using PS for food packing materials.

The effect of irradiation for Nafion membrane electrode rapid separation of hydrogen-methane by electrochemical hydrogen pumps

Designing an efficient and reliable tritium plant has become a major challenge to developing nuclear fusion, which focuses on efficient and safe hydrogen isotope separation and purification. The electrochemical hydrogen pump (EHP) developed in recent years can be used to separate and compress hydrogen. Herein, we used the commercial Nafion membrane electrode in the EHP, which has excellent H2/CH4 separation performance. When the cell voltage is at 0.8 V, the current density is 2.04 A/cm2, the hydrogen separation rate can reach 14.2 mL/ (min ·cm2), and the hydrogen purity is more than 99.99 %. The damage mechanism of electron beam irradiation on the membrane electrode was revealed. It was found that irradiation caused Nafion’s main chain and branch chain to break, producing hydroxyl and carboxyl functional groups. The degree of chain fracture increased with the radiation dose, perforation and cracks occurred in the proton exchange membrane (PEM). Under the electron beam irradiation dose of 10 kGy, the membrane electrode can still maintain excellent H2/CH4 separation performance, and the hydrogen permeability caused by cracks and perforations is at a very low level. This study reveals the change of macroscopic performance caused by the microscopic mechanism of membrane electrode irradiation damage, provides a promising way to separate hydrogen isotope gases and is expected to promote the development of tritium plants in fusion engineering.

Visualization of Biomolecular Radiation Damage at the Single-Particle Level Using Lanthanide-Sensitized DNA Origami.

Precise monitoring of biomolecular radiation damage is crucial for understanding X-ray-induced cell injury and improving the accuracy of clinical radiotherapy. We present the design and performance of lanthanide-DNA-origami nanodosimeters for directly visualizing radiation damage at the single-particle level. Lanthanide ions (Tb3+ or Eu3+) coordinated with DNA origami nanosensors enhance the sensitivity of X-ray irradiation. Atomic force microscopy (AFM) revealed morphological changes in Eu3+-sensitized DNA origami upon X-ray irradiation, indicating damage caused by ionization-generated electrons and free radicals. We further demonstrated the practical applicability of Eu3+-DNA-origami integrated chips in precisely monitoring radiation-mediated cancer radiotherapy. Quantitative results showed consistent trends with flow cytometry and histological examination under comparable X-ray irradiation doses, providing an affordable and user-friendly visualization tool for preclinical applications. These findings provide new insights into the impact of heavy metals on radiation-induced biomolecular damage and pave the way for future research in developing nanoscale radiation sensors for precise clinical radiography.

Research on electron beam irradiation in the multiscale structure of starch and its related applications: A review.

Electron beam irradiation (EBI), as a typical "green" emerging technology, can effectively alter the functional properties of starch by influencing its microstructure. This alteration enables starch to meet the current demands of consumers and the market for "health food." This paper reviews studies on modifying various starches using EBI and describes the changes in microstructure, physicochemical properties, and functional properties induced by this method. Additionally, the effects of EBI on starch-containing food products are discussed, along with issues to be addressed and research gaps in the synergistic treatment of modified starch. It is noted that the source, irradiation dose, and irradiation time all influence the effectiveness of starch modification. Given the characteristics of EBI technology, integrating physical, chemical, and biological modification methods can optimize the modification process and enhance efficiency. This technology can potentially diversify modified starch varieties and expand their applications. Furthermore, there remains significant research potential in producing modified starch using EBI technology and applying it to the food industry.

Growth and Production Character Response of Kuantan Singingi Local Rice Mutants Resulting from Gamma Irradiation

Rice (Oryza sativa L.) is a crucial crop with significant importance in various regions. In Riau, specifically in Kuantan Singingi Regency, it ranks as the fourth largest area for rice production, showcasing numerous local rice varieties with substantial development potential. This study aimed to generate mutants exhibiting early maturity and reduced plant height through gamma-ray induced mutations. A non-factorial Randomized Block Design (RAK) was employed, with the primary factor being the irradiation dose: R0 served as the control group without radiation, while the experimental group received an irradiation dose of 300 Gy, determined to be effective in prior research. Each treatment was replicated five times, utilizing a total of 600 plants per treatment. The findings indicated that rice plants subjected to 300 Gy irradiation exhibited shorter heights compared to those in the control group. Additionally, the stem circumference of plants irradiated with 300 Gy was significantly greater than that of the non-irradiated plants. Furthermore, the number of productive tillers was higher in the 300 Gy group compared to the control. However, the harvest age for rice plants exposed to 300 Gy was extended relative to those without radiation. Conversely, the length of the flag leaf in rice plants irradiated at 300 Gy was shorter than that of the control group. There remains a considerable need for data on the desired characteristics of rice mutants to facilitate advanced breeding efforts.

Influence of γ-radiation on magnetoelectrical properties of Bi0.85Sb0.15 (0.001≤x≥0.05) solid solution

Abstract The influence of γ-quantum on the magnetoelectric properties of Bi0.85Sb0.15 &lt;Pbx&gt; (0.001≤x≥0.05) thermoelectrics doped with lead atoms at ~77÷300K and magnetic field induction up to 1.0 Tesla has been studied. It was found that at low doses of gamma irradiation of the Bi0.85Sb0.15 &lt;Pb&gt; solid solution, point defects are formed, which lead to an increase in the concentration of free electrons n, specific electrical conductivity σ and a decrease in the absolute value of the thermo EMF coefficients α and RH. As the dose of γ-quanta increases in the process of subsequent restructuring, point defects accumulate, i.e. accumulation of point defects, which leads to a decrease in the concentration of current carriers and a corresponding change in σ, α. and RH.

Intracavitary cisplatin-fibrin followed by irradiation improved tumor control compared to the single treatments in a mesothelioma rat model

ObjectiveTo test the safety and efficacy of combination treatment for pleural mesothelioma (PM) with intracavitary cisplatin-fibrin (cis-fib) plus hemithoracic irradiation (IR) applied after lung-sparing surgery in an orthotopic immunocompetent rat model. MethodsWe randomized male F344 rats into 5 groups: cis-fib (n = 9), 10 Gy IR (n = 6), 20 Gy IR (n = 9), cis-fib+10 Gy IR (n = 6), and cis-fib+20 Gy IR (n = 9). Subpleural tumor implantation was performed on day 0 with 1 million syngeneic rat mesothelioma cells (IL45-luciferase). Tumors were resected on day 9, followed by treatment with intracavitary cis-fib or vehicle control (NaCl-fib). On day 12, computed tomography–guided local irradiation in a single high dose of the former tumor region was applied. ResultsWe observed only short-term side effects related to 20 Gy radiotherapy. Compared to 20 Gy, 10 Gy IR did not show an impact on tumor growth. At 3 days after treatment with 20 Gy IR (day 15 of the experiment), we detected significantly smaller tumors in the cis-fib+IR group compared to IR alone (mean tumor growth, 252% vs 539%; P = .04). On day 21, there was a significant difference in tumor growth between cis-fib–treated and cis-fib+IR– treated tumors (mean tumor growth, 2295% vs 660%; P = .01). ConclusionsLocalized treatment after tumor resection in PM aims to improve local tumor control. Irradiation applied in combination with intracavitary cis-fib in rats is safe up to a dosage of 20 Gy and shows an additive effect on tumor growth delay compared to the single treatments.