The European Commission (EC) adopted a new EU Global Health Strategy in November 2022. The goal is advancing global health through policies tackling key challenges. The ongoing impact of climate change, biodiversity and pollution on global health and the interconnected and borderless nature of health are foundational concepts for the Strategy. There is also a focus on digitisation and research opportunities. Three priorities for the strategy are better health and wellbeing, strengthened health systems and combating health threats through a One Health approach. These will be achieved by following 20 guiding principles between now and 2030. The Strategy is part of Global Gateway, which seeks to reduce the global investment gap worldwide. The EU is collaborating with the United Nations (UN) and the World Health Organization (WHO) to tackle global health issues and improve prevention, preparedness and response via the EU Global Health Strategy. The Strategy will replace the EC’s 2010 Communication on the EUâ–™s role in global health and comes with important updates, such as a focus on climate change, environmental degradation, humanitarian crises and food insecurity and their negative impacts on health. Antimicrobial resistance, mental health and challenges in the health and care systems landscape will also be confronted by harnessing research and digitisation, including artificial intelligence (AI), to enhance new opportunities. The emphasis on a One Health approach will enhance access to vaccines, improve global disease surveillance and strengthen global collaboration on health issues, with numerous stakeholders pledging political commitment and shared responsibility to achieving goals.