Background & Objectives: To investigate the influence of paravertebral analgesia on renal function in patients with intra-abdominal hypertension after various emergency surgery. Materials & Methods: The work is based on a study of treatment outcomes in 52 patients with generalized peritonitis (mean age 43,2 ± 3,84 years). All the patients were divided into 2 groups. The first (control) group included 24 patients who received postoperative conventional (antibiotics, analgesics, infusion-transfusion therapy, stimulate bowel, etc.) therapy. The second group involved 28 patients whom paravertebral analgesia was included in the complex of intensive therapy at Th-9–10 (1% - 50 mg lidocaine bilaterally (1.2-1.4mg/kg) every 4 hours). The glomerular filtration rate (GFR), filtration gradient (FG), urea and creatinine of blood,hourly urine output, and a verbal pain scale were studied in both groups. Measurement of intra-abdominal pressure (IAP) was performed by the method I. Kron (1984) through the bladder. Results: The analysis showed that both groups against the background of intensive therapy tend to decrease of IAP and improvement in renal function. However, the most prominent and persistent changes were observed in patients 2nd group. In this group, the baseline IAP of 15,7 ± 0,4 mm Hg, after 24 hours, dropped to 8,1 ± 0,4 mm Hg (P <0.05). In day 1 the IAP of first-group patients actually remained unchanged, and only since day 2 the decline had been significant (p <0.05). Glomerular filtration rate in patients with usage of paravertebral analgesia after a day has increased from 76,7 ± 6,4 ml / min to 83,0 ± 4,5 ml / min, reaching 100,5 ± 8,8 ml / min to the end of day 3. Filtration gradient also had a similar picture. At the same time the indications significantly differ from group 1 at all stages of the research. Indicators of blood urea in group 2 patients significantly decreased only on day 3 of the study compared with baseline (6,8 ± 0,7 mmol / l). A similar pattern was observed with serum creatinine levels. No significant changes were observed in patients of group 1. Conclusion: Our studies show that blockade of the sympathetic innervation due to the administering of lidocaine in the paravertebral space leads to a decrease of pain impulses and reduce stress of the abdominal wall and results of reduction intra-abdominal pressure. Moreover renal hyperemia is improved, which obviously leads to an increase in glomerular filtration rate and urine output. Apparently this is due to improvement of renal blood flow, glomerular vazodilatation and reduction tubular reabsorption. However, in order to decrease in blood urea and creatinine more time is needed. Disclosure of Interest: None declared