Intervals Of Several Hours Research Articles

КЛАСТЕРЫ ЦИКЛОНОВ И ИХ ВЛИЯНИЕ НА РАЗМЫВ БЕРЕГОВ КАЛИНИНГРАДСКОЙ ОБЛАСТИ

The shores of the Kaliningrad Region (the Russian part of the South-Eastern Baltic Sea) are regularly exposed to extreme storms, which leads to intensive abrasion and flooding of the land. Based on archival data, meteorological monitoring, forecast and synoptic maps, an analysis of extreme storms observed in the autumn-winter periods of the early 21st century was done. The cyclone type was determined using the HYSPLIT (Hybrid Single Particle Lagrangian Integrated Trajectory Model), which makes it possible to reconstruct the trajectory of the approach of the atmospheric vortex to the coast. The seasons with clusters of storms were identified, when deep cyclones affected the coasts of the Kaliningrad Region in a relatively short time. Regardless of the type of trajectory, storms cause destruction of both natural and infrastructure objects. But the shores of the northern exposure are most susceptible to destruction by “diving” cyclones, the wave regime of which has a high potential energy. Earlier it was noted that the frequency of cyclones with northerly winds increases. Clusters of northern cyclones are especially dangerous, as was in January 2022, when 4 atmospheric eddies affected the coast with an interval of several hours to 2–3 days. When the water level was high, the waves crashed on the coast, causing catastrophic damage. The coastal monitoring revealed numerous destruction of the banks, breakthroughs of the foredune, both flooding and collapse of forests, critical damage to coast protection and engineering structures, and infrastructure facilities. Dozens of hectares of coastal territories have been lost. There are environmental problems associated with numerous emissions into the marine environment of a huge amount of anthropogenic mega-, macro-, meso-, micro-garbage with a predominance of plastic after extreme storms.

Detectability of cannabinoids in the serum samples of cannabis users: Indicators of recent cannabis use? A follow‐up study

Forensic toxicologists are frequently required to predict the time of last cannabis consumption. Several studies suggested the utility of minor cannabinoids as indicators of recent cannabis use. Because several factors influence blood cannabinoid concentrations, the interpretation of serum cannabinoid concentrations remains challenging. To assess the informative value of serum cannabinoid levels in cannabis users (in total N = 117 patients, including 56 patients who stated an exact time of last cannabis use within 24 h before blood sampling), the detectability of cannabinoids, namely, delta-9-tetrahydrocannabinol (delta-9-THC), 11-hydroxy-delta-9-THC, 11-nor-9-carboxy-delta-9-THC, cannabichromene (CBC), cannabidiol (CBD), cannabinol (CBN), cannabidivarin, tetrahydrocannabivarin, cannabigerol (CBG), cannabicyclol, delta-8-THC, tetrahydrocannabinolic acid A, cannabichromenic acid, cannabidiolic acid (CBDA), cannabigerolic acid, cannabicyclolic acid (CBLA), 11-nor-9-carboxy-THCV (THCVCOOH), and 11-nor-CBN-9-COOH, was investigated. Excluding CBDA and CBLA, all investigated cannabinoids were detected in at least one analyzed sample. The interval between cannabis consumption and sample collection (reported by the patients) was not correlated with cannabinoid concentrations. Minor cannabinoids tended to be more easily detected in samples obtained shortly after consumption. However, some samples tested positive for minor cannabinoids despite an interval of several hours or even days between consumption and sampling (according to patients' statements). For instance, CBC, CBG, THCVCOOH, CBD, and CBN in certain cases could be detected more than 24 h after the last consumption of cannabis. Thus, findings of minor cannabinoids should always be interpreted with caution.

Using the satellite images for the territory of Ukraine

The purpose of this article is to identify the wind direction and speed using the images from geostationary satellites and through application of two-dimensional wind vectors, the magnitude and direction of which corresponds to the speed and direction of cloud masses, on a satellite image. The results may be used for making a short-term forecast of dangerous weather events within the territory of Ukraine.
 To make the technique work, it is necessary to select cloud areas on a satellite image using the threshold method. Then, based on the brightness temperature distribution between two tracking modules (parts of an image based on which two consecutive satellite images are compared), the maximum correlation coefficient for infrared brightness temperature is to be determined. The coefficient corresponds to the movement of cloud masses and sets the beginning and end of the wind direction vector.
 To determine the optimum application of the technique for the territory of Ukraine, the analysis of accuracy of tracking modules of different sizes was also performed. The analysis revealed that the accuracy of determining the wind vector direction depends on the tracking module size: the larger it is, the more accurate is the direction vector found, but given that the time interval between images is 15 minutes, the optimum algorithm to be used in Ukraine is the one with 5x5 pixel tracking module.
 The technique performance was also compared with the data of ICON and GFS forecast models. The results of the applied algorithm showed that the direction of air masses was more reliable than the data retrieved from the above-mentioned forecast models, because the algorithm analyzes the real-time movement of air masses while the forecast models assess the formation and movement of air masses in advance (with an interval of several hours up to dozens of hours). Numerical wind speed forecast of ICON and GFS models is more accurate, because the algorithm determines the wind speed based on the movement of cloud masses on satellite images whereas the forecast models consider several factors (pressure fields, development and subsequent evolution of cyclones, anticyclones, geographical characteristics etc.) which makes them more realistic.

Ultraviolet solar flare signatures in the framework of complex network.

Studying natural phenomena via the complex network approach makes it possible to quantify the time-evolving structures with too many elements and achieve a deeper understanding of interactions among the components of a system. In this sense, solar flare as a complex system with the chaotic behavior could be better characterized by the network parameters. Here, we employed an unsupervised network-based method to recognize the position and occurrence time of the solar flares by using the ultraviolet emission (1600 Å) recorded by the Atmospheric Imaging Assembly on board Solar Dynamics Observatory. Three different regions, the flaring active regions, the non-flaring active regions, and the quiet-Sun regions, were considered to study the variations of the network parameters in the presence and absence of flaring phases in various datasets over time intervals of several hours. The whole parts of the selected datasets were partitioned into sub-windows to construct networks based on computing the Pearson correlation between time series of the region of interest and intensities. Analyzing the network parameters such as the clustering coefficient, degree centrality, characteristic length, and PageRank verified that flare triggering has an influence on the network parameters around the flare occurrence time and close to the location of flaring. It was found that the values of the clustering coefficient and characteristic length approach those obtained for the corresponding random network in the flaring phase. These findings could be used for detecting the occurrence times and locations of the region at ultraviolet images.

Linalool acts as a fast and reversible anesthetic in Hydra.

The ability to make transgenic Hydra lines has allowed for quantitative in vivo studies of Hydra regeneration and physiology. These studies commonly include excision, grafting and transplantation experiments along with high-resolution imaging of live animals, which can be challenging due to the animal’s response to touch and light stimuli. While various anesthetics have been used in Hydra studies, they tend to be toxic over the course of a few hours or their long-term effects on animal health are unknown. Here, we show that the monoterpenoid alcohol linalool is a useful anesthetic for Hydra. Linalool is easy to use, non-toxic, fast acting, and reversible. It has no detectable long-term effects on cell viability or cell proliferation. We demonstrate that the same animal can be immobilized in linalool multiple times at intervals of several hours for repeated imaging over 2–3 days. This uniquely allows for in vivo imaging of dynamic processes such as head regeneration. We directly compare linalool to currently used anesthetics and show its superior performance. Linalool will be a useful tool for tissue manipulation and imaging in Hydra research in both research and teaching contexts.

The effect of ion irradiation on the dissolution of UO2 and UO2-based simulant fuel

The aim of this work was to study the separate effect of fission fragment damage on the dissolution of simulant UK advanced gas-cooled reactor nuclear fuel in water. Plain UO2 and UO2 samples, doped with inactive fission products to simulate 43 GWd/tU of burn-up, were fabricated. A set of these samples were then irradiated with 92 MeV 129Xe23+ ions to a fluence of 4.8 × 1015 ions/cm2 to simulate the fission damage that occurs within nuclear fuels. The primary effect of the irradiation on the UO2 samples, observed by scanning electron microscopy, was to induce a smoothening of the surface features and formation of hollow blisters, which was attributed to multiple overlap of ion tracks. Dissolution experiments were conducted in single-pass flow-through (SPFT) mode under anoxic conditions (<0.1 O2 ppm in Ar) to study the effect of the induced irradiation damage on the dissolution of the UO2 matrix with data collection capturing six minute intervals for several hours. These time-resolved data showed that the irradiated samples showed a higher initial release of uranium than unirradiated samples, but that the uranium concentrations converged towards ∼10−9 mol/l after a few hours. Apart from the initial spike in uranium concentration, attributed to irradiation induced surficial micro-structural changes, no noticeable difference in uranium chemistry as measured by X-ray electron spectroscopy or ‘effective solubility’ was observed between the irradiated, doped and undoped samples in this work. Some secondary phase formation was observed on the surface of UO2 samples after the dissolution experiment.

Photometry of the three eclipsing novalike variables EC 21178-5417, GS Pav and V345 Pav

As part of a project to better characterize comparatively bright, yet little studied cataclysmic variables time resolved photometry of the three eclipsing novalike variables EC 21178-5417, GS Pav und V345 Pav is presented. Previously known orbital periods are significantly improved and long-term ephemeris are derived. Variations of eclipse profiles, occurring on time scales of days to weeks, are analyzed. Out of eclipse the light curves are characterized by low scale flickering superposed on more gradual variations with amplitudes limited to a few tenths of a magnitude and profiles which at least in EC 21178-5417 and GS Pav roughly follow the same pattern in all observed cycles. Additionally, signs for variations on the time scale of some tens of minutes are seen in GS Pav, most clearly in two subsequent nights when in the first of these a signal with a period of 15.7 min was observed over several hours. In the second night variations with twice this period were seen. While no additional insight could be gained on quasi periodic oscillations (QPOs) and dwarf nova oscillations in EC 21178-5417, previously detected by Warner et al. (2003), and while such oscillations could not be found in V345 Pav, stacked power spectra of GS Pav clearly reveal the presence of QPOs over time intervals of several hours with periods varying between 200 s and 500 s in that system.

Transient evolution of the target erosion profile during magnetron sputtering: Dependence on gas pressure and magnetic configuration

The growth of the target erosion profile (racetrack) in DC magnetron sputtering has been experimentally studied at a modest target power. Unbalanced magnetron sputtering (UBMS) and balanced magnetron sputtering (BMS) of a copper target were conducted at Ar gas pressures between 0.38–2.0Pa at a constant DC discharge power of 100W. At time intervals of several hours throughout the target life, the target was removed from the chamber, and its erosion profile was measured with a height gauge. The racetrack width was found to have an interesting pressure dependence. Higher argon gas pressure resulted in a wider initial track width in both the UBMS and BMS configurations. As the sputter erosion of the target proceeded, the track width became narrower at higher gas pressures (≥1.0Pa). At lower gas pressures, the track width was mostly unchanged and even showed a slight increase in the case of 0.38Pa in UBMS. As a result, the order of the final width was reversed: the higher gas pressure resulted in a narrower track width. The origin of this behavior was ascribed to the difference in the plasma sheath thickness and the free path of secondary electrons.

Is there a “chronic Takotsubo syndrome”? Could “smart-phone”-based technology be of aid?

Reviewing the literature one encounters case reports of patients with recurrent Takotsubo syndrome (TTS), in whom the recurrent episodes are separated by months or years [ [1] http://www.ncbi.nlm.nih.gov/pubmed/?term=takotsubo (accessed last 3/19/15). Google Scholar ], or who had more than 2 episodes of TTS [ [2] Lagan J. Connor V. Saravanan P. Takotsubo cardiomyopathy case series: typical, atypical and recurrence. BMJ Case Rep. Mar 5 2015; (pii: bcr2014208741)https://doi.org/10.1136/bcr-2014-208741 Crossref PubMed Scopus (4) Google Scholar ], or who had one admission with TTS during which they experienced recurrent attacks of chest pain and/or dyspnea separated by quiescent time intervals of several hours, with parallel perturbations of the electrocardiogram repolarization changes [ [3] Sinha A. Rassiwala J. Goldschlager N. Takotsubo cardiomyopathy: how T waves behave under stress. JAMA Intern. Med. 2015; 175: 842-844 Crossref PubMed Scopus (3) Google Scholar ]. Some of these patients with such atypical clinical TTS are reported as having “intermittent substernal chest pain for the past few months that had worsened in the past weeks”, that culminated in an admission with documented TTS [ [3] Sinha A. Rassiwala J. Goldschlager N. Takotsubo cardiomyopathy: how T waves behave under stress. JAMA Intern. Med. 2015; 175: 842-844 Crossref PubMed Scopus (3) Google Scholar ]. Some other patients, particularly women with chronic stress, report during their single admission for TTS, that they had experienced occurrences of chest pain and/or dyspnea many weeks, months, or even years, prior to their documented TTS episode, were previously diagnosed as having angina, but found during their admission with TTS not to have obstructive coronary artery disease [ [2] Lagan J. Connor V. Saravanan P. Takotsubo cardiomyopathy case series: typical, atypical and recurrence. BMJ Case Rep. Mar 5 2015; (pii: bcr2014208741)https://doi.org/10.1136/bcr-2014-208741 Crossref PubMed Scopus (4) Google Scholar ]. In taking the history of a woman admitted recently with TTS, the author was told that the patient was often troubled with chest pain and dyspnea, for which she took to bed for hours to days at a time. Also he has noted that some patients, discharged after an admission for TTS, continue to complain of symptoms as the above, during their clinic follow-up appointments, and this is also reflected in the literature [ [2] Lagan J. Connor V. Saravanan P. Takotsubo cardiomyopathy case series: typical, atypical and recurrence. BMJ Case Rep. Mar 5 2015; (pii: bcr2014208741)https://doi.org/10.1136/bcr-2014-208741 Crossref PubMed Scopus (4) Google Scholar ].

Saturn's dayside ultraviolet auroras: Evidence for morphological dependence on the direction of the upstream interplanetary magnetic field.

We examine a unique data set from seven Hubble Space Telescope (HST) “visits” that imaged Saturn's northern dayside ultraviolet emissions exhibiting usual circumpolar “auroral oval” morphologies, during which Cassini measured the interplanetary magnetic field (IMF) upstream of Saturn's bow shock over intervals of several hours. The auroras generally consist of a dawn arc extending toward noon centered near ∼15° colatitude, together with intermittent patchy forms at ∼10° colatitude and poleward thereof, located between noon and dusk. The dawn arc is a persistent feature, but exhibits variations in position, width, and intensity, which have no clear relationship with the concurrent IMF. However, the patchy postnoon auroras are found to relate to the (suitably lagged and averaged) IMF Bz, being present during all four visits with positive Bz and absent during all three visits with negative Bz. The most continuous such forms occur in the case of strongest positive Bz. These results suggest that the postnoon forms are associated with reconnection and open flux production at Saturn's magnetopause, related to the similarly interpreted bifurcated auroral arc structures previously observed in this local time sector in Cassini Ultraviolet Imaging Spectrograph data, whose details remain unresolved in these HST images. One of the intervals with negative IMF Bz however exhibits a prenoon patch of very high latitude emission extending poleward of the dawn arc to the magnetic/spin pole, suggestive of the occurrence of lobe reconnection. Overall, these data provide evidence of significant IMF dependence in the morphology of Saturn's dayside auroras.Key PointsWe examine seven cases of joint HST Saturn auroral images and Cassini IMF dataThe persistent but variable dawn arc shows no obvious IMF dependencePatchy postnoon auroras are present for northward IMF but not for southward IMF

Role of Electrical Activity in Horizontal Axon Growth in the Developing Cortex: A Time-Lapse Study Using Optogenetic Stimulation

During development, layer 2/3 neurons in the neocortex extend their axons horizontally, within the same layers, and stop growing at appropriate locations to form branches and synaptic connections. Firing and synaptic activity are thought to be involved in this process, but how neuronal activity regulates axonal growth is not clear. Here, we studied axonal growth of layer 2/3 neurons by exciting cell bodies or axonal processes in organotypic slice cultures of the rat cortex. For neuronal stimulation and morphological observation, plasmids encoding channelrhodopsin-2 (ChR2) and DsRed were coelectroporated into a small number of layer 2/3 cells. Firing activity induced by photostimulation (475 nm) was confirmed by whole-cell patch recording. Axonal growth was observed by time-lapse confocal microscopy, using a different excitation wavelength (560 nm), at 10–20-min intervals for several hours. During the first week in vitro, when spontaneous neuronal activity is low, DsRed- and ChR2-expressing axons grew at a constant rate. When high-frequency photostimulation (4 or 10 Hz) for 1 min was applied to the soma or axon, most axons paused in their growth. In contrast, lower-frequency stimulation did not elicit this pause behavior. Moreover, in the presence of tetrodotoxin, even high-frequency stimulation did not cause axonal growth to pause. These results indicate that increasing firing activity during development suppresses axon growth, suggesting the importance of neuronal activity for the formation of horizontal connections.

Intriguing properties of the angucycline antibiotic auricin and complex regulation of its biosynthesis

Streptomyces bacteria are major producers of bioactive natural products, including many antibiotics. We identified a gene cluster, aur1, in a large linear plasmid of Streptomyces aureofaciens CCM3239. The cluster is responsible for the production of a new angucycline polyketide antibiotic auricin. Several tailoring biosynthetic genes were scatted in rather distant aur1 flanking regions. Auricin was produced in a very narrow growth phase interval of several hours after entry into stationary phase, after which it was degraded to non-active metabolites because of its instability at the high pH values reached after the production stage. Strict transcriptional regulation of the auricin biosynthetic gene cluster has been demonstrated, including feed-forward and feedback control by auricin intermediates via several of the huge number of regulatory genes present in the aur1 cluster. The complex mechanism may ensure strict confinement of auricin production to a specific growth stage.

Development and industrial application of soft sensors with on-line Bayesian model updating strategy

This paper deals with the issues associated with the development of data-driven models as well as model update strategy for soft sensor applications. A practical yet effective solution is proposed. Key process variables that are difficult to measure are commonly encountered in practice due to limitations of measurement techniques. Even with appropriate instruments, some measurements are only available through off-line laboratory analysis with typical sampling intervals of several hours. Soft sensors are inferential models that can provide continuous on-line prediction of hidden variables; such models are capable of combining real-time measurements with off-line lab data. Due to the prevalence of plant-model mismatch, it is important to update the model using the latest reference data. In this paper, parameters of data-driven models are estimated using particle filters under the framework of expectation–maximization (EM) algorithms. A Bayesian methodology for model calibration strategy is formulated. The proposed framework for soft sensor development is applied to an industrial process to provide on-line prediction of a quality variable.

The Impact of Red Wine on Blood Pressure Dizziness Continues

We read with great interest the article of Chiva-Blanch et al recently published in your journal.1 This randomized controlled trial evaluates the impact of dealcoholized red wine (DRW) on blood pressure (BP) in patients with high cardiovascular risk and concludes on its ability to lower BP. Although excited about the interesting results of this trial, we think several concerns exist that, if addressed in future studies, might lead to a better understanding of the findings and a wider acceptance of the conclusions. First, office measurement has been used to evaluate the impact of various interventions on BP. Although not specified in the article, the patients were likely to have the interventions (ie, beverage intake) during evening hours. As such, there has been an interval of several hours between the intervention and the measurement of BP, which took place during the office visit the next day. It has been shown that repeated alcohol intake has a biphasic impact on BP (ie, initially decreasing, …

Strict control of auricin production in Streptomyces aureofaciens CCM 3239 involves a feedback mechanism

The polyketide gene cluster aur1 is responsible for the production of the angucycline antibiotic auricin in Streptomyces aureofaciens CCM 3239. Auricin production is regulated in a complex manner involving several regulators, including a key pathway-specific positive regulator Aur1P that belongs to the family of 'atypical' response regulators. Production of auricin is induced after entry into stationary phase. However, auricin was produced in only a short time interval of several hours. We found that the decrease of auricin production was due to a strict regulation of auricin biosynthetic genes at the transcriptional level by a feedback mechanism; auricin and/or its intermediate(s) inhibited binding of Aur1P to its cognate biosynthetic promoter aur1Ap and consequently stopped its activation. In addition, we also determined that synthesised auricin is unstable during growth of S. aureofaciens CCM3239 in the production medium even though purified auricin is stable for days in various organic solvents. The critical parameter affecting its stability was pH. Auricin is stable at acid pH and unstable at neutral and alkaline pH. The drop in auricin concentration was due to an increase of pH shortly after induction of auricin production during cultivation of S. aureofaciens CCM3239.

Alternative Formulations for Incorporating Lateral Boundary Data into Limited-Area Models

Abstract Limited-area models (LAMs) use higher resolutions and more advanced parameterizations of physical processes than global numerical weather prediction models, but suffer from one additional source of error—the lateral boundary condition (LBC). The large-scale model passes the information on its fields to the LAM only over the narrow coupling zone at discrete times separated by a coupling interval of several hours. The LBC temporal resolution can be lower than the time necessary for a particular meteorological feature to cross the boundary. A LAM user who depends on LBC data acquired from an independent prior analysis or parent model run can find that usual schemes for temporal interpolation of large-scale data provide LBC data of inadequate quality. The problem of a quickly moving depression that is not recognized by the operationally used gridpoint coupling scheme is examined using a simple one-dimensional model. A spectral method for nesting a LAM in a larger-scale model is implemented and tested. Results for a traditional flow-relaxation scheme combined with temporal interpolation in spectral space are also presented.

Low frequency geomagnetic field fluctuations at cap and low latitude during October 29-31, 2003

On October-November 2003 complex interplanetary structures, originated by a series of solar eruptions, hit the Earth, triggering violent Sun-Earth connection events. In this paper we analyze the low frequency geomagnetic field fluctuations detected on the ground during Oct. 29-31, 2003, a time period characterized by extremely high solar wind speed values and by out-of-ecliptic interplanetary magnetic field orientation for intervals of several hours. We analyze geomagnetic field measurements at four high latitude stations located in the polar cap, three in the southern and one in the northern hemisphere. From a comparison with simultaneous measurements at low latitude, we address the question of the global character of the observed phenomena. The results show, for selected time intervals, the occurrence of simultaneous fluctuations at all the stations, with high coherence even between high and low latitude; it is interesting that these fluctuations are detected during open magnetospheric conditions, when the high latitude stations are situated well within the polar cap, i.e. far from closed field lines.

Acute HPA axis response to naltrexone differs in female vs. male smokers

Both opioid antagonist administration and cigarette smoking acutely increase hypothalamic-pituitary-adrenal (HPA) axis activity as measured by adrenocorticotropic hormone (ACTH) and cortisol levels. However, male and female smokers may differ in their response to the opioid antagonist naltrexone, which may be partially mediated by sex differences in HPA axis function. Smokers, as a group, have frequently been shown to have HPA axis dysfunction, which may have relevance to the course and maintenance of nicotine dependence. The purpose of this study was to examine possible sex differences in HPA axis function by comparing stress-hormone response to naltrexone within healthy male and female smokers. Additionally, exploratory analyses compared the combined effects of naltrexone and cigarette smoking on hormonal responsivity between the sexes. Thirty-eight healthy smokers (22 men) were tested in two separate morning sessions after 12h of smoking abstinence. For women, self-reports of menstrual cycle information were obtained prior to each session (date of last menstruation, cycle length, reproductive phase, etc.). Each participant received 50mg naltrexone or placebo capsule (in random order) and plasma levels of ACTH and cortisol were assessed at regular intervals for several hours. A subgroup of 12 participants underwent a similar, additional session in which they smoked a single cigarette three hours after naltrexone administration. Naltrexone significantly increased ACTH and cortisol levels in women, but not men (DrugxSexxTime, p<0.05). A post hoc analysis suggested that women at an estimated 'high estrogen' phase had a greater cortisol response (DrugxEstrogen level, p<0.05) than those at an estimated 'low estrogen' phase. Exploratory analyses showed that smoking a single cigarette potentiated naltrexone-induced increases in ACTH (p<0.05) and cortisol (p<0.01) in all participants. The findings support the hypothesis that women are more sensitive to opioid antagonism at the level of the HPA axis. Although further studies are needed to examine mechanisms underlying these responses, both results may have clinical implications for the use of naltrexone as a treatment for nicotine dependence.

Real-time on-line ultrasonic monitoring for bubbles in ceramic ‘slip’ in pottery pipelines

When casting ceramic items in potteries, liquid ‘slip’ is passed from a settling tank, through overhead pipelines, before being pumped manually into the moulds. It is not uncommon for bubbles to be introduced into the slip as it passes through the complex piping network, and indeed the presence of bubbles is a major source of financial loss to the ceramics industry worldwide. This is because the bubbles almost always remain undetected until after the ceramic items have been fired in a kiln, during which process bubbles expand and create unwanted holes in the pottery. Since there it is usually an interval of several hours between the injection of the slip into the moulds, and the inspection of the items after firing, such bubble generation goes undetected on the production line during the manufacture of hundreds or even thousands of ceramic units. Not only does this mean hours of wasted staff time, power consumption and production line time: the raw material which makes up these faulty items cannot even be recycled, as fired ceramic cannot be converted back into slip. Currently, the state-of-the-art method for detecting bubbles in the opaque ceramic slip is slow and invasive, can only be used off-line, and requires expertise which is rarely available. This paper describes the invention, engineering and in-factory testing across Europe of an ultrasonic system for real-time monitoring for the presence of bubbles in casting slip. It interprets changes in the scattering statistics accompanying the presence of the bubbles, the latter being detected through perturbations in the received signal when a narrow-band ultrasonic probing wave is transmitted through the slip. The device can be bolted onto the outside of the pipeline, or used in-line. It is automated, and requires no special expertise. The acoustic problems which had to be solved were severe, and included making the system capable of monitoring the slip regardless of the material of pipe (plastic, steel, etc.) and nature of the slip (which can be very variable). It must also be capable of detecting bubbles amongst the myriad solid particles and other species present in the flowing slip. The completed prototype was tested around several factories in Europe, and proved not only to be more versatile, but also more sensitive, than the state-of-the-art method.

Acute effects of sulfur mustard injury—Munich experiences

Sulfur mustard (SM) is a strong vesicant agent which has been used in several military conflicts. Large stockpiles still exist to the present day. SM is believed to be a major threat to civilian populations because of the persistent asymmetric threat by non-state actors, such as terrorist groups, its easy synthesis and handling and the risk of theft from stockpiles. Following an asymptomatic interval of several hours, acute SM exposure produces subepidermal skin blisters, respiratory tract damage, eye lesions and bone marrow depression. Iranian victims of SM exposure during the Iran–Iraq (1984–1988) war were treated at intensive care units of 3 Munich hospitals. All 12 patients were injured following aerial attacks with SM filled bombs, which exploded in a distance between 5 and 30 m. All patients soon noted an offensive smell of garlic, addle eggs or oil roasted vegetables. No individual protective equipment was used. Eye itching and skin blistering started 2 h after SM exposure. Some patients complained of nausea, dizziness and hoarseness. 4 h after exposure, most patients started vomiting. Eye symptoms worsened and most patients suffered from temporary blindness due to blepharospasm and lid oedema. Additionally, pulmonary symptoms such as productive cough occurred. Patients were transferred to Munich 4–17 days after SM exposure. On admission all patients showed significant skin blistering and pigmentation. Conjunctivitis and photophobia were the major eye symptoms. Pulmonary symptoms, including productive cough were persistent. Bronchoscopy revealed massive inflammation of the trachea with signs of necrosis. 3 patients needed tracheotomy. Chest X-ray did not yield abnormal observations. This presentation summarizes the experience of treating SM victims in Munich and discusses therapeutic implications.