Abstract
We read with great interest the article of Chiva-Blanch et al recently published in your journal.1 This randomized controlled trial evaluates the impact of dealcoholized red wine (DRW) on blood pressure (BP) in patients with high cardiovascular risk and concludes on its ability to lower BP. Although excited about the interesting results of this trial, we think several concerns exist that, if addressed in future studies, might lead to a better understanding of the findings and a wider acceptance of the conclusions. First, office measurement has been used to evaluate the impact of various interventions on BP. Although not specified in the article, the patients were likely to have the interventions (ie, beverage intake) during evening hours. As such, there has been an interval of several hours between the intervention and the measurement of BP, which took place during the office visit the next day. It has been shown that repeated alcohol intake has a biphasic impact on BP (ie, initially decreasing, …
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