A dual-parameter fiber-optic sensor based on fiber Bragg grating (FBG) cascaded with Fabry–Pérot interferometer (FPI) structure is described and demonstrated to measure temperature and gas pressure simultaneously. The proposed sensing structure consists of an extrinsic FPI in the form of hemispherical ultraviolet (UV) curing glue capped on a FBG end face. The spectral interference peak produced by the UV glue FPI is sensitive to ambient temperature and gas pressure variations, whereas the reflection spectrum of FBG only depends on temperature and insensitive to pressure change, therefore, the temperature and gas pressure can be simultaneously measured by this cascaded sensor. Experimental results show that the sensor has higher temperature and gas pressure sensitivities of 223.4 pm/° C and 24.99 nm/MPa in a range from 30 ∘C to 110 ∘C and from 0.1 MPa to 0.7 MPa. Utilizing the temperature-dependent sensitivity of FBG, a constructed sensitivity matrix is used to distinguish measurement of temperature and gas pressure, and the measurement resolutions are determined to be 0.086 ∘C and 0.730 KPa. This sensing architecture is not only an effective method for single-point multi-parameter measurement, but also has merits of high sensitivity, compactness, ease of fabrication and low cost, which make it valuable for biosensors and medical applications.