Superconductor–semiconductor hybrid circuits can combine the benefits of the high-speed and low-power operation of single-flux quantum circuits and high integration densities of CMOS technology such as memory. The Suzuki stack, a type of Josephson latching driver/amplifier, is a widely used interface circuit in Josephson–CMOS hybrid memories. Due to the limited cooling power at cryogenic temperatures, the power dissipation is becoming an important concern, especially in large-scale systems. An optimization technique to significantly reduce the power dissipation of Suzuki stack circuits is proposed in this article. The proposed design can reduce the power dissipation by 30–70% while causing a voltage drop of 2–9% in the output voltage depending on the circuit parameter configuration. The tradeoffs between the power dissipation and output voltage characteristics are discussed. The proposed design can operate correctly within at least <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\pm$</tex-math></inline-formula> 20% of process parameter variations as demonstrated with extensive simulations.