Industry has long been a driving force in the national economy of Chongqing, a traditional industrial hub in China. Current research provides limited understanding of the spatial associations between industrial manufacturing enterprises and CRD mortality in urban areas of Western China. This study employs location data of CRD death patients and Points of Interest (POI) representing industrial manufacturing enterprises from 2012 to 2020. It explores their spatial patterns and associations through spatial clustering identification, co-location, and association effects. Key spatial association characteristics identified include: (1) High-risk CRD mortality areas are predominantly located in Tongnan District and Kaizhou District in the western and northeastern parts of Chongqing, with an increase in CRD mortality rates correlated with age and a higher prevalence among females. (2) The optimal bandwidths for spatial association characteristics are 0.18 m and 0.475 m, respectively. (3) The construction and mining industries exert a more substantial impact on the mortality rates of younger CRD patients, with a notably stronger spatial impact on male patients compared to female patients. These insights are critical for guiding public health policy and spatial planning of industrial manufacturing enterprises in Chongqing.