Human-Computer Interaction (HCI) is a research discipline that optimizes human-machine interfaces. Ibero-America has become a leading region in HCI advances adapted to its unique socioeconomic environment. However, a global characterization of the research landscape for this discipline in the region still needs to be improved. Therefore, this study aimed to analyze the scientific literature on HCI in Ibero-America using bibliometric techniques, identifying key authors, institutions, conceptual structure, and research trends. The methodology employed consisted of a bibliometric analysis of 9812 documents from 1990-2023 from Scopus and Web of Science. The data were analyzed using Bibliometrix and VOSviewer for statistical and network analysis. The results revealed that Spain, Brazil, Portugal, Mexico, and Colombia are at the forefront of HCI research in the region, with more than 90 % of total publications experiencing an annual growth rate of approximately 14.6 %, driven by strong international collaborations. Key topics are human-computer interaction, virtual reality, augmented reality, and video games, while education is one of the main application areas. The main conclusion is that the HCI research landscape in Ibero-America is characterized by rapid evolution, international integration, and conceptual diversity, indicative of a mature and interdisciplinary field that responds to regional demands. The advancement of the field could be driven by increased private-sector funding. Future system designs in the region should prioritize cultural sensitivity and inclusion.