The influence of agricultural methods and soil and climatic conditions on soybean cultivation in the southern regions of the Amur Region was researched. Schemes of two-factor experiments to study the effectiveness of deepening the arable layer of soil during crop cultivation in 2014–2016 included the following options. Factor A – tillage: autumn – disk plowing or cultivation; spring disk plowing or cultivation; summer – inter-row cultivation with or without para-plowing. The options were combined in different ways, whereby the option of soil tillage with a disc harrow in autumn and spring was taken as control. Factor B: sowing with seeders SZ-5.4 and SP-3.6 L with row spacing (options – 15, 45 and 60 cm) with various tillage systems. In 2017–2018 experiments were carried out according to the following schemes. Factor A – tillage: in autumn tillage depth at 0.12 m with a disc harrower PM-8; in spring, before sowing – at 0.10 m (cultivator Case Tiger Mate 225 – control); autumn – tillage depth at 0.28 m (cultivator Lemken Karat 9/400); spring, before sowing – at 0.10 m (Case Tiger Mate 225). Factor B – seeding units included Amazon DMC 9000 (control); Amazon DMC 1200, Case Pro Disk 500 AFS, John Deer 1890, Lemken Solitair 12, Horsch Pronto 9 DC, Tom’ 12, SP-3.6 L. Deep autumn cultivation, in contrast with disk plowing, ensures a more favorable waterair regime for plants and an increase in soybean yield. Seeding units Case Pro Disk 500 AFS, John Deer 1890, Amazon DMC 9000 and SP-3.6 L used in combination with Lemken Karat 9/400 + Case Tiger Mate 255 machines for deepening the arable layer provided an increase in soybean yield by 25.0–38.3% compared to soil tillage with discs. It is recommended to use wide-span seeding units for soybean cultivation in large and medium-sized farms in fields with subdued relief in accordance with high-intensity technology. It is advisable to use SP-3.6 L seeder with a seed shoe for organic crop production in small-scale agricultural enterprises.