Physical Integrity Research Articles

Abstract 2369: EVOLVE-105, a differentiated CD20-targeted CD2 co-stimulatory T cell engager engineered for the treatment of B cell malignancies

Abstract Despite the recent approvals of CD20-targeted CD3 bispecific molecules in follicular lymphoma (Lunsumio™, mosunetuzumab) and diffuse large B cell lymphoma (Columvi™, glofitamab; and Epkinly™, epcoritamab), significant opportunities to improve patient outcomes in these indications remain. Targeted induction of T cell costimulatory receptors (signal 2) as a complement to T cell activation mediated by T cell receptor signal 1 is an attractive strategy to sustain and optimize the redirected T cell effector response to these tumors. Drug combinations of CD3-bispecifics and tumor-targeted costimulatory biologics such as CD19-41BBL and CD19-CD28 costimulatory agonists are promising approaches that have shown preclinical efficacy and are being investigated in the clinic. EVOLVE-105 is a CD20-targeted trispecific T cell engager biotherapeutic with an integrated, affinity-tuned CD3 and a CD2 co-stimulatory agonist. The advantages of physical integration include an increased probability of simultaneous T cell receptor and CD2 receptor engagement on each T cell and a simplified patient management strategy, compared to drug combinations of molecules individually targeting each receptor. EVOLVE-105 displays improved human T cell activation, increased T cell expansion, and tumor cell killing activity without a substantial increase in cytokine release compared to CD20xCD3 bispecifics with matching CD3 affinity which does not supply CD2 costimulation. EVOLVE-105 also displays superior potency compared to the CD20xCD3 clinical benchmarks mosunetuzumab, epcoritamab, and odronextamab. Importantly, the tumor-killing potency of EVOLVE-105 was within two-fold of the activity of glofitamab, while inducing less cytokine release, suggesting its potential to establish an improved therapeutic index. In cynomolgus monkeys, EVOLVE-105 demonstrated favorable tolerability and pharmacokinetics consistent with an attractive clinical developability profile. Sustained, dose-dependent B cell depletion in peripheral blood, lymph nodes, and spleen was observed. Circulating cytokine excursions, including IL-6, IFNγ, and TNFα at efficacious doses were markedly reduced by EVOLVE-105 treatment, in contrast to the circulating levels of cytokines reported for epcoritamab and glofitamab at their efficacious doses. EVOLVE-105 demonstrates favorable biophysical properties conducive to its development as intravenous and subcutaneous formulations. The emerging profile of EVOLVE-105 suggests its potential as a differentiated CD20-targeted immunotherapy capable of providing superior, more durable tumor control with a preferred cytokine release profile, compared to current CD20-targeted T cell engager therapies. Citation Format: Xingyue An, Mohosin Sarkar, Stella Martomo, Maria Hackett, Guixian Jin, Tiffany Liang, Danielle Klaskin, Tracy Lichter, Nana Adjoa Pels, Abudukadier Abulizi, Evelyn Teran, Afsana Sabrin, Oksana A. Sergeeva, Amber Fearnley, Hayden Karp, Julio Rodriguez, Eric M. Tam, Louis Matis, Jay S. Fine, Jeremy S. Myers. EVOLVE-105, a differentiated CD20-targeted CD2 co-stimulatory T cell engager engineered for the treatment of B cell malignancies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2369.

Analysis of Psychoanalytic Therapy Intervention: for Individuals with Post Traumatic Stress Disorder (PTSD)

Post Traumatic Stress Disorder (PTSD) is a psychiatric disorder that occurs after an individual experiences or witnesses a traumatic event that threatens their life or physical integrity. This study aims to analyze psychoanalytic therapy interventions for individuals with PTSD and assess their effectiveness in reducing PTSD symptoms and improving their quality of life. Psychoanalytic therapy is an interesting approach in helping individuals with PTSD by understanding the psychological conflicts that underlie symptoms and emotional problems. This research method uses a literature review of individuals with PTSD who have received psychoanalytic therapy. The data obtained were then analyzed to identify important themes related to the therapy process and the psychological changes that occurred. The results of the analysis showed that psychoanalytic therapy had a positive effect in reducing PTSD symptoms in individuals. The intervention provided an opportunity for them to explore and understand the root emotional issues related to the trauma, which in turn helped them face and cope with the psychological impact of the traumatic event. The therapeutic process also contributes to improved quality of life, deeper self-understanding and better adaptability.

The Physical Benefits of Sports, Basis for Enhanced Sports Program

This study conducts a comprehensive analysis by investigating the impact of sports activities on university students' daily lives and their promotional benefits in public awareness and community events. The findings reveal that students generally perceive positive influences in physical, mental, economic, and value integration domains due to sports activities. In the physical domain, students believe that sports make their daily routines more active, and gym fitness is both enjoyable and beneficial. Regarding mental health, students experience a relaxing feeling, enhanced concentration, and the development of positive values through sports. In the economic domain, students see opportunities, networking skills, and improved job prospects resulting from sports involvement. Analyzing the impact based on gender and age indicates no significant differences in most domains. However, variations exist in sports types, particularly in the mental health domain, where volleyball players show higher scores than football players. Furthermore, the study highlights the positive promotional benefits of sports in public awareness campaigns and fun community events. Students recognize the contribution of sports to health awareness, community engagement, and the attraction of external participants. In conclusion, this research emphasizes the importance of sports activities for the holistic development of university students. Practical recommendations are provided for the planning and promotion of university sports activities based on the study's outcomes.

Physical Education Teachers’ Commitment and Behavior Towards Continuing Education

This study analyses the commitment and behaviour of physical education teachers to continuing education around six dimensions, including pedagogical training, with the aim of developing an action plan based on the commitment of physical education teachers to continuing education and the profession in the areas of pedagogical training, sport-specific certification, adapted physical education, and technological integration. This study used quantitative research methods to explore the commitment to continuing education and professional action plans of these teachers. The results of the study revealed that physical education teachers' active participation in activities such as continuing education is a commitment to their professional development. The enhancement of these behaviours can better serve students; PE teachers' attitudes and subjective norms help to promote continuous learning and improvement; through participation in activities such as adaptive physical education and technology integration access, they can better apply theoretical knowledge to practical teaching and learning, and enhance the teaching effectiveness and student experience; PE teachers' commitment and behaviours to CPD is not only a responsibility, but also a mission, which is important for the teacher individuals, students and society as a whole have a positive and far-reaching impact.

The sportization of esports and its implications in the near future of sport

ABSTRACT Esports have transformed playing video games into a competitive activity that bears similarities to sports and the processes of sportization. Taking as a starting point the concept of sports as competitive games, the objective of this work is to analyse the sportization of esports, as well as the impact of esports on the concept of sports and their implications on sports in the immediate future. Sports and esports are two different realities that interact with each other. This is a conceptual problem for sports, and it also defines a practical challenge in the immediate future of sports. The virtual environment offers new possibilities in sports, such as broadening the possibilities of confrontation and competition development, contributing to reducing the environmental impact of certain sports, improving safety and maintaining the physical integrity of athletes, and increasing social justice and equality of chances in sports competitions. The challenge, therefore, is to try to bring esports and sports closer together, even moving toward hybrid sports, as addressed throughout this article.

Unfuturing peace: augmented reality image design for Guerrilla peacebuilding

This project explores the potential of image-making in augmented reality (AR) technologies as means of designing sustaining quality peace futures—unfuturing peace, focusing on Ukraine’s heroic defense against Russia’s 2022–2024 full-scale war of aggression as a case study. Employing the methodology of compositional interpretation and the conceptual tool “futures images,” the project theoretically and practically differentiates between defuturing and unfuturing as peace design processes in developing an essay of originally designed marker-based Augmented Reality Posters in Support of Ukraine as demos of sustaining quality peace arrangements. The posters reference the topics of (physical) integrity of Ukrainian symbols, global food security and the security of the LGBTQI+ community in Ukraine. The technological artistic process/outcomes of this AR image-making experiment and their relation to power layouts in peacebuilding form the bases for theorizing how AR-supported futures design in war-affected communities—unfuturing peace—could facilitate “guerrilla peacebuilding.” In outlining theoretical and practical premises of guerrilla peacebuilding, the project intersects Augmented Reality Posters in Support of Ukraine with explorations of guerrilla warfare and counterinsurgency efforts leading to the 2016 Havana Peace Agreements in Colombia as well as mobile technologies/power in guerrilla approaches to democratic development.

Physical integrity and bioefficacy of used long-lasting insecticidal nets in Makenene, Centre Region of Cameroon.

Long-lasting insecticide nets (LLINs) are the recommended tools against mosquito-borne diseases. However, their physical integrity and bioefficacy in the field could be affected by several factors. This study evaluated the physical integrity and bioefficacy of nets used in Makenene since 2016. Cross-sectional field surveys were carried out after 6 y. A questionnaire was first administered to the heads of households, and then the physical integrity of the LLINs was determined by calculating the proportional hole index (pHI). WHO cone bioassays were conducted to determine the bioefficacy of LLINs currently being used against wild strains of Anopheles gambiae s.l., Culex pipiens s.l., and laboratory-reared pyrethroid-susceptible strain of Anopheles coluzzii (Ngousso). Of the 167 LLINs examined in households, 39.5% were fairly good, 26.4% were acceptable, and 34.1% were damaged. The most torn faces of the nets were the sides used for entering and exiting. None of the 30 LLINs used for WHO cone bioassays was still effective against An. gambiae s.l. and Cx. pipiens s.l. while up to 85.7% of these LLINs were at least effective against the susceptible strain after 24 h, with a significant difference observed when comparing the mortality rates between wild and laboratory-susceptible strain of Anopheles (P-value < 0.01). Anopheles gambiae s.l. were all (100%) identified as An. gambiae s.s. by PCR. The LLINs distributed in Makenene since the 2016 campaign are only effective on susceptible strain and should be replaced for a better control of residual malaria transmission and the nuisance by Culex mosquitoes in the locality.

Body autonomy: women with disabilities and the quest for a sex life free from violence

The present paper aims to analyze the body autonomy of girls and women with disabilities and its influence on a sexual and reproductive life free from violence. Established in 1994, at the International Conference on Population and Development (or ICPD), the expression of bodily autonomy has entered the discourse of human rights advocates, activists, and experts. Other international texts point in the direction of "protecting and guaranteeing the right of all individuals to physical integrity, autonomy, and reproductive rights, and to provide access to essential services in support of these rights," such as the voluntary Nairobi Declaration (2019), the Convention on the Rights of Persons with Disabilities (2006), and the UN 2030 Agenda for Sustainable Development, which established, among its goals, the achievement of sexual and reproductive health and reproductive rights for all, reaffirming the importance of the theme for the development of a society with gender equality. With bibliographical research and statistical data, authors such as Gesser, Beauvoir, Butler Honneth, and Becker have been used to establish a dialogue about disability and its necessary intersectionalities, to understand the condition of women with disabilities within a patriarchal, sexist, ableist, and racist society that reifies and silences them, reducing their lives to the private sphere, as if they were objects. Thus, we conclude that education for bodily autonomy, through the emancipatory process of girls and women with disabilities is one of the paths to be followed for the eradication of gender violence against this vulnerable group.

MiPhDUO: microwave imaging via physics-informed deep unrolled optimization

Microwave imaging (MWI) is a non-invasive technique that can identify unknown scatterer objects’ features while offering advantages such as low cost and portable devices with respect to other imaging methods. However, MWI faces challenges in solving the underlying inverse scattering problem, which involves recovering target properties from its scattered fields. Existing methods include linearized and non-linear optimization approaches, but they have limitations respectively in terms of range of validity and computational complexity (in view of the possible occurrence of ‘false solutions’). In recent years, learning-based approaches have emerged as they can allow real-time imaging but usually lack generalizability and a direct connection to the underlying physics. This paper proposes a physics-informed approach that combines convolutional neural networks with physics-based calculations. It is based on a few cascaded operations, making use of the gradient of the relevant cost function, and successively improving the estimation of the unknown target. The proposed approach is assessed using simulated as well as experimental Fresnel data. The results show that the integration of physics with deep learning can contribute to improve reconstruction accuracy, generalizability, and computational efficiency in MWI.

Mobility-as-a-Service and unsustainable travel behaviour: Exploring the car ownership and public transport trip replacement side-effects of the MaaS paradigm

Car-centred development adds significantly to the climate change threat our planet faces. Mobility-as-a-Service (MaaS) is a concept looking to generate modal shift via the digital and physical integration of alternative on-demand transport services. Recent research raises concerns, however, that contrary to the hype, MaaS may result in unsustainable travel behaviour. On the one hand, future MaaS users that are now primarily drivers may not be ready to shift away from their cars, while, on the other hand, people regularly using public transport may substitute some of these journeys with MaaS-enabled car-sharing, ride-sharing and ride-hailing services. Herein, we study the effects of MaaS on intentions to own a car and to substitute public transport trips with car-centric services, via a UK-based quantitative survey. We use Principal Component Analysis and Ordinal Regression Modelling to see how MaaS-related perceptions referring to Added Value, Car Use Convenience and Enjoyment, Human Element Externalities, Trust in Functionality, Cost Incentives, Car Use Morality, Trust in Enabling Technology and Car Ownership Necessity affect usage intentions. Our results highlight some, typically less discussed, grey areas of MaaS and inform the design of policies, including car service disincentivitisation, responsible user benefits, MaaS rebranding and public transport investment prioritisation.

Crashworthiness optimisation and environmental impact assessment of a redesigned passenger coach integrating lean design-for-X framework

The transportation industry focuses on reducing vehicle weight for fuel economy and emissions. This emphasis promotes the use of coaches, which raises concerns about passenger safety in frontal collisions. The proposal is to correlate the crashworthiness of coaches with the replacement of fibreglass composite materials by a state-of-the-art polymer (DCPD). Based on the ECE R29 standard, FEM models solved by Pamcrash® assess the vehicle's crashworthiness. Cross-referencing these results with the Eco-Design X technique, two models are evaluated in terms of environmental impact. The LeanDfX methodology involves multiple analyses for design domains, including model optimisation, manufacturing processes, and eco-design. On a performance scale of 0% to 100%, different ‘X’ domains are evaluated. The Eco-Design study allowed the assessing the environmental impacts of the proposed solution compared to the original models, is conducted using Simapro v9.2.0.2 and the ReCiPe 2016 methodology. The novel design proposed modifications to the models resulted in significant structural behaviour improvements for driver's physical integrity. The cross results of Design-for-Crashworthiness and Design-for-Eco-Design using the innovative LeanDfX framework provide a new perspective to be integrated into the automotive industry. The use of DCPD is expected to lead to a more crashworthy and environmentally friendly design, while ensuring passenger safety.

Development Program of Basic Physical Movement Skills for Early Childhood in Guangzhou City, China

Background and Aim: The data highlights the persistent issue of high obesity rates among young children, aged 3-6, despite economic development and improved living standards. The overall physical fitness of children in this age group is deemed suboptimal, impacting their health, learning efficiency, and social adaptability. Recognizing early childhood as a critical phase for physical and mental development, the General Office of the Central Committee of the Communist Party of China and the General Office of the State Council emphasize the importance of physical education in the compulsory education stage. The recommended teaching model involves imparting health knowledge and basic motor skills, with an evolving focus on specialized motor skills. The study aims to investigate means and curriculum arrangements for physical fitness and skill exercises, intervening in basic motor skills to promote a holistic approach to physical and mental development in young children, ultimately contributing to the sustainable advancement of physical education. Materials and Methods: In this paper, using the methods of literature review, experimental method, expert interview method, observation method, and questionnaire survey method, an eight-week intervention experiment was carried out on 30, 5-6-year-old children, and the classroom teaching content was arranged in the way of physical fitness and basic motor skills integration. Results: The results of the two-month intervention experiment were as follows: the development of physical fitness and basic motor skills was better than that of the pre-intervention experiment; in terms of physical fitness: boys improved better than girls in standing long jump, 10-metre run, and throwing a tennis ball; girls improved better than boys in flexibility; and the development of coordination and balance was comparable between boys and girls. Regarding basic motor skills: boys outperformed girls in mobility skills; girls outperformed boys in biomechanical skills. Conclusion: In conclusion, the two-month intervention experiment exhibited positive overall outcomes in physical fitness and basic motor skills development, with distinct gender-specific variations. Boys showed superior progress in activities emphasizing strength and speed, while girls excelled in flexibility. Coordination and balance improvements were comparable between genders. The findings emphasize the importance of tailored approaches in physical education interventions to address diverse aspects of children's development.

A development Management Process to implement smart Sports in Higher Education Institutions in Heilongjiang Province, the People’s Republic of China

Background and Aim: Currently, education is entering a rapid stage of development in smart education. Starting in 2015, research on the comprehension and application of smart education has received notable recognition in academic circles. It has actively and effectively contributed to advancing a fresh phase of educational reform and enhancing educational progress. This research aims to construct the developing strategies to implement smart sports in higher education institutions in Heilongjiang Province. Materials and Methods: The participants in this research can be divided into four groups, which are as follows: (1) 20 teachers and 400 students were selected to participate in answering the questionnaires; (2) 7 experts were invited to in-depth interviews; (3) 19 experts were invited to conduct two-round Delphi study; and (4) 9 experts were invited to discuss and confirm the developing strategies to implement smart sports in higher education institutions in Heilongjiang province, based on POLC framework. Descriptive statistics, such as the calculation of the mean and standard deviation, are employed to assess the questionnaire data. The consensus data was analyzed by using the median and interquartile range. The criteria for analysis were a median of ≥ 3.50 and an interquartile range of ≤ 1.50. Results: the factors for the developing strategies were divided into four aspects as follows: 1. Planning, which includes Development Strategy which consists of 5 factors; 2. Organizing includes basic support which consists of 6 factors, and physical education curriculum integration setup and implementation which consists of 9 factors; 3. Leading includes a Sports Learning Environment which consists of 5 factors; and 4. Controlling includes Sports big data monitoring and evaluation which consists of 6 factors and Sports services and management which consist of 7 factors. Conclusion: The final development strategies for implementing smart sports in higher education institutions in Heilongjiang Province were acceptable.

Data and measurement mechanism integrated imaging method for electrical capacitance tomography

This study presents a new imaging paradigm for overcoming the challenges limiting the improvement of the imaging quality in the electrical capacitance technique. The new imaging model enables the integration of measurement physics, sparsity-induced prior and physics-informed multi-fidelity learning prior (PIMFLP), as well as the synergy between data-driven and measurement physics modeling paradigms. The transformed L1 norm is used to model the PIMFLP, and the maximum correntropy criterion is used as a data misfit term to restrict the adverse impact of noises or outliers. The PIMFLP is learned from data and characterizes the structural details of imaging targets. The half-quadratic optimization method is developed to overcome computational challenges in solving the novel imaging model. A new physics-informed multi-fidelity learning method is developed to predict PIMFLP by synergizing deep convolutional neural network with measurement physics, and a new bilevel optimization model solved by a new nested algorithm that merges the genetic algorithm and the split Bregman method is proposed for training. Comparisons with other popular reconstruction algorithms confirm that the new imaging method leads to the improved reconstruction accuracy and noise immunity, and opens up new possibilities for unlocking the potential of the measurement technology.

Violencia incesante: dos estudios de caso de migrantes por desplazamiento forzado hacia Estados Unidos

The persistent violence in Mexico continues to cause forced migration, forcing people to leave their communities to protect their physical integrity by resorting to requesting political asylum in the United States. This study describes the experience of people entering the United States through political asylum in two different time periods. For this purpose, a qualitative investigation was carried out, which included in-depth interviews with two people who were forcibly displaced in the state of Michoacán in 2014 and 2021. Among the main findings, the violence that continues in the State, caused by criminal organizations and the continuity of violence and the procedures for entering the United States seeking political asylum, which remain, painfully, very similar over the years.

Fire retardation, compressive strength and durability analysis of concrete reinforced with novel plasters: An experimental, computational and statistical research

Concrete is an essential component of the construction industry, valued for its high compressive strength (CS) and durability. However, when exposed to extreme conditions like fire without protective structural elements, its physical integrity deteriorates rapidly, leading to significant alterations in its mechanical properties. This research aims to provide a potential solution to this issue by assessing the fire resistance of various concrete samples, including unplastered (UNP), roughly plastered (RP), and those with contemporary insulation plaster (CIP) substitutions, at different thicknesses. These samples are subjected to varying temperatures and exposure times within an oven, followed by CS testing. These temperature levels and time intervals correspond to 300 °C, 450 °C, and 600 °C, with the time range is restricted to 60, 90, and 120-min, respectively. The results indicate that an increase in sample thickness correlates with a reduction in concrete degradation at high temperatures. Moreover, the findings reveal that after 120-min of exposure at 600 °C, UNP, RP, and CIP-reinforced samples achieve CSs of 27.435 MPa, 27.74 MPa, and 30.28 MPa, respectively. Notably, the 3 cm CIP-reinforced sample exhibits a CS exceeding 30 MPa under the most extreme conditions. The research incorporates regression and computational fluid dynamics (CFD) analyses to complement the experimental investigation. The regression analysis suggests that CIP-reinforced samples can withstand temperatures up to 600 °C for approximately 173-min, while the study implies that they could endure temperatures as high as 861 °C during a 120-min exposure.

An anti-mycobacterial conjugated oligoelectrolyte effective against Mycobacterium abscessus.

Infections caused by nontuberculous mycobacteria have increased more than 50% in the past two decades and more than doubled in the elderly population. Mycobacterium abscessus (Mab), one of the most prevalent of these rapidly growing species, is intrinsically resistant to numerous antibiotics. Current standard-of-care treatments are not satisfactory, with high failure rate and notable adverse effects. We report here a potent anti-Mab compound from the flexible molecular framework afforded by conjugated oligoelectrolytes (COEs). A screen of structurally diverse, noncytotoxic COEs identified a lead compound, COE-PNH2, which was bactericidal against replicating, nonreplicating persisters and intracellular Mab.COE-PNH2 had low propensity for resistance development, with a frequency of resistance below 1.25 × 10-9 and showed no detectable resistance upon serial passaging. Mechanism of action studies were in line with COE-PNH2 affecting the physical and functional integrity of the bacterial envelope and disrupting the mycomembrane and associated essential bioenergetic pathways. Moreover, COE-PNH2 was well-tolerated and efficacious in a mouse model of Mab lung infection. This study highlights desirable in vitro and in vivo potency and safety index of this COE structure, which represents a promising anti-mycobacterial to tackle an unmet medical need.

Automated radiosynthesis of mGluR5 PET tracer [18F]FPEB from aryl-chloro precursor and validation for clinical application.

The radioligand [18F]FPEB, used for PET imaging of the brain's metabotropic glutamate receptor subtype 5 (mGluR5), undergoes a thorough validation process to ensure its safety, efficacy, and quality for clinical use. The process starts by optimizing the synthesis of [18F]FPEB to achieve high radiochemical yield and purity. This study focuses on optimizing the radiolabeling process using an aryl-chloro precursor and validating the GMP production for clinical applications. Fully automated radiolabeling was achieved via one-step nucleophilic substitution reaction. [18F]FPEB was produced and isolated in high radioactivity and radiochemical purity. Throughout the validation process, thorough quality control measures are implemented. Radiopharmaceutical batch release criteria are established, including testing for physical appearance, filter integrity, pH, radiochemical purity, molar activity, radiochemical identity, chemical impurity, structural identity, stability, residual solvent, sterility, and endotoxin levels. In conclusion, the validation of [18F]FPEB involved a comprehensive process of synthesis optimization, quality control, which ensure the safety, efficacy, and quality of [18F]FPEB, enabling its reliable use in clinical PET. Here, we successfully radiolabeled and validated [18F]FPEB using aryl-chloro precursor according to GMP production for clinical application.

Unveiling the efficacy of latex gloves in preventing viral infections during needlestick injuries: An in vitro mixed-methods study

BackgroundGloves are personal protective equipment designed to prevent contamination and reduce the spread of microorganisms. This study aimed to assess in vitro the physical integrity of latex gloves and the retention of biological contamination in healthcare simulation. MethodThree different batches of latex procedure gloves from five different brands and specific batches were evaluated before use for physical integrity by the standard protocols of the Society for Testing and Materials (ASTM) and of the American Food and Drug Administration (FDA). Moreover, the retention of biological contamination by latex procedure gloves in needlestick injury simulation with crystal violet and bacteriophages were applied in order to mimic human blood and virus presence. ResultsBrands D and C showed the best and worst results in the immediate inspections and after 2 min, respectively. For Brand C, damage occurred in one finger/region in a total of 12 gloves, while seven gloves were damaged/unable to be worn. Brand D presented only two gloves with tears and/or holes in one finger/region. Regarding the viral contamination, in a simulated needlestick injury, data showed no significant difference among the groups. ConclusionAll glove brands presented physical damage that might affect the spread of microorganisms. The gloves did not exert an additional protective effect during a needlestick injury simulation in accordance with the two techniques used in this study.

Factors associated with mental health in medical students at UFAL/Arapiraca

This study aimed to identify the prevalence of depressive symptoms and suicidal ideation among medical students at the Federal University of Alagoas, Arapiraca campus. This was a cross-sectional study carried out between September and December 2022. The final sample consisted of 145 volunteers, 53.1% of whom were male. The results showed that 34.5% had depressive symptoms and 16.55% had suicidal ideation, with these conditions being associated with each other. In addition, students who declared themselves to be atheist/agnostic had more suicidal ideation compared to the others [p&lt;0.01]. These results indicate a higher prevalence of depressive symptoms and suicidal ideation in the sample investigated, pointing to the need to develop public policies that ensure the mental and physical integrity of medical students.