The fire incidences in Campo Grande have been a serious environmental problem. Therefore, this study is aimed at studying the trend of acute respiratory infections (IRA) from the year 2011 to 2017 and to correlate it with precipitation, wind speed, relative humidity, maximum and minimum temperatures, surface ozone concentration, optical depth, index of clarity and the number of outbreaks of fires. IRA records were obtained through DATASUS; the record of burn outbreaks at the National Institute for Space Research and the ozone concentration at the Federal University of Mato Grosso do Sul. There exists a positive and significant correlation between the number of burn outbreaks, wind velocity, ozone concentration, and optical depth with rates of hospitalizations for IRA. Also, a negative correlation exists between precipitation parameters, relative humidity, maximum and minimum temperatures. These results show the intensity of the problem and the great impact on the respiratory health of the population as well as on the economy due to increase in the number of hospitalizations and days of treatment.