Side Walls Research Articles

History and Perspectives of Hyperradical, Laterally Extended Parametrectomy (LEP).

Cervical cancer has been and still is a major global health problem and a major treatment challenge for which surgical interventions have played a key role throughout the past century. In early stages (I/A2-II/B), where high-risk factors are not present, the efficacy of surgical and radiotherapy treatment has been considered equivalent with different (treatment modality specific) complications and quality of life consequences. Negative prognostic factors in early stages of the disease (pelvic lymph-node positivity) and in more advanced stages (parametrial and/or surgical margins' tumor involvement) forecast the deterioration of outlooks for good life expectancy. In these high-risk cases, when radio- or chemoradiotherapy is contraindicated, we investigated the potential role of a more radical surgical approach than the traditional radical hysterectomy. Twenty-five years ago, a hyperradical surgical procedure for the treatment of high-risk cervical cancer patients was introduced in Budapest. The procedure was named as laterally extended parametrectomy (LEP) in Budapest Hungary. The surgical intention was the complete removal of the fibro-fatty tissue content of the pelvis, which contains the lymphatic vessels, lymph nodes, and tumor-affected pelvic side wall structures. We initiated observational studies on the primary treatment in parametrium and/or lymph-node tumor-positive early-stage cases and on second-line surgical therapy of pelvic side wall recurrent tumors following radiotherapy. Promising results of our observational studies propose that prospective randomized trials are worth to be initiated to clarify the potential of this treatment modality in this poor prognosis cohort of patients.

Finite element analysis of Cu-water nanofluid flow and heat transfer in a dynamically bulging enclosure

PurposeThe main purpose of this study is to analyze the heat transfer phenomena in a dynamically bulging enclosure filled with Cu-water nanofluid. This study examines the convective heat transfer process induced by a bulging area considered a heat source, with the enclosure's side walls having a low temperature and top and bottom walls being treated as adiabatic. Various factors, such as the Rayleigh number (Ra), nanoparticle volume fraction, Darcy effects, Hartmann number (Ha) and effects of magnetic inclination, are analyzed for their impact on the flow behavior and temperature distribution.Design/methodology/approachThe finite element method (FEM) is employed for simulating variations in flow and temperature after validating the results. Solving the non-linear partial differential equations while incorporating the modified Darcy number (10−3 ≤ Da ≤ 10−1), Ra (103 ≤ Ra ≤ 105) and Ha (0 ≤ Ha ≤ 100) as the dimensionless operational parameters.FindingsThis study demonstrates that in enclosures with dynamically positioned bulges filled with Cu-water nanofluid, heat transfer is significantly influenced by the bulge location and nanoparticle volume fraction, which alter flow and heat patterns. The varying impact of magnetic fields on heat transfer depends on the Rayleigh and Has.Practical implicationsThe geometry configurations employed in this research have broad applications in various engineering disciplines, including heat exchangers, energy storage, biomedical systems and food processing.Originality/valueThis research provides insights into how different shapes of the heated bulging area impact the hydromagnetic convection of Cu-water nanofluid flow in a dynamically bulging-shaped porous system, encompassing curved surfaces and various multi-physical conditions.

Size scale effect on mass burning flux and flame behavior of solid fuels

The study investigates the horizontal fuel size effect on free-burning fires for PMMA plates and wood cribs. The fuel size effect on mass burning flux and flame behavior is mainly discussed and compared with typical pool fires. For the PMMA plate and liquid pool, when the fuel size is small (< 10 cm), either the 3D sidewall burning of PMMA or the container wall heated by flame can promote the burning flux at the horizontal projection area. As the fuel size increases, these side wall burning or heating effects decrease, causing the drop in burning flux with fuel scale for both the PMMA plate and liquid pool. For small-scale wood cribs, fire cannot self-sustain due to the large airflow cooling. With the increase in wood crib size, the burning rate first remains constant and then gradually increases, driven by the enhanced internal radiation. As the fuel size increases above 20–30 cm, the flame radiation dominates the burning flux for all fuel types. Fire dynamics simulator (FDS) was adopted to simulate the horizontal size effect by setting a varied fire source (horizontal projection) area. First, the flame geometry and heat release rate (HRR) of simulations were validated against experimental results. Subsequently, the validated fire model generates cases covering a broad range of fire scales. Finally, a new correlation of flame height with the fire heat release rate and fuel size is proposed, and its prediction capability is validated in the numerical fire modeling. This study quantifies the size effect on the burning rate for common solid fuels and provides valuable information for the numerical modeling of multi-scale fires.

Numerical investigation of free convection inside square wavy enclosure using response surface methodology

AbstractFree convection is commonly applied in various engineering fields such as solar energy, electronic devices, nuclear energy, and heat exchangers. A computational simulation was used to analyze the natural heat transfer through convection in a wavy cavity with squared shape that was filled with tap water and saturated metal foam to assess the influence of hump configuration (square, triangle, circular, down semicircular, and up semicircular) and magnetic fields (magnetohydrodynamics) on heat transfer rate. The bottom wavy wall of the enclosure exhibits a high temperature (Th), whereas the top and side walls maintain a low temperature (Tc). The present paper will examine how the bottom wall hump number (N), aspect ratio (L), geometry inclination angle (θ), Hartman number (Ha), magnetic field intensity inclination angle (ɤ) affects the heat transfer rate at various Rayleigh numbers. When the circular hump design is used with specific parameters, including ɛ = 0.85, L = 1.25, N = 4, Tc = 0°C, θ = 0°, Ha = 600 and ɤ = 45°, for different Ra values, it leads to increased heat transfer and notable improvements in heat transfer enhancement (ɸ) and energy enhancement (e). The enhancements were measured at 2.5 times for heat transfer enhancement and 8.9 times for energy enhancement. Moreover, the ideal case of the current study had Ha = 600, L = 1.25, Ra = 30 × 103, and θ = 0° compared to the baseline case. Simulations were accomplished using CFD. The results demonstrate that the primary goal of the research was achieved by optimizing the design, leading to a significant improvement in hydrothermal performance for both ɸ = 2.5 and e = 8.9.

Controlling convective heat transfer of shear thinning fluid in a triangular enclosure with different obstacle positions

The free convection of a non-Newtonian fluid in an equilateral triangular cavity containing a triangle obstruction in various positions is investigated numerically in this paper. The research is carried out using the finite element method. The sloped side walls are adiabatic, while the bottom is kept heated. At the obstacle, three positions are examined. The effects of different power law indexes on free convection have been investigated. The temperature field, fluid flow, and heat transfer are all highly influenced by the obstacle's location, Rayleigh number, and power law index. The resulting outcomes are confirmed using existing results in the literature and verified using a grid sensitivity analysis. A comparison of the current results to those found in the literature demonstrates the study's dependability and trustworthiness.

New Acoustic Design for the Piscina Mirabilis Located nearby the Port of Misenum

Many heritage buildings from ancient Rome are being refurbished based on their original plan’s structure. One of them is the piscina mirabilis located nearby in Naples, which was a cistern used by the Romans to collect drinkable water for the navy waiting in the port of Misenum. The piscina mirabilis has similar architectural characteristics to a “cathedral”; however, its current precarious architectural state is the result of high levels of humidity that have caused the proliferation of mold on its vertical and horizontal surfaces over the centuries. Acoustic measurements were conducted inside the piscina mirabilis, highlighting an existing condition of the room being very reverberant, not suitable for occasional speech and conversations. The design proposed by the authors involves some mitigation solutions for the acoustics, mainly focused on controlling the low–medium frequencies and the realization of a restoration project consisting of a raised timber-floored walkway that runs along the perimeter walls, with the addition of water covering the existing floor as a natural element dominating the room volume, which represents the primary function of the building in antiquity. A waterfall was designed to be on the northern side wall. Acoustic studies were an important part of the refurbishment strategy, and a mitigation solution was devised to control medium–low frequencies by using inflated balloons of different sizes that were suspended from the ceiling vaults instead of widely used acoustic panels. The proposed strategy lowered the reverberation time by 3–4 s to accommodate a minimal level of conversational understanding. Such a solution is appropriate for this heritage building as well as other future conservation projects.

The historical origins of earnings management: a geographical discontinuity design based on the Great Wall

PurposeDoes the history of the bureaucratic system, along with the establishment of the Great Wall during the Ming and Qing dynasties (1368–1911), affect firm behavior across the borderlands of the Great Wall?Design/methodology/approachThe Ming and Qing dynasties built a centralized administrative system in the borderlands on the south side of the Great Wall, in contrast to the “feudal lordship” system on the north side. Employing a regression discontinuity analysis framework with the Great Wall as a geographical discontinuity, we examine the long-run effects of the Great Wall on firms’ earnings management.FindingsUsing a large sample of nonlisted firms in the central core frontier region, we show that the earnings management of firms in the region south of the Great Wall is significantly curtailed compared with firms in the north of it, and this effect is more pronounced for non-SOEs. Our findings are robust to a battery of tests to account for alternative explanations.Practical implicationsOverall, by emphasizing the role of institutions, like legal system, shaped in history on firms’ earnings management, this study sheds new light on institutional determinants of firms’ behaviors in earnings information disclosure.Originality/valueFirst, we enrich our understanding of the institutional determinants of firms’ financial reporting outcomes. Second, our findings shed new light on the long-term effects of historical ruling styles on modern corporate behavior.

A pilot study of the proarrhythmic effects of pimobendan injection in clinically healthy cats.

Pimobendan is not currently approved for use in cats, although its usefulness in feline hypertrophic cardiomyopathy has been suggested. Reports indicate an increase in arrhythmic events following oral administration to healthy cats. Given the greater potency of intravenous administration compared to oral intake, it is conceivable that the incidence of arrhythmias may be increased following pimobendan injection. Therefore, this study aimed to investigate the proarrhythmic effects of pimobendan injection in cats. Five clinically healthy cats underwent physical examination, echocardiography, blood pressure measurements, and 24-hour Holter electrocardiography immediately before and after receiving pimobendan as an intravenous bolus dose of 0.15mg/kg twice daily for 3 days. Additionally, a 24-hour Holter electrocardiography recording was conducted on the third day of pimobendan or placebo IV administration to assess heart rate, arrhythmias, and heart rate variability. Following pimobendan administration, there was a significant increase in total 24-hour heart rate. Echocardiography revealed a significant increase in mitral valve annulus systolic velocity (S') on the ventricular septal wall side, indicative of enhanced contractility. Only one cat exhibited paroxysmal ventricular tachycardia and an increase in the frequency of arrhythmic events. Conversely, in the remaining cats, a decreasing trend in the number of arrhythmias was observed. These findings indicate that intravenous administration of pimobendan may not be implicated in the onset of arrhythmias. Nevertheless, further research is warranted to explore the effects of intravenous pimobendan administration in cats with myocardial disease.

Physicochemical, mechanical and thermal analysis of unfired clay bricks: Kaolinite-PEG 6000 composite

This study aims to evaluate the potential of polyethylene glycol (PEG 6000), a recycled material, as an additive to improve unfired clay bricks. By proposing a sustainable alternative to traditional methods potentially linked to medical waste. This research explores the physicochemical, mechanical and thermal properties of unfired clay bricks modified by different contents of PEG 6000 (0%, 1%, 3%, 7%, 15% and 20% by weight) according to the standard NM 13.1 0.0442005. The testing methods comply with recognized building sector standards (Belgian NBN EN 771-3+A1 and American ASTM C675-17). The clay used was extracted from Berrechid city and it is identified as kaolinite and some trace of illite, which has non-swelling properties. The incorporation of PEG 6000 into the unfired clay bricks has notably reduced the porosity rate from 3.91 % to 1.21 %, an improvement of 69 % compared to the reference sample, leading to a decrease in the rate of capillary water absorption. The bulk density of the bricks has slightly decreased to 1670.07 kg/m3, which still allowed them to be classified as light bricks. The incorporation of 7% of PEG 6000 increased compressive strength and flexural strength up to 15.98 MPa and 0.959 KN respectively, an improvement of 63.23 % compared to the reference sample, making them suitable for the construction of interior and exterior walls according to the standard NBN EN 771-3+A1. However, thermal conductivity and specific heat capacity have been improved by 42.22 % compared to the reference sample, reaching 0.26 W/m.K and 0.89 kJ/kg.K respectively. Optimization showed that 7% of PEG 6000 is the optimal percentage for manufacturing high-performance bricks, taking into account all properties studied previously. Moreover, the simulations carried out by the TRANSYS software suggest significant energy gains in terms of insulation, achieving up to 58.33% energy savings. In essence, this research demonstrates the potential of PEG 6000 as a sustainable additive for unfired clay bricks, offering improved properties and promising energy efficiency benefits.

Experimental Broad-Based Curved Sidewall Aneurysms in Rabbits Mimicking Human Carotid Siphon Aneurysms: Proof of Feasibility and Comparability Using Computational Fluid Dynamics

Broad-based sidewall aneurysms of the carotidartery are primarily treated endovascularly. However,recurrence or rupture after treatment still poses a significant risk. Hence, reliable animal models mimicking this aneurysm type are essential for to evaluate the performanceof new advanced endovascular devices. Experimental aneurysms were created in 12 New Zealand white rabbits (2.5-3.5 kg). The human carotid siphon was mimicked with an end-to-end anastomosis of both common carotid arteries. A venous pouch was sutured on the convexity to mimic a broad-based side wall aneurysm. Patency and configuration were investigated 4 weeks postoperatively by 3-T magnetic resonance angiography. To compare flow conditions of broad-based sidewall aneurysms in rabbits and humans, exemplary computational fluid dynamics simulations were performed using species-specific blood viscosity values. We were able to achieve 0% peri- or postoperative mortality. Patency was confirmed by 3-T magnetic resonance angiography in 11 of 12 aneurysms (91.7%). Aneurysm lengths ranged from 6.4 to 9.8 mm and aneurysm necks from 7.3 to 9.8 mm. Computational fluid dynamics showed simple flow profiles with one vortex in rabbit as well as in human aneurysms. Wall shear stress rates were comparable using species-specific blood viscosity values (rabbit mean 1.65 Pa vs. human mean 1.7 Pa). The broad-based curved sidewall aneurysm model mimicking the carotid siphon showed high aneurysm patency rates with low morbidity. High comparability with human flow patterns and human intranaeurysmal biomechanical forces was shown using simulations.

Particle motion characteristics of vertical pipe on a the horizontal-vertical pneumatic conveying system installed dune models in the different curvature elbows

To minimize energy consumption in transportation, a dune model is developed and installed in elbow with varying radii of curvature in the horizontal-vertical pneumatic conveying system in this study. The experimental study focuses on the effect of dune model in elbow with different radius of curvature on the pneumatic conveying system in terms of pressure drop, additional pressure drop coefficient, and the power loss coefficient. Furthermore, the particle concentration and velocity distribution are measures by using the electrical capacitance tomography (ECT) and the high-speed particle image velocimetry (PIV) technology. Finally, the particle pulsation velocity is analyzed to reveal the particle motion mechanism of vertical pipe with dune model by using the fourier transform and wavelet transform. The results indicate that the minimum gas conveying velocity is reduced by installing the dune model, with a maximum reduction rate of 10.36 %, and the maximum reduction rate of power loss coefficient decreased is 11.56 %. At the same time, the particle concentration near the outside and inside wall of the pipe with dune is lower and higher than of without dune, and the particle axial velocities with dune are larger than the case of no dune, and the particle axial pulsation intensity with dune are larger than the case of no dune. Otherwise, the peak value of power spectrum of with dune is lower than that of no dune model in the low frequency region, and the wavelet fluctuation energy of low frequency has a great influence on the axial velocity of particles near the inside wall of pipe for the case of dune model.

The Riblet Short-Slot Coupler Using Substrate Integrated Waveguide (SIW) for High-frequency Applications

Substrate Integrated Waveguide (SIW) involves the conductive via holes immersed in a dielectric substrate that connects two substrate plates. This article presents a new SIW technique to enhance the operational bandwidth of the Riblet Short-Slot coupler. To demonstrate the proposed SIW technique, two Riblet Short-Slot couplers are designed and investigated at two different high-frequency ranges, Ku-band and K-band. The bandwidth of the proposed couplers is improved by introducing multiple layers of SIW vias at the center of the couplers’ side wall. Applying this approach minimizes the leakage loss between vias, indicating an improved overall operating bandwidth of 36.31% and 26.32% for Ku-band and K-band, respectively. All vias in both prototypes are realized using an alternative method, without using the Plated-Through-Hole Printed-Circuit-Board (PTH-PCB) machine. In addition, experimental results agree well with the simulated results.

Investigation on thermochemical heat charging and discharging behavior of Ca(OH)2/CaO in a fixed bed reactor

Thermochemical heat storage (TCHS) technology plays a crucial role in the energy system, essential for maintaining the balance between energy supply and demand. The Ca(OH)2/CaO system holds significant promise for TCHS thanks to its high energy storage density, cost-effectiveness, and minimal heat loss. However, further research is required to elucidate the coupling mechanisms of the various physicochemical processes involved and to optimize the overall system performance. This paper focuses on assessing and elucidating the multi-physics coupled transport rules during both the charging and discharging stages in a fixed-bed reactor based on the developed numerical model. Results manifest the bed temperature rapidly increases to around 950 K, then slows down as the endothermic reaction predominates, completing dehydration in 1,900 s. During discharging, hydration conversion advances in a “U”-shaped pattern from the vapor inlet and side wall to the outlet, driven by the high vapor content near the inlet and the lower temperature near the wall. Furthermore, a thorough sensitivity analysis of the main parameters such as thermal conductivity and porosity is conducted to determine how different operating conditions affect the charging and discharging processes. Finally, a new reactor structure is proposed, in which a gas-guide duct is added at the central axis of the reactor to improve mass transport and uniformly distributed finned heating tube bundles to enhance heat transfer. These two functions can shorten the charging period by 9 % and 16 % respectively. The results can aid in predicting thermochemical conversion behaviors and multi-physic coupling transport processes, while also providing a foundational reference for the design of TCHS systems.

Optimal classification of radiant time series for cooling load calculation of building air-conditioning systems

Building cooling load is caused by complex thermal effect. Design cooling load determines the capacity of air-conditioning assembly units and systems to maintain stable thermal environment and high operating efficiency. The radiant time series method (RTSM) is applicable for design cooling load calculation in engineering application. The radiant time series (RTS) should precisely match various room types by improving their accuracy and practicality. The room construction types require more explicit identification. This study proposes RTS classification method based on heat balance method (HBM) and CatBoost to obtain the representative RTSs for various room types. A new quantitative indicator, interior surface heat storage coefficient, is introduced to quantify the construction type. An accuracy evaluation is performed on the representative RTSs and design cooling loads calculated using them. The results show that interior wall type, ceiling type and floor type are important parameters for RTS classification. Compared to the HBM, the representative RTSs cause relative deviations of design cooling loads within 5 % for over 90 % of the room samples, with mean deviations within 2 %. This has demonstrated accurate RTS classification in this study. The appropriate representative RTSs with refined construction type can ensure accurate cooling load calculation and facilitate extensive application.

Highly-sensitive ultrathin flexible pressure sensor based on quasi-2D conductive network for human physiological signal monitoring

Ultrathin flexible pressure sensors are highly desirable for human physiological signal monitoring due to their portability and ability to conform to the body. However, existing ultrathin pressure sensors face challenges in balancing the sensitivity and their range. A spatial-dimensionally constrained strategy was proposed to construct an ultrathin active layer. In detail, multi-walled carbon nanotubes (MWCNTs) with an average length of ∼1.3 μm were intentionally spin-coated into a thin thermoplastic polyurethane (TPU) film with a thickness of 1.5 μm. By doing so, a quasi-2D MWCNTs conductive network is constructed, which enabled the sensor to have ultrahigh sensitivity of 27.04 kPa−1, a wide liner detection range of 0.2–24 kPa, ultrafast response time of 40 ms and a recovery time of 10 ms, and high durability in 1500 cycles under 0.2 kPa with loading/unloading frequency of 2 Hz. Thanks to this superior performance, the ultrathin pressure sensor can be used to monitor human movement and physiological signals, including finger touch, finger bending, wrist bending, and deep breathing. Moreover, the sensor can be attached to the side wall of the tip of the renal ureteroscope, allowing for the monitoring of renal pelvic pressure. Therefore, this spatial-dimensionally constrained strategy will open up a new way to fabricate highly sensitive ultrathin pressure sensors and have great application prospects in health monitoring.

Dual polarization for efficient III-nitride-based deep ultraviolet micro-LEDs

The deep ultraviolet (DUV) micro-light emitting diode (μLED) has serious electron leakage and low hole injection efficiency. Meanwhile, with the decrease in the size of the LED chip, the plasma-assisted dry etching process will cause damage to the side wall of the mesa, which will form a carrier leakage channel and produce non-radiative recombination. All of these will reduce the photoelectric performance of μLED. To this end, this study introduces polarized bulk charges into the hole supply layer (p-HSL) and the electron supply layer (n-ESL) respectively (dual-polarized structure) of the DUV μLED at an emission wavelength of 279 nm to enhance the binding of carriers and increase the injection efficiency of carriers. This is because the polarization-induced bulk charge can shield the polarized sheet charge on the interface and reduce the polarization electric field. The reduced polarization electric field in p-HSL can increase the effective barrier height of the conduction band in the p-type region and reduce the effective barrier height of the valence band. The decrease in the polarized electric field of n-HSL can reduce the thermal velocity of electrons, thereby enhancing the electron injection efficiency, reducing the Shockley–Read–Hall (SRH) recombination, and increasing the effective barrier height of the valence band. The study results indicate that the electron concentration and hole concentration of a μLED with dual polarization were increased by 77.93% and 93.6%, respectively. The optical power and maximum external quantum efficiency of μLED reached 31.04 W/cm2 and 2.91% respectively, and the efficiency droop is only 2.06% at 120 A/cm2. These results provide a new approach to solving the problem of insufficient carrier injection and SRH recombination in high-performance DUV μLEDs.

Two-dimensional spanwise flow regime influenced by tip vortex around a ground-mounted square cylinder in low turbulence uniform flow

The time series data of the lift force acting on a ground-mounted square cylinder in low-turbulence uniform flow reveal a distinctive pattern characterized by a predominant high-amplitude process modulated by intermittent low-amplitude fluctuations. This behavior arises from the intricate interplay between tip and Kármán vortices. However, conflicting interpretations persist, with some findings even presenting contradictory conclusions, particularly regarding the presence of symmetric shedding in the fluctuating lift force process with low amplitude. Furthermore, a clear consensus regarding the mechanism governing the interaction between the tip vortex and the spanwise vortex remains elusive. This study aims to elucidate the two-dimensional flow regime in the spanwise direction influenced by the tip vortex of a ground-mounted square cylinder in low-turbulence uniform flow through experimental investigation. Multiple-point synchronous pressure measurement and particle image velocimetry systems are utilized to measure wind pressure on the side walls and the corresponding flow field at 2/3 of the cylinder's height. The analysis confirms the presence of two distinct types of lift force coefficient behavior: low-amplitude fluctuation (LAF) characterized by longer durations and high-amplitude fluctuation (HAF) occurring in shorter intervals. Subsequently, the flow regime in the near wake corresponding to each mode of the lift force coefficient is discussed. It is observed that the LAF regime corresponds to symmetrical vortex shedding with a prolonged shear layer, maintaining nearly constant curvature. Conversely, for HAF, a pronounced Kármán vortex street is evident. This study conclusively demonstrates the existence of symmetrical vortex shedding, which predominantly contributes to the LAF component of the lift force.

Kritik Arsitektur terhadap Aspek Inklusif Aksesibilitas Hubungan Horizontal Antar Ruang atau Antar Bangunan Studi Kasus: Selasar RSP (Rumah Sakit Paru) Dr. H. A. Rotinsulu Bandung

Hallway of the Lung Hospital DR. H. A. Rotinsulu is one of the facilities that functions as the accessibility of relationships between spaces or between buildings. Tues as referred to in the Lung Hospital DR. H. A. Rotinsulu is a means of connecting circulation pathways between rooms or between buildings outside a building that is not limited by walls or limited by at most 1 (one) side wall. The object of Architectural Criticism is the hall of Dr. Lung Hospital. H.A Rotinsulu Bandung. Architectural criticism is carried out in the form of observations and measurements in the field on several walkway segments, based on the steepness of the contours that have been measured influenced by the long span of each walkway segment, which has been divided into observations according to the existing conditions of the walkways of Dr. Lung Hospital. H. A Rotinsulu Bandung, then a study was carried out in the form of an evaluation of the existing conditions of the walkway according to Ministerial Regulation PUPR No. 14 of 2017 concerning Requirements for Building Facilities and Law no. 8 of 2016 concerning Persons with Disabilities. The aspects studied are: 1. Needs for space for movement of users, 2. Circulation, 3. Guiding paths 4. Placement of gathering points, 5. Waiting area or right of way in transit to the hall rest. The basic dimensions of space and related facilities according to the object of observation refer to the Universal Design principle or the principle of inclusive design so that each user can move easily, safely, comfortably and independently.

The DUNE Far Detector Vertical Drift Technology. Technical Design Report

DUNE is an international experiment dedicated to addressing some of the questions at the forefront of particle physics and astrophysics, including themystifying preponderance of matter over antimatter in the early universe. The dual-site experiment will employ an intense neutrino beam focused on a near and a far detector as it aims to determine the neutrino mass hierarchy and to make high-precision measurements of the PMNS matrix parameters, including the CP-violating phase. It will also stand ready to observe supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model.The DUNE far detector implements liquid argon time-projection chamber (LArTPC) technology, and combines the many tens-of-kiloton fiducial mass necessary for rare event searches with the sub-centimeter spatial resolutionrequired to image those events with high precision. The addition of a photon detection system enhances physics capabilities for all DUNE physics drivers and opens prospects for further physics explorations. Given its size, the far detector will be implemented as a set of modules, with LArTPC designs that differ from one another as newer technologies arise.In the vertical drift LArTPC design, a horizontal cathode bisects the detector, creating two stacked drift volumes in which ionization charges drift towards anodes at either the top or bottom. The anodes are composed of perforated PCB layers with conductive strips, enabling reconstruction in 3D.Light-trap-style photon detection modules are placed both on the cryostat's side walls and on the central cathode where they are optically powered.This Technical Design Report describes in detail the technical implementations of each subsystem of this LArTPC that, together with the other far detector modules and the near detector, will enable DUNE to achieve its physics goals.

A prospective study examining the value of three-dimensional transvaginal ultrasonography during the diagnosis and evaluation of Asherman syndrome

Research questionWhat is the value of three-dimensional (3D) transvaginal ultrasonography (TVS) in the diagnosis and assessment of Asherman syndrome? DesignThis was a prospective study conducted at a hysteroscopy centre. ResultsA total of 685 participants were recruited, 65 dropped out and 620 were finally enrolled and analysed. The overall sensitivity, specificity and accuracy of 3D-TVS in the diagnosis of Asherman syndrome were 95.7%, 80.7% and 93.5%, respectively, and the sensitivity and accuracy were significantly higher than those of two-dimensional (2D) TVS (P < 0.001). The likelihood of 2D-TVS missing a case of mild intrauterine adhesions (IUA) was 43.7%, compared with only 6.2% for 3D-TVS. The frequency of involvement of each anatomical area by adhesions in decreasing order was right and left uterine side walls (both 80%), central or mid-cavity (31%), right cornual region (26%), left cornual region (23%), fundal wall (15%) and isthmus (4.5%). The correlation between 3D-TVS and hysteroscopy in each of the seven anatomical areas was analysed separately. The results showed good agreement with regard to the three uterine walls (fundus, left lateral and right lateral), with kappa values of 0.678–0.811. The likelihood of the IUA being severe in nature when there were five or more areas, three or four areas, or one or two areas was 82%, 37.1% and 6.3%, respectively (P < 0.001). ConclusionsThe diagnostic value of 3D-TVS is higher than that of 2D-TVS. In clinical practice, 3D-TVS should whenever possible replace 2D-TVS as the initial method of assessment to decide if hysteroscopy is necessary and to help with planning surgery.