The article considers the directions of intensification of the processes of clustering in the regions of Ukraine. Based on the analysis of the experience of clustering is proposed zoning, taking into account the collisions of national business and industry, as well as regulatory policy. The subject of the study is innovative clusters and their role in the sustainable development of regions. The purpose of the study: to develop practical recommendations to ensure and stimulate the processes of clustering in the context of InDev regions of Ukraine. Methodology. For this purpose the following tasks were solved step by step: the peculiarities of InDev region in the economic and social progress of territories in the context of clustering processes were determined; the strategic prospects for the formation of InDev system of Ukrainian regions and the directions of intensification of clustering processes were substantiated; the key problems of innovation clusters development in Ukraine were systematized taking into account international experience of their creation; the management basis for the formation of innovation cluster models was developed; normative legal acts for information support and proper organizational and economic support of the process of innovation clusters formation were elaborated; methodological support for the processes of diagnostics of innovation clustering in the InDev system of the region was improved. Theoretical (analysis, systematization and generalization of scientific results; process modeling) and statistical (express-analysis) methods were used. Conclusions. Recommendations on the diagnosis of processes of innovation development of regions and processes of innovation clustering on the basis of express-diagnostics procedure, which is based on the assessment of parameters of innovation clustering. According to the results of innovation clustering regions of Ukraine for the first cluster recommended principles of management support processes clustering: the development and implementation of a policy of active integration with Europe, a free economic zone with the EU and other countries of the world; investments in innovation infrastructure; stimulation of venture financing; creation of business gas pedals and platforms of innovative design; organization of technoparks, involving foreign investments, grant projects, budget financing. The second cluster is recommended: involvement of scientific institutions in the processes of active learning business incubators and business gas pedals, adaptation and dissemination of benchmarking technology for innovation clustering. The third cluster is recommended: implementation of industry-specific target projects by InDev, creation of innovation infrastructure facilities based on clustering processes, implementation of regional programs to support business and individual industries, formation of new industry projects to develop production (new production facilities, logistics centers, etc.).