Fracture research of natural gas pipelines with cracks is an important part of pipeline integrity evaluation. Based on the cohesive zone model (CZM), a numerical analysis is conducted of the dynamic fracture of X80 steel pipelines under explosion load. The factors considered include the crack propagation length, crack propagation velocity, dynamic crack tip opening angle (CTOA) and gas pressure. The results show that the whole cracking process can be divided into three stages: rapid cracking, stable propagation, and deceleration and stop cracking. When in the rapid cracking stage, the axial cracking of the pipeline is dominant. However, in the stable propagation stage, lateral expansion plays a more significant role. Besides, there exist upper limits on the length and velocity of crack propagation. In addition, it is also found that the time for the inflection point of rapid cracking and stable propagation is later than that to reach the velocity peak. The dynamic CTOA decreases with axial crack propagation, and the steady-state value of the CTOA is positively correlated with the load. The high-pressure gas escapes from the pipeline along the crack, resulting in the increase of air pressure outside the pipeline. Moreover, the peak pressure outside the pipeline is approximately linear its the initial crack length. The present research on the dynamic fracture mechanics behavior of the pipeline provides a necessary supplement for the test.