Laser deposition manufacturing (LDM) has drawn unprecedented attention for its advantages in manufacturing large-scale and complex metal components. During the process of LDM, a large thermal gradient is generated due to thermal cycling and heat accumulation. As a result, large residual stress and deformation are formed in the LDM metal components. Then, the dimensional accuracy of the metal components becomes poor. To achieve deformation control and increase dimensional accuracy, the deformation prediction of metal components is very meaningful and directional. However, the traditional thermoelastic–plastic method can only achieve deformation prediction for small-scale LDM metal components. Because of the low computational efficiency, it is extremely difficult to meet deformation prediction demand for large-scale metal components. Based on feature partitioning and the inherent strain method, a rapid deformation prediction method is proposed for large-scale metal components in this manuscript. Firstly, to solve the problem of poor consistency of formation quality due to the randomness of the partition process, the partitioning process was established according to typical geometric features. Secondly, the inherent strain values for different partitions were obtained by considering the effects of the extraction method, mesh size, equivalent value layer, and partition size on the inherent strain values. Then, using the inherent strain method, the deformation of large-scale components was predicted rapidly. Comparing the simulation results with the experimental results, the following conclusions were obtained. The deformation predicted by the method proposed in this manuscript is consistent with the deformations predicted using the traditional thermoelastic–plastic method and the experimental method. Significantly, applying the method proposed in this manuscript to predict the deformation of LDM metal components, computational efficiency is improved by 27.25 times compared with results using the conventional thermoelastic–plastic method.