Infrared Laser Therapy Research Articles

Advances of Oxidative Stress Impact in Periodontitis: Biomarkers and Effective Targeting Options.

Periodontitis is the most common inflammatory oral disease that affects around 15% of adults and contributes to severe periodontal tissue destruction with subsequent tooth loosening and loss. Among the main pathogenic mechanisms underlying periodontitis, excessive reactive oxygen species production and oxidative stress play a predominant role in inducing both local and systemic damage. Current therapeutic approaches have expanded the conventional methods combined with herbal antioxidant compounds to free radical-scavenging nanomaterials and infrared laser therapy, offering promising pre-clinical evidence in periodontitis management. Herein, we review the pathogenic mechanisms of reactive oxygen species tissue damage, along with recent advances in oxidative stress biomarkers and novel targeting options.

Photobiomodulation therapy on puncture-associated pain: A controlled randomized double-blind clinical trial.

Dental fear and phobia are prevalent worldwide, with local anesthesia being the most feared procedure. This study aimed to determine whether photobiomodulation therapy (PBMT), used as a pre-anesthetic, could modulate puncture pain and enhance the effectiveness of local anesthesia. In this controlled, randomized, double-blind study, 49 participants were divided into an experimental group (n = 24), which received infrared laser therapy (100 mW, at 808 nm, 8 J, 80 s at a single point) immediately before standard anesthesia; and control group (n = 25), which received the standard anesthetic technique and sham laser. Pain levels were measured using the visual analog scale, and anesthetic efficacy was assessed through electrical tests (latency), percentage of failures, and cartridge usage. Anxiety levels were evaluated using the Beck Anxiety Inventory. Cardiovascular parameters were evaluated through blood pressure, oxygen levels, and heart rate. This randomized, double-blind study found no difference between groups in these experimental conditions. The bias toward a positive PBMT result was sufficiently removed. Autonomic responses of the PBMT group were maintained stable during the procedure.

Effect of Visible and Infrared Photobiomodulation on Diabetic Foot Ulcers.

Introduction: Diabetes is a highly prevalent disease worldwide. Despite routine treatments, there is no effective treatment approach for patients with diabetic foot ulcers (DFUs). A new approach to reduce complications and control DFU is low-level laser therapy (LLLT). In the present study, we evaluated the therapeutic effects of LLLT on the symptoms of DFU patients. Methods: Sixty diabetic patients with DFU were included in this randomized clinical trial and were randomly allocated into two groups of laser (n=30) and control (n=30) with signed written consent. The LLLT group underwent visible and infra-red laser therapy and conventional medical treatment, while the control group received only conventional medical treatment. The total laser irradiation sessions of the patients were 20 sessions, (three sessions a week) and each session lasted for 30 minutes over the entire surface of the wound. The power density per session for each laser was calculated to be 35.65 mW/cm2 with an energy density of 64.17 J/cm2. Results: The mean area of ulcers in the LLLT group reduced significantly (P<0.001) from 441.7±365.5 mm2 before LLLT to 163.9±213.9 mm2 from the baseline up to the last session of LLLT, indicating a 62.99% reduction in mean ulcer area. In the control group, the mean ulcer area did not change significantly. Wagner's classification of the patients in the LLLT group reduced to lower grades significantly (P<0.01), while the classification moved towards higher grades in the control group (P<0.08). Conclusion: In this study, we showed the effectiveness of LLLT in the reduction of the surface and depth of DFUs. The results documented that patients experienced significant improvements in the healing of their foot ulcers after laser therapy. It is recommended that the LLLT be considered as a non-invasive method for the treatment of DFU patients.

The effect of combined physiotherapy on humoral immunity, cytokine profile and inflammatory reactions in patients with rhinosinusitis polyposa

In patients with rhinosinusitis polyposa, activation of type 2 eosinophilic inflammation with an increase in serum concentrations of interleukins 4, 5, and 13 and immunoglobulins A, M, G, and E is noted. At the same time, the relationship between these indicators and the quality of life of the patient is sharply intensified, which indicates the appearance of pathological correlation pleiades. The drug Dupilumab has a normalizing effect on the inflammatory component of the disease and optimizes the cytokine regulation of humoral immunity. The additional use of an alternating magnetic field somewhat enhances these effects, whereas the maximum therapeutic effect was provided by the use of the drug, an alternating magnetic field, and low‑intensity infrared laser therapy.

Infrared laser therapy decreases systemic oxidative stress and inflammation in hypercholesterolemic mice with periodontitis

BackgroundNear-infrared irradiation photobiomodulation (NIR-PBM) has been successfully used in periodontal treatment as an adjuvant tool to locally improve cell function and regeneration. Although the relationship between periodontitis and systemic disease constitutes an important aspect of periodontal clinical research, the systemic effects of NIR-PBM in periodontitis are not well known. In this study, we aimed to investigate the effects of NIR-PBM on systemic oxidative stress and inflammation in an apolipoprotein E (ApoE) knockout mouse model of periodontal disease (PD).MethodsWe evaluated alveolar bone loss by measuring the distance from the cementoenamel junction (CEJ) to the alveolar bone crest (ABC), reactive oxygen species (ROS) production in blood cells, inflammatory activity, plasma cholesterol levels, and lipid peroxidation levels in three experimental groups: (1) ApoEC, control group without intervention; (2) ApoEP, first molar ligation-induced periodontitis for 4 weeks; and (3) ApoEP + PBM, exposed to 808 nm continuous wave, ø ~ 3 mm2, 100 mW, 60 s of NIR-PBM for 7 consecutive days after 4 weeks of periodontitis. At the end of the experimental protocols, ApoEP mice presented significantly increased alveolar bone loss, ROS production, inflammatory activity, plasma cholesterol, and lipid peroxidation levels compared to the ApoEC group (P < 0.05). NIR-PBM for 7 days in the ApoEP + PBM mice significantly decreased systemic ROS production, inflammatory response, plasma cholesterol, and lipid peroxidation levels, similar to those found in the ApoEC group (P > 0.05). However, it was not capable of preventing alveolar bone loss (P > 0.05 compared to ApoEP mice).ConclusionA 7-day treatment with NIR-PBM effectively reduces systemic oxidative stress and inflammatory parameters in hypercholesterolemic mice with PD. However, more studies with longer evaluation times are needed to confirm the systemic effects of locally applied NIR-PBM on PD associated with hypercholesterolemia.

Autophagy response to the use of a comprehensive health program

Background. Much attention has recently been paid to the molecular mechanisms of healing. Autophagy is one of the important intracellular mechanisms responsible for cell purity and sanogenesis. Evaluation of the complex impact of factors included in health programs on autophagy activity is of scientific and practical interest. Aim: to characterize the autophagy response in patients of different weight, sex, and age under the influence of a complex of health-improving factors. Material and methods. The study involved 77 patients aged 18 years and older who underwent a health course for 19–21 days. The complex of recreational activities included: diet therapy (calorie restriction by 40–50 %), physiotherapy exercises, manual and hardware massage, mud therapy, magnetic infrared laser and bioresonance therapy, and infrared sauna. The patients underwent a general clinical examination, clinical and biochemical blood tests (a complete blood count, total cholesterol, fractions of LDL, HDL, triglycerides); the content of total fat was determined by the impedance method on the device. To assess the basic and induced autophagy, the generally accepted indicator of the Beclin 1 protein concentration, which was determined by ELISA, was used. Blood draw was carried out in the morning under fasting condition on the 2nd and 12th days after arrival. Statistical data processing was carried out using the SPSS STATISTICS program (26.0). To compare the mean values, the parametric Student’s t-test and non-parametric Mann-Whitney U test were used; the correlation analysis was carried out according to Pearson. Relationships and differences were considered significant at p&lt;0.05. Results. It was found that in the initial state, the basic activity of autophagy in individuals with a BMI less than 30 kg/m2, as well as in men and patients over 60 years of age, is significantly reduced. The response to recreational activities was characterized by autophagy activation in the entire group, especially in patients over 60 years of age in individuals with a BMI over 30 kg/m2 compared with baseline; it was more pronounced in men than in women. The amount of fat mass lost did not correlate with the activity of induced autophagy, but the latter positively correlated with HDL and negatively correlated with TC and LDL. The noted positive clinical effects from the use of a health-improving program make it possible to attribute the variant of the autophagy reaction to reparative autophagy. Conclusion. A complex of recreational activities, including diet therapy, physiotherapy exercises, manual and hardware massage, mud therapy, magnetic infrared laser therapy, bioresonance therapy, and a phyto-barrel is a physiological activator of reparative autophagy. In order to prescribe personalized programs, it is necessary to take into account such available indicators as gender, age, weight, and obesity.

Effects of Red and Infrared Laser Therapy in Patients with Tinnitus: A Double-Blind, Clinical, Randomized Controlled Study Combining Light with Ultrasound, Drugs and Vacuum Therapy.

tinnitus is a symptom with no specific cause known to date, and there are no associated pharmacogenomics of hearing disorders and no FDA-approved drugs for tinnitus treatment. The effectiveness of drug treatments is not reproducible on idiopathic patients and inexistent in refractory patients. Personalized treatments for these patients are a great clinical need. Our study investigated the outcome of potential alternative and complementary treatment modalities for idiopathic and refractory tinnitus patients. we were the first to evaluate the tinnitus handicap inventory (THI) score changes over the course of treatment up to 15 days after complete cessation of treatment for novel transmeatal low-level laser therapy (LLLT) modalities using light alone, as well as LLLT combined with vacuum therapy (VT), ultrasound (US), Ginkgo biloba (GB) and flunarizine dihydrochloride (FD), while also comparing all treatment outcomes with laser puncture (LP), FD alone and GB alone. a positive treatment outcome (superior to a placebo effect) was achieved by using either LP or transmeatal LLLT, whereas short-term antagonistic effects of VT, US, GB and FD when combined with LLLT. For transmeatal LLLT, an improvement in the treatment outcome was observed by increasing the irradiation time from 6 min to 15 min (with 100-mW of applied laser power at 660 nm). Finally, a lasting therapeutic effect higher than the placebo was observed at 15 days after treatment upon combining LLLT with VT, GB or by using FD alone, by using the transmeatal LLLT alone or by using LP. LP and Transmeatal LLLT can be promising alternative treatments for idiopathic and refractory tinnitus patients. Future studies should investigate the long-term effects of LLLT in tinnitus patients, as well as the dosimetry and wavelength of transmeatal LLLT.

Dynamics of the lipoperoxidation process in the oral fluid of patients with chronic generalized periodontitis with the complex application of laser therapy and interval hypoxic training

The performed research is devoted to the study of lipid peroxidation processes in patients with chronic generalized periodontitis under the conditions of the course application of infrared laser therapy and normobaric interval hypoxic training. The results of the study allow us to conclude that the development of inflammatory destructive processes in periodontal tissues closely correlates with manifestations of oxidative stress, which develops as a result of an imbalance in the pro-oxidants-antioxidants system. Supplementing the standard therapy of chronic generalized periodontitis with the course use of physiotherapeutic factors in the mono-influence mode is accompanied by an increase in the potential of the antioxidant protection of the oral cavity. The complex use of physiofactors contributes to an increase in the activity of the antioxidant system, realized through the mechanisms of functional potentiation. The close relationship revealed between lipid peroxidation products and index characteristics of dental status, reflecting the pathogenetic role of pro-oxidant factors in the development of chronic generalized periodontitis, allows us to consider biomarkers of peroxide metabolism and the antioxidant protection coefficient as criteria for the effectiveness of the treatment.

Correction of Mitochondrial Dysfunction in the Complex Rehabilitation of COVID-19 Patients.

Objective. To study the efficacy of courses of i.v., Cytoflavin in combination with the standard rehabilitation program for postcovid syndrome for correction of postcovid asthenia. Materials and methods. Follow-up investigations were carried out in 45 patients with postcovid syndrome at the second stage of rehabilitation. Patients were divided into two groups of comparable sex and age. The volume of lung damage was also similar in both groups, at 25–80%. The 24 patients making up the comparison group received standard postcovid rehabilitation: pulsed magnetotherapy, inhalation therapy, aeroionotherapy, infrared laser therapy, courses of aerobic training, rational psychotherapy, and successive drug therapy. The 21 patients of the study group additionally received intravenous Cytoflavin daily for 10 days. The dynamics of increases in scores on the Rehabilitation Routing Scale, the Hamilton Depression Rating Scale (HDRS), the Asthenic Status Scale, and the 6-minute walk test at admission and discharge were also monitored. Results and conclusions. Addition of courses of intravenous Cytoflavin to the complex rehabilitation program for postcovid syndrome significantly improved the general functional state of the body, decreased levels of depression and asthenization, and increased physical exercise tolerance.

Dynamics of the quality of life of patients with periimplantitis with complex use of laserotherapy and low-frequency electrostatic field

The article is devoted to the study of the dynamics of the quality of life of patients with peri-implantitis in the course of combined use of a low-frequency electrostatic field and low-intensity infrared laser therapy. It has been shown that in the initial state, the quality of life of patients with peri-implantitis is significantly reduced in comparison with the group of healthy individuals. The high sensitivity of the «Chewing food» domain in relation to disease progression was established, which allows considering this domain as the effectiveness of the treatment provided. The course combined use of an infrared laser and a low-frequency electrostatic field in the treatment of post-prosthetic inflammatory complications during dental implantation, along with high clinical efficacy, has a maximum corrective effect on the quality of life of patients. Additional evidence of the obtained data, objectifying the subjective opinion of patients in relation to their quality of life, is the results of correlation adaptometry. This technique, based on the parameters of the correlation matrix, makes it possible to distinguish a state of stable homeostatic equilibrium, in which changes in regressor factors (clinical-functional, biochemical, psychological, and other variables) are not reflected at the level of the resulting trait, the function of which was performed by the quality of life. The use of correlation adaptometry confirmed the high efficiency of combined physiotherapy in relation to the quality of life of patients with peri-implantitis, which indicates the formation of a high level of functional reserves and adaptive abilities of the body.

Experience in the Use of Physical Factors in the Rehabilitation of Patients after Pneumonia Associated with COVID-19

To date, a new coronavirus disease caused by the SARS-CoV-2 virus (also known as COVID-19) has become a serious public health problem worldwide. Unfortunately, there are no specific drugs for the treatment of this infection until now. It is known that COVID-19 is caused by the SARS-CoV-2 betacoronavirus, which mainly affects the cells of the respiratory and digestive systems. There are scientific data on the effectiveness of a number of physiotherapy methods for a new coronavirus infection, which justifies their inclusion in the complex rehabilitation within the in-patient stage. Aim. This work aimed at the scientific justification of the physical factors use in the rehabilitation programs of patients after pneumonia associated with COVID-19. Material and methods. 60 patients (40 women and 20 men) who had suffered from COVID-19 pneumonia were examined. The time from the onset of the disease was on average 2 months. The study involved patients with mild and moderate pneumonia. The patients were randomly divided into 2 groups. The first group (30 patients) received low-intensity magnetic therapy for the chest area, infrared laser therapy for the lung roots, chest massage, therapeutic gymnastics and a course of hyperbaric oxygenation. The second group (30 patients) received high-intensity magnetic stimulation of the respiratory muscles, infrared laser therapy on the lung roots, chest massage, therapeutic gymnastics and a course of hyperbaric oxygenation. Results. As a result of the conducted rehabilitation programs, there was an improvement in the well-being of patients in both groups.There was a decrease in shortness of breath, an increase in physical activity, a decrease and disappearance of pain in the chest area. This was confirmed by a significant reliable dynamics of the 6-minute walk test and the laser Doppler flowmetry parameters and spirometry. Positive dynamics in the C — reactive protein parameter and a tendency to improve the D –dimer parameter were revealed. The changes in the studied parameters were more significant in patients of the second group. Conclusion. Thus, analyzing the results obtained, it can be argued that the developed comprehensive treatment programs for patients who have suffered pneumonia associated with COVID-19 lead to clinical improvement in this category of patients. However, more significant changes in the studied parameters were noted in the group of patients that received a comprehensive program that included a high-intensity electromagnetic field.

Effect of the association of infra-red and red wavelength photobiomodulation therapy on the healing of post-extraction sockets of third lower molars: a split-mouth randomized clinical trial.

The aim of this study was to evaluate the effect of photobiomodulation therapy (PBMT) with the association of red and infra-red laser therapy in the healing of the post-extraction sockets of third lower molars. Twenty patients were submitted to extraction of lower third molars and the post-extraction sockets were treated using two different approaches in a randomized split-mouth design: The test side received the PBMT with red (λ 660nm) and infra-red laser therapy (λ 808nm) and the control side was not irradiated. The PBMT was applied immediately and 3 and 7days after the surgical procedure. Post-extraction socket healing was assessed by the bone repair score, bone density, and fractal dimension analysis 7 and 90days after the surgical procedure, using cone-beam computed tomography images. Additionally, clinical analyses were performed 3, 7, 14, 30, and 90days after the surgical procedure, considering the occurrence of pain, edema, and bleeding, as well as the quality of the oral mucosa repair, assessed using a visual analogue scale. The clinical analysis showed that PBMT reduced edema and improved the repair of oral mucosa at 7days after surgery, while the tomographic analysis showed no significant differences between groups. Dual-wavelength PBMT improved the post-operative clinical course in patients undergoing lower third molar extraction, without altering bone repair.

The influence of delivery power losses and full operating parametry on the effectiveness of diode visible-near infra-red (445-1064nm) laser therapy in dentistry-a multi-centre investigation.

The development of protocols for laser-assisted therapy demands strict compliance with comprehensive operating parametry. The purpose of this investigation was to examine the accuracy of correlation between laser control panel and fibre emission power values in a selection of diode dental lasers. Through retrospective analysis using successive systematic review and meta-analysis, it is clear that there is inconsistency in the details, and possible inaccuracies in laser power applied and associated computed data. Through a multi-centre investigation, 38 semi-conductor ("diode") dental laser units were chosen, with emission wavelengths ranging from 445 to 1064nm. Each unit had been recently serviced according to manufacturer's recommendations, and delivery fibre assembly checked for patency and correct alignment with the parent laser unit. Subject to the output capacity of each laser, four average power values were chosen using the laser control panel-100 mW, 500 mW, 1.0W, and 2.0W. Using a calibrated power meter, the post-fibre emission power value was measured, and a percentage power loss calculated. For each emission, a series of six measurements were made and analysed to investigate sources of power losses along the delivery fibre, and to evaluate the precision of power loss determinations. Statistical analysis of a dataset comprising % deviations from power setting levels was performed using a factorial ANOVA model, and this demonstrated very highly significant differences between devices tested and emission power levels applied (p < 10-142 and < 10-52 respectively). The devices × emission power interaction effect was also markedly significant (p < 10-66), and this confirmed that differences observed in these deviations for each prior power setting parameter were dependent on the device employed for delivery. Power losses were found to be negatively related to power settings applied. Significant differences have emerged to recommend the need to standardize a minimum set of parameters that should form the basis of comparative research into laser-tissue interactions, both in vitro and in vivo.

The Use of the Infrared Laser Therapy of 890-910 NM for the Treatment Breast Cancer (Experimental and Clinical Study)

The experimental studies were conducted with Walker's carcinosarcoma n256 (from the U.S.A. bank), cancer of the mammary gland (RMK-1). Spontaneous –mice with mammary glands cancer (type B). The tasks were as follows: to study the effect of different doses LLLT on the growth of experimental tumors. Evaluation of the effectiveness by applying LLLT in combination with various chemotherapeutic agents (vincristin, 5-Fu, ciclophosphan). Research of LLLR effect on different types of tumors show that this treatment can be used for tumors-statistic effect and for increasing life-span in animals. Applying LLLR in combination with chemotherapeutic agents causes tumors-static action. The most effective combination was LLLT + vincristin which caused the inhibition of tumor growth in Walker's carcinosarcoma-by 92,87%, in RMK-1 - by 90,29% in comparing to controls. The combination of LLLT with HpD showed - the effect of laser therapy takes place in 30 min before the irradiation and is accompanied by a sharp reduction of the preparation's accumulation in the tumor cells.

Laser therapy effect on endothelial dysfunction in patients after the surgery for orthognathic disorders

To optimize postoperative rehabilitation by applying low-intensity laser irradiation (LILI) with different wavelengths in the early postoperative period to prevent inflammatory complications. After radiological examination and ultrasound diagnostics of the periodontal tissue vessels, surgical methods of orthognathic treatment were performed, after completion of which a course of LILI was carried out. The VEGF its receptors (sVEGF-R1; sVEGF-R2) content was measured by enzyme immunoassay using standard reagent kits. The laser therapy using 635 nm laser light was applied directly to the vestibular and oral surfaces of the gingival tissues and in the operation area, changeable by the scanning method, for 1.5 minutes (5 W power); the pulsed infrared laser therapy (PILT) with the 904 nm wavelength (light pulse duration 100 s, power 15 W, 1500 Hz) applied epicutaneously to the operation projective zones (four control points of the upper and lower jaw) through the skin of the cheek, in stable method (1.5 minutes) with a time range between red and infrared wavelength LILI not exceeding 100 s (1.5 minutes). Vascular and endothelial dysfunction after laser irradiation with different wavelengths is better controlled by increasing the microcapillary blood flow (66.7% gain; p<0.05) in arteriolar and 70.3% in venular sections of capillaries (p<0.01), which is associated by vasodilatation: diameter increased by 26.9% compared to that under the influence of red laser radiation (by 13.0%) and infrared laser radiation (by 7.2%); p<0.01). Early laser therapy using the low-intensity laser irradiation with different wavelengths improves vasoactive processes of hemoregulation in dental tissues associated with the elimination of vasospasm caused by operative stress, activation of arteriolodilatory effects, contributes to the prevention of development of inflammatory complications.

Association of photobiomodulation therapy and therapeutic exercises in relation to pain intensity and neck disability in individuals with chronic neck pain: a systematic review of randomized trials.

Exercise is often pointed out as an effective form of treatment in the clinical management of chronic neck pain (CNP). However, due to its complex range of causal factors and great diversity of signs and symptoms, other resources such as photobiomodulation therapy (PBMT) have been routinely used for the treatment of CNP. The aim of this study was to systematically review the literature on the use of the association of PBMT and therapeutic exercises in relation to pain intensity and neck disability in individuals with CNP. PubMed, Medline (via Ovid), Embase (via Ovid), Cinahl (via Ebsco), and Central (via Cochrane library) databases were searched using the following terms: "laser," "low-level laser," "photobiomodulation," "light emitting diodes," "phototherapy," "exercise," "chronic neck pain." After verification and implementation of eligibility criteria, seven manuscripts were considered eligible for data analysis. These manuscripts had methodological quality between 5 and 8 points on the PEDro scale. Most studies used low infrared laser therapy to perform PBMT, with a wide range of parameters and energy density between 2 and 7J/cm2 and a total treatment time between 2 and 6weeks. Four studies showed significant benefits in terms of pain intensity at short-term follow-up and one at intermediate-term follow-up. However, only one showed a minimal clinically important change. No studies have shown significant improvement in disability. This review demonstrates that the association of PBMT with therapeutic exercises in general promotes significant benefits only for the intensity of pain. However, it does not seem to promote a minimally effective clinical difference in individuals with CNP.

Influence of the combined application of physiotherapeutic factors on microhemodynamic parameters and the level of oxygenation of tissues of the peri-implant zone in inflammatory complications in patients with orthopedic constructions on dental implants

The article analyzes the role of microcirculatory disorders in the pathogenesis of inflammatory complications (peri-implantitis) in patients with orthopedic constructions on dental implants and substantiates the possibility of a complex course application of low-intensity infrared laser therapy and low-frequency electrostatic therapy. It was shown that the initial state of patients with peri-implantitis is characterized by significantly low values of the level of general perfusion and its intensity, as well as the predominance of shunt mechanisms that reduce the values of the nutritive link of blood flow. The cause of the revealed disorders is the low level of functioning of the vasodilation mechanisms, caused by inflammatory and destructive processes in the peri-implant tissues. The use of a complex of physiotherapeutic exposure was characterized by a more pronounced corrective effect on the parameters of microcirculation and oxidative metabolism in comparison with standard dental treatment. The observed dynamics of microcirculatory systems of tissues of the peri-implant zone under the conditions of the complex influence of physiotherapeutic factors is aimed at the formation of adaptive reactions of local hemodynamics to the local needs of soft and bone tissues experiencing an inflammatory process around the implant, as well as strengthening the mechanisms of long-term adaptation of trophic relations in tissue peri-implant microregions. Taking into account the pathogenetic significance of microhemodynamic disorders in the formation of clinical manifestations of peri-implantitis, the revealed activating effect of the technology of the combined use of a laser and low-frequency electrostatic therapy serves as an objective proof of its therapeutic efficacy.

Dynamics of the clinical state of patients with peri-implantitis under conditions of complex application of physiotherapy technologies

The article presents the results of the treatment of inflammatory complications in patients with orthopedic constructions on dental implants using the course complex application of low-intensity infrared laser therapy and low-frequency electrostatic therapy. It has been shown that under the influence of a complex of physiotherapeutic factors, a more pronounced inverse dynamics of the clinical manifestations of peri-implantitis is observed in comparison with the standard treatment regimen, which has a positive effect on the indicators of the secondary stability of the implants themselves. The mechanisms of realization of the therapeutic efficiency of a low-intensity laser and a low-frequency electrostatic field are considered from the medical and biological point of view. The analysis of the study allows concluding that the course complex application of physiotherapeutic technologies in the treatment of post-prosthetic inflammatory complications during dental implantation is highly effective. The addition of the standard treatment regimen with the combined use of a low-frequency electrostatic field and laser therapy has a positive effect on the regression of the clinical manifestations of peri-implantitis and on the index indicators of the patients’ dental status. The increase in therapeutic efficiency observed when using a low-frequency electrostatic field in combination with an infrared laser of the complex is realized due to the potentiating type of interaction of physical factors, which is based on various points of application and the mechanisms of their corrective activity.

Estimation of long-term results of complex application of laserotherapy and low-frequency electrostatic field in patients with postprothetic inflammatory complications during dental implantation

BACKGROUND: Previous studies have shown high clinical efficacy of the course combined use of a low-frequency electrostatic field and low-intensity infrared laser therapy in patients with peri-implantitis. It was shown that the use of these physiotherapeutic factors is accompanied by the development of anti-inflammatory and analgesic effects, increased tissue blood flow in the area of therapeutic exposure, as well as activation of trophic-regenerative processes that determine the degree of osseointegration of implants. However, along with resolving the issue of the current relief of clinical manifestations of peri-implantitis, an important point is the study of the long-term effect of the treatment method used. Evaluation of long-term results makes it possible to determine the duration of the preservation of the therapeutic effect, which makes it possible to determine the optimal parameters of the frequency and frequency of the therapeutic effects.&#x0D; AIMS: Evaluation of complex physiotherapeutic treatment of patients with post-prosthetic inflammatory complications during dental implantation in the long-term period (after 6 and 12 months).&#x0D; MATERIAL AND METHODS: The study was carried out with the participation of 132 patients aged 35 to 57 years with a clinically and radiologically confirmed diagnosis of class I and II peri-implantitis. All patients were divided into 4 groups by the method of simple fixed randomization. The first group (control group, 31 patients) received standard dental treatment, including professional oral hygiene, removal of dental plaque and granulation, and debridement of peri-implant pockets. In the second group (main I, 31 patients), in addition to the standard therapy, a course of laser therapy was carried out using the BTL-4000 physiotherapy apparatus. In the third group (main II, 30 patients), the standard treatment was supplemented with a course of low-frequency electrotherapy. The fourth group (main III, 31 patients), along with standard treatment, received low-frequency electrotherapy in combination with laser therapy. Long-term results were assessed 6 and 12 months after the end of therapy using clinical-functional, biochemical and psychological methods.&#x0D; RESULTS: The course combined use of a laser and a low-frequency electrostatic field as a supplement to the standard treatment protocol for patients with peri-implantitis ensures the maximum preservation of higher indicators characterizing the restoration of the functions of the dentition, aesthetic parameters of the face and an increase in the quality of life of patients in general.&#x0D; CONCLUSION: Taking into account the risk of developing a possible exacerbation of the inflammatory process, as well as the dynamics of the studied clinical and functional parameters in patients with peri-implantitis in the long-term period, it was concluded that it is necessary to conduct repeated courses of combined use of an infrared laser and low-frequency electrostatic therapy in 69 months.

Correction of mitochondrial dysfunction in the complex rehabilitation of COVID-19

To study the effectiveness of a course of intravenous administration of cytoflavin in combination with a standard rehabilitation program for post-COVID fatigue syndrome caused by mitochondrial dysfunction. The dynamic examination of 45 patients with post-COVID syndrome at the second stage of rehabilitation was carried out. The patients were subdivided into 2 groups comparable in gender and age. The volume of lung damage in patients of both groups was also comparable at range of 25-80%. Twenty-four patients of the control group were treated with the standard post-COVID rehabilitation protocol: pulse magnetic therapy, inhalation therapy, aeroion therapy, infrared laser therapy, course aerobic training, psychotherapy, and standard drug therapy. Twenty-one patients of the main group additionally received intravenous administration of cytoflavin daily for 10 days. The dynamics of the scores on the Rehabilitation Routing Scale, HDRS, the Asthenic Status Scale, and the 6-minute walk test was analyzed. The additional intravenous administration of cytoflavin at the complex rehabilitation of post-COVID syndrome can significantly improve the therapeutic results: it significantly improves the overall functional state, reduces depression and fatigue level and increases tolerance to physical exertion.