This research paper explores the importance of innovative behavior as a crucial skill in the 21st century. Rapid technological advancements and globalization make the world dynamic and competitive. This research investigates the influence of transformational leadership, motivation, and organizational culture on innovative behavior and job performance among female employees in the textile industry of Karachi, with a focus on gender equality as per the Sustainable Development Goals (SDG). Data from 144 female workers from different textile industries were analyzed using correlation, regression, and moderation analyses. The results reveal significant positive correlations between transformational leadership, motivation, organizational culture, innovative behavior, and job performance. Regression analyses confirm the predictive power of transformational leadership and organizational culture on job performance, highlighting the importance of nurturing effective leadership and fostering a positive organizational culture. While motivation exhibits significant correlations with innovative behavior and job performance, its direct impact is less pronounced in regression models, suggesting mediation by other factors. Organizational culture moderates the relationships between leadership, motivation, and employee outcomes, emphasizing the need to consider contextual factors in understanding workplace dynamics. These findings offer valuable insights for organizational leaders and managers seeking to optimize performance and create supportive work environments, with implications for leadership development, motivational strategies, and cultural interventions. Future research should explore longitudinal and cross-industry comparisons to deepen understanding and inform evidence-based practices for promoting gender equality and enhancing employee outcomes in the textile industry and beyond. The relevance of innovative behavior is essential for the success of individuals and organizations in particular, and of societies and nations in general, to tackle the challenges the 21st century continues to throw at us and shape the future in a more desirable direction