Independent Samples Kruskal-Wallis Research Articles

Abstract TMP92: Circadian Variability in Pediatric Stroke

Introduction: Ischemic stroke in adults demonstrates circadian variation in the timing of onset of symptoms, with the highest risk between 6am and noon (1-4). The influence of circadian timing on stroke biology may differ between children and adults, possibly related to the immature circadian system, variations in school versus work schedules, and diverse stroke pathophysiology (5). The goal of our study was to assess whether timing of ischemic stroke onset demonstrates circadian variability in children. Methods: We queried the International Pediatric Stroke Study, an international multicenter observational registry of children <18 years with arterial ischemic stroke (AIS). Included patients were aged 29 days-18 years with outpatient AIS and known time of stroke symptom onset. Clinical and radiographic features were compared according to 4 distinct time epochs: 6:00-11:59 (morning), 12:00-17:59 (afternoon), 18:00-23:59 (evening) and 00:00-5:59 (night). Clinical outcomes were defined by the Pediatric Stroke Outcome Measure (PSOM). Baseline, clinical and outcome characteristics were compared between the 4 time epochs using independent samples Kruskal-Wallis and Chi-square tests. Pairwise comparisons were conducted where needed. Results: A total of 478 patients met inclusion criteria, 54% male, mean age 9.9±SD 5.7 years. Time of stroke onset by hour is shown in Figure 1. Most strokes occurred in the afternoon (n=185, 38.7%), followed by morning (n=156, 32.6%). Table 1 shows demographic and clinical characteristics by time epoch; clinical and arteriopathy risk factors were more prevalent in nighttime strokes (23/36, 70%, p=0.034). Median PSOM scores at 6 months appeared to be better after evening strokes (0.5, IQR 0-1.5) as compared to morning strokes (1, IQR 0.5-2) and afternoon strokes (1, IQR 0.5-3, p=0.033), but failed adjustment for multiple comparisons (figure 2). Conclusion: Circadian influence on stroke timing appears to differ between adults and children. Further prospective studies with larger sample sizes are needed to understand the impact of circadian rhythm on stroke in childhood.

Analysis of ultrasonographic measurements of inferior vena cava and abdominal aorta diameters in neonates

Objective: To analyze the ultrasonographic measurements of inferior vena cava (IVC) and abdominal aorta in healthy full-term neonates throughout the early postnatal period. Methods: Prospective observational study was conducted. A total of 132 healthy full-term neonates, who were born at the Kunshan First People's Hospital between May 1st and August 30th, 2023, were enrolled as the study subjects. Two-dimensional and M-mode ultrasonography were used to measure the maximum and minimum diameters of the IVC and abdominal aorta in the early postnatal period. The IVC collapsibility index, the ratio of maximum IVC diameter to abdominal aorta diameter, and the ratio of minimum IVC diameter to abdominal aorta diameter were calculated. These neonates were stratified by gender, birth mode, gestational age and birth weight (<3 000 or ≥3 000 g), and independent sample t-test or Kruskal-Wallis H test was used to compare the ultrasonography measurements by different groups. Results: Among the 132 neonates, 81 were males, with a gestational age of (39.2±1.0) weeks, and a birth weight of (3 326±409) g. There were no significant statistical differences in the the maximum and minimum diameters of the IVC and abdominal aorta assessed by both two-dimensional and M-modes between the first and second days (all P>0.05). Additionally, no statistical differences were observed in the ultrasonographic measurements among neonates of different sexes, birth modes, and gestational ages (all P>0.05); but there were statistically differences between the group with birth weight of <3 000 g and the group with birth weight of ≥3 000 g (all P<0.05). There were no statistically differences in IVC collapsibility index, the ratio of the maximum diameter of IVC to the diameter of abdominal aorta, and the ratio of the minimum diameter of IVC to the diameter of abdominal aorta between the group with birth weight of <3 000 g and the group with birth weight of≥3 000 g (all P>0.05). Conclusions: The diameters of the IVC and abdominal aorta in healthy full-term neonates during the early postnatal period are correlated with birth weight. The IVC collapsibility index and the ratio of IVC diameter to abdominal aorta diameter are unrelated to birth weight and can be used to assess newborn blood volume or right cardiac preload.

Experiences of psychological, social and organisational work environments in occupational health service in Sweden: a cross-sectional survey

BackgroundThe aim of this study was to compare and describe different professionals’ experiences of workplace psychological and social factors in occupational health (OH) organizations in Sweden.MethodsThis cross-sectional study with a descriptive and comparative design included 472 respondents with common professions in the occupational health service (OHS) in Sweden. Data were collected with “The General Nordic Questionnaire for Psychological and Social Factors at Work” (QPSNordic). The professions have been compared pairwise using the Independent Samples Kruskal-Wallis test, adjusted by Bonferroni correction for multiple tests on subscales and single items and these are presented descriptively.ResultsThe experience of the psychological and social work environment on job task measurement level differed between the professionals. Experiences on social and organizational as well as on individual measurement levels are similar between the professionals who perceive them as satisfactory. Out of the 472 respondents, 7% reported that they had seen someone being subjected to harassment and bullying at the workplace during the last six months.ConclusionsThe experience among the professionals differs most in the Job task measurement level. The results indicate that although different OH professionals experience psychological and social factors at work in different ways, their experiences are generally satisfactory even though harassment and bullying do exist. The research about occupational health professionals and their work environment is sparse. Further applied research is needed for the planning and development of occupational health services in Sweden.

Impact of vertical facial type on alveolar bone thickness and tooth morphology: A retrospective CBCT-based clinical study

IntroductionThe relationship between vertical facial patterns and the morphology of the alveolar bone and teeth is crucial for successful orthodontic treatment planning. This study aimed to evaluate the relationship between vertical facial patterns, bone thickness, and root-crown dimensions in the maxillary anterior teeth. MethodsThis retrospective study screened 300 cone-beam computed tomography (CBCT) scans of orthodontic patients between December 2022 and November 2023, with 115 meeting the inclusion criteria. Buccal and lingual alveolar bone thickness, along with crown and root lengths of maxillary anterior teeth, were measured and compared across short, normal, and long facial types, classified according to the Frankfort-Mandibular Plane Angle. One-way ANOVA, independent-samples Kruskal-Wallis, and post-hoc tests were used for statistical analysis. ResultsSignificant differences in alveolar bone thickness were observed across facial types, with short facial types showing consistently greater thickness in the apical and mid-palatal regions compared to normal and long facial types (p < 0.05). No significant differences in crown or root lengths were found among the facial types. ConclusionFacial type significantly influences alveolar bone thickness, particularly in short facial types, which demonstrate greater bone support. These findings underscore the importance of considering facial type in orthodontic treatment planning to minimize complications.

Female sexual dysfunctions in multiple sclerosis patients with lower urinary tract symptoms: an Italian case-control study.

Multiple sclerosis (MS) is a recurrent, autoimmune, and inflammatory demyelinating chronic disease that typically manifests in young adulthood and exerts adverse effects on sexual functions. The study evaluated the prevalence of sexual dysfunctions (SDs) and the relationship with neurological disability, depression, and lower urinary tract symptoms (LUTS) in a cohort of MS female patients, comparing these results with those of healthy women. From January 2023 to January 2024, consecutive premenopausal female patients with MS, were recruited and the examination included urinalysis, ultrasonography and a urodynamic test according to the International Continence Society standard. Descriptive statistics were reported as mean and standard deviation for continuous variables (analyzed by independent samples Mann-Whitney U test and independent samples Kruskal-Wallis test) while categorical variables were reported as frequency and percentage (analyzed by chi-square test with Fisher's exact test). Female Sexual Function Index (FSFI) total score and all FSFI subscales scores were significantly lower in patients with MS vs healthy control subjects (P < .001); FSFI total scores and all FSFI subscale scores were statistically significantly lower in patients with MS with an International Prostate Symptom Score ≥20 (P < .001) and considering a cutoff for Beck Depression Inventory-II score ≥17, depression was present in 61% (n = 47 of 77) of patients with MS and completely absent in the control group. The knowledge that SDs are a common problem in MS and in other chronic illnesses can alleviate the feeling of stigma and talking openly of sexual problems can be helpful for the patients and so the doctor-patient relationship can be reinforced. The sample was drawn from a single center, and larger multicenter studies that include both genders are needed to obtain strong results. Our findings confirm the idea of a polygenic and multifactorial etiology of female SDs in MS. Therefore, women with MS should be evaluated in terms of SDs during follow-ups.

Examination of the Relationship Between Mindfulness in Society and Life Satisfaction

Aim: This study aimed to examine the relationship between mindfulness in society and quality of life. Materials and Methods: The data for this study were collected in July 2022 throughout Turkey through an online survey application using the snowball sampling method. The research was completed with 387 participants aged 18 and over in Turkey. The Independent Sample t-test, ANOVA, Mann-Whitney U, Kruskal-Wallis H, Bonferroni correction, and Spearman correlation coefficient were employed in the data analysis. Results: Participants in the 35-44 age range, those who were married, those with income more than expenses, those with postgraduate education, and those who reported being present in the moment were found to have higher levels of life satisfaction (p

The Relationship between Sleep Quality and Smartphone Addiction among Adolescents

Introduction: Technological developments have increased the usage of mobile equipment. Using a smartphone became a part of life and accentuated its usage day aftr day especially in adolescent groups. Aim: The study was aimed to examine the relationship between sleep quality and smartphone addiction of adolescents. Method: This cross-sectional study was carried out with 1192 high school students between March and June 2019. Data were collected with the Personal Information Form, Pittsburg Sleep Quality Index, Smartphone Addiction Scale. The data were evaluated through percentile distributions, means, independent samples t-test, Kruskal-Wallis test, ANOVA, and Pearson correlation analyses. Results: The mean age of adolescents was determined to be 15.79 ± 0.96, with the mean total score of the Pittsburg Sleep Quality Index was 6.05 ± 3.04 and the Smartphone Addiction Scale was 36.01 ± 10.82. Statistically signifiant diffrences were observed among adolescents concerning gender, grade, daily smartphone usage duration, internet accessibility, and the use of smartphones before bedtime, impacting both sleep quality and smartphone addiction (p &lt; 0.05). A positive and meaningful correlation was found between sleep quality and smartphone addiction in adolescents (p &lt; 0.05). Conclusion: As the smartphone addiction increases, sleep quality decreases. Adequate sleep is crucial during the growth spurt period. It is evaluated that early diagnosis and prevention of smartphone addiction in adolescents could make a signifiant contribution to the protection and promotion of adolescent health.

Exploring the impact of massification of higher education on the labour force participation and empowerment of Malaysian women

This paper aims to investigate the mismatch between the massification of higher education and the participation of women in the labour force in Malaysia. The objective is to statistically uncover the effect of educational attainment on the female labour force participation rate. The paper analyzed the data collected from various sources, like the World Bank, the World Economic Forum, and the Department of Statistics Malaysia. The paper employed various hypotheses tests, including the independent samples T-test, Mann-Whitney test, and Kruskal-Wallis test, to assess the relationship and determine whether to accept or reject the study hypotheses. The finding showed that females substantially outnumbered males among higher education’s graduates. Despite this improvement, women remain underrepresented in the labour force compared to the rate of their education attainment as well as that of men. The paper statistically rejects the notion that there is a positive linear connection between educating women and labour force participation. It is not all about educating women; decision-makers have to search for other factors that hinder women from fully participating in the labour force, particularly in the world of Muslim nations. The paper enriches the literature on gender parity and contributes to the ongoing debate about the effect of education on female labour force participation.

Effects of Capsaicin on Migration and Alkaline Phosphatase Activity of Dental Pulp Cells.

Dental pulp, a specialized mesenchymal tissue within teeth, is pivotal in dental health and tissue repair. Capsaicin, the primary pungent component of chili peppers, is known for its diverse pharmacological properties. While capsaicin's effects on various cell types have been studied, its impact on dental pulp cells remains relatively unexplored. This study investigated the influence of pure capsaicin extract on dental pulp cell behavior, focusing on cell viability, proliferation, migration, and alkaline phosphatase (ALP) activity. Capsaicin solution was prepared and diluted to various concentrations (1 nM, 0.01 µM, 0.1 µM, 1 µM, 10 µM, and 100 µM), then was tested on rat dental pulp cells (RPC-C2A). Cell viability and proliferation were assessed using the MTT assay. Boyden chamber tests and wound healing were used for evaluating cell migration. The activity of ALP was determined to show cell function during dental pulp repair. The data were analyzed using a one-way analysis of variance or an independent-sample Kruskal-Wallis, followed by multiple comparison tests. Capsaicin of 100 µM exhibited cytotoxicity, whereas those with lower concentrations stimulated cell proliferation. Wound healing assays revealed increased cell migration, particularly when cultured with 1 nM capsaicin (p = 0.002). Boyden chamber assays demonstrated enhanced cell invasion without statistical significance. ALP activity of dental pulp cells increased significantly at 1 nM (p < 0.001) and 1 µM (p = 0.021) capsaicin concentrations, indicating potential dentinogenesis and pulp repair. Capsaicin of lower concentrations, less than 10 µM, is likely to promote proliferation, migration, and ALP activity of dental pulp cells. Our findings offer potential applications for capsaicin as a medication for dental pulp repair.

Hyperandrogenism associated with polycystic ovary syndrome may have a protective effect against fracture risk in female athletes: A pilot study.

Polycystic ovary syndrome (PCOS), characterized by polycystic ovaries, anovulation, and hyperandrogenism, is believed to be an evolutionary mismatch disease. Past research has examined PCOS as a uniform disease, despite variation in phenotypes across diagnostic categories, but establishing an evolutionary mismatch requires a focus on individual traits. We suggest PCOS hyperandrogenism may have been beneficial in ancestral environments because it reduced fracture risk and associated morbidity and mortality due to increased bone mineral density (BMD). We test this hypothesis by assessing fracture frequency, a proxy for BMD, in highly active females with and without PCOS hyperandrogenism. Sixty-seven reproductive-aged women were surveyed and grouped as: high intensity interval training (HIIT; a proxy for metabolic and physical stress) athletes with hyperandrogenic PCOS (31.24%), HIIT athletes without PCOS (29.85%), and nonathletes with hyperandrogenic PCOS (38.81%). Fracture occurrence was compared between the groups using independent samples Kruskal-Wallis tests for non-normally distributed data, and multiple regression analysis was used to examine anthropometrics, lifestyle and reproductive factors, PCOS status, and exercise frequency on fracture occurrence. Fracture occurrence was higher in non-PCOS athletes (3.8 ± 4.3) than PCOS-athletes (1.2 ± 1.4, p = .11) and PCOS-non-athletes (1.0 ± 1.4, p < .01). PCOS-athletes and nonathletes did not differ significantly in fracture occurrence (p = .33). These results were independent of factors associated with bone health. These preliminary findings suggest females with PCOS-related hyperandrogenism may be less likely to experience bone fractures and provide an initial step to explaining why PCOS has persisted despite marked negative reproductive consequences in modern populations.

2 Neurocognition and Functional Status Among Ethnoculturally Diverse Older Adults: Support for the External Validity of the ADAS-Cog

Objective:Alzheimer’s Disease (AD) and dementia present major and escalating public health concerns for the U.S., especially among ethnoculturally diverse (e.g., Latinx, non-Latinx Black [NLB]) populations who represent an increasing percentage of the older adult population in the US and bear greater AD burden compared to non-Latinx Whites (NLWs). Notably, neurocognition and functional status are highly correlated in those with AD. However, little has been done to understand these associations and validate functional measures across geographically diverse, multiethnic samples. The aims of this study were to characterize the neurocognition and functional status of a large, multiethnic sample and subsequently examine any associations between neurocognition and functional status among Latinx, NLB, and NLW older adults.Participants and Methods:This cross-sectional, retrospective study utilized archival data drawn from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). ADNI is a national, longitudinal, multi-site, observational study aiming to measure the progression of AD (see https://adni-info.org). Study measures included the: 1) Alzheimer’s Disease Assessment Scale Cognitive subscale (ADAS-cog; 13-items), a global neurocognitive battery evaluating neurocognition in people with AD; 2) Functional Activities Questionnaire (FAQ; 10-item questionnaire) to assess functional status; 3) Geriatric Depression Scale (GDS; 15-item questionnaire) for depression; and 4) American National Adult Reading Test (ANART; 50-word test) for reading level. The sample included 1537 older adults who completed baseline visits for the ADNI study, 1333 of whom were NLW, 123 NLB, and 81 Latinx. The average age of the sample was 73 years, average 16 years of education, and 53% male. Compared to the NLW group, the NLB and Latinx groups were significantly younger and had a higher percentage of female participants. Compared to NLW and Latinx groups, the NLB group also had significantly fewer years of education and lower reading scores. Potential confounds (i.e., demographic variables, depression) were identified a priori based on the literature and subsequently analyzed for inclusion as covariates in the primary analyses. Analyses revealed variables were non-normally distributed, therefore Independent Samples Kruskal-Wallis tests and Spearman’s Correlations were computed to examine differences and correlations between ethnocultural groups.Results:After controlling for age and education, Latinx and NLB groups had significantly higher ADAS-cog and FAQ scores than the NLW group (Hs = 9.50-21.53, ps &lt; .05). Spearman’s partial correlations controlling for age, education, gender, and depression revealed that higher ADAS-cog scores were associated with higher FAQ scores within Latinx (p=.49, p&lt;.001), NLB (p=.66, p&lt;.001), and NLW (p=.60, p&lt;.001) groups.Conclusions:Findings indicate that neurocognition is positively associated with functional status and support the ecological and external validity of the ADAS-cog and FAQ for use with NLB and Latinx older adults, in addition to previously established work with more homogenous samples. Study strengths include the overall sample size, geographic diversity, and standardization of research approaches. Study limitations include high education level and low comorbidity rates present in the sample, limiting the generalizability of the results, in addition to the unbalanced ethnocultural groups, further emphasizing the need for increased inclusion efforts of ethnoculturally diverse older adults into brain health research studies.

Use of technology as a mediator for loneliness

Abstract This study seeks to identify the significant predictors of loneliness among older adults during the COVID-19 pandemic and asks if using technology can help older adults mitigate the effects of loneliness during periods of social isolation. Data from Wave 9, COVID-19 Survey 2 (Summer, 2021) of the Survey of Health, Aging, and Retirement in Europe (SHARE) were used to determine which factors were meaningful influences on loneliness among older adults during the second wave of the COVID-19 pandemic N = 10 countries in 3 healthcare system clusters. Statistical analysis for this study consists of two steps: Independent-Samples Kruskal-Wallis and the Dunn-Bonferroni tests; then, logistic regression analyses were used to examine differences between 3 cluster identities. The Kruskal-Wallis test shows that the rate of loneliness varies significantly different countries [χ2(9)=583.6;p&amp;lt; .001], with Latvia/Lithuania having the highest rates. Dunn's pairwise tests were conducted for the 3 country clusters with very strong evidence (p &amp;lt; 0.001) of a difference between rate of loneliness between clusters, with cluster 3 countries of Latvia/Lithuania reporting greatest loneliness; and, age, home care, employment, and financial support (p &amp;lt; 0.001) being significant for the use of technology with all clusters having significance. Only cluster 1 showed significance for use of technology for mitigating loneliness (p &amp;lt; 0.05). Findings from this study suggest that, among higher performing health system countries, technology was a significant mediator of loneliness during the second wave of the COVID-19 pandemic. Findings demonstrate that poorer performing countries could benefit from increased capacity for technology-based public health interventions to reduce loneliness among older adults. Key messages • Public health interventions can use technology to mitigate feelings of loneliness among older adults. • Public health programming can focus on introducing technology-based interventions for older adults.

The Relationship between Emotional Expression, Life Satisfaction, and Psychological Resilience in Gay Men in Turkey

This study examined the relationship between psychological resilience, life satisfaction, and emotional expression levels in male gay individuals. This correlational study included 40 gay males who were LGBTI Association members and 40 heterosexual men who shared similar sociodemographic characteristics. Along with the informed consent form, the participants were given a sociodemographic form, the Expression of Emotions Scale, the Life Satisfaction Scale, and the Resilience Scale for Adults. Correlation analysis was performed to reveal the relationship between variables. Independent sample T-tests, Mann-Whitney U, and Kruskal-Wallis analyses were used for group comparisons. Compared with heterosexual men, gay men scored higher on measures of emotional expression and resilience. According to the age of self-awareness and previous psychological therapy status, the ratings of gay males for expressing their feelings differ significantly. In addition, there was a significant difference in resilience scores according to smoking status. Male gay individuals have higher emotional expression skills and psychological resilience levels than heterosexual individuals. Additionally, it was found that emotional expression and life satisfaction were positively correlated in gay people.

Disparities in US Lung Cancer Clinical Trial Enrollment.

Disparities within clinical trial enrollment are well-documented, reducing the generalizability of results. Although nearly 30years have passed since Congress passed the NIH Revitalization Act to encourage the participation of minoritized populations in clinical trials, these patients continue to be underrepresented. This study aimed to investigate lung cancer clinical trial enrollment disparities for race/ethnicity, sex, and age. We queried the National Institutes of Health: US National Library of Medicine database of clinical trials for all US-based lung cancer clinical trials completed between 2004 and 2021 and collected data on race and ethnicity, gender, and age breakdown. This data was compared to Surveillance, Epidemiology, and End Results (SEER) database data. Independent sample t-tests and Kruskal-Wallis's approach were used to analyze the data. Of 311 eligible trials with exclusive US enrollment, 136 (44%) reported race and ethnicity breakdown for the patient cohort representing 9869 patients. Hispanic, Non-Hispanic American Indian/Alaska Native, Non-Hispanic Black, and Non-Hispanic Unreported participants were underrepresented (p = 0.001, p = 0.005, p = 0.014, p = 0.002, respectively). Non-Hispanic White participants were overrepresented (p = 0.018). Disparities worsened from 2017 to 2021 for Hispanic patients (p = 0.03). No significant differences were found for sex or age. Disparities for clinical lung cancer trial enrollment have not shown statistically significant improvement since 2004, and representation remains unequal, especially for racial and ethnic minorities.

The Relationship between Epistemological Beliefs and Technological, Pedagogical, and Content Knowledge (TPACK)

Changing developments in the 21st century have also affected technology and the epistemological beliefs of teachers. For this purpose, the epistemological beliefs and Technological, Pedagogical, and Content Knowledge (TPACK) levels of primary school teachers and social studies teachers, gender, age, professional seniority, educational status, branch variables, and the relationship between epistemological belief and TPACK were examined in this study. The study group of the research consists of primary school teachers working in public primary school and social studies teachers working in public secondary schools in the provinces and districts of Istanbul, Antalya and Isparta. The selection of the study was made with the appropriate sampling method, which is one of the non-accidental sampling methods. 178 primary school teachers and 48 social studies teachers participated in the research. Independent sample t-test, Kruskal-Wallis test and Pearson Correlation Analysis were used in data analysis. According to the results obtained from the research, both primary school and social studies teachers have a high level of belief in the sub-dimension of effort. It was observed that both primary school teachers and social studies teachers had high TPACK levels. Considering the epistemological belief scale, no significant difference was observed according to the age, education level and professional seniority of the primary school teachers. There was no significant difference in social studies teachers according to the gender variable. According to the results obtained from the TPACK scale and its sub-dimensions, a significant difference was observed in terms of gender and professional seniority of primary school and social studies teachers. A low level of positive correlation was found between the effort scores of the primary school teachers and TK, CT, TPK, TCK and TPACK total scores.

Workflow in Simultaneous acute code Stroke activations in the emergency department (P6-5.021)

<h3>Objective:</h3> To assess the effect of simultaneous acute code stroke activation (ACSA) in the emergency department on the door-to-needle (DTN) time of patients with acute ischemic stroke eligible for reperfusion therapies. <h3>Background:</h3> Simultaneous emergency call activations carry increased workload that could possibly compromise quality parameters and patient outcomes. <h3>Design/Methods:</h3> All ACSA from March 2021 to August 2022 from the QuICR (Quality Improvement and Clinical Research Alberta Stroke Program) Registry were assessed. We defined Simultaneity based on the Canadian Triage and Acuity Scale, average local DTN and door-to-puncture (DTP) times: ACSA 30 min prior to any patient receiving intravenous thrombolysis (IVT) and/or endovascular thrombectomy (EVT); ACSA within 60 min of any patient receiving IVT and ACSA within 120 min of any patient receiving EVT. The simultaneity grade 1 was 2 patients care overlap as per simultaneous ACSA definition, grade 2 was 3 patients care overlap and grade 3 was &gt;3 patients care overlap. Independent sample Kruskal-Wallis test was applied to assess the between-group differences in median treatment times. <h3>Results:</h3> 496 patients (20.9%, n=2364) underwent acute reperfusion therapy with a mean±SD age of 70.4±14.6 years, 45%(n=224) were female and a median (IQR) NIHSS of 12 (10) during the study period. Simultaneous ACSA was 163 (32.9%). The median (IQR) DTN time in the non-simultaneous group(n=205), grades 1 (n=76), 2 (n=13) and 3 (n=4) simultaneities was 38 (22)min, 39.5 (21)min, 45 (26)min, 58.5 (19.5)min respectively (p=0.27). The median (IQR) DTP time in the non-simultaneous group (n=187), in grades 1 (n=69), 2 (n=27) and 3 (n=6) simultaneities was 99 (42)min, 93 (48)min, 98 (39)min and 153 (112.75)min respectively (p=0.6). <h3>Conclusions:</h3> Simultaneous ACSA occurs in one-third of patients receiving reperfusion therapies. No differences were noted in treatment times between the study groups. Novel strategies are required to understand the effect of simultaneous ACSA on the acute stroke team and emergency department. <b>Disclosure:</b> Dr. Sarmiento has nothing to disclose. Miss Bhangoo has nothing to disclose. The institution of Dr. Jeerakathil has received research support from University Hospital Foundation. Dr. Shuaib has nothing to disclose. Dr. Buck has nothing to disclose. Ms. Taralson has nothing to disclose. Ms. Moniz has nothing to disclose. Dr. Kate has nothing to disclose.

In vitro effect of beer, red and white wine on the morphology and surface roughness of human enamel.

Beer, red and white wine are acidic drinks whose frequent consumption can increase the risk of dental erosion. To establish the effect of beer, red and white wine on the morphology and surface roughness (SR) of human enamel using different exposure times in a cyclic deand remineralization model in vitro. The experiment included 33 surgically extracted impacted human third molars from patients aged 18-25 years. Enamel samples obtained by cutting crowns (n = 132) were submitted to alternate cycles of demineralization in (1) beer, (2) red wine, (3) white wine, (PC) positive control (orange juice), and remineralization in artificial saliva, which also represented a medium for negative control (NC). The experiment included cycles with different exposure times in alcoholic beverages and orange juice of 15, 30 and 60 min. Thus, 12 groups were formed (for each drink and each exposure time) containing 10 samples each, while the NC group consisted of 12 samples. Experiments were repeated 3x/day for 10 days. Enamel surface alterations were determined by stylus profilometry (average surface roughness (Ra)) and scanning electron microscopy (SEM). The Shapiro-Wilk test, independent samples Kruskal-Wallis test and multiple comparisons (all pairwise) were performed. With increasing exposure time, there was a positive correlation with Ra for white wineand orange juice-immersed samples (60 min compared to 15 min), which was also observed using SEM. There was no significant difference in the Ra between the other experimental samples for the same exposure time. This study confirms a certain erosive potential of beer, red and white wine, and a significant relationship with pH, titratable acidity (TA) and SR, but not with the exposure time for all tested alcoholic beverages. Moreover, differences among the ultrastructural patterns caused by alcoholic beverages over the enamel surface were observed.

The transition journey of EU vs. NON-EU countries for waste management.

This study aims to identify macroeconomic indicators that can be used as predictors of waste management on the European continent. The study was conducted taking in account the intensification of urbanizations, the increase of standard of leaving that fuels to consumerism phenomenon, and imposed challenges for waste management. The research focuses on the interval from 2010 to 2020 for 37 European countries grouped according to EU15/EU28/non-EU and EU/non-EU members. As macroeconomic indicators, human development index (HDI), GDP/capita. GNI/capita, general government expenditure with environment protection, people at risk of poverty or social exclusion, population by educational attainment level, sex, and age (%)-less than primary, primary and lower secondary education (levels 0-2) were used. A multilinear regression model with collinearity diagnosis was applied to find out the direction and intensity of the contribution of independent variables and to hierarchy the predictors of waste management.. For multiple comparison between and inside of each grouping of countries, statistical inference methods were used: one-way ANOVA with Bonferroni post hoc test multiple comparisons and independent samples Kruskal-Wallis test with Dunn's post hoc test. The main conclusions of the study are that EU15 countries have the highest average values for most indicators of waste management, comparative with EU28 and with non-EU countries, followed by a group of EU28 countries. For indicators of recycling rate of packaging waste by type of packaging-metallic and recycling rate of e-waste, the non-EU countries have the highest values of mean compared with the EU15 and EU28 groups of countries. This can be explained by the high level of development of the some non-euro area countries (Iceland, Norway, Switzerland, Liechtenstein) that have intense concerns about waste recycling and have the necessary financial strength to carry out complex environmental protection programs.

Coping Strategies Adopted by Regular Undergraduate International Students in Southern Ghana Universities on Their Adjustment Needs

The study investigated the coping strategies adopted by regular undergraduate international students of the universities in southern Ghana on their adjustment needs. The descriptive design of the quantitative research approach was employed for the study. The research instrument used to elicit responses was a questionnaire. The data were analysed using descriptive statistics (mean, standard deviation, frequency and percentage) and inferential statistics (Independent samples t-test and Kruskal-Wallis H test). The findings showed that there was no significant difference in the coping strategies on the adjustment needs of undergraduate regular international students based on both gender and age. It was recommended, among other things, that policy makers and management of the universities must take into account the reality of the adjustment needs of regular undergraduate international students and consider effective ways of making their stay in southern Ghana’s universities less stressful. Keywords: coping strategies, adjustment needs, international students, emotions, gender DOI: 10.7176/JEP/14-10-03 Publication date: April 30 th 2023

MP77-08 PROSTATE CANCER PRESENTATION IN A COMMUNITY SETTING A DECADE SINCE THE USPSTF GRADE D RECOMMENDATION

You have accessJournal of UrologyCME1 Apr 2023MP77-08 PROSTATE CANCER PRESENTATION IN A COMMUNITY SETTING A DECADE SINCE THE USPSTF GRADE D RECOMMENDATION Franklin Gaylis, Edward Cohen, Paul Dato, Rose Prime, Julie Cramer, Katayune Golshan, Sonia Romo, Sepi Mahooti, Michael Leapman, Robert Topp, and William Catalona Franklin GaylisFranklin Gaylis More articles by this author , Edward CohenEdward Cohen More articles by this author , Paul DatoPaul Dato More articles by this author , Rose PrimeRose Prime More articles by this author , Julie CramerJulie Cramer More articles by this author , Katayune GolshanKatayune Golshan More articles by this author , Sonia RomoSonia Romo More articles by this author , Sepi MahootiSepi Mahooti More articles by this author , Michael LeapmanMichael Leapman More articles by this author , Robert ToppRobert Topp More articles by this author , and William CatalonaWilliam Catalona More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003351.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The United States Preventative Services Task Force (USPSTF) issued a grade “D” recommendation against PSA-based prostate cancer (PCa) screening in 2012. We present an analysis of a prospectively collected data repository including PCa tumor burden, Gleason score group, PSA and prostate biopsy positivity rates in a community setting a decade since the Task Force recommendation METHODS: We identified 7,914 patients undergoing prostate biopsy between April 2011 and December 2021 from the Genesis Healthcare Partner’s (large urology group practice) electronic medical record (EMR). For 2011, we annualized the number of biopsies performed based on an imputed estimate from April through December of 2011. We compiled the number of prostate biopsies and proportions of biopsies demonstrating cancer, Gleason score (6, 7, 8-10), and the maximum positive biopsy core percentage involvement with cancer. Statistical analysis included Chi Square and a one-way ANOVA. RESULTS: The annual biopsy rate was significantly higher in 2011 (997 cases [748 actual cases plus 249 estimated cases] than for all other years. Chi Square analysis indicated a significant consistent increase (p<0.001) in the percentage of positive biopsies between 2011 (44.25%) and 2021 (65.91%). The proportion of low grade disease significantly decreased (p<0.001) between 2011 and 2021 from 49.12% to 33.33%, while the proportion high grade disease significantly increased (p<0.001) from 16.47% to 27.59%. The proportion of intermediate grade disease significantly increased (p<0.001) from 34.41% in 2011 to 39.08% in 2021. The mean maximum positive biopsy core percentage was lower in 2011 (48.00+.33%) versus 2021 (55.00+.29%) (p<0.001). A non-parametric independent samples Kruskal-Wallis test with Bonferroni post hoc comparisons indicated that the median PSA levels were similar during 2011-2012 (6.7 – 6.9 ng/ml) and were significantly lower (p<.05) than the median PSA values measured during 2020-2021 (8.5 – 9 ng/ml). Study limitations include uncertainty about the extent of adoption of USPSTF guidelines in the practices, possible inaccurate attribution of causality (versus imaging and biomarker effects). Its strengths include prospective acquisition of granular data and findings that align with studies showing increases in metastatic disease and PCa-specific mortality during this interval. CONCLUSIONS: We identified a temporal association between the USPSTF 2012 recommendation against screening and increasing volume and proportion of high-grade prostate cancer. This trend was not reversed following the 2018 ‘Grade C’ revision to the USPSTF guideline. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e1104 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Franklin Gaylis More articles by this author Edward Cohen More articles by this author Paul Dato More articles by this author Rose Prime More articles by this author Julie Cramer More articles by this author Katayune Golshan More articles by this author Sonia Romo More articles by this author Sepi Mahooti More articles by this author Michael Leapman More articles by this author Robert Topp More articles by this author William Catalona More articles by this author Expand All Advertisement PDF downloadLoading ...