AbstractPure titanium due to its high corrosion resistance, low stiffness and good mechanical properties is commonly used in medicine for orthopaedic applications. However, its material properties (especially in the case of $${\upalpha }$$ α -titanium) require a further enhancement to fulfil its role. The thermoplastic deformation in mid-temperature is proposed as a method for microstructure improvement. Titanium samples were compressed in different temperatures and strain rates to determine the best conditions for grain fragmentation—the main factor responsible for strength and hardness increase. The thermoplastic stress–strain curves were registered. Then microstructure observations and electron backscatter analysis were performed on the chosen samples. Finally, mechanical response of the previously deformed material was obtained in room temperature compression tests. A significant grain fragmentation was recorded for the material deformed in 400 $$^{\circ }\hbox {C}$$ ∘ C , at 0.1/s and 1/s strain rates. Desirable results were also noticed for the deformation performed at 500–600 $$^{\circ }\hbox {C}$$ ∘ C . However, high temperatures (700–800 $$^{\circ }\hbox {C}$$ ∘ C ) and strain rates (10/s) resulted in dynamic recrystallization, causing undesirable grain growth. An increase in hardness was observed in all cases, with higher values recorded in lower deformation temperatures. Room temperature compression tests revealed slight increase of ductility.