Increase In Distance Research Articles

Simulation Study of Crack Extension in Concrete Blast Walls Under Blast Impacts

To study the crack propagation law of concrete blast wall (CBW) under explosion impact, this paper uses ANSYS/LS-DYNA finite element software to numerically simulate the crack growth law under the influence of different explosion loads and explosion distances. The results show that: after the explosion, the change of composite velocity of each measuring point on the wall at a certain distance from the explosion point is mainly divided into three stages: explosive initiation stage, the composite velocity and acceleration of each measuring point are zero; In the accelerated crack growth stage, the acceleration of each measuring point reaches the peak value; At the stage of uniform crack growth, the crack will no longer accelerate its diffusion. When the explosion distance is fixed, the explosion load is positively correlated with the number of radial cracks; When the explosion load is small, there are only inconspicuous circumferential cracks in the center of the wall. When TNT equivalent is 15g, 25g, and 30g, CBW circumferential cracks increase and mainly concentrate in the center, and gradually expand outward to the boundary in the form of concentric circles. At the same time, when the explosion load is constant, the explosion distance is negatively related to the number of cracks, mainly radial cracks, while circumferential cracks are always distributed in the center of the wall. In the range of simulated explosion distance, the cracks only appear at the boundary and gradually change from square to round with the increase of explosion distance, and the crack area decreases. The research results can provide a theoretical basis for avoiding such accidents and a powerful reference for accident investigators to determine the location and intensity of explosion sources.

Failure evaluation mechanism of cement sheath sealing integrity under casing eccentricity during multistage fracturing

A microannulus (MA) is the primary reason for sustained casing pressure in multi-stage fractured-shale gas wells. However, the effect of the casing eccentricity on the long horizontal section has not been considered. In this study, a full-scale integrity tester for cement sheaths is adopted to measure the cumulative plastic deformation. Numerical models are applied to evaluate the development of the cumulative plastic deformation and quantify the MA width considering casing centralization and eccentricity in the context of multiple loading and unloading cycles. Subsequently, the influences of the eccentricity distance and angle, cement-sheath mechanical variables, and different well depths on the cumulative sheath plastic deformation and sheath MA development are explored. The research results demonstrate that casing eccentricity significantly increases the cumulative sheath plastic deformation compared with that of the casing-centered condition. Consequently, the risk of sealing integrity failure increases. The accumulated plastic deformation increases when the eccentricity distance increases. In contrast, the initial plastic deformation increases as the eccentricity angle increases. However, the cumulative plastic deformation decreases after a specific loading and unloading cycle count. Affected by the coupled influence of the internal casing pressure and fracturing stages, the width of the MA in the horizontal section increased from the toe to the heel, and the casing eccentricity significantly increased the MA width at each stage, thus increasing the risk of gas channeling. Finally, an engineering case is considered to study the influence of casing eccentricity. The results show that cement slurries that form low and high elastic moduli can be applied to form a cement sheath when the fracturing stage is lower or higher than a specific value, respectively. The results of this study offer theoretical references and engineering support for the integrity control of cement sheath sealing.

Experimental Investigations on the Cavitation Bubble Dynamics near the Boundary of a Narrow Gap

Cavitation bubbles near narrow gaps widely exist within microfluidic control devices. In the present paper, a laser-induced cavitation bubble is arranged in a narrow gap composed of two parallel plates. The inception position of the bubble is set to be at the same distance from the two plates so that the dynamic behaviors of the bubble are symmetrical. The collapse and rebound dynamics of the bubble near the boundary of a narrow gap are investigated through high-speed photography. The bubble behaviors (e.g., shape deformation, translational movement, and jet characteristics) are analyzed while considering the influence of the dimensionless distance between the bubble and the boundary and the dimensionless gap width. The principal findings include the following: (1) When the dimensionless distance is small, a violent jet towards the gap is generated during the bubble collapse stage, along with a weak counter-jet towards the boundary appearing during the rebound stage. (2) As the dimensionless distance increases, the translational distance of the bubble during the collapse stage initially decreases, then increases, and finally decreases to zero. (3) Within the parameter range considered in this paper, the dimensionless width mainly affects the expansion degree and movement direction of the bubble cloud during its rebound and subsequent stages. The above research findings can provide experimental support for bubble-driven flow control, pumping, and liquid mixing in microfluidic channels.

Evaluation of the Effect of Halo Gravity Traction on Lung Volume in Advanced and Severe Kyphoscoliosis Patients in Chest Radiography

Aim: To evaluate the effect of preoperative halo gravity traction on lung volume in patients with advanced and rigid kyphoscoliosis using planimetric measurements from chest radiography. Method: Ten patients with a mean age of 20.5±0.9 with a diagnosis of severe and severe kyphoscoliosis who underwent halo gravity traction between 2019 and 2021 were included in our study. Direct chest radiographs taken before and after traction were analyzed retrospectively. In order to evaluate the effectiveness of traction, planimetric evaluations were made on radiographs. Results: In the evaluation of radiological parameters, mean thoracic coronal cobb angle, lumbar cobb angle, thoracic kyphosis angle, lumbar lordosis angle, C1-S1 distance and lung volume before and after the procedure were 96.670°±8.4535°, 88,090°±4.5989°, 37.020°±11.5893°, 38.540°±11.1269°, 73.150°±7.0412°, 65.590°±7.3927°, 59.100°±9.5467°, 55.100°±9.0238°, It was 371.590mm± 64.2410mm, 408.330 mm±80.8229 mm and 967.730 mm3±318.404 mm3, 1155.180mm3±332.868 mm3. The decrease in thoracic kyphosis, lumbar lordosis, thoracic cobb and lumbar cobb angles and the increase in lung volume and distance between C1-S1 were statistically significant (p<0.05). Conclusion: Traction application is a safe method for deformities. It is effective in correcting sagittal and coronal curvatures. It is a method that is effective in pulmonary functions as well as increasing the lung volume radiologically.

Trend change analysis in the assessment of body balance during posture adjustment in reaction to anterior-posterior ground perturbation.

Postural adjustments (PA) occur to counteract predictable perturbations and can be impaired as a result of musculoskeletal and neurological dysfunctions. The most common way to detect PA is through electromyography measurements or center of pressure (COP) position measurements, where analysis in time domain and frequency domain are the most common. Aim of the research was to determine whether a new method of analyzing stabilographic measurements-the COP trend change analysis (TCI) of temporary posture corrections- can expand understanding of changes in balance strategy connected with PA. The study group involved 38 individuals (27women, 11men) aged 23±2.6 years. Measurements were performed using a stabilographic platform placed on a perturbation platform. The tests involved three measurements with forward and backward momentary movements of the platform. Participants were tested in three conditions-knowing the nature, time and direction of perturbation (Tr3), knowing only the nature of perturbation (Tr2) and without any information about the perturbation (Tr1). Statistically significant differences were revealed in the last second of Tr3 for the mean velocity of COP (p<0.05) and for two TCI parameters-TCI_dV (p<0.05) and TCI_dS (p<0.01). The increase in TCI_dV was related to the increase in the mean distance between trend changes (TCI_dS) and constant value of the mean time between trend changes (TCI_dT). The increase of the mean value of TCI_dS was the result of smaller number of posture corrections with the distance 0-2 mm and lager number with the distance 4-6 mm. Obtained results proved that the TCI analysis is a method enabling an extended analysis of PA, indicating the nature of changes occurring in posture corrections-longer momentary jumps of COP-related to a change in the strategy of maintaining balance before a known disorder, which has not been analyzed in this type of research so far.

Lower Limits of Petrophysical Properties Allowing Natural Gas Accumulation in Marine Sandstones: An Example from the Qiongdongnan Basin, Northern South China Sea

The lower limits of petrophysical properties for an effective reservoir are among the key parameters for assessing hydrocarbon reserves and are therefore directly related to hydrocarbon exploration and development strategies. However, the lower limits for marine sandstone gas reservoirs are still not clear and the impact factors also remain to be discussed. This study analysed the lower petrophysical property limits of an effective sandstone reservoir in the Qiongdongnan Basin using porosity, permeability and gas testing. The results showed that the lower porosity and permeability limits of effective reservoirs developed in the deltas are 8.9% and 1.2 × 10−3 μm2, respectively, and 11.3% and 4.0 × 10−3 μm2 in the submarine canyons and fans, respectively. Sedimentary facies, sediment transport distance, grain size and burial depth of sandstone significantly influence the lower physical property limits. The lower porosity and permeability limits increase with the increase in sediment transport distance as well as the decrease in sandstone grain size and burial depth. Sediment sources and sedimentary facies determine whether sandstone can become an effective reservoir in the Qiongdongnan Basin. Specifically, the sediment source dramatically influences the petrophysical properties of sandstone. The sandstone sourced from the Red River has higher porosity and permeability, followed by the sandstone sourced from the Hainan Uplift, and the sandstone sourced from the palaeo-uplift within the basin has the lowest porosity and permeability. The feldspar dissolution by CO2 and organic acid is the primary formation mechanism of the effective reservoir in the Lingshui Formation, whereas the dissolution of glauconite is more common in the sandstone reservoirs of the Sanya and Meishan formations.

Geographical distance, investment strategies and performance of venture capital: evidence from Chinese enterprises

ABSTRACT A growing body of evidence suggests that geographical distance plays an important role for venture capital (VC) investment. This study explores whether and how the geographical distance between the lead VC firms (VCFs) and the invested entrepreneurial firms (IEFs) influences the investment strategies of VCFs and their performance. The results show: (1) The geographical distance has a significant positive effect on the performance of VC investments. (2) As distance increases, lead VCFs will tend to be conservative on investments by improving project screening criteria and adopting syndication strategies and multiple-rounds of staged financing, which can dramatically improve the successful exit from the invested projects. This study has useful theory and policy implications for VCFs, entrepreneurial firms and local governments.

Long-term effects of enhanced external counterpulsation in the management of patients with coronary artery disease complicated by heart failure: data from the EXCEL study

Aim. To study the long-term effect of complex therapy with enhanced external counterpulsation (EECP) on exercise tolerance, quality of life, and systolic cardiac function in patients with stable coronary artery disease (CAD) complicated by heart failure (HF).Material and methods. Open randomized study EXCEL (NCT05913778) included 118 patients with verified stable CAD complicated by NYHA class II-III HF with reduced or mildly reduced ejection fraction (EF). The patients were randomized into group 1 (n=59) who received optimal therapy and EECP (35 hours, 2 courses per year) or group 2 (n=59), who recived optimal drug therapy and EECP (35 hours, 1 course per year). All patients underwent a 6-minute walk test (6MWT) at baseline, 12, 24 and 36 months, the assessment of clinical status, Minnesota Living with Heart Failure Questionnaire (MLHFQ), N-terminal pro-brain natriuretic peptide (NTproBNP) levels, LVEF and clinical outcomes.Results. In both groups, we revealed an improvement of HF class (average HF class after 36 months decreased in the 1st group from 2,40 to 1,86 (p&lt;0,001), and in the 2nd group from 2,37 to 2,17 (p&lt;0,001)) and clinical status of patients. A significant increase in 6MWT distance after 24 months was revealed in both groups — in group 1 by 59,4% (95% confidence interval (CI) 36,9-76,8), and in group 2 — by 34,3% (95% CI 26,7-40,1). The proportions of patients with an increase in 6MWD distance &gt;20% in groups 1 and 2 after 36 months were 100% (n=59) and 79,7% (n=47) (p&lt;0,001), respectively. There was a significant decrease in the MLHFQ score after 36 months in the 1st group by 43,8% (95% CI 40,5-47,1), and in the 2nd group by 30,0% (95% CI 26,4-33,6), NT-proBNP decrease, as well as an increase in LVEF. There were no deaths in group 1, while in group 2, mortality was 3,4%.Conclusion. A 36-month follow-up of patients with CAD complicated by HF receiving EECP revealed stable improvements in exercise tolerance, quality of life, systolic cardiac function, more pronounced in the group with 2 courses of EECP per year, as well as a decrease in the incidence of adverse outcomes.

Exploring the Micropore Functional Mechanism of N2O Adsorption by the Eucalyptus Bark-based Porous Carbon.

Nitrous oxide (N2O), recognized as a significant greenhouse gas, has received insufficient research attention in the past. In view of their low energy consumption and cost-effectiveness, the application of porous materials in adsorption is increasingly regarded as a potent strategy to reduce N2O pollution. In this study, a series of microporous porous carbons with a preeminent specific surface area (244.54-2018.08 m2 g-1), which are derived from the fast-growing eucalyptus bark, were synthesized by KOH activation at high temperatures. The obtained materials demonstrated a relatively fine N2O capture capability (0.19-0.68 mmol g-1) at normal temperature and pressure. More importantly, the optimal pore size affecting N2O adsorption (0.8 and 1.0 nm) has been detected, which is a meaningful view that has never been put forward in previous studies. The rationality of the N2O adsorption mechanism was also validated by combining the experimental analysis and Grand Canonical Monte Carlo (GCMC) simulation. The calculated results showed that 0.8 and 1.0 nm of the porous carbon were the preferred pore sizes for N2O adsorption, and the interaction force between N2O and the pore wall decreased with the increase of distance. This study provides a significant theoretical basis for the preparation of biomass porous carbon with excellent N2O adsorption performance and practical adsorption application.

Wake measurement of wind turbine under yawed conditions using UAV anemometry system

This study employs a UAV anemometry system to assess the wind field around a yawed wind turbine, particularly focusing on its wake during operational conditions. The research findings reveal that the evolution of wind turbine wakes follows distinct patterns at various downstream distances. Turbulence intensity notably amplifies within regions characterized by significant fluctuations in mean wind speed. Specifically, in yawed conditions, the areas with the highest turbulence generated by the rotor coincide with zones exhibiting pronounced variations in mean wind speed. The heightened turbulence within the wake region to some extent constrains the safety and economic viability of wind farms. Turbulence intensity increases significantly in the region where the average wind speed changes greatly, that is, under the yaw state of the wind turbine, this region is characterized with the strongest turbulence generated by the rotor. The UAV anemometry system's wind speed assessment closely matches predictions from the Y-3DJGF model, accounting for wake experience coefficient adjustments. Furthermore, in yaw conditions, the wind turbine's wake trajectory exhibits some deviation from the incident flow's direction, with an initial increase in slope followed by gradual stabilization. As the downstream distance increases, the trajectory will eventually establish a consistent trend with the incident flow. The cost-effective and flexible UAV anemometry system enhances wind field measurements, offering an innovative approach for wind energy sector research and engineering.

How the Listener’s Attention Dynamically Switches Between Different Speakers During a Natural Conversation

The neural mechanisms underpinning the dynamic switching of a listener’s attention between speakers are not well understood. Here we addressed this issue in a natural conversation involving 21 triadic adult groups. Results showed that when the listener’s attention dynamically switched between speakers, neural synchronization with the to-be-attended speaker was significantly enhanced, whereas that with the to-be-ignored speaker was significantly suppressed. Along with attention switching, semantic distances between sentences significantly increased in the to-be-ignored speech. Moreover, neural synchronization negatively correlated with the increase in semantic distance but not with acoustic change of the to-be-ignored speech. However, no difference in neural synchronization was found between the listener and the two speakers during the phase of sustained attention. These findings support the attenuation model of attention, indicating that both speech signals are processed beyond the basic physical level. Additionally, shifting attention imposes a cognitive burden, as demonstrated by the opposite fluctuations of interpersonal neural synchronization.

Iota‐carrageenan (𝑖C) hydrogel oscillations under constant electric field and stability diagrams

AbstractSoft actuators belong to a type of actuators made of soft materials which are capable of converting applied energy to mechanical motion. They have been utilized in several fields due to their flexibility, low weight, inexpensiveness and simple fabrication. In this work, iota‐carrageenan (𝑖C) was chosen as the starting material for a hydrogel‐based actuator. The 𝑖C hydrogels were fabricated via a simple solvent‐casting technique at various concentrations: 2.4% (v/v), 2.8% (v/v) and 3.2% (v/v). All 𝑖C hydrogels were characterized for their chemical, thermal, rheological and morphological properties as well as the actuation performances under applied electric field. The 𝑖C hydrogels showed monotonic increases in the static bending distance and dielectrophoretic force with increasing electric field strength. Above the critical electrical field strengths, the ribbon‐like 𝑖C hydrogels oscillated back and forth due to the competition between the dielectrophoresis force, the resisting elastic force, the weight and the inertia force. Stability diagrams were constructed for the first time separating static bending from oscillation behavior under constant applied electric fields. © 2024 Society of Chemical Industry.

Insights into the action of phylogenetically diverse microbial expansins on the structure of cellulose microfibrils

BackgroundMicrobial expansins (EXLXs) are non-lytic proteins homologous to plant expansins involved in plant cell wall formation. Due to their non-lytic cell wall loosening properties and potential to disaggregate cellulosic structures, there is considerable interest in exploring the ability of microbial expansins (EXLX) to assist the processing of cellulosic biomass for broader biotechnological applications. Herein, EXLXs with different modular structure and from diverse phylogenetic origin were compared in terms of ability to bind cellulosic, xylosic, and chitinous substrates, to structurally modify cellulosic fibrils, and to boost enzymatic deconstruction of hardwood pulp.ResultsFive heterogeneously produced EXLXs (Clavibacter michiganensis; CmiEXLX2, Dickeya aquatica; DaqEXLX1, Xanthomonas sacchari; XsaEXLX1, Nothophytophthora sp.; NspEXLX1 and Phytophthora cactorum; PcaEXLX1) were shown to bind xylan and hardwood pulp at pH 5.5 and CmiEXLX2 (harboring a family-2 carbohydrate-binding module) also bound well to crystalline cellulose. Small-angle X-ray scattering revealed a 20–25% increase in interfibrillar distance between neighboring cellulose microfibrils following treatment with CmiEXLX2, DaqEXLX1, or NspEXLX1. Correspondingly, combining xylanase with CmiEXLX2 and DaqEXLX1 increased product yield from hardwood pulp by ~ 25%, while supplementing the TrAA9A LPMO from Trichoderma reesei with CmiEXLX2, DaqEXLX1, and NspEXLX1 increased total product yield by over 35%.ConclusionThis direct comparison of diverse EXLXs revealed consistent impacts on interfibrillar spacing of cellulose microfibers and performance of carbohydrate-active enzymes predicted to act on fiber surfaces. These findings uncover new possibilities to employ EXLXs in the creation of value-added materials from cellulosic biomass.

The impact of high-speed railway construction on regional economic development in Hubei Province

Based on the panel data of 16 cities in Hubei Province from 2009 to 2019 (excluding the data during Covid-19 pandemic period), we construct multi-temporal difference-in-differences model (DID) and Spatial Durbin model (SDM) to explore the impact of the High-speed Railway (HSR) construction on the regional economic development in terms of direct economic effect, indirect economic effect and spatial spillover effect. The main conclusions of this paper are as follows: firstly, HSR construction promotes the economic development of cities in Hubei Province in a long time and in a large spatial scope. And the impacts on the economic development are significantly heterogeneous among different types of cities. Also, HSR construction has widened the economic development gap among cities to some extent. Secondly, the upgrading of an industrial structure and the improvement of urbanization level both play mediating roles in the economic impact of HSR construction. Thirdly, the HSR construction has significant spatial spillover effect on economic development, but the spillover effect becomes insignificant with the increase of distance.

Effect of Entrainment on the Liquid Film Behavior in Pipe Elbows

Multiphase flow entrainment in natural gas engineering significantly influences the safety and efficiency of oil companies since it affects both the flow and the heat transfer process, but its mechanisms are not fully understood. Additionally, current computational fluid dynamics (CFD) methodologies seldom consider entrainment behavioral changes in pipe elbows. In this article, a verified CFD method is used to study the entrainment behavior, mechanism, and changes in an elbow. The results show that droplet diameter in a developed annular flow follows a negative skewness distribution; as the radial distance (from the wall) increases, the fluctuation in the droplets becomes stronger, and the velocity difference between the gas and the droplets increases linearly. Turbulence bursts and vortices sucking near the wall jointly contribute to droplet entrainment. As the annular flow enters the elbow, the secondary flow promotes the film expansion to the upper and lower parts of the pipe. Droplets re-occur near the elbow exit intrados, and their size is much smaller than those in the upstream pipe. Vortices sucking under low gas velocity play an important role in this process. These findings provide guidelines for safety and flow assurance issues in natural gas production and transportation and bridge the gap between multiphase flow theory and natural gas engineering.

Multi-Temporal Analysis of the Impact of Summer Forest Dynamics on Urban Heat Island Effect in Yan’an City

In this study, MODIS land products and China land cover datasets were used to extract normalized difference vegetation index, land surface temperature, and vegetation cover type in Yan’an City during the summers of 2017–2022. On this basis, analysis of spatial change and correlation were carried out as a way to study the mitigation effect on urban heat islands in Yan’an City with forest. The study showed that: (1) The coverage of normalized difference vegetation index over 0.4 in summer in Yan’an City increased from 59.38% to 69.12%, and the vegetation showed good growth conditions. It has a spatial distribution pattern of more in the south and less in the north. (2) The proportion of the urban heat island in Yan’an City increased from 15.51% to 16.86%. Urban heat island intensity fluctuated year by year, with the maximum urban heat island intensity of 6.26 °C appearing in 2019. It has a spatial distribution pattern of less in the south and less in the north. The transition rate of temperature field grade from low to high is 73.32%, and the transition rate to low is only 0.31%. (3) There is a negative correlation between land surface temperature and normalized difference vegetation index in Yan’an City. Vegetation has a mitigating effect on the UHI and the best cooling effect among the vegetation is shown by forest. The cooling effect of forest in Yan’an City is attenuated by an increase in distance, and the effective range is greater than 1000 m. In this study, the regulation effect of forest on the urban heat island was obtained by digging deeper into the intrinsic connection between spatial change in vegetation cover and land surface temperature change in Yan’an City. It provides an important reference for the formulation of meteorological protection policy as well as the promotion of sustainable development of the urban ecological environment and is of guiding significance for future urban planning and ecological construction.

Does ecological network affect the construction land spatial development intensity? -An empirical study based on the main urban area of Jinan, China

The ecological network as the cornerstone of urban ecological security protection, understanding the interaction between ecological network and construction land spatial development intensity (CLSDI), which is crucial for guiding the orderly utilization of territorial space and promoting regional sustainable development. However, the information on the complex spatial and temporal interactions between ecological networks and CLSDI has not yet been adequately studied. This study takes the main urban area of Jinan City as an example, and explores the spatial and temporal coupling relationship and change rule of ecological network and CLSDI during 2006–2018 through spatial multiple buffer analysis tools, and proposes the optimization path of construction land spatial development under the perspective of ecological network. The results showed that: from 2006 to 2018, there is a significant spatial effect between CLSDI and ecological network elements; within the buffer zone of 300–3000 m for ecological sources and nodes, CLSDI rises with the increase of buffer zone distance; while the ecological corridor exhibits decreased CLSDI within the 500-m buffer zone, the 500–3000-m CLSDI tends to increase. Based on the empirical analysis, the optimization path of construction land spatial development is proposed from three aspects: ecological source, corridor and node. The 300 m control range of the ecological source is designated as a “specific protection zone”, and strictly control the increase of the CLSDI within the zone; the ecological corridor is set up with differential protection and utilization zoning, and CLSDI and activity types are controlled in a hierarchical and classified manner; the CLDSI around the ecological nodes is strictly controlled in order to prevent encroachment of construction activities on the nodes. This study provides a reference value for constructing a territorial spatial pattern coordinated with ecological protection and development of construction.

Conjugation of sulpiride with a cell penetrating peptide to augment the antidepressant efficacy and reduce serum prolactin levels

Depression ranks as the fourth most prevalent global disease, with suicide incidents occurring at a younger age. Sulpiride (SUL), an atypical antidepressant drug acting as a dopamine D2 receptor antagonist and possessing anti-inflammatory properties, exhibits limited ability to penetrate the blood brain barrier (BBB). This weak penetration hampers its inhibitory effect on prolactin release in the pituitary gland, consequently leading to hyperprolactinemia. In order to enhance the central nervous system efficacy of sulpiride and reduce serum prolactin levels, we covalently linked sulpiride to VPALR derived from the nuclear DNA repair protein ku70. In vivo study on depressive mice using intraperitoneal injection of VPALR-SUL demonstrated a significant increase in struggle time and total distance compared to those treated with only sulpiride while also reducing serum prolactin concentration. The pharmacokinetic study results showed that VPALR-SUL prolonged half-life and increased bioavailability. In conclusion, VPALR-SUL exhibited potential for enhancing sulpiride transport across the BBB, augmenting its antidepressant effects, and reducing serum prolactin levels. This study laid a foundation for improving sulpiride delivery and developing novel antidepressants.

Effects of Limosilactobacillus reuteri ID-D01 Probiotic Supplementation on Exercise Performance and Gut Microbiota in Sprague-Dawley Rats.

The gut microbiota composition in animals and humans has recently been found to be influenced by exercise. Although Limosilactobacillus reuteri strains have notable probiotic properties that promote human health, understanding of its effects in combination with exercise and physical activity is limited. Therefore, this study examined the effects of L. reuteri ID-D01, a human-derived probiotic, on exercise performance and fatigue in Sprague-Dawley rats. Organ weight, maximal running distance, serum biochemistry, muscle performance, microbial community composition, and short-chain fatty acid (SCFA) levels were assessed. Results indicated that ID-D01 supplementation significantly improved endurance performance. Rats in the probiotic group demonstrated a significant increase in maximal running distance compared with that in the control group (p < 0.05). Additionally, levels of fatigue markers, such as lactate and creatine phosphokinase, were significantly reduced in the ID-D01-administered groups, suggesting its potential to alleviate exercise-induced fatigue. Microbiome analysis revealed a distinct shift in gut microbiota composition in response to ID-D01 administration. The group that received ID-D01 probiotics exhibited a significant increase in the abundance of SCFA-producing bacteria, particularly Akkermansia spp., compared with that in the control groups. Furthermore, they showed elevated production of SCFAs, such as acetate and butyrate. In conclusion, this study demonstrated that ID-D01 can enhance exercise performance and reduce fatigue. Herein, we highlighted that human-derived probiotics could improve physical performance, as observed by changes in gut microbiota composition and SCFA production.

Effect of TiO2 Nanofillers on the Mechanical and Abrasive Wear Properties of Epoxy Reinforced with Carbon Fabric Hybrid Composites.

Recent studies show that nanofillers greatly contribute to the increase in the mechanical and abrasive behaviors of the polymer composite. In the current study, epoxy composites were made by hand lay-up with the reinforcement of carbon fabric and titanium dioxide (TiO2) nanoparticles as secondary reinforcement in weight percentages of 0.5, 1.0, and 2.0. Hardness, tensile, and abrasive wear tests have been carried out for the fabricated composites. The obtained results confirm that as the percentage of filler addition increases, hardness of the carbon epoxy (CE) composite increases, and significant enhancement of 10.25% hardness is confirmed in 2 wt % nano TiO2-added CE composite. The CE composite filled with 2 wt % of TiO2 nanofiller shows 15.77 and 9.15% improvement of tensile strength and modulus, respectively, compared to unfilled CE composites. The abrasive wear volume exhibits a nearly linear increasing trend as the abrading distance increases. In addition, it is discovered that the abrasive wear volume is greater for higher applied loads. The inclusion of nano TiO2 reduced the wear loss in the CE composite for all abrading distances, regardless of the load, low or high. The scanning electron microscopy analysis of worn surfaces was carried out to analyze the contribution of the filler to improve the wear resistance.