Objective To investigate different fentanyl medication methods on propofol intravenous anesthesia painless abortion, to provide a reference for clinical treatment. Methods 120 patients undergoing painless abortion were selected, according to the random number table they were divided into Ciliao point group, subcutaneous group, intravenous injection group, 40 cases in each group.Intravenous injection group used intravenous anesthetic propofol, Ciliao point group used Ciliao hole injection anesthesia, subcutaneous group used fentanyl anesthesia subcutaneous injection.The anesthesia, analgesia and other clinical indicators of complications were compared among the three groups. Results The anesthesia excellent and good rate of Ciliao point group was 97.50%, which was higher than the subcutaneous group, intravenous injection group, the differences were significant(χ2=4.132, 3.894, all P 0.05).Postoperative 4h, 8h, VAS scores of Ciliao point group were (2.32±0.56)points, (1.13±0.23)points, which were lower than those in the subcutaneous group, intravenous injection group, the differences were significant (t=8.656, 8.843, 6.587, 6.335, all P<0.05).The propofol use times, the amount of Ciliao point group were (1.14±0.14), (116.37±14.35)mg respectively, which were less than those in the subcutaneous group, intravenous injection group, the differences were significant (t=6.645, 5.587, 6.132, 5.854, all P<0.05).The incidence rate of adverse reaction of Ciliao point group was 2.50%, which of the subcutaneous group was 20.00%, which of the intravenous group was 25.00%, the differences were statistically significant (χ2=6.596, 7.454, all P<0.05). Conclusion Fentanyl uased at Ciliao point can enhance the clinical effect of anesthesia with less postoperative pain and reduce incidence of adverse reactions, it is worthy of clinical application. Key words: Fentanyl; Propofol; Anesthesia