The clinical efficacy of multiple antibiotic in treating tubal infertility infected by ureaplasma urealyticum and chlamydia trachomatis

Abstract

Objective To observe the clinical efficacy and adverse reactions of antibiotic in treating tubal infertility,which provide support in the clinical applicaiton.Methods 68 cases of tubal infertility caused by Uu and Ct were randomly divided into the control group and observation group according to random digital table.There were 34 cases in each group.The control group was taken hydrotubation.The observation group was given doxycycline 0.1g orally twice a day for 7 days and azithromycin according the results of drug sensitive test on the basis of the control group.In two groups mycoplasma and chlamydia positive rate,pregnancy,clinical efficacy and adverse reactions were compared.Results After 7 days of treatment,Uu positive rate in the observation group was 14.7%.Ct positive rate was 17.6%.Uu positive rate in the control group was 58.8%.Ct positive rate was 64.7%;Uu positive rate and Ct the positive rate in both group showed significant difference（χ^2 =14.23,15.54,all P〈0.05）.The total effective rate in the observation group was 85.3%.In the control group,the total effective rate was 58.8%.The rate in the two groups showed significant difference（χ^2 =5.91,P〈0.05）.Adverse reactions occurring rate in the control group was 17.6%,and the incidence rate of adverse reactions in the observation group was 26.4%.The rate of adverse reactions had no significant difference between the two groups（χ^2 =0.77,P 〉0.05）.Conclusion Antibiotic in treating patients with tubal infertility showed significant clinical efficacy and little side effects.We could draw a conclusion that this program was worthy of further clinical application and study. Key words: Infertility,female; Mycoplasma; Positive rate; Pregnancy