You have accessJournal of UrologyKidney Cancer: Evaluation & Staging (II)1 Apr 2013732 VISCERAL OBESITY AND RISK OF HIGH-GRADE DISEASE IN CLINICAL T1A RENAL CELL CARCINOMA Yao Zhu, Hong-Kai Wang, and Ding-Wei Ye Yao ZhuYao Zhu Shanghai, China, People's Republic of More articles by this author , Hong-Kai WangHong-Kai Wang Shanghai, China, People's Republic of More articles by this author , and Ding-Wei YeDing-Wei Ye Shanghai, China, People's Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.295AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Accurate assessment of disease characteristics is a prerequisite for treatment decision making in small renal masses. The aim of the current study was to evaluate the association between visceral obesity and Fuhrman grade (FG) in patients with cT1a renal cell carcinoma (RCC). METHODS We retrospectively collected data on 186 patients with surgically treated cT1a RCC. Single-slice computed tomography images were used to measure the area of visceral and subcutaneous adipose tissue. Visceral obesity was calculated as the proportion of visceral adipose tissue to overall adipose tissue (VAT%). Other analyzed factors included clinical characteristics (age, gender, body mass index and tumor size) and anatomic features of the tumor defined by RENAL nephrometry score. The association between predictors and high-grade disease (FG III or IV) were assessed using logistic regression analyses. RESULTS Fourty-seven (25.3%) tumors were classified as high-grade. VAT% was higher in male participants, but didn't correlate with body mass index, age or tumor size. In univariate analyses, VAT% and tumor size were significantly associated with higher FG. Multivariate analysis showed that VAT% (odds ratio=1.06, p=0.0018) and tumor size (odds ratio=1.91, p=0.047) were independent predictors of high-grade cancer. Addition of VAT% to a model including clinical characteristics and anatomic features of the tumor remarkably improved its discriminatory ability (p=0.0010). CONCLUSIONS Increased visceral obesity was found to be strongly associated with higher FG in patients with cT1a RCC. Further studies are needed to confirm these findings and discover the underlying biological mechanism. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e301 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yao Zhu Shanghai, China, People's Republic of More articles by this author Hong-Kai Wang Shanghai, China, People's Republic of More articles by this author Ding-Wei Ye Shanghai, China, People's Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
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