Identification Subtest Research Articles

Factors Associated With Persisting Olfactory Dysfunction After COVID‐19

ABSTRACTBackgroundFortunately, the majority of COVID‐19 patients recover from olfactory dysfunction (OD) within the first couple of weeks. However, from approximately 5% up to 20% continue to suffer from OD even more than 1 year after the onset. Nonetheless, factors associated with long‐lasting OD are hardly known. The aim of this study was to identify favourable and disadvantageous markers of persisting OD in COVID‐19 patients.MethodologySixty‐six patients (46 female; mean age: 39.9 years) that suffer from OD longer than 6 months due to laboratory‐confirmed SARS‐CoV‐2 infection have participated in this longitudinal study. Participants completed comprehensive psychophysical chemosensory tests (i.e., Sniffin' Sticks = TDI) and questionnaires twice at our department—on average 219 ± 80 (T‐1) and 489 ± 89 (T‐2) days after the onset of symptoms, respectively. Olfactory recovery rates were associated with demographic factors and questionnaires using linear regression analysis.ResultsPatients below 40 years of age improved better (TDI: 4.1 ± 4.3 vs. 0.7 ± 5.8; p = 0.008) and achieved statistically significant higher scores (TDI: 31.5 ± 4.0 vs. 27.3 ± 6.7; p = 0.033) regarding psychophysical chemosensory tests. Furthermore, linear regression analysis revealed that parosmia was associated with worse orthonasal smell function (T‐1: β = −0.346, p = 0.004; T‐2: β = −0.384, p = 0.001), especially concerning identification subtest (T‐1: β = −0.395, p = 0.001; T‐2: β = −0.398, p < 0.001). Moreover, increasing parosmia between T‐1and T‐2 led to worse orthonasal olfactory function (β = −0.294, p = 0.016).ConclusionsOlder age and parosmia seem to be unfavourable factors of persisting OD in COVID‐19 patients.

The first quick olfactory test specific for Alzheimer's disease and French culture.

Olfactory identification disorder is considered a promising early biomarker of Alzheimer's disease (AD). The QUICK TODA2 can be used as a short olfactory screening tool specific for French AD patients. The selection of AD specific odorants and the design of this screening were the main objectives of this twofold study. In study 1, the TODA2 olfactory test was administered to 43 mild-AD patients and 45 healthy controls (HC) in five memory centres in France. The selection of AD specific odorants was based on the differences in the proportion of correct answers and in the threshold means between AD and HC groups. In study 2, another set of 19 mild-AD patient were included at the memory centre of Nice Hospital. All participants completed the olfactory assessment pipeline including the QUICK TODA2, TODA2 and Sniffin' Sticks Identification sub-Test (SST-i). The individual scores of the three tests were correlated. In study 1, ten TODA2 odorants could significantly differentiate AD participants from controls. We selected the six most AD-sensitive items to design the QUICK TODA2. In study 2, we reported strong significant correlations between QUICK TODA2 and TODA2 (ρ(17) = 0.68, p = 0.001**), SST-i and QUICK TODA2 (ρ(17) = 0.65, p = 0.002**), SST-i and TODA2 (ρ(17) = 0.57, p = 0.01*). QUICK TODA2 is a 5-min non-invasive olfactory AD screening tool dedicated to French culture. Its results converge with those of longer, validated olfactory tests. It could be used as a quick screening tool in the general daily practice before an extensive assessment in memory centres.

The Human Nose as a Chemical Sensor in the Perception of Coffee Aroma: Individual Variability

The flavor of foods and beverages is generally composed of a mixture of volatile compounds, however not all the molecules that form an aroma are sensorially relevant. The odor-active compounds present in a mixture are different for each subject, both in quantitative and qualitative terms. This means that the ability of the human nose to act as a chemical sensor varies among individuals. In this study, we used the headspace of roasted coffee beans as a complex olfactory stimulus and, by means of the coupled Gas Chromatography-Olfactometry (GC-O) technique, the single components of coffee flavor were separated. Each subject, previously classified for his/her olfactory status (normosmic, hyposmic or anosmic) by means of the Sniffin’ Sticks battery (composed of Threshold, Discrimination and Identification subtests), had to identify and evaluate each smelled molecule. The results show that the individual ability to detect individual compounds during the GC-O experiments and the odor intensity reported during the sniffing of pen #10 (the pen of the identification test) containing coffee aroma were related to TDI olfactory status (based on the score obtained from the sum composed of Threshold, Discrimination and Identification scores). We also found that the number of total molecules and of molecules smelling of coffee is linearly related to the TDI olfactory score. Finally, the odor intensity reported when sniffing pen #10 containing coffee aroma is positively correlated with the number of molecules detected and the average intensity reported. In conclusion, our findings show that the human perception of both individual compounds and complex odors is strongly conditioned by the olfactory function of subjects.

Applicability of Sniffin' Sticks Identification Test as a Screening Tool for Olfactory Dysfunction in Northeast China.

BACKGROUND Because most case of smell loss are unrecognized, a valid and reliable screening test for olfactory function is needed. The Sniffin' Sticks test is one of the most widely used olfactory tests. As olfaction can be affected by environment and social background, we investigated the regional applicability of Sniffin' Sticks identification subtest as a screening tool. MATERIAL AND METHODS Normosmic volunteers were recruited between May 2021 and August 2021. We collected data on participants' age, sex, and educational level. The Self-Reported Mini-Olfactory Questionnaire and identification test of Sniffin' Sticks test battery were used to assess their olfactory function. RESULTS A total of 688 subjects (316 male, 371 female) volunteered for the screening test. The mean age of participants was 30±7.69 years (range, 15-63 years), and the average score of all subjects was 12.7±0.81 points. The 3 least recognized items among all 16 tests were lemon (correct identification rate 5.4%), clove (correct identification rate 1.5%), and apple (correct identification rate 0.7%). For Self-Reported Mini-Olfactory Questionnaire, 48 of the 687 subjects (7%) stated that they could not recognize the smell of freshly mowed grass. CONCLUSIONS We investigated the applicability of using Sniffin' Sticks Identification test and Self-MOQ as a screening tool for olfactory dysfunction in northeast China. Most of the subjects enrolled in this study failed to reach the normative standard for their age groups in the Sniffin' Sticks test. We suggest the deletion or replacement of items with extremely low correct identification rates and that physicians who use the Sniffin's Sticks test in clinical practice test the applicability in advance to avoid misdiagnosis.

Parosmia assessment with structured questions and its functional impact in patients with long-term COVID-19-related olfactory dysfunction.

Parosmia assessment with structured questions and its functional impact in patients with long-term COVID-19-related olfactory dysfunction.

Olfactory dysfunction and olfactory bulb volume in patients with deviated nasal septum

The purpose of the study is to demonstrate the possibility and information content of olfactory bulb volume measuring in healthy volunteers and patients with deviated nasal septum, as well as the relationship between the volume of the olfactory bulb and olfactory function. Material and methods. 28 men with deviated nasal septum aged 24 to 35 years (main group) and 21 clinically healthy volunteers, men aged 23 to 33 years (control group) were examined. All patients underwent checkup of the ENT organs and examinations on a 1.5 T MRI machine with 12-channel head coil. The sense of smell was examined using the extended Sniffin Sticks test (SST) (“Buerhard”, Hamburg, Germany) with the definition of 3 parameters: threshold, identification and discrimination. Results. In accordance with the design of the work, threshold, discrimination, identification subtests and MRI examination of the head were performed with the measurement of the olfactory bulb volume of patients in the main group and volunteers in the control group. In all participants in the control group was diagnosed normosmia in accordance with the TDI indicator, and in patients with deviated nasal septum – hyposmia. Olfactory function in patients deviated nasal septum was significantly lower on the narrower side as indicated for odor thresholds, odor recognition, and odor identification (P<0.01). It was found that olfactory bulb volumes are larger on the wider side than on the narrower side (P<0.01). Conclusion. Asymmetry in the size and volume of OB is observed only in patients with deviated nasal septum, it is absent in healthy volunteers. MRI visualization and morphometry of olfactory bulb, in addition to identifying of the nasal cavity, paranasal sinuses state, are informative in the process of preoperative examination of patients with deviated nasal septum. Olfactory bulb volume definition should be used for personalized diagnosis and quantitative assessment of olfactory dysfunction.

Postoperative Olfaction Alteration Following Laparoscopic Bariatric Surgery.

Introduction: Bariatric surgery is an effective method of treatment for morbid obesity that is known to change nutritional habits. Proper nutrition has an impact on postoperative recovery and outcomes. Diet preferences depend on flavour and olfaction stimuli. Some studies show long-term changes in the sense of smell after bariatric surgery, but little research has addressed olfactory function shortly after surgery. Observations of olfactory changes that occur immediately after bariatric surgery may lead to improvements in postoperative care. Aim: The aim of this study is to investigate the impact of bariatric surgery on olfactory changes in the short postoperative period. Material and methods: This is a prospective study of patients undergoing laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB) between April 2018 and December 2018. The control group consists of patients who underwent various non-oncological elective surgical procedures. Patients’ olfaction was tested qualitatively and quantitatively the day before and 24 h after surgery. Sniffin Sticks test consists of three subtests: odor threshold, discrimination, and identification. Results: The study enrolled 83 patients (LSG = 39; LRYGB = 14; control = 30). Mean scores in the threshold subtest differed significantly in the bariatric group, 9.3 ± 3.9 before the surgery and 8.2 ± 3.0 a day after the surgery (p = 0.032). There were no significant differences between scores from the discrimination subtest, identification subtest and the mean total scores in the bariatric group. There was no observed change in the intensity of the smell in the control group. Analyzing the results of patients undergoing LSG and LRYGB separately, we only showed significant differences in the case of LSG. Mean score from the 1st test (9.12 ± 3.97 vs. 7.75 ± 2.98; p = 0.0339) and mean total score (32.83 ± 5.45 vs. 30.67 ± 4.88; p = 0.0173) differ between repetitive measurements in LSG patients. Conclusions: Our study shows deterioration of odor threshold in the bariatric surgery group compared to the control group 24 h after surgery. However, this change occurred only in patients undergoing LSG.

Prevalence of language and pre‐literacy difficulties in an Australian cohort of 5‐year‐old children experiencing adversity

Early reading success is predicated on language and pre-literacy skills. Children who are behind their peers in language and pre-literacy development before formal schooling are less likely to be proficient beginner readers, and difficulties may persist throughout primary school and beyond. We know children experiencing adversity are at greater risk of early language and pre-literacy difficulties; we do not know the prevalence of these difficulties in an Australian adversity context. To investigate the prevalence and co-occurrence of language and pre-literacy difficulties in a cohort of Australian 5-year-old children experiencing social adversity. Data were drawn from a large Australian community-based trial of nurse home visiting (right@home), which aimed to support women experiencing social adversity from pregnancy until their child turned 2 years of age. Social adversity was determined by two of more risk factors: young pregnancy, not living with another adult, no support, poorer health, current smoker, long-term illness, anxious mood, not finishing high school, no household income and no previous employment. Children whose mothers were enrolled in the control group (receiving usual maternal and child healthcare) were included in the current study (n = 359). Language and pre-literacy skills were measured at age 5 using the Clinical Evaluation of Language Fundamental Preschool-Second Edition (CELF-P2) and the School Entry Alphabetic and Phonological Awareness Readiness Test (SEAPART). Language difficulties were defined as ≥ 1.25 standard deviations (SD) below the Australian normative mean on CELF-P2 Core Language scores. Pre-literacy difficulties were defined as children scoring in the Beginner (versus Developing or Competent) criterion-referenced level on the SEAPART First Sound Identification and/or Alphabet Letter Identification subtests. Co-occurrence of language and pre-literacy difficulties was also determined. At the 5-year follow-up, 201/359 (56%) children were assessed (mean age = 5.1 years, SD = 0.1). Mean Core Language score for this cohort (91.8, SD = 15.9) was 0.54 SD below the normative mean (100, SD = 15). The proportion of children presenting with language difficulties was 24.9%. Regarding pre-literacy skills, 43.8% of children were 'Beginner' for identifying first sounds and 58.6% for identifying alphabet letters/sounds. There was also considerable overlap whereby 76.7% of children with language difficulties also exhibited pre-literacy difficulties. This is the first empirical Australian-based study highlighting the high prevalence and co-occurrence of language and pre-literacy difficulties in preschool children experiencing social adversity. Clinicians should be aware of co-morbid language and pre-literacy difficulties in disadvantaged populations and consider both areas during assessment and intervention planning. What this paper adds What is already known on the subject The prevalence of language and literacy difficulties is substantially higher in cohorts experiencing social adversity when compared with more advantaged families. There is some evidence that adversity also contributes to pre-literacy difficulties, but less is known here. What this paper adds to existing knowledge This study presents new prevalence data showing high rates of language and pre-literacy difficulties for 5-year-old children experiencing adversity within an Australian context. It is the first to explore these skills in a large cohort of pre-schoolers recruited from community settings in Australia. What are the potential or actual clinical implications of this work? In this cohort experiencing adversity, most children who presented with language difficulties likewise exhibited pre-literacy difficulties. This concordance reflects how early oral language and pre-literacy skills develop together. Clinicians should assess both skills in preschool populations-especially those working with children experiencing adversity-to ensure all children have strong foundations to become proficient beginner readers.

Olfactory function and viral recovery in COVID-19.

BackgroundOlfactory and taste disorders were reported in up to 30%–80% of COVID‐19 patients. The purpose of our study was to objectively assess smell impairment in COVID‐19 patients and to correlate olfactory function with viral recovery.MethodsBetween 15 and 30 April 2020, hospitalized patients with confirmed SARS‐CoV‐2 infection underwent an objective assessment of olfactory function with the Smell Identification subtest of the Sniffin’ Sticks Test (SI‐SST). Association between viral recovery and SI‐SST performance was evaluated.Results51 patients were enrolled (49% males, mean age 66.2 ± 14.6 years). At the time of test administration, 45% were clinically recovered and 39% were virus‐free. Objective hyposmia/anosmia was found in 45% of the patients. Subjective olfactory disorders showed no association with the clinical or viral recovery status of the patients. On the contrary, none of the patients with anosmia and the 5% of hyposmic patients at test had viral recovery. The relative risk for hyposmic patients to be still positive at swab test was 10.323 (95% CI 1.483–71.869, p < .0001). Logistic regression analysis showed an independent and significant correlation between viral clearance and SI‐SST scores (OR = 2.242; 95% CI 1.322–3.802, p < .003). ROC curve analysis confirmed that a SI‐SST > 10.5 predicts viral clearance with 79% sensitivity and 87% specificity (AUC = 0.883).ConclusionHyposmia is part of COVID‐19 symptoms; however, only objectively assessed olfactory function is associated with viral recovery. SI‐SST is an easy and safe instrument, and further large multicentric studies should assess its value to predict infection and recovery.

Assessment of odor hedonic perception: the Sniffin\u2019 sticks parosmia test (SSParoT)

Qualitative olfactory dysfunction is characterized as distorted odor perception and can have a profound effect on quality of life of affected individuals. Parosmia and phantosmia represent the two main subgroups of qualitative impairment and are currently diagnosed based on patient history only. We have developed a test method which measures qualitative olfactory function based on the odors of the Sniffin’ Sticks Identification subtest. The newly developed test is called Sniffin’ Sticks Parosmia Test (SSParoT). SSParoT uses hedonic estimates of two oppositely valenced odors (pleasant and unpleasant) to assess hedonic range (HR) and hedonic direction (HD), which represent qualitative olfactory perception. HR is defined as the perceivable hedonic distance between two oppositely valenced odors, while HD serves as an indicator for overall hedonic perception of odors. This multicenter study enrolled a total of 162 normosmic subjects in four consecutive experiments. Cluster analysis was used to group odors from the 16-item Sniffin’ Sticks Identification test and 24-additional odors into clusters with distinct hedonic properties. Eleven odor pairs were found to be suitable for estimation of HR and HD. Analysis showed agreement between test–retest sessions for all odor pairs. SSparoT might emerge as a valuable tool to assess qualitative olfactory function in health and disease.

Olfactory and Gustatory Dysfunction in Patients With Autoimmune Encephalitis.

Objective: To test the hypothesis that olfactory (OF) and gustatory function (GF) is disturbed in patients with autoimmune encephalitides (AE).Methods: The orthonasal OF was tested in 32 patients with AE and 32 age- and sex-matched healthy controls (HC) with the standardized Threshold Discrimination Identification (TDI) score. This validated olfactory testing method yields individual scores for olfactory threshold (T), odor discrimination (D), and identification (I), along with a composite TDI score. The GF was determined by the Taste Strip Test (TST).Results: Overall, 24/32 (75%) of patients with AE, but none of 32 HC (p < 0.001) had olfactory dysfunction in TDI testing. The results of the threshold, discrimination and identification subtests were significantly reduced in patients with AE compared to HC (all p < 0.001). Assessed by TST, 5/19 (26.3%) of patients with AE, but none of 19 HC presented a significant limitation in GF (p < 0.001). The TDI score was correlated with the subjective estimation of the olfactory capacity on a visual analog scale (VAS; rs = 0.475, p = 0.008). Neither age, sex, modified Rankin Scale nor disease duration were associated with the composite TDI score.Conclusions: This is the first study investigating OF and GF in AE patients. According to unblinded assessment, patients with AE have a reduced olfactory and gustatory capacity compared to HC, suggesting that olfactory and gustatory dysfunction are hitherto unrecognized symptoms in AE. Further studies with larger number of AE patients would be of interest to verify our results.

Updated Sniffin\u2019 Sticks normative data based on an extended sample of 9139 subjects

PurposeTo provide up-to-date and detailed normative data based on a large-scale sample, increasing diagnostic validity by reference to narrow age groups as previous normative values were based upon smaller sample sizes—especially in the group of older subjects.MethodData were obtained from 9139 healthy subjects (4928 females aged 5–96 years and 4211 males aged 5–91 years). The standard “Sniffin’ Sticks” test was applied, comprising threshold (T), discrimination (D) and identification (I) subtests, and yielding a TDI sum score.ResultsHyposmia was established at a TDI score of less than 30.75. Age-related changes were found in each domain, most pronounced for thresholds. Individuals aged 20–30 years performed best, whereas children below the age of 10 and adults above the age of 71 scored only half as well. Sex-related differences were in favor of women.ConclusionsData provide guidance for assessing individual olfactory performance in relation to specific age groups. Significant gender and age effects were observed, with a most pronounced increase of olfactory test scores between age 5 through 20 years and a dramatic decrease at the age of 60 through 71 years.

Pleasantness of olfactory and trigeminal stimulants in different Italian regions

Although individuals categorize odors according to their pleasantness, experience may also influence odor perception-a phenomenon that partially explains why different populations perceive odors differently. Italy, which comprises 20 regions, is characterized by very different cultures. In the present study, we investigated for the first time how Italian regional differences can affect odor perception. 254 healthy volunteers coming from northern, central, southern Italy, and Sicily, one of the two major Italian islands, were recruited in Padua, Rome, Naples, and Syracuse, respectively. Olfactory function was tested with Sniffin' Sticks identification subtest. Subjects who had a score in the range within the mean identification value±1 SD, in accordance with the age classes identified in the literature, were asked to judge the odor pleasantness of 20 substances. The hedonic tone of the odorants was categorized as pleasant, neutral, unpleasant, and very unpleasant. Some odorants were appreciated more in northern Italy than in the other parts of the country, whereas others were appreciated more in the south and in Sicily than in the north. Unpleasant odorants were judged less unpleasant in central Italy. Some odorants such as strawberry and vanilla were perceived similarly in all the regional areas. Our study indicates that in Italy, hedonic perception of odorants differs probably in relation with genetic, cultural, and environmental factors. Further investigation is needed to delve deeper into the factors that influence the quality odor perception amongst humans.

The Effects of Rate on Single-Word Reading Assessment

The purpose of this study was to examine the effects of introducing rapid stimulus presentation durations while limiting response durations on the decoding profiles of college students with reading disorders. Eighteen college-aged individuals with typical reading abilities and 12 college-aged adults who exhibited reading difficulties participated. Participants completed a series of 4 experimental word-naming tasks. Two Word Attack subtests and 2 Word Identification subtests were administered while introducing more rapid stimulus presentation durations along with limited response times. Standard scores and response times were collected. Each individual's results were subjected to a subtyping procedure based on relative decoding strengths and weaknesses. More rapid conditions were associated with higher sight word decoding scores and lower phonological decoding scores. The results indicated that the subtyping patterns differed drastically depending on the presentation conditions. The authors hypothesize that the experimental conditions potentially yield a more reliable assessment of the 2 independent methods of single-word reading. The ability to subtype or categorize readers on the basis of their relative strengths and weaknesses is highly dependent on the reliability of the measures used to assess those relative strengths and weaknesses.

Olfactory dysfunction predicts early transition to a Lewy body disease in idiopathic RBD.

The aim of the present study was to determine the predictive value of olfactory dysfunction for the early development of a synuclein-mediated neurodegenerative disease in subjects with idiopathic REM sleep behavior disorder (iRBD) over an observational period of 5 years. Thirty-four patients with polysomnography-confirmed iRBD underwent olfactory testing using the entire Sniffin' Sticks test assessing odor identification, odor discrimination, and olfactory threshold. Patients with iRBD were prospectively followed up over a period of 4.9 ± 0.3 years (mean ± SD). The diagnosis of neurodegenerative diseases was based on current clinical diagnostic criteria. After 2.4 ± 1.7 years (mean ± SD), 9 patients (26.5%) with iRBD developed a Lewy body disease (6 Parkinson disease and 3 dementia with Lewy bodies). The entire Sniffin' Sticks test and the identification subtest had the same overall diagnostic accuracy of 82.4% (95% confidence interval: 66.1%-92.0%) in predicting conversion. The relative risk for a Lewy body disease in the lowest tertile of olfactory function was 7.3 (95% confidence interval: 1.8-29.6) compared with the top 2 tertiles. Assessment of olfactory function, particularly odor identification, may help to predict the development of a Lewy body disease in patients with iRBD over a relatively short time period and thus to identify patients suitable for future disease modification trials.

Influence of random answers on interpretation of the Sniffin’ Stick identification test in nasal polyposis

ObjectiveThe Sniffin’ Stick identification subtest, a validated tool to evaluate the sense of smell, is based on the recognition of 16 different odours. The patient is required to choose an answer from among four proposed odours, which introduces the possibility of obtaining random correct answers, especially in patients with an altered sense of smell.This study was designed to evaluate the influence of these random correct answers on interpretation of the simplified version of the Sniffin’ Stick test comprising threshold and identification tests in patients with nasal polyposis. Materials and methodsForty-two consecutive patients with nasal polyposis operated according to the nasalization procedure were enrolled in this prospective study. Odour threshold and identification tests of the Sniffin’ Stick kit were performed before and 1 month after surgery. Random correct answers on the identification (I) test (IH) were subtracted from the global number of correct answers (IG) to calculate a real identification score (IR), corresponding to the number of correct answers unrelated to chance. ResultsTwo groups of patients were identified: one group with no random correct answers (IH0) (n=17) and another group giving 1 to 7 random correct answers (IH1–7) (n=25). In the IH1–7 group, significantly more patients had an immeasurable threshold (T=0) than a measurable threshold (21 versus 4, P=0.0001). In this subgroup of 21 patients [IH1–7, T=0], the mean IR score was significantly lower than the mean IG score (P<0.0001) and 13 patients were classified as [IR=0; T=0]. Among these 13 patients classified as severe anosmia [IR=0; T=0] preoperatively, only 3 remained severe anosmic [IR=0; T=0] postoperatively. ConclusionRandom answers to the I identification test were more numerous among patients unable to detect n-Butanol on the T threshold test than among patients able to detect n-butanol. Calculation of the IR identification score allows more precise interpretation of the results of the identification test in patients with severe anosmia.

Polska wersja testu Sniffin’ Sticks – adaptacja i normalizacja

IntroductionSniffin’ Sticks Test (SST) is a complex smell test, enabling the diagnosis of various aspects of olfactory sensitivity. It is one of the most popular tools for olfactory testing all over the world; however, so far it has not been commonly used in Poland. AimThe presented study had the following aims: assessment of the applicability of the SST in Poland, adaptation of the identification subtest, normalization of the whole battery and comparison of the Polish results to the norms in the original tool. Materials and methodsWe tested olfactory sensitivity of 281 healthy volunteers aged 18–87 years. We used the full version of the SST (threshold, discrimination and identification subtests). ResultsThe results of the presented study are the modified version of the identification test response questionnaire and clearly defined normative values for the Polish people of different ages. Normative values and results in Poland were not significantly different from the previously reported findings for the original, German tool. Additionally, consistent with previous reports, olfactory sensitivity of the eldest group of the Polish people was lower than performance in younger age groups. ConclusionsThe presented findings suggest that the adapted version of the Sniffin’ Sticks Test might be used for both medical and research purposes in Poland.

A Closer Look at Phonology as a Predictor of Spoken Sentence Processing and Word Reading

The goal of this study was to tease apart the roles of phonological awareness (pA) and phonological short-term memory (pSTM) in sentence comprehension, sentence production, and word reading. Children 6- to 10-years of age (N = 377) completed standardized tests of pA ('Elision') and pSTM ('Nonword Repetition') from the Comprehensive Test of Phonological Processing. Concepts and Following Directions (CFD) and Formulated Sentences (FS) were taken from the Clinical Evaluation of Language Fundamentals-Fourth Edition, as measures of sentence comprehension and production, respectively. Children also completed the Word Identification (Word Id) and Word Attack (Word Att) subtests of the Woodcock Reading Mastery Test-Third Edition. Hierarchical multiple regression analyses controlling for age and nonverbal IQ revealed that Elision was the only significant predictor of CFD and FS. While Elision was the strongest predictor of Word Id and Word Att, Nonword Repetition accounted for additional variance in both reading measures. These results emphasize the usefulness of breaking down phonological processing into multiple components and they also have implications language and reading disordered populations.

Olfactory dysfunction in patients with neuromyelitis optica.

Background. Neuromyelitis optica (NMO) is a severely disabling autoimmune disorder of the CNS, which mainly affects the optic nerves and spinal cord. However, recent studies have shown that extra-opticospinal are more common in NMO than previously thought. Objective. To investigate olfactory function (OF) in patients with neuromyelitis optica (NMO) versus healthy controls (HC). Methods. Psychophysical testing of the orthonasal OF was performed using the Threshold-Discrimination-Identification test (TDI), measuring different qualities of olfaction, in 10 unselected NMO patients and 10 HC. Results. Five of 10 NMO patients (50%) showed hyposmia, while all 10 HC were normosmic. Moreover, NMO patients had significantly lower mean TDI-scores compared to HC, based on a poorer performance in both the Discrimination and the Identification subtests. Conclusions. Our results suggest that hyposmia might be part of the expanding clinical spectrum of NMO.

Detecting Different Types of Reading Difficulties: A Comparison of Tests

The focus of this paper is on the assessment of the two main processes that children must acquire at the single word reading level: word recognition (lexical) and decoding (nonlexical) skills. Guided by the framework of the dual route model, this study aimed to (1) investigate the impact of item characteristics on test performance, and (2) determine to what extent widely used reading measures vary in their detection of lexical and nonlexical reading difficulties. Thirty children with reading difficulties were administered selected reading subtests from the Woodcock-Johnson III, the Wechsler Individual Achievement Test – Second Edition, the Castles and Coltheart Reading Test 2 (CC2), as well as a measure of nonverbal IQ. Both within-subjects analyses and descriptive data are presented. Results suggest that in comparison to a pure measure of irregular word reading, children with reading difficulties perform better on word identification subtests containing both regular and irregular word items. Furthermore, certain characteristics (e.g., length, similarity to real words) appear to influence the level of difficulty of nonword items and tests. The CC2 subscales identified the largest proportions of children with reading difficulties. Differences between all test scores were of statistical and clinical significance. Clinical and theoretical implications are discussed.